Joey Mao

Journal Article Nature · May 14, 2025 Humans have evolved an extraordinarily expanded and complex cerebral cortex associated with developmental and gene regulatory modifications1-3. Human accelerated regions (HARs) are highly conserved DNA sequences with human-specific nucleotide substitutions ... Full text Link to item Cite

De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.

Journal Article Sci Adv · January 24, 2025 Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target prot ... Full text Link to item Cite

Apoptotic cell-derived metabolites in efferocytosis-mediated resolution of inflammation.

Journal Article Cytokine & growth factor reviews · December 2021 The resolution of inflammation, as part of standard host defense mechanism, is the process to guarantee timely termination of inflammatory responses and eventual restoration of tissue homeostasis . It is mainly achieved via efferocytosis, during which pro- ... Full text Cite

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