Overview
Dr. Gonzalez’s experiences have afforded a highly collaborative and multidisciplinary research program focused on advancing public health by promoting the safe, effective, and individualized use of drugs, with an emphasis on pediatric populations. His research interests include clinical pharmacology and applying mathematical modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of drugs, guide drug dosage selection, and improve drug safety. Dr. Gonzalez’s research program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and he has published >115 peer-reviewed publications and >40 abstracts. He has been the major advisor for 8 PhD students (5 completed, 3 in training) and 15 postdoctoral fellows.
Current Appointments & Affiliations
Recent Publications
Training the Next Generation of Pediatric Clinical Pharmacologists: Insights and Trainee Perspectives Over 10 Years.
Journal Article J Clin Pharmacol · March 2025 The limited number of researchers with expertise necessary toaddress treatment gaps for children presents an ongoing challenge. The NationalInstitutes of Health established a national Pediatric Clinical Pharmacology T32Training Program in 2012 to train a m ... Full text Link to item CitePopulation Pharmacokinetics of Caffeine in Infants with Hypoxic-Ischemic Encephalopathy: A Phase I, Dose-Escalating Trial.
Journal Article J Clin Pharmacol · February 12, 2025 The mainstay of treatment for infants with hypoxic-ischemic encephalopathy (HIE) is cooling. Caffeine may be an important adjunct to cooling and provide neuroprotection via its anti-inflammatory and anti-oxidative properties. This study aimed to characteri ... Full text Link to item CitePharmacokinetics of Dexamethasone in Children and Adolescents with Obesity.
Journal Article Journal of clinical pharmacology · December 2024 Dexamethasone is a synthetic glucocorticoid approved for treating disorders of various organ systems in both adult and pediatric populations. Currently, approved pediatric dosing recommendations are weight-based, but it is unknown whether differences in de ... Full text CiteRecent Grants
Real-world Data Enables Pharmacokinetic/Pharmacodynamic Drug Dosing in Critically Ill Children
ResearchCo-Mentor · Awarded by National Institutes of Health · 2025 - 2029National Career Development Program for Researchers in Pediatric Clinical Pharmacology
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2028Pharmacokinetic and pharmacodynamic study of montelukast in premature infants with BPD (PRISM)
ResearchPD/PI · Awarded by National Institutes of Health · 2023 - 2028View All Grants