Overview
The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level. We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors that give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.
Current Appointments & Affiliations
Assistant Professor of Neurobiology
·
2022 - Present
Neurobiology,
Basic Science Departments
Assistant Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Publications
GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury.
Journal Article Neuron · April 16, 2025 Astrocytes in the spinal cord dorsal horn (SDH) play a pivotal role in synaptic transmission and neuropathic pain. However, the precise classification of SDH astrocytes in health and disease remains elusive. Here, we reveal Gpr37l1 as a marker and function ... Full text Link to item CiteProximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.
Journal Article Nat Commun · August 9, 2024 One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism ri ... Full text Link to item CiteSingle molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
Journal Article Mol Neurodegener · June 11, 2024 BACKGROUND: LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson's disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of immunological res ... Full text Link to item CiteRecent Grants
Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Distal mRNA localization and translation in neural stem cells of the developing brain
ResearchCollaborator · Awarded by National Institutes of Health · 2018 - 2028View All Grants
Education, Training & Certifications
University of Miami ·
2016
Ph.D.