Scholars@Duke
Ekta Dembla

Ekta Dembla

Research Associate, Senior
Neurobiology

Selected Publications

Development of Retinal Astroglia.

Journal Article Annu Rev Vis Sci · September 2025 Müller cells and retinal nerve fiber layer astrocytes are the major astroglia of the mammalian retina. They have numerous important functions in adulthood for maintaining neuronal homeostasis as well as in developing retina, where they facilitate key event ... Full text Link to item Cite

Early Changes in Exo- and Endocytosis in the EAE Mouse Model of Multiple Sclerosis Correlate with Decreased Synaptic Ribbon Size and Reduced Ribbon-Associated Vesicle Pools in Rod Photoreceptor Synapses.

Journal Article International journal of molecular sciences · October 2021 Multiple sclerosis (MS) is an inflammatory disease of the central nervous system that finally leads to demyelination. Demyelinating optic neuritis is a frequent symptom in MS. Recent studies also revealed synapse dysfunctions in MS patients and MS mouse mo ... Full text Cite

Biogenesis of large dense core vesicles in mouse chromaffin cells.

Journal Article Traffic (Copenhagen, Denmark) · March 2021 Large dense core vesicle (LDCVs) biogenesis in neuroendocrine cells involves: (a) production of cargo peptides processed in the Golgi; (b) fission of cargo loaded LDCVs undergoing maturation steps; (c) movement of these LDCVs to the plasma membrane. These ... Full text Cite

Disturbed Presynaptic Ca2+ Signaling in Photoreceptors in the EAE Mouse Model of Multiple Sclerosis.

Journal Article iScience · December 2020 Multiple sclerosis (MS) is a demyelinating disease caused by an auto-reactive immune system. Recent studies also demonstrated synapse dysfunctions in MS patients and MS mouse models. We previously observed decreased synaptic vesicle exocytosis in photorece ... Full text Cite

Synaptic ribbons foster active zone stability and illumination-dependent active zone enrichment of RIM2 and Cav1.4 in photoreceptor synapses.

Journal Article Scientific reports · April 2020 Rod photoreceptor synapses use large, ribbon-type active zones for continuous synaptic transmission during light and dark. Since ribbons are physically connected to the active zones, we asked whether illumination-dependent changes of ribbons influence Cav1 ... Full text Cite

The Calcineurin-Binding, Activity-Dependent Splice Variant Dynamin1xb Is Highly Enriched in Synapses in Various Regions of the Central Nervous System.

Journal Article Frontiers in molecular neuroscience · January 2017 In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb. Calcineurin is a Ca2+-regulated phosphatase that enhances dynami ... Full text Cite

Deciphering dead-end docking of large dense core vesicles in bovine chromaffin cells.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · October 2013 Large dense core vesicle (LDCV) exocytosis in chromaffin cells follows a well characterized process consisting of docking, priming, and fusion. Total internal reflection fluorescence microscopy (TIRFM) studies suggest that some LDCVs, although being able t ... Full text Cite