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Hilmar Lapp CV

Dir, IT
Biostatistics & Bioinformatics
Box 90090, North Building 119, Durham, NC 27708
304 Research Drive, North Building 119, Durham, NC 27708
CV

Research Interests


My research interests broadly fall into biological and biomedical data science, in particular enabling data and knowledge to be more findable, accessible, interoperable, and reusable ("FAIR"). My research program for >15 years has focused on allowing the vast body of observational data expressed in natural language descriptions to be fully computable, through the use of knowledge representation and discovery technologies, in particular ontologies and machine reasoning. I have been funded for this work by the National Science Foundation (NSF) through a series of collaborative grants, as part of which I design and build eScience infrastructure, including data standards, ontologies, data integration systems, and reusable programming interfaces and tools.

Specifically, I am one of the PIs of Phenoscape, a >10 year collaborative project aiming to make evolutionary phenotype descriptions amenable to large-scale computation and reuse, by allowing machines to understand their semantics. Within the recently created HDR Imageomics Institute, where I am part of the leadership team, my research work centers around fully reproducible and automated machine learning (ML) workflows, and making  structured knowledge available to ML algorithms. I was also a PI of the Phyloreferencing project, a collaborative effort to enable machines to understand phylogenetic clade definitions and to use them for reproducible computational data integration of taxon-linked data.

Selected Grants


HDR Institute: Imageomics: A new frontier of biological information powered by knowledge-guided machine learning

ResearchPrincipal Investigator · Awarded by Ohio State University · 2021 - 2026

Collaborative Research: ABI Innovation: Enabling machine-actionable semantics for comparative analyses of trait evolution

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2017 - 2023

HARDAC-M: Enabling memory-intensive computation for genomics

EquipmentPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2020 - 2021

Collaborative Research: ABI Innovation: An Ontology-Based system for Querying Life in a Post-Taxonomic Age

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2015 - 2020

Phenoscape Knowledgebase Interop Codefest

ConferencePrincipal Investigator · Awarded by University of South Dakota · 2017 - 2018

ABI Development: Ontology Enabled Reasoning Across Phenotypes from Evolution and Model Organisms

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2011 - 2017

HARDAC+:Reproducible HPC for next-generation genomics

EquipmentCo-Principal Investigator · Awarded by North Carolina Biotechnology Center · 2016 - 2017

ABI Development: Dryad: Scalable and Sustainable Infrastructure for the Publication of Data

ResearchBioinformatics Specialist · Awarded by National Science Foundation · 2012 - 2015

National Evolutionary Synthesis Center

ResearchBioinformatics Specialist · Awarded by National Science Foundation · 2009 - 2014

A Digital Repository for Preservation and Sharing of Data Underlying Published Works in Evolutionary Biology

ResearchBioinformatics Specialist · Awarded by National Science Foundation · 2008 - 2013

External Relationships


  • Amazon, Inc
  • Dryad Digital Data Repository
  • Open Bioinformatics Foundation (OBF)
  • Phoenix Bioinformatics
  • Ronin Institute for Independent Scholarship

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.