Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Research Associate, Pharmacology, University of North Carolina - Chapel Hill 2013 - 2018
  • Ph.D., University of Washington 2011
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2018 - 2020
• Expertise
• 

  Subject Headings

  • Muser Mentor
• Research
• 

  Selected Grants

  • SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
  • High throughput platform to engineer light-controlled inhibitors against Guanine Exchange Factors of the Dbl Family awarded by National Institutes of Health 2022 - 2026
  • Novel Immunogens to Elicit Broadly Cross-reactive Antibodies That Target the Hemagglutinin Head Trimer Interface awarded by National Institutes of Health 2021 - 2025
  • Collaboratory of AIDS Researchers for Eradication (CARE) awarded by University of North Carolina - Chapel Hill 2021 - 2023
  • SHIV/HIV Env-antibody coevolution as a molecular guide to V3 glycan targeted vaccine design awarded by University of Pennsylvania 2022 - 2023
  • Immunogen Design Strategies To Direct Hiv-1 Broadly Neutralizing Antibody Maturation By Probability-Based Targeting Of Critical Mutations awarded by National Institutes of Health 2019 - 2021
  • Coronavirus Vaccine Design awarded by State of North Carolina 2020 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.
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    • Swanson, Olivia, Brianna Rhodes, Avivah Wang, Shi-Mao Xia, Robert Parks, Haiyan Chen, Aja Sanzone, et al. “Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.” Cell Rep 36, no. 7 (August 17, 2021): 109561. https://doi.org/10.1016/j.celrep.2021.109561.
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    • Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.
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    • Marston, Daniel J., Marco Vilela, Jaewon Huh, Jinqi Ren, Mihai L. Azoitei, George Glekas, Gaudenz Danuser, John Sondek, and Klaus M. Hahn. “Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis.” Nat Chem Biol 16, no. 8 (August 2020): 826–33. https://doi.org/10.1038/s41589-020-0542-9.
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    • Azoitei, Mihai L., Jungsik Noh, Daniel J. Marston, Philippe Roudot, Christopher B. Marshall, Timothy A. Daugird, Sidney L. Lisanza, et al. “Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.” J Cell Biol 218, no. 9 (September 2, 2019): 3077–97. https://doi.org/10.1083/jcb.201812073.
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    • O’Shaughnessy, Ellen C., Orrin J. Stone, Paul K. LaFosse, Mihai L. Azoitei, Denis Tsygankov, John M. Heddleston, Wesley R. Legant, et al. “Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor.” J Cell Biol 218, no. 9 (September 2, 2019): 3153–60. https://doi.org/10.1083/jcb.201903019.
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    • Azoitei, M. L., Y. A. Ban, O. Kalyuzhny, J. Guenaga, A. Schroeter, J. Porter, R. Wyatt, and William R. Schief. “Computational design of protein antigens that interact with the CDR H3 loop of HIV broadly neutralizing antibody 2F5.” Proteins 82, no. 10 (October 2014): 2770–82. https://doi.org/10.1002/prot.24641.
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    • Azoitei, Mihai L., Yih-En Andrew Ban, Jean-Philippe Julien, Steve Bryson, Alexandria Schroeter, Oleksandr Kalyuzhniy, Justin R. Porter, et al. “Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.” J Mol Biol 415, no. 1 (January 6, 2012): 175–92. https://doi.org/10.1016/j.jmb.2011.10.003.
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    • Azoitei, Mihai L., Bruno E. Correia, Yih-En Andrew Ban, Chris Carrico, Oleksandr Kalyuzhniy, Lei Chen, Alexandria Schroeter, et al. “Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.” Science 334, no. 6054 (October 21, 2011): 373–76. https://doi.org/10.1126/science.1209368.
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    • Carter, Laura L., Michael W. Leach, Mihai L. Azoitei, Junqing Cui, Jeffrey W. Pelker, Jason Jussif, Steve Benoit, et al. “PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.” J Neuroimmunol 182, no. 1–2 (January 2007): 124–34. https://doi.org/10.1016/j.jneuroim.2006.10.006.
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    • Marusic, Suzana, Michael W. Leach, Jeffrey W. Pelker, Mihai L. Azoitei, Naonori Uozumi, Junqing Cui, Marina W. H. Shen, et al. “Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis.” J Exp Med 202, no. 6 (September 19, 2005): 841–51. https://doi.org/10.1084/jem.20050665.
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  • Conference Papers

    • Azoitei, M. L., J. Noh, M. J. Sandi, P. Roudot, R. K. Rottapel, G. Danuser, and K. M. Hahn. “Novel biosensor reveals the regulation and coordination of GEF-H1 with protrusion machinery.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
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