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Mario-Juan Borgnia

Adjunct Professor in the Department of Biochemistry
Biochemistry
255C Nanaline H Duke, Durham, NC 27710

Current Appointments & Affiliations


Adjunct Professor in the Department of Biochemistry · 2018 - Present Biochemistry, Basic Science Departments

In the News


Published April 6, 2021
Duke Team Makes Cryo-EM Microscope Even Better Than Before
Published May 15, 2019
A Giant Tool to See the Tiniest Things

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Recent Publications


Advances in automation for cryo-electron tomography data collection.

Journal Article Curr Opin Struct Biol · December 2025 Cryo-electron microscopy has become the preferred method for determining structures of macromolecular complexes both in isolation, using single particle analysis, and in their cellular contexts, using cryo-electron tomography (Cryo-ET) combined with subvol ... Full text Link to item Cite

Structural insights into proteolysis-dependent and -independent suppression of the master regulator DELLA by the gibberellin receptor.

Journal Article Proc Natl Acad Sci U S A · August 12, 2025 The perception of the phytohormone gibberellin (GA) by its nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1) triggers polyubiquitination and proteasomal degradation of master growth regulators-DELLA proteins-mediated by the SCFSLY1/GID2 E3 ubiquitin l ... Full text Link to item Cite

Molecular basis of the urate transporter URAT1 inhibition by gout drugs.

Journal Article Nat Commun · June 4, 2025 Hyperuricemia is a condition when uric acid, a waste product of purine metabolism, accumulates in the blood. Untreated hyperuricemia can lead to crystal formation of monosodium urate in the joints, causing a painful inflammatory disease known as gout. Thes ... Full text Link to item Cite
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Recent Grants


Structural and Mechanistic Basis of ss-arrestin2 Signaling Through the MAPK JNK3

FellowshipCo-Sponsor · Awarded by American Heart Association · 2026 - 2027

A Hybrid Computational Platform for High-resolution Structure Determination Using Cryo-EM

ResearchSignificant Contributor · Awarded by National Institute of General Medical Sciences · 2021 - 2026

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Education, Training & Certifications


Israel Institute of Technology (Israel) · 1996 D.S.Sc.