Current Appointments & Affiliations
Associate Professor in Orthopaedic Surgery
·
2024 - Present
Orthopaedic Surgery,
Clinical Science Departments
Assistant Research Professor in Cell Biology
·
2016 - Present
Cell Biology,
Basic Science Departments
Assistant Research Professor in Pharmacology and Cancer Biology
·
2019 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Radiation-induced bone loss in mice is ameliorated by inhibition of HIF-2α in skeletal progenitor cells.
Journal Article Sci Transl Med · November 29, 2023 Radiotherapy remains a common treatment modality for cancer despite skeletal complications. However, there are currently no effective treatments for radiation-induced bone loss, and the consequences of radiotherapy on skeletal progenitor cell (SPC) surviva ... Full text Link to item CiteUtilizing Low Oxygen Tension to Reduce Hematopoietic Cells in Murine Bone Marrow Stromal Cell Cultures.
Journal Article J Vis Exp · April 21, 2023 Currently, there remains a lack of universally accepted markers to prospectively isolate a homogeneous population of skeletal stem cells (SSCs). For this reason, BMSCs, which support hematopoiesis and contribute to all the functions of the skeleton, contin ... Full text Link to item CiteABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.
Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2023 The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors. While the pathways controlling normoxic degradatio ... Full text Open Access CiteRecent Grants
Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone
ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2022 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Training Program in Developmental and Stem Cell Biology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027View All Grants
Education, Training & Certifications
University of Toronto (Canada) ·
2010
Ph.D.