Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1971
  • B.S., The George Washington University 1964
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  Previous Appointments & Affiliations

  • Adjunct Associate Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 1997 - 2003
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Costello, M Joseph, Lisa A. Brennan, Ashik Mohamed, Kurt O. Gilliland, Sönke Johnsen, and Marc Kantorow. “Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells.” Plos One 11, no. 8 (2016): e0160785. https://doi.org/10.1371/journal.pone.0160785.
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    • Costello, M Joseph, Lisa A. Brennan, Subharsee Basu, Daniel Chauss, Ashik Mohamed, Kurt O. Gilliland, Sönke Johnsen, Sue Menko, and Marc Kantorow. “Autophagy and mitophagy participate in ocular lens organelle degradation.” Exp Eye Res 116 (November 2013): 141–50. https://doi.org/10.1016/j.exer.2013.08.017.
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    • Costello, M Joseph, Ashik Mohamed, Kurt O. Gilliland, W Craig Fowler, and Sönke Johnsen. “Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction.” Exp Eye Res 116 (November 2013): 411–18. https://doi.org/10.1016/j.exer.2013.10.015.
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    • Mohamed, Ashik, Kurt O. Gilliland, Sangeetha Metlapally, Sönke Johnsen, and M Joseph Costello. “Simple fixation and storage protocol for preserving the internal structure of intact human donor lenses and extracted human nuclear cataract specimens.” Mol Vis 19 (2013): 2352–59.
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    • Costello, M Joseph, Alain Burette, Mariko Weber, Sangeetha Metlapally, Kurt O. Gilliland, W Craig Fowler, Ashik Mohamed, and Sönke Johnsen. “Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts.” Exp Eye Res 101 (August 2012): 72–81. https://doi.org/10.1016/j.exer.2012.06.005.
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    • Wang, Yunfang, Cai-Bin Cui, Mitsuo Yamauchi, Patricia Miguez, Marsha Roach, Richard Malavarca, M Joseph Costello, et al. “Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds.” Hepatology 53, no. 1 (January 2011): 293–305. https://doi.org/10.1002/hep.24012.
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    • Costello, M Joseph, Sönke Johnsen, Sangeetha Metlapally, Kurt O. Gilliland, Lesley Frame, and Dorairajan Balasubramanian. “Multilamellar spherical particles as potential sources of excessive light scattering in human age-related nuclear cataracts.” Exp Eye Res 91, no. 6 (December 2010): 881–89. https://doi.org/10.1016/j.exer.2010.09.013.
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    • Wang, Yunfang, Hsin-Lei Yao, Cai-Bin Cui, Eliane Wauthier, Claire Barbier, Martin J. Costello, Nicholas Moss, et al. “Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates.” Hepatology 52, no. 4 (October 2010): 1443–54. https://doi.org/10.1002/hep.23829.
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    • Dixon, R. D. S., D. K. Arneman, A. S. Rachlin, N. R. Sundaresan, M. J. Costello, S. L. Campbell, and C. A. Otey. “Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin (Journal of Biological Chemistry (2008) 283 (6222-6231)).” Journal of Biological Chemistry 283, no. 40 (October 3, 2008): 27344.
    • Costello, M. J., Sönke Johnsen, Sangeetha Metlapally, Kurt O. Gilliland, Balasubramanya Ramamurthy, Pravin V. Krishna, and Dorairajan Balasubramanian. “Ultrastructural analysis of damage to nuclear fiber cell membranes in advanced age-related cataracts from India.” Exp Eye Res 87, no. 2 (August 2008): 147–58. https://doi.org/10.1016/j.exer.2008.05.009.
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    • Gilliland, Kurt O., Sonke Johnsen, Sangeetha Metlapally, M Joseph Costello, Balasubramanya Ramamurthy, Pravin V. Krishna, and Dorairajan Balasubramanian. “Mie light scattering calculations for an Indian age-related nuclear cataract with a high density of multilamellar bodies.” Mol Vis 14 (March 24, 2008): 572–82.
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    • Dixon, Richard D. S., Daniel K. Arneman, Andrew S. Rachlin, Naresh R. Sundaresan, M Joseph Costello, Sharon L. Campbell, and Carol A. Otey. “Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin.” J Biol Chem 283, no. 10 (March 7, 2008): 6222–31. https://doi.org/10.1074/jbc.M707694200.
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    • Metlapally, S., M. J. Costello, K. O. Gilliland, B. Ramamurthy, P. V. Krishna, D. Balasubramanian, and S. Johnsen. “Analysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye-Bueche theory.” Exp Eye Res 86, no. 2 (February 2008): 434–44. https://doi.org/10.1016/j.exer.2007.11.018.
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    • Costello, M Joseph, Sönke Johnsen, Kurt O. Gilliland, Christopher D. Freel, and W Craig Fowler. “Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory.” Invest Ophthalmol Vis Sci 48, no. 1 (January 2007): 303–12. https://doi.org/10.1167/iovs.06-0480.
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    • Marsili, Stefania, Rudolf I. Salganik, Craig D. Albright, Christopher D. Freel, Sonke Johnsen, Robert L. Peiffer, and M Joseph Costello. “Cataract formation in a strain of rats selected for high oxidative stress.” Exp Eye Res 79, no. 5 (November 2004): 595–612. https://doi.org/10.1016/j.exer.2004.06.008.
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    • Gilliland, Kurt O., Christopher D. Freel, Sonke Johnsen, W. Craig Fowler, and M Joseph Costello. “Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts.” Exp Eye Res 79, no. 4 (October 2004): 563–76. https://doi.org/10.1016/j.exer.2004.05.017.
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    • Maddala, Rupalatha, Pei-Feng Deng, Joseph M. Costello, Eric F. Wawrousek, Jacob S. Zigler, and Vasantha P. Rao. “Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.” Lab Invest 84, no. 6 (June 2004): 679–92. https://doi.org/10.1038/labinvest.3700105.
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    • Kim, D. H., M. J. Costello, P. B. Duncan, and D. Needham. “Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles.” Langmuir 19, no. 20 (September 30, 2003): 8455–66. https://doi.org/10.1021/la034779c.
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    • Freel, Christopher D., Kurt O. Gilliland, Harold E. Mekeel, Frank J. Giblin, and M Joseph Costello. “Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model.” Exp Eye Res 76, no. 4 (April 2003): 405–15. https://doi.org/10.1016/s0014-4835(03)00004-6.
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    • Freel, C. D., K. J. Al-Ghoul, J. R. Kuszak, and M. J. Costello. “Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopy.” Bmc Ophthalmology 3 (January 6, 2003): 1–9. https://doi.org/10.1186/1471-2415-3-1.
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    • Freel, Christopher D., Kurt O. Gilliland, C. Wesley Lane, Frank J. Giblin, and M Joseph Costello. “Fourier analysis of cytoplasmic texture in nuclear fiber cells from transparent and cataractous human and animal lenses.” Exp Eye Res 74, no. 6 (June 2002): 689–702. https://doi.org/10.1006/exer.2001.1166.
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    • Gilliland, K. O., C. D. Freel, C. W. Lane, W. C. Fowler, and M. J. Costello. “Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts.” Mol Vis 7 (June 22, 2001): 120–30.
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    • Al-Ghoul, K. J., R. K. Nordgren, A. J. Kuszak, C. D. Freel, M. J. Costello, and J. R. Kuszak. “Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis.” Exp Eye Res 72, no. 3 (March 2001): 199–214. https://doi.org/10.1006/exer.2000.0937.
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    • Taylor, V. L., and M. J. Costello. “Fourier analysis of textural variations in human normal and cataractous lens nuclear fiber cell cytoplasm.” Exp Eye Res 69, no. 2 (August 1999): 163–74. https://doi.org/10.1006/exer.1999.0679.
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    • Ghoul, K. J. al-, and M. J. Costello. “Light microscopic variation of fiber cell size, shape and ordering in the equatorial plane of bovine and human lenses.” Mol Vis 3 (February 2, 1997): 2.
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    • Taylor, V. L., K. J. al-Ghoul, C. W. Lane, V. A. Davis, J. R. Kuszak, and M. J. Costello. “Morphology of the normal human lens.” Invest Ophthalmol Vis Sci 37, no. 7 (June 1996): 1396–1410.
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    • Ghoul, K. J. al-, and M. J. Costello. “Fiber cell morphology and cytoplasmic texture in cataractous and normal human lens nuclei.” Curr Eye Res 15, no. 5 (May 1996): 533–42. https://doi.org/10.3109/02713689609000764.
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    • Al-Ghoul, K. J., C. W. Lane, V. L. Taylor, W. C. Fowler, and M. J. Costello. “Distribution and type of morphological damage in human nuclear age-related cataracts.” Exp Eye Res 62, no. 3 (March 1996): 237–51. https://doi.org/10.1006/exer.1996.0029.
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    • Al-Ghoul, K. J., V. L. Taylor, and M. J. Costello. “Continuous variation of fiber cell size, shape and ordering in the equatorial plane of bovine lenses.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Kuszak, J. R., K. L. Peterson, M. J. Costello, A. J. Bron, and J. F. Koretz. “The structural basis of the crystalline lens sulcus.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Taylor, V. L., K. J. Al-Ghoul, C. W. Lane, R. Peiffer, and M. J. Costello. “Fourier analysis of normal and cataractous nuclear fiber cell cytoplasms.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Al-Ghoul, K. J., and M. J. Costello. “Erratum: Fiber cell morphology and cytoplasmic texture in cataractous and normal human lens nuclei (Current Eye Research (1996) 15 5 (533-542)).” Current Eye Research 15, no. 7 (January 1, 1996): 806. https://doi.org/10.3109/02713689609003467.
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    • Dai, J. D., M. Joseph Costello, and L. I. Gilbert. “The prothoracic glands of manduca sexta: A microscopic analysis of gap junctions and intercellular bridges.” Invertebrate Reproduction and Development 25, no. 2 (January 1, 1994): 93–110. https://doi.org/10.1080/07924259.1994.9672375.
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    • Ghoul, K. J. al-, and M. J. Costello. “Morphological changes in human nuclear cataracts of late-onset diabetics.” Exp Eye Res 57, no. 4 (October 1993): 469–86. https://doi.org/10.1006/exer.1993.1149.
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    • Costello, M. J., C. W. Lane, D. L. Hatchell, P. Saloupis, and L. M. Cobo. “Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes.” Invest Ophthalmol Vis Sci 34, no. 7 (June 1993): 2174–85.
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    • Costello, M. J., T. N. Oliver, and L. M. Cobo. “Cellular architecture in age-related human nuclear cataracts.” Invest Ophthalmol Vis Sci 33, no. 11 (October 1992): 3209–27.
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    • Wilkison, W. O., R. M. Bell, K. A. Taylor, and M. J. Costello. “Structural characterization of ordered arrays of sn-glycerol-3-phosphate acyltransferase from Escherichia coli.” J Bacteriol 174, no. 20 (October 1992): 6608–16. https://doi.org/10.1128/jb.174.20.6608-6616.1992.
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    • Costello, M. J., T. J. McIntosh, and J. D. Robertson. “Distribution of gap junctions and square array junctions in the mammalian lens.” Invest Ophthalmol Vis Sci 30, no. 5 (May 1989): 975–89.
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    • Costello, M. J., J. Escaig, K. Matsushita, P. V. Viitanen, D. R. Menick, and H. R. Kaback. “Purified lac permease and cytochrome o oxidase are functional as monomers.” J Biol Chem 262, no. 35 (December 15, 1987): 17072–82.
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    • Costello, M. J., and R. D. Fetter. “Freeze-fracture methods: preparation of complementary replicas for evaluating intracellular ice damage in ultrarapidly cooled specimens.” Methods Enzymol 127 (1986): 704–18. https://doi.org/10.1016/0076-6879(86)27055-x.
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    • Costello, M. J., T. J. McIntosh, and J. D. Robertson. “Membrane specializations in mammalian lens fiber cells: distribution of square arrays.” Curr Eye Res 4, no. 11 (November 1985): 1183–1201. https://doi.org/10.3109/02713688509003364.
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    • Frey, T. G., L. A. Kuhn, J. S. Leigh, M. J. Costello, and S. H. Chan. “Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction.” J Inorg Biochem 23, no. 3–4 (March 1985): 155–62. https://doi.org/10.1016/0162-0134(85)85020-0.
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    • Costello, M. J., P. Viitanen, N. Carrasco, D. L. Foster, and H. R. Kaback. “Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli.” J Biol Chem 259, no. 24 (December 25, 1984): 15579–86.
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    • Costello, M. J., S. Meiboom, and M. Sammon. “Electron microscopy of a cholesteric liquid crystal and its blue phase.” Physical Review A 29, no. 5 (January 1, 1984): 2957–59. https://doi.org/10.1103/PhysRevA.29.2957.
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    • Frey, T. G., M. J. Costello, and S. H. P. Chan. “Selective contrast in electron microscopy of crystalline cytochrome oxidase.” Ultramicroscopy 13, no. 1–2 (January 1, 1984): 85–91. https://doi.org/10.1016/0304-3991(84)90059-7.
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    • Morris, S. J., M. J. Costello, J. D. Robertson, T. C. Südhof, W. F. Odenwald, and D. H. Haynes. “The chromaffin granule as a model for membrane fusion: implications for exocytosis.” J Auton Nerv Syst 7, no. 1 (January 1983): 19–33. https://doi.org/10.1016/0165-1838(83)90066-8.
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    • Costello, M. J., and T. G. Frey. “Membranous cytochrome c oxidase. A freeze-fracture electron microscopic analysis.” J Mol Biol 162, no. 1 (November 25, 1982): 131–56. https://doi.org/10.1016/0022-2836(82)90165-6.
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    • Frey, T. G., M. J. Costello, B. Karlsson, J. C. Haselgrove, and J. S. Leigh. “Structure of the cytochrome c oxidase dimer. Electron microscopy of two-dimensional crystals.” J Mol Biol 162, no. 1 (November 25, 1982): 113–30. https://doi.org/10.1016/0022-2836(82)90164-4.
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    • Simon, S. A., G. Zampighi, T. J. McIntosh, M. J. Costello, H. P. Ting-beall, and J. D. Robertson. “The structure of junctions between lens fiber cells.” Biosci Rep 2, no. 5 (May 1982): 333–41. https://doi.org/10.1007/BF01115119.
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    • Corless, J. M., and M. J. Costello. “Isolation, rapid freezing, and freeze-fracture methods for frog retinal photoreceptors.” Methods Enzymol 81 (1982): 585–93. https://doi.org/10.1016/s0076-6879(82)81082-3.
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    • McIntosh, T. J., and M. J. Costello. “Effects of n-alkanes on the morphology of lipid bilayers. A freeze-fracture and negative stain analysis.” Biochim Biophys Acta 645, no. 2 (July 20, 1981): 318–26. https://doi.org/10.1016/0005-2736(81)90203-0.
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    • Ting-Beall, H. P., M. J. Costello, D. Shoemaker, and V. F. Holland. “Ultrastructure of hemoglobin-depleted human erythrocyte resealed ghosts.” Biochim Biophys Acta 640, no. 3 (February 6, 1981): 807–11. https://doi.org/10.1016/0005-2736(81)90111-5.
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    • Corless, J. M., and M. J. Costello. “Paracrystalline inclusions associated with the disk membranes of frog retinal rod outer segments.” Exp Eye Res 32, no. 2 (February 1981): 217–28. https://doi.org/10.1016/0014-4835(81)90010-5.
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    • Barry, D. T., M. J. Costello, and S. M. Gruner. “Freeze-fracture study of vesicle disruption and inversion in isolated bovine rod outer segment disks.” Exp Eye Res 30, no. 5 (May 1980): 501–10. https://doi.org/10.1016/0014-4835(80)90034-2.
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    • Costello, M. J. “Ultra-rapid freezing of thin biological samples.” Scan Electron Microsc, no. Pt 2 (1980): 361–70.
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    • Costello, M. J., and T. Gulik-Krzywicki. “Correlated x-ray diffraction and freeze-fracture studies on membrane model systems. Perturbations induced by freeze-fracture preparative procedures.” Biochim Biophys Acta 455, no. 2 (December 2, 1976): 412–32. https://doi.org/10.1016/0005-2736(76)90315-1.
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    • Corless, J. M., W. H. Cobbs, M. J. Costello, and J. D. Robertson. “On the asymmetry of frog retinal rod outer segment disk membranes.” Exp Eye Res 23, no. 3 (September 1976): 295–324. https://doi.org/10.1016/0014-4835(76)90130-5.
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  • Conference Papers

    • Costello, M Joseph. “Cryo-electron microscopy of biological samples.” In Ultrastruct Pathol, 30:361–71, 2006. https://doi.org/10.1080/01913120600932735.
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    • Costello, M. J., K. O. Gilliland, and C. D. Freel. “Morphological evidence for adhesive role of thin-symmetric junctions in undulating membranes of lens nuclear fiber cells.” In Microscopy and Microanalysis, 8:1004–5, 2002. https://doi.org/10.1017/s1431927602106842.
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    • Costello, M. J. “Cryopreservation of biological specimens.” In Proceedings  Annual Meeting, Microscopy Society of America, 492–93, 1993.
    • Costello, M. J., K. J. Al-Ghoul, T. N. Oliver, C. W. Lane, M. Wodnicka, and P. Wodnicki. “Polymorphism of fiber cell junctions in mammalian lens.” In Proceedings  Annual Meeting, Microscopy Society of America, 200–201, 1993.
    • Costello, M. J., and J. Escaig. “Preparation of thin, fine-grained, tantalum metal replicas for freeze-fracture electron microscopy.” In Scanning Microsc Suppl, 3:189–99, 1989.
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