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Daniel Gonzalez

Associate Professor in Medicine
Medicine, Clinical Pharmacology
P.O. Box 17969, Duke Clinical Reserach Institute, Durham, NC 27715
300 W. Morgan Street, Durham, NC 27701

Overview


Dr. Daniel Gonzalez is an Associate Professor in the Division of Clinical Pharmacology of the Department of Medicine at the Duke University School of Medicine, and a member of the Duke Clinical Research Institute. He also has a secondary appointment in the Department of Pharmacology and Cancer Biology. Dr. Gonzalez received his PharmD and PhD from the University of Florida College of Pharmacy in 2008 and 2012, respectively. He then completed a postdoctoral fellowship through the UNC-Duke Collaborative Clinical Pharmacology T32 Postdoctoral Training Program. Following completion of his post-doctoral training, Dr. Gonzalez served as a faculty member at the UNC Eshelman School of Pharmacy between 2014 and 2023 and moved to Duke University in 2023. 

Dr. Gonzalez’s experiences have afforded a highly collaborative and multidisciplinary research program focused on advancing public health by promoting the safe, effective, and individualized use of drugs, with an emphasis on pediatric populations. His research interests include clinical pharmacology and applying mathematical modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of drugs, guide drug dosage selection, and improve drug safety. Dr. Gonzalez’s research program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and he has published >115 peer-reviewed publications and >40 abstracts. He has been the major advisor for 8 PhD students (5 completed, 3 in training) and 15 postdoctoral fellows.

Current Appointments & Affiliations


Associate Professor in Medicine · 2024 - Present Medicine, Clinical Pharmacology, Medicine
Associate Professor in Pharmacology and Cancer Biology · 2024 - Present Pharmacology & Cancer Biology, Basic Science Departments
Member in the Duke Clinical Research Institute · 2023 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Population Pharmacokinetics of Caffeine in Infants with Hypoxic-Ischemic Encephalopathy: A Phase I, Dose-Escalating Trial.

Journal Article J Clin Pharmacol · July 2025 The mainstay of treatment for infants with hypoxic-ischemic encephalopathy (HIE) is cooling. Caffeine may be an important adjunct to cooling and provide neuroprotection via its anti-inflammatory and anti-oxidative properties. This study aimed to characteri ... Full text Link to item Cite

Exploring the Influence of Obesity and CYP2 C19 Genotype on Lansoprazole Pharmacokinetics in Pediatric Patients: A Population Modeling Approach.

Journal Article Clin Pharmacokinet · July 2025 BACKGROUND AND OBJECTIVE: Pediatric pharmacokinetics pose unique challenges, particularly concerning drug dosing in the presence of obesity and genetic variability in drug-metabolizing enzymes such as cytochrome P450 (CYP) 2C19. This study aimed to develop ... Full text Link to item Cite

Leveraging In Silico and Artificial Intelligence Models to Advance Drug Disposition and Response Predictions Across the Lifespan.

Journal Article Clin Transl Sci · June 2025 Incorporating inter-individual differences in drug disposition and responses is essential for ensuring the safe and effective use of drugs in real-world patients. Despite ongoing efforts, lower participation of children, older individuals, pregnant and bre ... Full text Link to item Cite
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Recent Grants


Best Pharmaceuticals for Children Act Pediatric Trials Network

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2032

Real-world Data Enables Pharmacokinetic/Pharmacodynamic Drug Dosing in Critically Ill Children

ResearchCo-Mentor · Awarded by National Institutes of Health · 2025 - 2029

National Career Development Program for Researchers in Pediatric Clinical Pharmacology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2028

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Education, Training & Certifications


University of Florida · 2012 Ph.D.
University of Florida · 2008 Pharm.D.