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Lloyd Williams

Assistant Professor of Ophthalmology
Ophthalmology, Corneal Diseases
2351 Erwin Road, Box 3802, Durham, NC 27705

Selected Publications


Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB-Mediated Autoinflammatory Disease with Retinal Dystrophy.

Journal Article Ophthalmology · April 2023 PURPOSE: We aimed to characterize the ocular phenotype of patients with ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome and their response to therapy. DESIGN: Single-center observational case study. PARTICIPANT ... Full text Link to item Cite

Endoscopic-assisted removal of intraocular foreign body embedded in ciliary sulcus

Journal Article American Journal of Ophthalmology Case Reports · September 1, 2022 Purpose: To report a novel approach for removal of intraocular foreign body in the ciliary sulcus. Observations: A 72-year-old male presented with an intraocular foreign body embedded in the ciliary body, localized with ultrasound biomicroscopy. An intraop ... Full text Cite

Pseudoexfoliation and Cataract Syndrome Associated with Genetic and Epidemiological Factors in a Mayan Cohort of Guatemala.

Journal Article Int J Environ Res Public Health · July 6, 2021 The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and genetic ... Full text Link to item Cite

Impact and Trends in Global Ophthalmology.

Journal Article Curr Ophthalmol Rep · 2020 PURPOSE OF REVIEW: Our goal is to provide a review of the impact, global estimates, and projection of vision impairment as well as ongoing systems for eye care delivery. RECENT FINDINGS: Many of the blinding diseases in developing countries are preventable ... Full text Link to item Cite

ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.

Journal Article Genet Med · September 2019 PURPOSE: To identify the molecular cause in five unrelated families with a distinct autosomal dominant ocular systemic disorder we called ROSAH syndrome due to clinical features of retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migrain ... Full text Link to item Cite

In vitro pilot analysis of uniformity, circularity, and concentricity of DSAEK donor endothelial grafts prepared by a microkeratome.

Journal Article Cornea · February 2014 PURPOSE: The aim of this study was to analyze Descemet stripping automated endothelial keratoplasty donor endothelial grafts, prepared by using a microkeratome, in terms of uniformity, circularity, and concentricity. METHODS: In this pilot study, 12 human ... Full text Link to item Cite

Local control and results of Leksell Gamma Knife therapy for the treatment of uveal melanoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · 2014 BACKGROUND AND OBJECTIVE: To evaluate the effectiveness of Leksell Gamma Knife stereotactic radio-surgery (Elekta, Stockholm, Sweden) with respect to local tumor control, visual acuity, and radiation side effects for uveal melanoma. PATIENTS AND METHODS: R ... Full text Link to item Cite

An inherited disorder with splenomegaly, cytopenias, and vision loss.

Journal Article Am J Med Genet A · March 2012 We describe a novel inherited disorder consisting of idiopathic massive splenomegaly, cytopenias, anhidrosis, chronic optic nerve edema, and vision loss. This disorder involves three affected patients in a single non-consanguineous Caucasian family, a moth ... Full text Link to item Cite

Comparison of Hanna and Hessburg-Barron trephine and punch systems using histological, anterior segment optical coherence tomography, and elliptical curve fitting models

Journal Article Clinical Ophthalmology · January 1, 2011 Background: This study analyzes the characteristics of donor and recipient tissue preparation between the Hessburg-Barron and Hanna punch and trephine systems by using elliptical curve fitting models, light microscopy, and anterior segment optical coherenc ... Full text Cite

The Use of Glycerol-Preserved Corneas in the Developing World

Journal Article Middle East African Journal of Ophthalmology · 2010 Cite

Dose de-escalation with gamma knife radiosurgery in the treatment of choroidal melanoma.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2009 PURPOSE: Single-fraction targeted radiation therapy delivered by the Leksell Gamma Knife system is a minimally invasive treatment option for choroidal melanoma that has been used as an alternative to enucleation, proton beam therapy, or brachytherapy. Prev ... Full text Link to item Cite

Correlation of visual outcome and patient satisfaction with preoperative keratometry after hyperopic laser in situ keratomileusis.

Journal Article J Cataract Refract Surg · July 2008 PURPOSE: To prospectively study the dependence of visual outcomes and patient satisfaction on corneal keratometry (K) in hyperopic laser in situ keratomileusis (LASIK). SETTING: John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, Uni ... Full text Link to item Cite

Etiology of Obesity

Chapter · 2001 Obesity is an all too common medical condition, frustrating to both patients and practitioners. ... Cite

Hexosamines Regulate Leptin Production in Human Subcutaneous Adipocytes1

Journal Article The Journal of Clinical Endocrinology & Metabolism · October 2000 Full text Cite

Ophthalmic Manifestations of ROSAH (Retinal Dystrophy, Optic Nerve Edema, Splenomegaly, Anhidrosis, and Headache) Syndrome, an Inherited NF κB-Mediated Autoinflammatory Disease with Retinal Dystrophy.

Journal Article Ophthalmology · April 2023 PURPOSE: We aimed to characterize the ocular phenotype of patients with ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome and their response to therapy. DESIGN: Single-center observational case study. PARTICIPANT ... Full text Link to item Cite

Endoscopic-assisted removal of intraocular foreign body embedded in ciliary sulcus

Journal Article American Journal of Ophthalmology Case Reports · September 1, 2022 Purpose: To report a novel approach for removal of intraocular foreign body in the ciliary sulcus. Observations: A 72-year-old male presented with an intraocular foreign body embedded in the ciliary body, localized with ultrasound biomicroscopy. An intraop ... Full text Cite

Pseudoexfoliation and Cataract Syndrome Associated with Genetic and Epidemiological Factors in a Mayan Cohort of Guatemala.

Journal Article Int J Environ Res Public Health · July 6, 2021 The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and genetic ... Full text Link to item Cite

Impact and Trends in Global Ophthalmology.

Journal Article Curr Ophthalmol Rep · 2020 PURPOSE OF REVIEW: Our goal is to provide a review of the impact, global estimates, and projection of vision impairment as well as ongoing systems for eye care delivery. RECENT FINDINGS: Many of the blinding diseases in developing countries are preventable ... Full text Link to item Cite

ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.

Journal Article Genet Med · September 2019 PURPOSE: To identify the molecular cause in five unrelated families with a distinct autosomal dominant ocular systemic disorder we called ROSAH syndrome due to clinical features of retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migrain ... Full text Link to item Cite

In vitro pilot analysis of uniformity, circularity, and concentricity of DSAEK donor endothelial grafts prepared by a microkeratome.

Journal Article Cornea · February 2014 PURPOSE: The aim of this study was to analyze Descemet stripping automated endothelial keratoplasty donor endothelial grafts, prepared by using a microkeratome, in terms of uniformity, circularity, and concentricity. METHODS: In this pilot study, 12 human ... Full text Link to item Cite

Local control and results of Leksell Gamma Knife therapy for the treatment of uveal melanoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · 2014 BACKGROUND AND OBJECTIVE: To evaluate the effectiveness of Leksell Gamma Knife stereotactic radio-surgery (Elekta, Stockholm, Sweden) with respect to local tumor control, visual acuity, and radiation side effects for uveal melanoma. PATIENTS AND METHODS: R ... Full text Link to item Cite

An inherited disorder with splenomegaly, cytopenias, and vision loss.

Journal Article Am J Med Genet A · March 2012 We describe a novel inherited disorder consisting of idiopathic massive splenomegaly, cytopenias, anhidrosis, chronic optic nerve edema, and vision loss. This disorder involves three affected patients in a single non-consanguineous Caucasian family, a moth ... Full text Link to item Cite

Comparison of Hanna and Hessburg-Barron trephine and punch systems using histological, anterior segment optical coherence tomography, and elliptical curve fitting models

Journal Article Clinical Ophthalmology · January 1, 2011 Background: This study analyzes the characteristics of donor and recipient tissue preparation between the Hessburg-Barron and Hanna punch and trephine systems by using elliptical curve fitting models, light microscopy, and anterior segment optical coherenc ... Full text Cite

The Use of Glycerol-Preserved Corneas in the Developing World

Journal Article Middle East African Journal of Ophthalmology · 2010 Cite

Dose de-escalation with gamma knife radiosurgery in the treatment of choroidal melanoma.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2009 PURPOSE: Single-fraction targeted radiation therapy delivered by the Leksell Gamma Knife system is a minimally invasive treatment option for choroidal melanoma that has been used as an alternative to enucleation, proton beam therapy, or brachytherapy. Prev ... Full text Link to item Cite

Correlation of visual outcome and patient satisfaction with preoperative keratometry after hyperopic laser in situ keratomileusis.

Journal Article J Cataract Refract Surg · July 2008 PURPOSE: To prospectively study the dependence of visual outcomes and patient satisfaction on corneal keratometry (K) in hyperopic laser in situ keratomileusis (LASIK). SETTING: John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, Uni ... Full text Link to item Cite

Etiology of Obesity

Chapter · 2001 Obesity is an all too common medical condition, frustrating to both patients and practitioners. ... Cite

Hexosamines Regulate Leptin Production in Human Subcutaneous Adipocytes1

Journal Article The Journal of Clinical Endocrinology & Metabolism · October 2000 Full text Cite

Identification and correlation of microstructural defects with flux pinning in Ni-doped melt textured YBa2Cu3O7−δ

Journal Article Applied Physics Letters · July 11, 1994 Microstructural examination using transmission electron microscopy has been conducted on melt textured Ni-doped and pristine YBaCu3O7−δ. Magnetization hysteresis suggests that the observed microstructural imperfections strongly influence flux pinni ... Full text Cite