Recent Publications
Emerging roles of ubiquitin-specific proteases in the cardiovascular system.
Journal Article Mol Pharmacol · November 24, 2025 The universal posttranslational modification ubiquitination was originally discovered in the 1980s as a tag appended to cellular proteins to mark them for degradation by the 26S proteasomal complex. Subsequent discoveries have established ubiquitination as ... Full text Link to item CiteTargeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model.
Journal Article Biomolecules · July 2025 Heart failure (HF) has become an epidemic, with a prevalence of ~7 million cases in the USA. Despite accounting for nearly 50% of all HF cases, heart failure with a preserved ejection fraction (HFpEF) remains challenging to treat. Common pathophysiological ... Full text CiteInflammation-induced endothelial cell activation and angiogenic sprouting are downmodulated by ubiquitin-specific peptidase 20.
Journal Article bioRxiv · May 24, 2025 Nuclear factor-κB (NFκB) mediates inflammation-driven angiogenesis, which promotes growth of atherosclerotic plaques and tumors. The deubiquitinase ubiquitin-specific peptidase 20 (USP20) suppresses NFκB activation in vascular smooth muscle cells (SMCs) an ... Full text Link to item CiteRecent Grants
Engineering a New Class of Therapies for Heart Failure
ResearchPostdoctoral Associate · Awarded by American Heart Association · 2025 - 2030Regulation of myocardial GPCRs by USP20 in normal and hypertrophied heart
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2021 - 2025View All Grants