Hilal Rather

Journal Article PNAS Nexus · April 2025 Aging has been identified as a leading risk factor for many diseases, including neurodegenerative disorders. While cellular senescence has been linked to age-related neurodegenerative conditions, its involvement in peripheral stress-associated brain disord ... Full text Link to item Cite

Bacterial Nanovesicles as Interkingdom Signaling Moieties Mediating Pain Hypersensitivity.

Journal Article ACS nano · January 2025 Gut dysbiosis contributes to multiple pathologies, yet the mechanisms of the gut microbiota-mediated influence on systemic and distant responses remain largely elusive. This study aimed to identify the role of nanosized bacterial extracellular vesicles (bE ... Full text Cite

Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer's disease and other aging-related disorders.

Journal Article Ageing research reviews · December 2023 The term extracellular vesicles (EVs) refers to a variety of heterogeneous nanovesicles secreted by almost all cell types, primarily for intercellular communication and maintaining cellular homeostasis. The role of EVs has been widely reported in the genes ... Full text Cite

The β-Secretase 1 Enzyme as a Novel Therapeutic Target for Prostate Cancer.

Journal Article Cancers · December 2023 Recent studies have demonstrated the association of APP and Aβ with cancer, suggesting that BACE1 may play an important role in carcinogenesis. In the present study, we assessed BACE1's usefulness as a therapeutic target in prostate cancer (PCa). BACE1 exp ... Full text Cite

A Liquid Biopsy-Based Approach to Isolate and Characterize Adipose Tissue-Derived Extracellular Vesicles from Blood.

Journal Article ACS nano · June 2023 Obesity is a major risk factor for multiple chronic diseases. Anthropometric and imaging approaches are primarily used to assess adiposity, and there is a dearth of techniques to determine the changes in adipose tissue (AT) at the molecular level. Extracel ... Full text Cite

Polycaprolactone-collagen nanofibers loaded with dexamethasone and simvastatin as an osteoinductive and immunocompatible scaffold for bone regeneration applications.

Journal Article Biomaterials and biosystems · December 2022 Physiological inflammation has been shown to promote bone regeneration; however, prolonged inflammation impedes the osteogenesis and bone repair process. To overcome the latter we aimed to develop a dual drug delivering nanofibrous scaffold to promote oste ... Full text Cite

Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation.

Journal Article Biomolecules · March 2022 Cocaine use disorder has been reported to cause transgenerational effects. However, due to the lack of standardized biomarkers, the effects of cocaine use during pregnancy on postnatal development and long-term neurobiological and behavioral outcomes have ... Full text Cite

Single-Step Fabrication of Core-Shell Microgels for the Controlled Release of rhBMP-2 and Simvastatin to Induce Osteogenesis

Journal Article ACS Applied Polymer Materials · November 13, 2020 Dual delivery of bioactive molecules (drugs and growth factors) has been attempted to enhance multiple processes during tissue regeneration. For bone tissue engineering, many attempts have been made to enhance osteogenesis coupled angiogenesis, which plays ... Full text Cite

Dual drug-delivering polycaprolactone-collagen scaffold to induce early osteogenic differentiation and coupled angiogenesis.

Journal Article Biomedical materials (Bristol, England) · May 2020 Bone regeneration is a multi-step, overlapping process, in which angiogenesis and osteogenesis are the key players. Several attempts have been made to promote angiogenesis-coupled osteogenesis using scaffolding technology. However, the recreation of functi ... Full text Cite

Polymeric microgels for bone tissue engineering applications–a review

Journal Article International Journal of Polymeric Materials and Polymeric Biomaterials · April 12, 2020 Microgels have recently gained exposure as a potential scaffold either alone or in combination with other scaffold for bone tissue engineering. Microgel has been defined as a small size particle of cross linked polymer chains with the ability of swelling a ... Full text Cite

Extracellular matrix mimicking polycaprolactone-chitosan nanofibers promote stemness maintenance of mesenchymal stem cells via spheroid formation.

Journal Article Biomedical materials (Bristol, England) · April 2020 The development of clinical applications has led to a perpetual increase in the demand for mesenchymal stem cells (MSCs). However, the ex vivo expansion of MSCs while maintaining their stemness and differentiation potential remains an immense challenge. MS ... Full text Cite

Fabrication of multifunctional cellulose/TiO₂ /Ag composite nanofibers scaffold with antibacterial and bioactivity properties for future tissue engineering applications.

Journal Article Journal of biomedical materials research. Part A · April 2020 In the present work, a novel strategy was explored to fabricate nanofiber scaffolds consisting of cellulose assimilated with titanium dioxide (TiO2 ) and silver (Ag) nanoparticles (NPs). The concentration of the TiO2 NPs in the compos ... Full text Cite

Synthesis and biological studies of amphiphilic carbazole pyridinium conjugates

Journal Article Journal of Porphyrins and Phthalocyanines · January 1, 2020 Amphiphilic carbazole pyridinium conjugates are synthesized and characterized by IR, 1H and 13C NMR and ESI-MS spectrometry. The pyridinium group is attached on the 3-position of the carbazole ring and long alkyl chains are linked to the central N atom. Th ... Full text Cite

Dual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering.

Journal Article Materials science & engineering. C, Materials for biological applications · October 2019 Bone fracture healing is a multistep and overlapping process of inflammation, angiogenesis and osteogenesis. It is initiated by inflammation, causing the release of various cytokines and growth factors. It leads to the recruitment of stem cells and formati ... Full text Cite

Biomimetic polycaprolactone-chitosan nanofibrous substrate influenced cell cycle and ECM secretion affect cellular uptake of nanoclusters.

Journal Article Bioactive materials · March 2019 Biomimetic cell culture substrates are developed as an alternative to the conventional substrates. They provide necessary biochemical and biophysical cues to the cells from their surrounding environment for their optimal growth, behaviour and physiology. C ... Full text Cite

Nano-delivery of food-derived biomolecules: An overview

Chapter · October 12, 2018 Certain bioactive molecules present in food have therapeutic effects such as antioxidant, anti-carcinogenic, anti-mutagenic, anti-ageing and anti-inflammatory activity. Although these molecules can be consumed via food, their effects are often subordinated ... Full text Cite

Highly selective nicotinohydrazide based ‘turn-on’ chemosensor for the detection of bioactive zinc(II): Its biocompitability and bioimaging application in cancer cells

Journal Article Sensors and Actuators B Chemical · October 1, 2018 A novel optically active (E)-N’-(5-allyl-2-hydroxy-3-methoxybenzylidene) nicotinohydrazide (receptor 3) was synthesized by simple Schiff base condensation of 5-allyl-2-hydroxy-3-methoxybenzaldehyde with nicotinohydrazide. The ability of receptor 3 was inve ... Full text Cite

Appraisal of 1-Butylimidazole-Derived Ionic Liquids as Anthelmintic Agents: An Experimental and In Silico Approach

Journal Article Chemistryselect · July 13, 2018 We have synthesized and characterized 1-butyl-3-alkylimidazolium derived ionic liquids (ILs) functionalized with various alkyl groups (-C2H5, -C4H9, -C6H13, -C8H17, and ... Full text Cite

Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application.

Journal Article Bioactive materials · June 2018 Skin wound healing involves a coordinated cellular response to achieve complete reepithelialisation. Elevated levels of reactive oxygen species (ROS) in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing proce ... Full text Cite

Rational design of imidazolium based salts as anthelmintic agents

Journal Article Journal of Molecular Liquids · April 1, 2018 In present study, we have applied a combined experimental and computational approach to explicate several bred-in-the-bone notions for the rational designing of imidazolium derive salts as anthelmintic agents. Thirty derivatives of 1-methyl-3-alkylimidazol ... Full text Cite

Polycaprolactone-chitosan nanofibers influence cell morphology to induce early osteogenic differentiation.

Journal Article Biomaterials science · October 2016 Osteogenic differentiation is highly correlated with cell morphology. Morphological changes are a stimulus as well as a consequence of the differentiation process. Besides, geometrical, biochemical and mechanical properties of a substrate can modulate cell ... Full text Cite