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David Wayne Van Wyck

Assistant Consulting Professor in the Department of Neurology
Neurology, Neurocritical Care
40 Medicine Circle, Box 3824, Durham, NC 27710
40 Medicine Circle, Box 3824, Durham, NC 27710

Selected Publications

ApoE Mimetic Peptides as Therapy for Traumatic Brain Injury.

Journal Article Neurotherapeutics · October 2023 The lack of targeted therapies for traumatic brain injury (TBI) remains a compelling clinical unmet need. Although knowledge of the pathophysiologic cascades involved in TBI has expanded rapidly, the development of novel pharmacological therapies has remai ... Full text Link to item Cite

Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.

Journal Article Exp Brain Res · September 2022 The treatment of traumatic brain injury (TBI) in military populations is hindered by underreporting and underdiagnosis. Clinical symptoms and outcomes may be mitigated with an effective pre-injury prophylaxis. This study evaluates whether CN-105, a 5-amino ... Full text Link to item Cite

Associations between Features of External Ventricular Drain Management, Disposition, and Shunt Dependence

Journal Article Journal of Neuroanaesthesiology and Critical Care · March 1, 2021 Background In the United States, nearly 25,000 patients annually undergo percutaneous ventriculostomy for the management of increased intracranial pressure with little consensus on extraventricular drain management. To characterize relationships between ex ... Full text Open Access Cite

23.4% Hypertonic Saline: A Tactical Option for the Management of Severe Traumatic Brain Injury With Impending or Ongoing Herniation.

Journal Article J Spec Oper Med · 2021 There are limited options available to the combat medic for management of traumatic brain injury (TBI) with impending or ongoing herniation. Current pararescue and Tactical Combat Casualty Care (TCCC) guidelines prescribe a bolus of 3% or 5% hypertonic sal ... Full text Link to item Cite

Beyond the burn: Studies on the physiological effects of flamethrowers during World War II.

Journal Article Mil Med Res · February 27, 2020 Flamethrowers are widely considered one of warfare's most controversial weapons and are capable of inflicting gruesome physical injuries and intense psychological trauma. Despite being the last of the major combatants in World War II (WWII) to develop them ... Full text Open Access Link to item Cite

The Prehospital Evaluation and Care of Moderate/Severe TBI in the Austere Environment.

Conference Mil Med · January 7, 2020 Increased resource constraints secondary to a smaller medical footprint, prolonged evacuation times, or overwhelming casualty volumes all increase the challenges of effective management of traumatic brain injury (TBI) in the austere environment. Prehospita ... Full text Link to item Cite

Lower Extremity Compartment Syndrome From Prolonged Limb Compression and Immobilization During an Airborne Operation.

Journal Article J Spec Oper Med · 2016 Acute compartment syndrome (ACS) involving the leg can occur in association with various traumatic and nontraumatic conditions, and it can have serious longterm consequences when unrecognized or untreated. Nontraumatic causes of ACS, such as those associat ... Full text Link to item Cite