Overview
The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level. We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors that give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.
Current Appointments & Affiliations
Assistant Professor of Neurobiology
·
2022 - Present
Neurobiology,
Basic Science Departments
Assistant Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Publications
Circuit-specific gene editing for precision modulation of neuronal activity with CRISPR-rabies virus.
Journal Article bioRxiv · November 7, 2025 CRISPR gene editing has revolutionized our ability to study and manipulate specific genes, enabling novel insights into gene function and potential therapies for brain disorders. Recent advances in cell-type-specific regulatory elements and viral delivery ... Full text Link to item CiteSingle-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.
Journal Article Nat Commun · July 4, 2025 Duplication 15q (dup15q) syndrome is a leading genetic cause of autism spectrum disorder, offering a key model for studying autism-related mechanisms. Using single-cell and single-nucleus RNA sequencing of cortical organoids from dup15q patient-derived iPS ... Full text Link to item CiteGPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury.
Journal Article Neuron · April 16, 2025 Astrocytes in the spinal cord dorsal horn (SDH) play a pivotal role in synaptic transmission and neuropathic pain. However, the precise classification of SDH astrocytes in health and disease remains elusive. Here, we reveal Gpr37l1 as a marker and function ... Full text Link to item CiteRecent Grants
Dissecting and modulating cell type and circuit-specific epigenetic mechanisms of cocaine addiction
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE
ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029View All Grants
Education, Training & Certifications
University of Miami ·
2016
Ph.D.