Overview
Dr. Gonzalez’s experiences have afforded a highly collaborative and multidisciplinary research program focused on advancing public health by promoting the safe, effective, and individualized use of drugs, with an emphasis on pediatric populations. His research interests include clinical pharmacology and applying mathematical modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of drugs, guide drug dosage selection, and improve drug safety. Dr. Gonzalez’s research program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and he has published >115 peer-reviewed publications and >40 abstracts. He has been the major advisor for 8 PhD students (5 completed, 3 in training) and 15 postdoctoral fellows.
Current Appointments & Affiliations
Recent Publications
Population Pharmacokinetics of Caffeine in Infants with Hypoxic-Ischemic Encephalopathy: A Phase I, Dose-Escalating Trial.
Journal Article J Clin Pharmacol · July 2025 The mainstay of treatment for infants with hypoxic-ischemic encephalopathy (HIE) is cooling. Caffeine may be an important adjunct to cooling and provide neuroprotection via its anti-inflammatory and anti-oxidative properties. This study aimed to characteri ... Full text Link to item CiteExploring the Influence of Obesity and CYP2 C19 Genotype on Lansoprazole Pharmacokinetics in Pediatric Patients: A Population Modeling Approach.
Journal Article Clin Pharmacokinet · July 2025 BACKGROUND AND OBJECTIVE: Pediatric pharmacokinetics pose unique challenges, particularly concerning drug dosing in the presence of obesity and genetic variability in drug-metabolizing enzymes such as cytochrome P450 (CYP) 2C19. This study aimed to develop ... Full text Link to item CiteLeveraging In Silico and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan.
Journal Article Clin Transl Sci · June 2025 Incorporating inter-individual differences in drug disposition and responses is essential for ensuring the safe and effective use of drugs in real-world patients. Despite ongoing efforts, lower participation of children, older individuals, pregnant and bre ... Full text Link to item CiteRecent Grants
Best Pharmaceuticals for Children Act Pediatric Trials Network
ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2032Real-world Data Enables Pharmacokinetic/Pharmacodynamic Drug Dosing in Critically Ill Children
ResearchCo-Mentor · Awarded by National Institutes of Health · 2025 - 2029National Career Development Program for Researchers in Pediatric Clinical Pharmacology
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2028View All Grants