Scholars@Duke
Cristine Radojicic
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Selected Publications

Hereditary angioedema with normal C1 esterase inhibitor: Current paradigms and clinical dilemmas.

Journal Article Allergy Asthma Proc · May 1, 2024 Background: A diagnosis of hereditary angioedema (HAE) with normal C1 esterase inhibitor (HAE-nl-C1-INH) can be challenging and pharmacologic management is not well defined. Objective: The objective was to discuss practical considerations in the clinical m ... Full text Link to item Cite

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.

Journal Article JAMA internal medicine · September 2023 ImportanceFewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard of care to remove the penicillin allergy label in adults is specialized testing involving prick and intradermal skin testing followed by an oral ... Full text Open Access Cite

Guidelines for management of hereditary angioedema: What is new? What is missing?

Journal Article Allergy Asthma Proc · January 1, 2022 Background: Hereditary angioedema is an autosomal dominant disease that presents with recurrent episodic swelling of the submucosal and/or subcutaneous tissues of the cutaneous, gastrointestinal, and respiratory systems. Evaluation and treatment guidelines ... Full text Link to item Cite

Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital.

Journal Article JAMA Netw Open · May 3, 2021 IMPORTANCE: Penicillin allergies are frequently mislabeled, which may contribute to use of less-preferred alternative antibiotics. OBJECTIVE: To evaluate a pharmacist-led allergy assessment program's association with antimicrobial use and clinical outcomes ... Full text Link to item Cite

Caregivers' role in managing hereditary angioedema and perceptions of treatment-related burden.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare genetic disease that results in recurrent, debilitating, and potentially life-threatening swelling episodes in the extremities, genitals, gastrointestinal tract, and upper airway. Patients can experience significant bu ... Full text Link to item Cite

Physician and patient perspectives on the management of hereditary angioedema: a survey on treatment burden and needs.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare disorder caused by genetic mutations that lead to recurrent episodes of swelling in various parts of the body. Prophylactic treatment is common for patients with HAE, and the therapeutic options have expanded in recent ... Full text Link to item Cite

Patient perspectives on the treatment burden of injectable medication for hereditary angioedema.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare, chronic disease characterized by debilitating swelling episodes in various parts of the body. Patients experience significant burdens related to the symptoms and management of HAE, which can affect their daily lives a ... Full text Link to item Cite

Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report.

Journal Article Allergy Asthma Clin Immunol · April 19, 2021 BACKGROUND: Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimize care for patients with HAE, an in ... Full text Link to item Cite

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.

Journal Article Allergy · November 2020 BACKGROUND: Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study. OBJECTIVE: To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study ... Full text Link to item Cite

Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature Review.

Journal Article J Allergy Clin Immunol Pract · June 2020 Consensus guidelines recommend plasma-derived C1 inhibitor (C1-INH) as first-line treatment in pregnant women with hereditary angioedema (HAE). We conducted a systematic review of the literature that describes experience with plasma-derived C1-INH during p ... Full text Link to item Cite

Hereditary angioedema with normal C1 esterase inhibitor: Current paradigms and clinical dilemmas.

Journal Article Allergy Asthma Proc · May 1, 2024 Background: A diagnosis of hereditary angioedema (HAE) with normal C1 esterase inhibitor (HAE-nl-C1-INH) can be challenging and pharmacologic management is not well defined. Objective: The objective was to discuss practical considerations in the clinical m ... Full text Link to item Cite

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.

Journal Article JAMA internal medicine · September 2023 ImportanceFewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard of care to remove the penicillin allergy label in adults is specialized testing involving prick and intradermal skin testing followed by an oral ... Full text Open Access Cite

Guidelines for management of hereditary angioedema: What is new? What is missing?

Journal Article Allergy Asthma Proc · January 1, 2022 Background: Hereditary angioedema is an autosomal dominant disease that presents with recurrent episodic swelling of the submucosal and/or subcutaneous tissues of the cutaneous, gastrointestinal, and respiratory systems. Evaluation and treatment guidelines ... Full text Link to item Cite

Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital.

Journal Article JAMA Netw Open · May 3, 2021 IMPORTANCE: Penicillin allergies are frequently mislabeled, which may contribute to use of less-preferred alternative antibiotics. OBJECTIVE: To evaluate a pharmacist-led allergy assessment program's association with antimicrobial use and clinical outcomes ... Full text Link to item Cite

Caregivers' role in managing hereditary angioedema and perceptions of treatment-related burden.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare genetic disease that results in recurrent, debilitating, and potentially life-threatening swelling episodes in the extremities, genitals, gastrointestinal tract, and upper airway. Patients can experience significant bu ... Full text Link to item Cite

Physician and patient perspectives on the management of hereditary angioedema: a survey on treatment burden and needs.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare disorder caused by genetic mutations that lead to recurrent episodes of swelling in various parts of the body. Prophylactic treatment is common for patients with HAE, and the therapeutic options have expanded in recent ... Full text Link to item Cite

Patient perspectives on the treatment burden of injectable medication for hereditary angioedema.

Journal Article Allergy Asthma Proc · May 1, 2021 Hereditary angioedema (HAE) is a rare, chronic disease characterized by debilitating swelling episodes in various parts of the body. Patients experience significant burdens related to the symptoms and management of HAE, which can affect their daily lives a ... Full text Link to item Cite

Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report.

Journal Article Allergy Asthma Clin Immunol · April 19, 2021 BACKGROUND: Hereditary angioedema (HAE) is a rare disease characterized by unpredictable, potentially life-threatening attacks, resulting in significant physical and emotional burdens for patients and families. To optimize care for patients with HAE, an in ... Full text Link to item Cite

Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.

Journal Article Allergy · November 2020 BACKGROUND: Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study. OBJECTIVE: To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study ... Full text Link to item Cite

Experience with Intravenous Plasma-Derived C1-Inhibitor in Pregnant Women with Hereditary Angioedema: A Systematic Literature Review.

Journal Article J Allergy Clin Immunol Pract · June 2020 Consensus guidelines recommend plasma-derived C1 inhibitor (C1-INH) as first-line treatment in pregnant women with hereditary angioedema (HAE). We conducted a systematic review of the literature that describes experience with plasma-derived C1-INH during p ... Full text Link to item Cite

Reply.

Journal Article J Allergy Clin Immunol Pract · April 2019 Full text Link to item Cite

LIVER CIRRHOSIS AND WEIGHT LOSS AS PRESENTING FEATURES OF SYSTEMIC MASTOCYTOSIS

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2016 Link to item Cite

ANAPHYLAXIS AFTER A LABORATORY RAT BITE

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2016 Link to item Cite

Omalizumab use during pregnancy for CIU: a tertiary care experience.

Journal Article Eur Ann Allergy Clin Immunol · July 2016 The treatment of antihistamine and steroid resistant Chronic Idiopathic Urticaria (CIU) during pregnancy poses a challenge due to teratogenicity of immunosuppressants. Omalizumab is a recently FDA approved therapy for CIU and is classified as pregnancy cat ... Link to item Cite

A RARE CASE OF IMMEDIATE HYPERSENSITIVITY REACTION TO A HAIR-BLEACHING PRODUCT

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2015 Link to item Cite

Penicillin allergy: A practical guide for clinicians.

Journal Article Cleveland Clinic journal of medicine · May 2015 Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as 'penicillin-allergic' are able to tolerat ... Full text Cite

IGE-MEDIATED ALLERGY TO BACITRACIN: KEY CONCEPTS ILLUSTRATED VIA A CASE SERIES.

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2014 Link to item Cite

BUCKWHEAT ALLERGY- NEW ALLERGEN TO WATCH IN THE US

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2012 Link to item Cite

BUCK WHEAT ALLERGY-NEW ALLERGEN TO WATCH IN THE US.

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2012 Link to item Cite

Utility of routine laboratory testing in management of chronic urticaria/angioedema.

Journal Article Ann Allergy Asthma Immunol · September 2011 BACKGROUND: Laboratory tests are routinely ordered to identify or rule out a cause in patients with chronic urticaria/angioedema (CUA). The results of these tests are usually within normal limits or unremarkable. OBJECTIVE: To investigate the proportion of ... Full text Link to item Cite

Safety Of Allergen Immunotherapy On College Campuses

Conference Journal of Allergy and Clinical Immunology · February 2011 Full text Cite

Glatiramer acetate: successful desensitization for treatment of multiple sclerosis.

Journal Article Ann Allergy Asthma Immunol · April 2010 BACKGROUND: Glatiramer acetate is an immunomodulatory drug that is widely prescribed for the treatment of multiple sclerosis. It is frequently associated with local injection site reactions and generalized urticaria. It is also associated with immediate po ... Full text Link to item Cite

Allergy Fellowship Training: Developing Educators and Life-long Learners

Conference Journal of Allergy and Clinical Immunology · February 2010 Full text Cite

Sinusitis

Chapter · January 1, 2010 Full text Cite

DETERMINING TRUE PENICILLIN ALLERGY IN PRE-LUNG TRANSPLANT PATIENTS

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · November 1, 2009 Link to item Cite

Utility Of Routine Laboratory Testing In Management Of Chronic Urticaria/Angioedema

Journal Article Journal of Allergy and Clinical Immunology · February 2009 Full text Cite

Analysis of adherence to immunotherapy

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · January 1, 2008 Link to item Cite

Declining immunoglobulin levels in a patient with diffuse interstitial lung disease

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · January 1, 2008 Link to item Cite

Allergic reaction to flaxseed in a "hypo-allergenic" cereal.

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · January 1, 2007 Link to item Cite

Toxic Shock Syndrome as a differential diagnosis of rash and hypogammaglobulinemia.

Conference ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY · January 1, 2007 Link to item Cite

Sinusitis: allergies, antibiotics, aspirin, asthma.

Journal Article Cleve Clin J Med · July 2006 Sinusitis is very common, so it is important to understand its pathophysiology, diagnosis, and medical and surgical treatments. In cases of chronic sinusitis, adjunctive therapies and evaluation by subspecialists may be warranted. Some special testing is n ... Full text Link to item Cite

MANAGEMENT OF GLATIRAMER (COPAXONE) REACTIONS: EXPERIENCE WITH DESENSITIZATION.

Conference Journal of Investigative Medicine · January 2004 Full text Cite

A prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit.

Journal Article Infect Control Hosp Epidemiol · May 2003 BACKGROUND: Patients with penicillin allergy admitted to the intensive care unit (ICU) frequently receive non-beta-lactam antimicrobials for the treatment of infection. The use of these antimicrobials, more commonly vancomycin and fluoroquinolones, is asso ... Full text Link to item Cite