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Colleen Wu

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery
308 Research Drive, LSRC Rm B329, Durham, NC 27708

Current Appointments & Affiliations


Associate Professor in Orthopaedic Surgery · 2024 - Present Orthopaedic Surgery, Clinical Science Departments
Assistant Research Professor in Cell Biology · 2016 - Present Cell Biology, Basic Science Departments
Assistant Research Professor in Pharmacology and Cancer Biology · 2019 - Present Pharmacology & Cancer Biology, Basic Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published December 5, 2023
Protecting Bones from Cancer Treatment

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Recent Publications


Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells.

Journal Article Sci Transl Med · November 29, 2023 Radiotherapy remains a common treatment modality for cancer despite skeletal complications. However, there are currently no effective treatments for radiation-induced bone loss, and the consequences of radiotherapy on skeletal progenitor cell (SPC) surviva ... Full text Link to item Cite

Utilizing Low Oxygen Tension to Reduce Hematopoietic Cells in Murine Bone Marrow Stromal Cell Cultures.

Journal Article J Vis Exp · April 21, 2023 Currently, there remains a lack of universally accepted markers to prospectively isolate a homogeneous population of skeletal stem cells (SSCs). For this reason, BMSCs, which support hematopoiesis and contribute to all the functions of the skeleton, contin ... Full text Link to item Cite

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2023 The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors. While the pathways controlling normoxic degradatio ... Full text Open Access Cite
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Recent Grants


Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2022 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

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Education, Training & Certifications


University of Toronto (Canada) · 2010 Ph.D.