Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Harvard Medical School 2013 - 2017
  • Ph.D., The Ohio State University College of Medicine 2013
  • D.V.M., University of Madras (India) 2006
• 

  Previous Appointments & Affiliations

  • Medical Instructor in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2021 - 2022
• Research
• 

  Selected Grants

  • Role of eosinophils in SIV infection awarded by National Institutes of Health 2022 - 2024
  • Natural killer cell receptor-expressing B cells as regulators of mucosal immunity in SIV infection awarded by National Institutes of Health 2021 - 2022
  • Microbial and innate immune mechanisms of oral inflammation during SIV infection awarded by National Institutes of Health 2021 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Woolley, Griffin, Matthew Mosher, Kyle Kroll, Rhianna Jones, Brady Hueber, Sho Sugawara, Cordelia Manickam, et al. “Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events.” J Virol 97, no. 1 (January 31, 2023): e0151922. https://doi.org/10.1128/jvi.01519-22.
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    • Rascle, Philippe, Griffin Woolley, Stephanie Jost, Cordelia Manickam, and R Keith Reeves. “NK cell education: Physiological and pathological influences.” Front Immunol 14 (2023): 1087155. https://doi.org/10.3389/fimmu.2023.1087155.
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    • Jones, Rhianna, Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Brady Hueber, Griffin Woolley, Spandan V. Shah, Scott Smith, Valerie Varner, and R Keith Reeves. “Systemic and mucosal mobilization of granulocyte subsets during lentiviral infection.” Immunology 164, no. 2 (October 2021): 348–57. https://doi.org/10.1111/imm.13376.
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    • Jones, Rhianna, Kyle Kroll, Courtney Broedlow, Luca Schifanella, Scott Smith, Brady Hueber, Spandan V. Shah, et al. “Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.” Sci Rep 11, no. 1 (July 15, 2021): 14507. https://doi.org/10.1038/s41598-021-93918-x.
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    • Sugawara, Sho, Cordelia Manickam, and R Keith Reeves. “TRIGGERED: could refocused cell signaling be key to natural killer cell-based HIV immunotherapeutics?” Aids 35, no. 2 (February 2, 2021): 165–76. https://doi.org/10.1097/QAD.0000000000002743.
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    • Manickam, Cordelia, Sho Sugawara, and R Keith Reeves. “Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020.” Plos Pathog 16, no. 8 (August 2020): e1008820. https://doi.org/10.1371/journal.ppat.1008820.
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    • Ram, Daniel R., Christian F. Arias, Kyle Kroll, Brady Hueber, Cordelia Manickam, Rhianna A. Jones, Scott T. Smith, Spandan V. Shah, Valerie H. Varner, and R Keith Reeves. “Characterization of Rhesus Macaque Liver-Resident CD49a+ NK Cells During Retrovirus Infections.” Front Immunol 11 (2020): 1676. https://doi.org/10.3389/fimmu.2020.01676.
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    • Manickam, Cordelia, and R Keith Reeves. “Silent damage? Occult HCV replication and histological disease may occur following apparent HCV clearance.” Ebiomedicine 47 (September 2019): 12–13. https://doi.org/10.1016/j.ebiom.2019.08.029.
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    • Ram, Daniel R., Cordelia Manickam, Olivier Lucar, Spandan V. Shah, and R Keith Reeves. “Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?” J Leukoc Biol 105, no. 6 (June 2019): 1253–59. https://doi.org/10.1002/JLB.MR0718-303R.
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    • Manickam, Cordelia, Haiying Li, Spandan V. Shah, Kyle Kroll, and R Keith Reeves. “Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees.” Int Immunol 31, no. 3 (March 5, 2019): 175–80. https://doi.org/10.1093/intimm/dxy076.
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    • Manickam, Cordelia, Spandan V. Shah, Junsuke Nohara, Guido Ferrari, and R Keith Reeves. “Monkeying Around: Using Non-human Primate Models to Study NK Cell Biology in HIV Infections.” Front Immunol 10 (2019): 1124. https://doi.org/10.3389/fimmu.2019.01124.
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    • Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, and R Keith Reeves. “CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.” Cell Rep 25, no. 10 (December 4, 2018): 2766-2774.e3. https://doi.org/10.1016/j.celrep.2018.11.020.
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    • Manickam, Cordelia, Chiadika Nwanze, Daniel R. Ram, Spandan V. Shah, Scott Smith, Rhianna Jones, Brady Hueber, et al. “Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract.” Aids 32, no. 12 (July 31, 2018): 1571–78. https://doi.org/10.1097/QAD.0000000000001855.
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    • Chettimada, Sukrutha, David R. Lorenz, Vikas Misra, Simon T. Dillon, R Keith Reeves, Cordelia Manickam, Susan Morgello, Gregory D. Kirk, Shruti H. Mehta, and Dana Gabuzda. “Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy.” Sci Rep 8, no. 1 (May 8, 2018): 7227. https://doi.org/10.1038/s41598-018-25515-4.
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    • Ram, Daniel R., Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, and R Keith Reeves. “Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques.” Plos Pathog 14, no. 5 (May 2018): e1007104. https://doi.org/10.1371/journal.ppat.1007104.
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    • Manickam, Cordelia, Spandan V. Shah, Olivier Lucar, Daniel R. Ram, and R Keith Reeves. “Cytokine-Mediated Tissue Injury in Non-human Primate Models of Viral Infections.” Front Immunol 9 (2018): 2862. https://doi.org/10.3389/fimmu.2018.02862.
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    • Manickam, Cordelia, Amanda J. Martinot, Rhianna A. Jones, Valerie Varner, and R Keith Reeves. “Hepatic immunopathology during occult hepacivirus re-infection.” Virology 512 (December 2017): 48–55. https://doi.org/10.1016/j.virol.2017.08.037.
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    • Manickam, Cordelia, Lynn Wachtman, Amanda J. Martinot, Luis D. Giavedoni, and R Keith Reeves. “Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).” Plos One 12, no. 1 (2017): e0170240. https://doi.org/10.1371/journal.pone.0170240.
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    • Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, and R Keith Reeves. “Innate Lymphoid Cells in HIV/SIV Infections.” Front Immunol 8 (2017): 1818. https://doi.org/10.3389/fimmu.2017.01818.
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    • Manickam, Cordelia, Premeela Rajakumar, Lynn Wachtman, Joshua A. Kramer, Amanda J. Martinot, Valerie Varner, Luis D. Giavedoni, and R Keith Reeves. “Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.” J Virol 90, no. 20 (October 15, 2016): 9153–62. https://doi.org/10.1128/JVI.01051-16.
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    • Dwivedi, Varun, Cordelia Manickam, Santosh Dhakal, Basavaraj Binjawadagi, Kang Ouyang, Jagadish Hiremath, Mahesh Khatri, Jacquelyn Gervay Hague, Chang Won Lee, and Gourapura J. Renukaradhya. “Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs.” Vet Microbiol 186 (April 15, 2016): 157–63. https://doi.org/10.1016/j.vetmic.2016.02.028.
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    • Reeves, R Keith, Haiying Li, Stephanie Jost, Eryn Blass, Hualin Li, Jamie L. Schafer, Valerie Varner, et al. “Antigen-specific NK cell memory in rhesus macaques.” Nat Immunol 16, no. 9 (September 2015): 927–32. https://doi.org/10.1038/ni.3227.
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    • Binjawadagi, Basavaraj, Varun Dwivedi, Cordelia Manickam, Kang Ouyang, Jordi B. Torrelles, and Gourapura J. Renukaradhya. “An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination.” Int J Nanomedicine 9 (2014): 1519–35. https://doi.org/10.2147/IJN.S59924.
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    • Binjawadagi, Basavaraj, Varun Dwivedi, Cordelia Manickam, Kang Ouyang, Yun Wu, Ly James Lee, Jordi B. Torrelles, and Gourapura J. Renukaradhya. “Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs.” Int J Nanomedicine 9 (2014): 679–94. https://doi.org/10.2147/IJN.S56127.
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    • Manickam, C., and R. Keith Reeves. “Modeling HCV disease in animals: Virology, immunology and pathogenesis of HCV and GBV-B infections.” Frontiers in Microbiology 5, no. DEC (January 1, 2014). https://doi.org/10.3389/fmicb.2014.00690.
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    • Ouyang, Kang, Shireen A. Woodiga, Varun Dwivedi, Carolyn M. Buckwalter, Anirudh K. Singh, Basavaraj Binjawadagi, Jagadish Hiremath, et al. “Pretreatment of epithelial cells with live Streptococcus pneumoniae has no detectable effect on influenza A virus replication in vitro.” Plos One 9, no. 3 (2014): e90066. https://doi.org/10.1371/journal.pone.0090066.
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    • Dwivedi, Varun, Cordelia Manickam, Basavaraj Binjawadagi, and Gourapura J. Renukaradhya. “PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs.” Vet Microbiol 166, no. 1–2 (September 27, 2013): 47–58. https://doi.org/10.1016/j.vetmic.2013.04.029.
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    • Manickam, Cordelia, Varun Dwivedi, Ruthi Patterson, Tracey Papenfuss, and Gourapura J. Renukaradhya. “Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs.” Vet Microbiol 162, no. 1 (February 22, 2013): 68–77. https://doi.org/10.1016/j.vetmic.2012.08.021.
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    • Manickam, Cordelia, Varun Dwivedi, Jayla Miller, Tracey Papenfuss, and Gourapura J. Renukaradhya. “Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs.” Viral Immunol 26, no. 1 (February 2013): 102–8. https://doi.org/10.1089/vim.2012.0065.
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    • Renukaradhya, Gourapura J., Varun Dwivedi, Cordelia Manickam, Basavaraj Binjawadagi, and David Benfield. “Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective.” Anim Health Res Rev 13, no. 1 (June 2012): 21–37. https://doi.org/10.1017/S1466252312000023.
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    • Dwivedi, Varun, Cordelia Manickam, Basavaraj Binjawadagi, Daniel Linhares, Michael P. Murtaugh, and Gourapura J. Renukaradhya. “Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions.” Virol J 9 (February 16, 2012): 45. https://doi.org/10.1186/1743-422X-9-45.
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    • Dwivedi, Varun, Cordelia Manickam, Basavaraj Binjawadagi, Dechamma Joyappa, and Gourapura J. Renukaradhya. “Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs.” Plos One 7, no. 12 (2012): e51794. https://doi.org/10.1371/journal.pone.0051794.
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    • Binjawadagi, Basavaraj, Varun Dwivedi, Cordelia Manickam, Jordi B. Torrelles, and Gourapura J. Renukaradhya. “Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces ROS production.” Viral Immunol 24, no. 6 (December 2011): 475–82. https://doi.org/10.1089/vim.2011.0040.
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    • Dwivedi, Varun, Cordelia Manickam, Ruthi Patterson, Katie Dodson, Matthew Weeman, and Gourapura J. Renukaradhya. “Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs.” Vaccine 29, no. 23 (May 23, 2011): 4067–76. https://doi.org/10.1016/j.vaccine.2011.03.005.
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    • Dwivedi, Varun, Cordelia Manickam, Ruthi Patterson, Katie Dodson, Michael Murtaugh, Jordi B. Torrelles, Larry S. Schlesinger, and Gourapura J. Renukaradhya. “Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant.” Vaccine 29, no. 23 (May 23, 2011): 4058–66. https://doi.org/10.1016/j.vaccine.2011.03.006.
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    • Renukaradhya, Gourapura J., Cordelia Manickam, Mahesh Khatri, Abdul Rauf, Xiangming Li, Moriya Tsuji, Gireesh Rajashekara, and Varun Dwivedi. “Functional invariant NKT cells in pig lungs regulate the airway hyperreactivity: a potential animal model.” J Clin Immunol 31, no. 2 (April 2011): 228–39. https://doi.org/10.1007/s10875-010-9476-4.
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    • Khatri, Mahesh, Varun Dwivedi, Steven Krakowka, Cordelia Manickam, Ahmed Ali, Leyi Wang, Zhuoming Qin, Gourapura J. Renukaradhya, and Chang-Won Lee. “Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus.” J Virol 84, no. 21 (November 2010): 11210–18. https://doi.org/10.1128/JVI.01211-10.
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  • Conference Papers

    • Manickam, Cordelia, Kyle Kroll, Rhianna Jones, and Roger Reeves. “Single cell based high-throughput Ig and TCR repertoire sequencing analysis in rhesus macaques.” In Journal of Medical Primatology, 51:292–93, 2022.
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    • Manickam, Cordelia, Kyle Kroll, Rhianna Jones, and Roger Reeves. “Multiplex imaging and analysis of novel natural killer-like B cells in non-human primates.” In Journal of Medical Primatology, 51:292–292, 2022.
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