Current Appointments & Affiliations
Adjunct Professor in the Department of Biochemistry
·
2018 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export.
Journal Article Immunity · January 14, 2025 Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. Recent studies showed that ATP-binding cassette subfamily C member 1 ... Full text Link to item CiteMolecular basis of neurosteroid and anticonvulsant regulation of TRPM3.
Journal Article Nat Struct Mol Biol · January 14, 2025 Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent discoveries of autosom ... Full text Link to item CiteSpontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates.
Journal Article Nat Commun · January 4, 2025 Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3' of uridine (U). While prior structural data shows that to cleave double stranded RNA, Ns ... Full text Link to item CiteRecent Grants
A Hybrid Computational Platform for High-resolution Structure Determination Using Cryo-EM
ResearchSignificant Contributor · Awarded by National Institute of General Medical Sciences · 2021 - 2025View All Grants
Education, Training & Certifications
Israel Institute of Technology (Israel) ·
1996
D.S.Sc.