Dmitry Velmeshev | Scholars@Duke

Dmitry Velmeshev
Assistant Professor of Neurobiology

The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level. We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors that give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.

Current Appointments & Affiliations

Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2022

Contact Information

dmitry.velmeshev@duke.edu

Background
Education, Training, & Certifications
- Ph.D., University of Miami 2016
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Analysis of epigenetic and neuronal circuit changes in autism on the single-cell level awarded by National Institutes of Health 2022 - 2025
- Understanding the role of epigenetic regulation during human neural lineage commitment awarded by Brain Research Foundation 2023 - 2025
External Relationships
- Galvanize Therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Marsan, Elise, Dmitry Velmeshev, Arren Ramsey, Ravi K. Patel, Jiasheng Zhang, Mark Koontz, Madeline G. Andrews, et al. “Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.” J Clin Invest 133, no. 6 (March 15, 2023). https://doi.org/10.1172/JCI164919.
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  - Trobisch, Tim, Amel Zulji, Nikolas A. Stevens, Sophia Schwarz, Sven Wischnewski, Mikail Öztürk, Javier Perales-Patón, et al. “Cross-regional homeostatic and reactive glial signatures in multiple sclerosis.” Acta Neuropathol 144, no. 5 (November 2022): 987–1003. https://doi.org/10.1007/s00401-022-02497-2.
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  - Andrews, Madeline G., Tanzila Mukhtar, Ugomma C. Eze, Camille R. Simoneau, Jayden Ross, Neelroop Parikshak, Shaohui Wang, et al. “Tropism of SARS-CoV-2 for human cortical astrocytes.” Proc Natl Acad Sci U S A 119, no. 30 (July 26, 2022): e2122236119. https://doi.org/10.1073/pnas.2122236119.
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  - Zhang, Jiasheng, Dmitry Velmeshev, Kei Hashimoto, Yu-Hsin Huang, Jeffrey W. Hofmann, Xiaoyu Shi, Jiapei Chen, et al. “Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.” Nature 588, no. 7838 (December 2020): 459–65. https://doi.org/10.1038/s41586-020-2709-7.
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  - Huang, Wei, Aparna Bhaduri, Dmitry Velmeshev, Shaohui Wang, Li Wang, Catherine A. Rottkamp, Arturo Alvarez-Buylla, David H. Rowitch, and Arnold R. Kriegstein. “Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.” Cell 182, no. 3 (August 6, 2020): 594-608.e11. https://doi.org/10.1016/j.cell.2020.06.027.
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  - Herrero, Maria Jesus, Dmitry Velmeshev, David Hernandez-Pineda, Saarthak Sethi, Shawn Sorrells, Payal Banerjee, Catherine Sullivan, Abha R. Gupta, Arnold R. Kriegstein, and Joshua G. Corbin. “Identification of amygdala-expressed genes associated with autism spectrum disorder.” Mol Autism 11, no. 1 (May 27, 2020): 39. https://doi.org/10.1186/s13229-020-00346-1.
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  - Velmeshev, Dmitry, Marco Magistri, Emilia Maria Cristina Mazza, Patrick Lally, Nathalie Khoury, Evan Ross D’Elia, Silvio Bicciato, and Mohammad Ali Faghihi. “Cell-Type-Specific Analysis of Molecular Pathology in Autism Identifies Common Genes and Pathways Affected Across Neocortical Regions.” Mol Neurobiol 57, no. 5 (May 2020): 2279–89. https://doi.org/10.1007/s12035-020-01879-5.
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  - Bhaduri, Aparna, Elizabeth Di Lullo, Diane Jung, Sören Müller, Elizabeth Erin Crouch, Carmen Sandoval Espinosa, Tomoko Ozawa, et al. “Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.” Cell Stem Cell 26, no. 1 (January 2, 2020): 48-63.e6. https://doi.org/10.1016/j.stem.2019.11.015.
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  - Schirmer, Lucas, Dmitry Velmeshev, Staffan Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, et al. “Neuronal vulnerability and multilineage diversity in multiple sclerosis.” Nature 573, no. 7772 (September 2019): 75–82. https://doi.org/10.1038/s41586-019-1404-z.
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  - Sorrells, Shawn F., Mercedes F. Paredes, Dmitry Velmeshev, Vicente Herranz-Pérez, Kadellyn Sandoval, Simone Mayer, Edward F. Chang, et al. “Immature excitatory neurons develop during adolescence in the human amygdala.” Nat Commun 10, no. 1 (June 21, 2019): 2748. https://doi.org/10.1038/s41467-019-10765-1.
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  - Velmeshev, Dmitry, Lucas Schirmer, Diane Jung, Maximilian Haeussler, Yonatan Perez, Simone Mayer, Aparna Bhaduri, Nitasha Goyal, David H. Rowitch, and Arnold R. Kriegstein. “Single-cell genomics identifies cell type-specific molecular changes in autism.” Science 364, no. 6441 (May 17, 2019): 685–89. https://doi.org/10.1126/science.aav8130.
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  - Mayer, Simone, Jiadong Chen, Dmitry Velmeshev, Andreas Mayer, Ugomma C. Eze, Aparna Bhaduri, Carlos E. Cunha, et al. “Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.” Neuron 102, no. 1 (April 3, 2019): 143-158.e7. https://doi.org/10.1016/j.neuron.2019.01.027.
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  - Nowakowski, Tomasz J., Aparna Bhaduri, Alex A. Pollen, Beatriz Alvarado, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, Maximilian Haeussler, et al. “Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.” Science 358, no. 6368 (December 8, 2017): 1318–23. https://doi.org/10.1126/science.aap8809.
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  - Sartor, Gregory C., Samuel K. Powell, Dmitry Velmeshev, David Y. Lin, Marco Magistri, Hannah J. Wiedner, Andrea M. Malvezzi, Nadja S. Andrade, Mohammad A. Faghihi, and Claes Wahlestedt. “Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens.” Mol Cell Neurosci 85 (December 2017): 183–89. https://doi.org/10.1016/j.mcn.2017.10.003.
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  - Grieco, Steven F., Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Mohammad A. Faghihi, Richard S. Jope, and Eleonore Beurel. “Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3.” World J Biol Psychiatry 18, no. 6 (September 2017): 445–56. https://doi.org/10.1080/15622975.2016.1224927.
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  - Chang, Kun-Che, Jonathan Hertz, Xiong Zhang, Xiao-Lu Jin, Peter Shaw, Brooke A. Derosa, Janet Y. Li, et al. “Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.” J Neurosci 37, no. 19 (May 10, 2017): 4967–81. https://doi.org/10.1523/JNEUROSCI.3430-13.2017.
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  - Pardo, Marta, Yuyan Cheng, Dmitry Velmeshev, Marco Magistri, Hagit Eldar-Finkelman, Ana Martinez, Mohammad A. Faghihi, Richard S. Jope, and Eleonore Beurel. “Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.” Jci Insight 2, no. 6 (March 23, 2017): e91782. https://doi.org/10.1172/jci.insight.91782.
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  - Magistri, Marco, Nathalie Khoury, Emilia Maria Cristina Mazza, Dmitry Velmeshev, Jae K. Lee, Silvio Bicciato, Pantelis Tsoulfas, and Mohammad Ali Faghihi. “A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells.” Eur J Neurosci 44, no. 10 (November 2016): 2858–70. https://doi.org/10.1111/ejn.13382.
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  - Peschansky, Veronica J., Chiara Pastori, Zane Zeier, Katya Wentzel, Dmitry Velmeshev, Marco Magistri, José P. Silva, and Claes Wahlestedt. “The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.” Mol Cell Neurosci 74 (July 2016): 49–57. https://doi.org/10.1016/j.mcn.2016.03.008.
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  - Velmeshev, Dmitry, Patrick Lally, Marco Magistri, and Mohammad Ali Faghihi. “CANEapp: a user-friendly application for automated next generation transcriptomic data analysis.” Bmc Genomics 17 (January 13, 2016): 49. https://doi.org/10.1186/s12864-015-2346-y.
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  - Magistri, Marco, Dmitry Velmeshev, Madina Makhmutova, Prutha Patel, Gregory C. Sartor, Claude-Henry Volmar, Claes Wahlestedt, and Mohammad Ali Faghihi. “The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.” Curr Alzheimer Res 13, no. 9 (2016): 985–95. https://doi.org/10.2174/1567205013666160427101832.
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  - Bobkova, Natalia V., Mikhail Evgen’ev, David G. Garbuz, Alexei M. Kulikov, Alexei Morozov, Alexander Samokhin, Dmitri Velmeshev, et al. “Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.” Proc Natl Acad Sci U S A 112, no. 52 (December 29, 2015): 16006–11. https://doi.org/10.1073/pnas.1516131112.
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  - Trakhtenberg, Ephraim F., Melina I. Morkin, Karan H. Patel, Stephanie G. Fernandez, Alan Sang, Peter Shaw, Xiongfei Liu, et al. “The N-terminal Set-β Protein Isoform Induces Neuronal Death.” J Biol Chem 290, no. 21 (May 22, 2015): 13417–26. https://doi.org/10.1074/jbc.M114.633883.
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  - Magistri, Marco, Dmitry Velmeshev, Madina Makhmutova, and Mohammad Ali Faghihi. “Transcriptomics Profiling of Alzheimer's Disease Reveal Neurovascular Defects, Altered Amyloid-β Homeostasis, and Deregulated Expression of Long Noncoding RNAs.” J Alzheimers Dis 48, no. 3 (2015): 647–65. https://doi.org/10.3233/JAD-150398.
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  - Peschansky, Veronica J., Chiara Pastori, Zane Zeier, Dario Motti, Katya Wentzel, Dmitry Velmeshev, Marco Magistri, et al. “Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.” Front Genet 6 (2015): 263. https://doi.org/10.3389/fgene.2015.00263.
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  - Fatemi, Roya Pedram, Dmitry Velmeshev, and Mohammad Ali Faghihi. “De-repressing LncRNA-Targeted Genes to Upregulate Gene Expression: Focus on Small Molecule Therapeutics.” Mol Ther Nucleic Acids 3, no. 11 (November 18, 2014): e196. https://doi.org/10.1038/mtna.2014.45.
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  - Slepak, Vladlen, Alexey Pronin, Konstantin Levay, Dmitry Velmeshev, Mohammad Faghihi, and Valery Shestopalov. “Expression of olfactory GPCR signaling genes in the eye (662.15).” The Faseb Journal 28, no. S1 (April 2014). https://doi.org/10.1096/fasebj.28.1_supplement.662.15.
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  - Pronin, Alexey, Konstantin Levay, Dmitry Velmeshev, Mohammad Faghihi, Valery I. Shestopalov, and Vladlen Z. Slepak. “Expression of olfactory signaling genes in the eye.” Plos One 9, no. 4 (2014): e96435. https://doi.org/10.1371/journal.pone.0096435.
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  - Velmeshev, Dmitry, Marco Magistri, and Mohammad Ali Faghihi. “Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders.” Mol Autism 4, no. 1 (September 4, 2013): 32. https://doi.org/10.1186/2040-2392-4-32.
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  - Park, June-Hee, Zachary Glass, Kasim Sayed, Tatyana V. Michurina, Alexander Lazutkin, Olga Mineyeva, Dmitry Velmeshev, Walter F. Ward, Arlan Richardson, and Grigori Enikolopov. “Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain.” Eur J Neurosci 37, no. 12 (June 2013): 1987–93. https://doi.org/10.1111/ejn.12249.
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- Book Sections
  - Magistri, Marco, and Dmitry Velmeshev. “Identification of Long Noncoding RNAs Associated to Human Disease Susceptibility.,” 1543:197–208, 2017. https://doi.org/10.1007/978-1-4939-6716-2_10.
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  - Pastori, Chiara, Dmitry Velmeshev, and Veronica Julia Peschansky. “Deep-RACE: Comprehensive Search for Novel ncRNAs Associated to a Specific Locus.,” 1543:129–43, 2017. https://doi.org/10.1007/978-1-4939-6716-2_6.
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- Preprints
  - Velmeshev, Dmitry, Yonatan Perez, Zihan Yan, Jonathan E. Valencia, David R. Castaneda-Castellanos, Lucas Schirmer, Simone Mayer, et al. “Single-cell analysis of prenatal and postnatal human cortical development.” Cold Spring Harbor Laboratory, October 25, 2022. https://doi.org/10.1101/2022.10.24.513555.
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  - Gao, Yudong, Matthew Trn, Daichi Shonai, Jieqing Zhao, Erik J. Soderblom, S Alexandra Garcia-Moreno, Charles A. Gersbach, et al. “Chemico-genetic Analysis of Native Autism Proteomes Reveals Shared Biology Predictive of Functional Modifiers.” Cold Spring Harbor Laboratory, October 7, 2022. https://doi.org/10.1101/2022.10.06.511211.
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  - Velmeshev, Dmitry, Manideep Chavali, Tomasz J. Nowakowski, Mohini Bhade, Simone Mayer, Nitasha Goyal, Beatriz Alvarado, et al. “Molecular diversity and lineage commitment of human interneuron progenitors.” Cold Spring Harbor Laboratory, May 14, 2021. https://doi.org/10.1101/2021.05.13.444045.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Preprints

Recent Courses