Mansi D Amin

Journal Article Ann Diagn Pathol · December 2024 Autoimmune hepatitis (AIH) is a chronic inflammatory autoimmune disease with either acute or chronic presentation. Previous scoring systems have primarily focused on chronic hepatitis, but none have been validated in an acute setting of pediatric patients. ... Full text Link to item Cite

Oral vancomycin is associated with improved inflammatory bowel disease clinical outcomes in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD): A matched analysis from the Paediatric PSC Consortium.

Journal Article Aliment Pharmacol Ther · May 2024 BACKGROUND: Data on oral vancomycin for primary sclerosing cholangitis (PSC)-associated inflammatory bowel disease (IBD) are limited. AIMS: Using data from the Paediatric PSC Consortium, to examine the effect of vancomycin on IBD activity. METHODS: In this ... Full text Link to item Cite

Impact of psychosocial factors on medication level variability index and outcomes in pediatric liver transplant recipients.

Journal Article Pediatr Transplant · February 2023 BACKGROUND: Caregivers play an important role in maintaining a functioning graft after pediatric liver transplantation. Therefore, the psychosocial factors of both patients and caregivers can have a critical impact on transplant outcomes. Appropriate asses ... Full text Link to item Cite

The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children

Journal Article Hepatology · March 2021 Background and AimsDisease progression in children with primary sclerosing cholangitis (PSC) is variable. Prognostic and risk‐stratification tools exist for adult‐onset PSC, but not for c ... Full text Cite

Assessing the Validity of Adult‐derived Prognostic Models for Primary Sclerosing Cholangitis Outcomes in Children

Journal Article Journal of Pediatric Gastroenterology and Nutrition · January 2020 ABSTRACTBackground:Natural history models for primary sclerosing cholangitis (PSC) are derived from adult patient data, but have never been validated in children. It is unclear how accurat ... Full text Cite

Gamma Glutamyltransferase Reduction Is Associated With Favorable Outcomes in Pediatric Primary Sclerosing Cholangitis

Journal Article Hepatology Communications · November 2018 Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist for children with PSC. We evaluated the association between g ... Full text Cite

Unique Inflammatory Bowel Disease Phenotype of Pediatric Primary Sclerosing Cholangitis

Journal Article Journal of Pediatric Gastroenterology and Nutrition · October 2017 ABSTRACTObjectives:In adults, primary sclerosing cholangitis (PSC), a cholestatic liver disease characterized by inflammation/fibrosis of intra/extrahepatic bile ducts, associates with a m ... Full text Cite

The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration

Journal Article Hepatology · August 2017 There are limited data on the natural history of primary sclerosing cholangitis (PSC) in children. We aimed to describe the disease characteristics and long‐term outcomes of pediatric PSC. We retrospectively collected all pediatric PSC cases from 3 ... Full text Cite

Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.

Journal Article J Hepatol · August 2016 BACKGROUND & AIMS: Pediatric liver cancer is a rare but serious disease whose incidence is rising, and for which the therapeutic options are limited. Development of more targeted, less toxic therapies is hindered by the lack of an experimental animal model ... Full text Link to item Cite

Drug-induced liver injury in children

Journal Article Current Opinion in Pediatrics · October 2015 Full text Cite