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Laura Ann Previll

Assistant Consulting Professor in the Department of Medicine
Medicine, Geriatrics
DUMC 3003, Durham, NC 27710
508 Fulton Street, Durham, NC 27705

Selected Publications

Machine learning functional impairment classification with electronic health record data.

Journal Article J Am Geriatr Soc · September 2023 BACKGROUND: Poor functional status is a key marker of morbidity, yet is not routinely captured in clinical encounters. We developed and evaluated the accuracy of a machine learning algorithm that leveraged electronic health record (EHR) data to provide a s ... Full text Open Access Link to item Cite

Sequential implementation of the EQUIPPED geriatric medication safety program as a learning health system.

Journal Article International journal for quality in health care : journal of the International Society for Quality in Health Care · September 2020 ObjectivesTo present the three-site EQUIPPED academic health system research collaborative, which engaged in sequential implementation of the EQUIPPED medication safety program, as a learning health system; to understand how the organizations work ... Full text Cite

Geriatric Resource Teams: Equipping Primary Care Practices to Meet the Complex Care Needs of Older Adults.

Journal Article Geriatrics (Basel, Switzerland) · October 2019 Primary care practices lack the time, expertise, and resources to perform traditional comprehensive geriatric assessment. In particular, they need methods to improve their capacity to identify and care for older adults with complex care needs, such as cogn ... Full text Cite

Systems-Based Practice to Improve Care Within and Beyond the Emergency Department.

Journal Article Clinics in geriatric medicine · August 2018 There is evidence that an emergency department (ED) visit signifies a period of vulnerability for older adults. Transition between the ED and community care can be fraught with challenges. There are essential elements for improved care transition from the ... Full text Cite

Complications from Swallowed Dentures: A Case Report and Review

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · May 1, 2016 Link to item Cite

Falling from a rare diagnosis (XGI): Complexity in Geriatrics

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2015 Link to item Cite

Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.

Journal Article PloS one · January 2012 While oxidative stress has been linked to Alzheimer's disease, the underlying pathophysiological relationship is unclear. To examine this relationship, we induced oxidative stress through the genetic ablation of one copy of mitochondrial antioxidant supero ... Full text Cite

Increased expression of p130 in Alzheimer disease.

Journal Article Neurochemical research · April 2007 A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that d ... Full text Cite

Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.

Journal Article J Neurochem · December 2006 Extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase pathway, has been increasingly implicated in the pathogenesis of Alzheimer's disease due to its critical role in brain function. While we previously demonstrated ... Full text Link to item Cite

Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease.

Journal Article Mol Neurodegener · October 3, 2006 BACKGROUND: Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data reporting the predisposition of women to AD has led to a numb ... Full text Link to item Cite

Oncogenic parallels in Alzheimer disease

Journal Article International Journal of Neuroprotection and Neuroregeneration · February 1, 2006 Vulnerable neuronal populations in Alzheimer disease display a phenotype that is characteristic, in many ways, of cancer cells. This includes the ectopic expression of a hoard of proliferative cell cycle markers and aberrant activation of mitogenic and onc ... Cite