Justin Davis

Journal Article Non-coding RNA · June 2024 Telomerase is an enzyme involved in the maintenance of telomeres. Telomere shortening due to the end-replication problem is a threat to the genome integrity of all eukaryotes. Telomerase inside cells depends on a myriad of protein-protein and RNA-protein i ... Full text Open Access Cite

Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei.

Journal Article Frontiers in cell and developmental biology · January 2023 Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which provide ... Full text Open Access Cite

Telomerase ribonucleoprotein and genome integrity-An emerging connection in protozoan parasites.

Journal Article Wiley interdisciplinary reviews. RNA · September 2022 Telomerase has an established role in telomere maintenance in eukaryotes. However, recent studies have begun to implicate telomerase in cellular roles beyond telomere maintenance. Specifically, evidence is emerging of cross-talks between telomerase mediate ... Full text Open Access Cite

In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei.

Journal Article Nucleic acids research · December 2021 Telomerase is a unique ribonucleoprotein (RNP) reverse transcriptase that utilizes its cognate RNA molecule as a template for telomere DNA repeat synthesis. Telomerase contains the reverse transcriptase protein, TERT and the template RNA, TR, as its core c ... Full text Open Access Cite