Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 1971
  • B.S., George Washington University 1964
• 

  Duke Appointment History

  • Adjunct Associate Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 1997 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Costello, MJ, Brennan, LA, Mohamed, A, Gilliland, KO, Johnsen, S, and Kantorow, M. "Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells." PloS one 11, no. 8 (January 2016): e0160785-.  Full Text
    • Costello, MJ, Mohamed, A, Gilliland, KO, Fowler, WC, and Johnsen, S. "Ultrastructural analysis of the human lens fiber cell remodeling zone and the initiation of cellular compaction." Experimental Eye Research 116 (November 1, 2013): 411-418.  Full Text
    • Costello, MJ, Brennan, LA, Basu, S, Chauss, D, Mohamed, A, Gilliland, KO, Johnsen, S, Menko, AS, and Kantorow, M. "Autophagy and mitophagy participate in ocular lens organelle degradation." Experimental Eye Research 116 (2013): 141-150.  Full Text
    • Mohamed, A, Gilliland, KO, Metlapally, S, Johnsen, S, and Costello, MJ. "Simple fixation and storage protocol for preserving the internal structure of intact human donor lenses and extracted human nuclear cataract specimens." Molecular Vision 19 (January 2013): 2352-2359.
    • Costello, MJ, Burette, A, Weber, M, Metlapally, S, Gilliland, KO, Fowler, WC, Mohamed, A, and Johnsen, S. "Electron tomography of fiber cell cytoplasm and dense cores of multilamellar bodies from human age-related nuclear cataracts." Experimental Eye Research 101 (2012): 72-81.  Full Text
    • Wang, Y, Cui, C-B, Yamauchi, M, Miguez, P, Roach, M, Malavarca, R, Costello, MJ, Cardinale, V, Wauthier, E, Barbier, C, Gerber, DA, Alvaro, D, and Reid, LM. "Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds." Hepatology (Baltimore, Md.) 53, no. 1 (January 2011): 293-305.  Full Text
    • Costello, MJ, Johnsen, S, Metlapally, S, Gilliland, KO, Frame, L, and Balasubramanian, D. "Multilamellar spherical particles as potential sources of excessive light scattering in human age-related nuclear cataracts." Experimental Eye Research 91, no. 6 (December 2010): 881-889.  Full Text
    • Wang, Y, Yao, H-L, Cui, C-B, Wauthier, E, Barbier, C, Costello, MJ, Moss, N, Yamauchi, M, Sricholpech, M, Gerber, D, Loboa, EG, and Reid, LM. "Paracrine signals from mesenchymal cell populations govern the expansion and differentiation of human hepatic stem cells to adult liver fates." Hepatology (Baltimore, Md.) 52, no. 4 (October 2010): 1443-1454.  Full Text
    • Dixon, RDS, Arneman, DK, Rachlin, AS, Sundaresan, NR, Costello, MJ, Campbell, SL, and Otey, CA. "Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin (Journal of Biological Chemistry (2008) 283 (6222-6231))." Journal of Biological Chemistry 283, no. 40 (October 3, 2008): 27344-null.
    • Gilliland, KO, Johnsen, S, Metlapally, S, Costello, MJ, Ramamurthy, B, Krishna, PV, and Balasubramanian, D. "Mie light scattering calculations for an Indian age-related nuclear cataract with a high density of multilamellar bodies." Molecular Vision 14 (March 24, 2008): 572-582.
    • Dixon, RDS, Arneman, DK, Rachlin, AS, Sundaresan, NR, Costello, MJ, Campbell, SL, and Otey, CA. "Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin." The Journal of Biological Chemistry 283, no. 10 (March 2008): 6222-6231.  Full Text
    • Metlapally, S, Costello, MJ, Gilliland, KO, Ramamurthy, B, Krishna, PV, Balasubramanian, D, and Johnsen, S. "Analysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye-Bueche theory." Experimental Eye Research 86, no. 2 (February 2008): 434-444.  Full Text
    • Costello, MJ, Johnsen, S, Metlapally, S, Gilliland, KO, Ramamurthy, B, Krishna, PV, and Balasubramanian, D. "Ultrastructural analysis of damage to nuclear fiber cell membranes in advanced age-related cataracts from India." Experimental Eye Research 87, no. 2 (2008): 147-158.  Full Text
    • Costello, MJ, Johnsen, S, Gilliland, KO, Freel, CD, and Fowler, WC. "Predicted light scattering from particles observed in human age-related nuclear cataracts using mie scattering theory." Investigative Ophthalmology & Visual Science 48, no. 1 (January 2007): 303-312.  Full Text
    • Maddala, R, Deng, P-F, Costello, JM, Wawrousek, EF, Zigler, JS, and Rao, VP. "Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse." Laboratory Investigation; a Journal of Technical Methods and Pathology 84, no. 6 (June 2004): 679-692.  Full Text
    • Gilliland, KO, Freel, CD, Johnsen, S, Fowler, WC, and Costello, MJ. "Distribution, spherical structure and predicted Mie scattering of multilamellar bodies in human age-related nuclear cataracts." Experimental Eye Research 79, no. 4 (2004): 563-576.  Full Text
    • Marsili, S, Salganik, RI, Albright, CD, Freel, CD, Johnsen, S, Peiffer, RL, and Costello, MJ. "Cataract formation in a strain of rats selected for high oxidative stress." Experimental Eye Research 79, no. 5 (2004): 595-612.  Full Text
    • Kim, DH, Costello, MJ, Duncan, PB, and Needham, D. "Mechanical properties and microstructure of polycrystalline phospholipid monolayer shells: Novel solid microparticles." Langmuir 19, no. 20 (September 30, 2003): 8455-8466.  Full Text
    • Freel, CD, Gilliland, KO, Mekeel, HE, Giblin, FJ, and Costello, MJ. "Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model." Experimental Eye Research 76, no. 4 (April 2003): 405-415.  Full Text
    • Freel, CD, Al-Ghoul, KJ, Kuszak, JR, and Costello, MJ. "Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopy." Bmc Ophthalmology 3 (January 6, 2003): 1-9.  Full Text
    • Freel, CD, Gilliland, KO, Lane, CW, Giblin, FJ, and Costello, MJ. "Fourier analysis of cytoplasmic texture in nuclear fiber cells from transparent and cataractous human and animal lenses." EXPERIMENTAL EYE RESEARCH 74, no. 6 (June 2002): 689-702.  Full Text  Link to Item
    • Gilliland, KO, Freel, CD, Lane, CW, Fowler, WC, and Costello, MJ. "Multilamellar bodies as potential scattering particles in human age-related nuclear cataracts." MOLECULAR VISION 7, no. 18 (June 22, 2001): 120-130.  Link to Item
    • Al-Ghoul, KJ, Nordgren, RK, Kuszak, AJ, Freel, CD, Costello, MJ, and Kuszak, JR. "Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis." Experimental Eye Research 72, no. 3 (March 2001): 199-214.  Full Text
    • Taylor, VL, and Costello, MJ. "Fourier analysis of textural variations in human normal and cataractous lens nuclear fiber cell cytoplasm." Experimental Eye Research 69, no. 2 (August 1999): 163-174.  Full Text
    • Al-Ghoul, KJ, and Costello, MJ. "Erratum: Fiber cell morphology and cytoplasmic texture in cataractous and normal human lens nuclei (Current Eye Research (1996) 15 5 (533-542))." Current Eye Research 15, no. 7 (August 20, 1996): 806-null.
    • Taylor, VL, al-Ghoul, KJ, Lane, CW, Davis, VA, Kuszak, JR, and Costello, MJ. "Morphology of the normal human lens." Investigative Ophthalmology & Visual Science 37, no. 7 (June 1996): 1396-1410.
    • al-Ghoul, KJ, and Costello, MJ. "Fiber cell morphology and cytoplasmic texture in cataractous and normal human lens nuclei." Current Eye Research 15, no. 5 (May 1996): 533-542.  Full Text
    • Al-Ghoul, KJ, Lane, CW, Taylor, VL, Fowler, WC, and Costello, MJ. "Distribution and type of morphological damage in human nuclear age-related cataracts." Experimental Eye Research 62, no. 3 (March 1996): 237-251.  Full Text
    • Al-Ghoul, KJ, Taylor, VL, and Costello, MJ. "Continuous variation of fiber cell size, shape and ordering in the equatorial plane of bovine lenses." Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Kuszak, JR, Peterson, KL, Costello, MJ, Bron, AJ, and Koretz, JF. "The structural basis of the crystalline lens sulcus." Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Taylor, VL, Al-Ghoul, KJ, Lane, CW, Peiffer, R, and Costello, MJ. "Fourier analysis of normal and cataractous nuclear fiber cell cytoplasms." Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
    • Dai, JD, Joseph Costello, M, and Gilbert, LI. "The prothoracic glands of manduca sexta: A microscopic analysis of gap junctions and intercellular bridges." Invertebrate Reproduction and Development 25, no. 2 (January 1, 1994): 93-110.  Full Text
    • al-Ghoul, KJ, and Costello, MJ. "Morphological changes in human nuclear cataracts of late-onset diabetics." Experimental Eye Research 57, no. 4 (October 1993): 469-486.  Full Text
    • Costello, MJ, Lane, CW, Hatchell, DL, Saloupis, P, and Cobo, LM. "Ultrastructure of fiber cells and multilamellar inclusions in experimental diabetes." Investigative Ophthalmology & Visual Science 34, no. 7 (June 1993): 2174-2185.
    • Costello, MJ, Oliver, TN, and Cobo, LM. "Cellular architecture in age-related human nuclear cataracts." Investigative Ophthalmology & Visual Science 33, no. 11 (October 1992): 3209-3227.
    • Wilkison, WO, Bell, RM, Taylor, KA, and Costello, MJ. "Structural characterization of ordered arrays of sn-glycerol-3-phosphate acyltransferase from Escherichia coli." J Bacteriol 174, no. 20 (October 1992): 6608-6616.  Link to Item
    • Costello, MJ, McIntosh, TJ, and Robertson, JD. "Distribution of gap junctions and square array junctions in the mammalian lens." Invest Ophthalmol Vis Sci 30, no. 5 (May 1989): 975-989.  Link to Item
    • Costello, MJ, Escaig, J, Matsushita, K, Viitanen, PV, Menick, DR, and Kaback, HR. "Purified lac permease and cytochrome o oxidase are functional as monomers." The Journal of biological chemistry 262, no. 35 (December 1987): 17072-17082.
    • Costello, MJ, and Fetter, RD. "Freeze-fracture methods: preparation of complementary replicas for evaluating intracellular ice damage in ultrarapidly cooled specimens." Methods in Enzymology 127 (January 1986): 704-718.
    • Costello, MJ, McIntosh, TJ, and Robertson, JD. "Membrane specializations in mammalian lens fiber cells: distribution of square arrays." Curr Eye Res 4, no. 11 (November 1985): 1183-1201.  Link to Item
    • Frey, TG, Kuhn, LA, Leigh, JS, Costello, MJ, and Chan, SH. "Cytochrome oxidase: structural insights from electron microscopy and from secondary structure prediction." Journal of Inorganic Biochemistry 23, no. 3-4 (March 1985): 155-162.  Full Text
    • Costello, MJ, Viitanen, P, Carrasco, N, Foster, DL, and Kaback, HR. "Morphology of proteoliposomes reconstituted with purified lac carrier protein from Escherichia coli." The Journal of Biological Chemistry 259, no. 24 (December 1984): 15579-15586.
    • Costello, MJ, Meiboom, S, and Sammon, M. "Electron microscopy of a cholesteric liquid crystal and its blue phase." Physical Review A 29, no. 5 (January 1, 1984): 2957-2959.  Full Text
    • Frey, TG, Costello, MJ, and Chan, SHP. "Selective contrast in electron microscopy of crystalline cytochrome oxidase." Ultramicroscopy 13, no. 1-2 (January 1, 1984): 85-91.  Full Text
    • Morris, SJ, Costello, MJ, Robertson, JD, Südhof, TC, Odenwald, WF, and Haynes, DH. "The chromaffin granule as a model for membrane fusion: implications for exocytosis." Journal of the Autonomic Nervous System 7, no. 1 (January 1983): 19-33.  Full Text
    • Costello, MJ, and Frey, TG. "Membranous cytochrome c oxidase. A freeze-fracture electron microscopic analysis." Journal of Molecular Biology 162, no. 1 (November 1982): 131-156.  Full Text
    • Frey, TG, Costello, MJ, Karlsson, B, Haselgrove, JC, and Leigh, JS. "Structure of the cytochrome c oxidase dimer. Electron microscopy of two-dimensional crystals." Journal of Molecular Biology 162, no. 1 (November 1982): 113-130.  Full Text
    • Simon, SA, Zampighi, G, McIntosh, TJ, Costello, MJ, Ting-beall, HP, and Robertson, JD. "The structure of junctions between lens fiber cells." Bioscience Reports 2, no. 5 (May 1982): 333-341.  Full Text
    • Corless, JM, and Joseph Costello, M. "[80] Isolation, Rapid Freezing, and Freeze-Fracture Methods for Frog Retinal Photoreceptors." Methods in Enzymology 81, no. C (January 1, 1982): 585-593.  Full Text
    • McIntosh, TJ, and Costello, MJ. "Effects of n-alkanes on the morphology of lipid bilayers. A freeze-fracture and negative stain analysis." Biochimica Et Biophysica Acta 645, no. 2 (July 1981): 318-326.  Full Text
    • Corless, JM, and Costello, MJ. "Paracrystalline inclusions associated with the disk membranes of frog retinal rod outer segments." Experimental Eye Research 32, no. 2 (February 1981): 217-228.  Full Text
    • Ting-Beall, HP, Costello, MJ, Shoemaker, D, and Holland, VF. "Ultrastructure of hemoglobin-depleted human erythrocyte resealed ghosts." Biochimica Et Biophysica Acta 640, no. 3 (February 1981): 807-811.  Full Text
    • Barry, DT, Costello, MJ, and Gruner, SM. "Freeze-fracture study of vesicle disruption and inversion in isolated bovine rod outer segment disks." Experimental Eye Research 30, no. 5 (May 1980): 501-510.  Full Text
    • Costello, MJ. "Ultra-rapid freezing of thin biological samples." Scanning Electron Microscopy , no. Pt 2 (January 1980): 361-370.
    • Costello, MJ, and Gulik-Krzywicki, T. "Correlated x-ray diffraction and freeze-fracture studies on membrane model systems. Perturbations induced by freeze-fracture preparative procedures." Biochimica Et Biophysica Acta 455, no. 2 (December 1976): 412-432.  Full Text
    • Corless, JM, Cobbs, WH, Costello, MJ, and Robertson, JD. "On the asymmetry of frog retinal rod outer segment disk membranes." Exp Eye Res 23, no. 3 (September 1976): 295-324.  Link to Item
    • al-Ghoul, KJ, and Costello, MJ. "Light microscopic variation of fiber cell size, shape and ordering in the equatorial plane of bovine and human lenses." Molecular Vision 3 (February 2, 1997): 2-null.

  • Conference Papers

    • Costello, MJ. "Cryo-electron microscopy of biological samples." September 2006.  Full Text
    • Costello, MJ, Gilliland, KO, and Freel, CD. "Morphological evidence for adhesive role of thin-symmetric junctions in undulating membranes of lens nuclear fiber cells." November 20, 2002.
    • Costello, MJ, Al-Ghoul, KJ, Oliver, TN, Lane, CW, Wodnicka, M, and Wodnicki, P. "Polymorphism of fiber cell junctions in mammalian lens." December 1, 1993.
    • Costello, MJ. "Cryopreservation of biological specimens." December 1, 1993.
    • Costello, MJ, and Escaig, J. "Preparation of thin, fine-grained, tantalum metal replicas for freeze-fracture electron microscopy." January 1989.

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