Scholars@Duke
Olga Theresa Gupta

Olga Theresa Gupta

Associate Professor of Pediatrics
Pediatrics, Endocrinology
olga.hardy@duke.edu
Box 31242 Med Ctr, Durham, NC 27710
Dept of Pediatrics, Durham, NC 27710

Selected Publications

Disparities in diabetes technology utilization in youth with diabetes.

Journal Article BMJ Open Diabetes Res Care · November 4, 2025 BACKGROUND: Diabetes technology can improve glycemic variability and diabetes outcomes, but there are disparities in patient use. AIMS: Identify racial, ethnic, and socioeconomic disparities in technology utilization and determine provider-, patient-, and ... Full text Open Access Link to item Cite

Pharmacological management of pediatric metabolic dysfunction-associated steatotic liver disease.

Journal Article J Pediatr Gastroenterol Nutr · January 2025 Pediatric obesity, characterized by a body mass index (BMI) at or above the 95th percentile for age, affects a substantial number of children and adolescents worldwide. Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non ... Full text Link to item Cite

The Expanding Problem of Regional Adiposity: Revisiting a 1985 Diabetes Classic by Ohlson et al.

Journal Article Diabetes · May 1, 2024 Body fat distribution is a predictor of metabolic health in obesity. In this Classics in Diabetes article, we revisit a 1985 Diabetes article by Swedish investigators Ohlson et al. This work was one of the first prospective population-based studies that es ... Full text Link to item Cite

Body composition in early pubescent children with obesity: effects following 1 year of nonintervention.

Journal Article J Appl Physiol (1985) · April 1, 2024 Little is known about whether body composition changes differently between children with and without obesity following 1 year of nonintervention. Therefore, we investigated body composition in early pubescent children (8-12 yr) with and without obesity bef ... Full text Link to item Cite

Internet-based cognitive behavioral therapy intervention for youth with type 1 diabetes and depressive symptoms: a pilot and feasibility study.

Journal Article Mhealth · 2024 Depression is more common in youth with type 1 diabetes (T1D) compared to youth without diabetes. This study aims to assess the efficacy of Competent Adulthood Transition with Cognitive Humanistic and Interpersonal Teaching (CATCH-IT), an internet-based co ... Full text Link to item Cite

HEALTH DISPARITIES IN DIABETES TECHNOLOGY UTILIZATION IN YOUTH WITH DIABETES

Conference DIABETES TECHNOLOGY & THERAPEUTICS · 2024 Cite

Electronic phenotypes to distinguish clinician attention to high body mass index, hypertension, lipid disorders, fatty liver and diabetes in pediatric primary care: Diagnostic accuracy of electronic phenotypes compared to masked comprehensive chart review.

Journal Article Pediatr Obes · October 2023 BACKGROUND/OBJECTIVES: Electronic phenotyping is a method of using electronic-health-record (EHR) data to automate identifying a patient/population with a characteristic of interest. This study determines validity of using EHR data of children with overwei ... Full text Link to item Cite

The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.

Journal Article J Pediatr · December 2022 OBJECTIVES: To evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of the previous 2 years. STUDY DESIGN: Multicenter (n = 24 centers), hospital-based, retro ... Full text Open Access Link to item Cite

Longitudinal Outcomes in Adolescents After Referral for Metabolic and Bariatric Surgery.

Journal Article J Pediatr Gastroenterol Nutr · December 1, 2021 BACKGROUND: Metabolic and bariatric surgery (MBS) can be a well tolerated and effective treatment option for severe obesity in adolescents. We compared outcomes for adolescents that did and did not proceed to surgery. METHODS: A single-center longitudinal ... Full text Link to item Cite

Distribution of comorbidities as primary diagnoses by obesity class among patients in a large US paediatric healthcare system.

Journal Article Clin Obes · October 2021 There is little documentation of the distribution of specific health conditions across obesity classes (I, II, III), especially for paediatric populations who are seen for routine care in large United States US healthcare systems. The aim of this study was ... Full text Link to item Cite

Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.

Journal Article Nat Metab · November 2020 Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT perivascular (PDGFRβ+) cells, termed fibro-inflammatory progenitors (FIPs), activate proinflamm ... Full text Link to item Cite

Impact of insulin reduction on glycemic control in children attending a residential diabetes camp.

Journal Article Pediatr Diabetes · December 2019 BACKGROUND/OBJECTIVES: Children attending diabetes camp are more active, increasing the risk of hypoglycemia. Decreasing initial insulin doses may reduce this risk. The objectives of our study were to compare glycemic control between campers receiving mult ... Full text Link to item Cite

A Pilot Study Evaluating a Binge-Eating Screener in Children: Development of the Children's Brief Binge-Eating Questionnaire in a Pediatric Obesity Clinic.

Journal Article Clin Pediatr (Phila) · September 2019 Children referred to pediatric obesity programs are at high risk of binge-eating disorder (BED) symptoms. Our goal was to develop and evaluate the Children's Brief Binge-Eating Questionnaire (CBBEQ) as a rapid screen of BED symptomatology. Seventy patients ... Full text Link to item Cite

Improving medication adherence in the pediatric population using integrated care of companion animals.

Journal Article Patient Educ Couns · October 2018 Medication non-adherence occurs in more than half of children with chronic conditions. Unfortunately, most strategies for improving adherence have had limited success in the pediatric population highlighting the need for novel interventions that establish ... Full text Link to item Cite

Camp-based multi-component intervention for families of young children with type 1 diabetes: A pilot and feasibility study.

Journal Article Pediatr Diabetes · June 2018 BACKGROUND: Managing type 1 diabetes mellitus (T1DM) in preschool-aged children has unique challenges that can negatively impact glycemic control and parental coping. OBJECTIVE: To evaluate the impact of a camp-based multi-component intervention on glycate ... Full text Link to item Cite

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.

Journal Article Cardiovasc Diabetol · July 7, 2017 BACKGROUND: Omentin-1, also known as Intelectin-1 (ITLN1), is an adipokine with plasma levels associated with diabetes, obesity, and coronary artery disease. Recent studies suggest that ITLN1 can mitigate myocardial ischemic injury but the expression of IT ... Full text Link to item Cite

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.

Journal Article Mol Metab · December 2016 OBJECTIVE: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is a recently identified LD-associated protein in hepatocytes that promotes ... Full text Link to item Cite

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Journal Article Cell Metab · September 13, 2016 "Beige" adipocytes reside in white adipose tissue (WAT) and dissipate energy as heat. Several studies have shown that cold temperature can activate pro-opiomelanocortin-expressing (POMC) neurons and increase sympathetic neuronal tone to regulate WAT beigin ... Full text Link to item Cite

Association between Responsible Pet Ownership and Glycemic Control in Youths with Type 1 Diabetes.

Journal Article PLoS One · 2016 Type 1 diabetes mellitus (T1DM) a chronic characterized by an absolute insulin deficiency requires conscientious patient self-management to maintain glucose control within a normal range. Family cohesion and adaptability, positive coping strategies, social ... Full text Link to item Cite

Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?

Journal Article Trends Endocrinol Metab · October 2015 Visceral adiposity and pathological adipose tissue remodeling, a result of overnutrition, are strong predictors of metabolic health in obesity. Factors intrinsic to visceral adipose depots are likely to play a causal role in eliciting the detrimental effec ... Full text Link to item Cite

Activated Kupffer cells inhibit insulin sensitivity in obese mice.

Journal Article FASEB J · July 2015 Obesity promotes insulin resistance associated with liver inflammation, elevated glucose production, and type 2 diabetes. Although insulin resistance is attenuated in genetic mouse models that suppress systemic inflammation, it is not clear whether local r ... Full text Link to item Cite

Syndrome X (Metabolic Syndrome) for Generation Z! Why?

Journal Article Metab Syndr Relat Disord · June 2015 Full text Link to item Cite

A novel behavioral intervention in adolescents with type 1 diabetes mellitus improves glycemic control: preliminary results from a pilot randomized control trial.

Journal Article Diabetes Educ · April 2015 PURPOSE: The purpose of this study was to develop and pilot-test an innovative behavioral intervention in adolescents with type 1 diabetes mellitus (T1DM) incorporating structured care of a pet to improve glycemic control. METHODS: Twenty-eight adolescents ... Full text Link to item Cite

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction.

Journal Article Nat Commun · March 19, 2014 We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific en ... Full text Link to item Cite

Engaging teens and parents in collaborative practice: perspectives on diabetes self-management.

Journal Article Diabetes Educ · 2014 PURPOSE: The purpose of this exploratory focus group study was to describe the perspectives of teens and their parents about self-management knowledge, behaviors (including division of labor associated with T1D management), and resources used to manage T1D ... Full text Link to item Cite

Parental mastery of continuous subcutaneous insulin infusion skills and glycemic control in youth with type 1 diabetes.

Journal Article Diabetes Technol Ther · July 2013 OBJECTIVE: The purpose of this study is to determine whether parental knowledge of the continuous subcutaneous insulin infusion (CSII) device affects glycemic control as measured by hemoglobin A1c (A1C) level. SUBJECTS AND METHODS: Parents of children with ... Full text Link to item Cite

Increased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents.

Journal Article Pediatr Obes · February 2013 BACKGROUND: Metabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn. OBJECTIVES: The aim of this pilot study was to assess the correlation ... Full text Link to item Cite

What causes the insulin resistance underlying obesity?

Journal Article Curr Opin Endocrinol Diabetes Obes · April 2012 PURPOSE OF REVIEW: The association between obesity and insulin resistance is an area of much interest and enormous public health impact, with hundreds of articles being published in the last year focused on the possible mechanisms that underlie this associ ... Full text Link to item Cite

Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents.

Journal Article J Pediatr Endocrinol Metab · 2012 Behavioral changes are the first line of treatment for dyslipidemia in adolescents, but outcome data on the effectiveness of this approach are inconsistent. This study aims to assess the effect of a 13-week multicomponent wellness intervention program, whi ... Full text Link to item Cite

Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.

Journal Article Surg Obes Relat Dis · 2011 BACKGROUND: Obesity is a strong risk factor for resistance to insulin-mediated glucose disposal, a precursor of type 2 diabetes and other disorders. However, not all obese individuals are insulin resistant. We sought to identify the molecular pathways that ... Full text Link to item Cite

Body mass index, treatment practices, and mortality in patients with acute heart failure.

Journal Article Coron Artery Dis · December 2009 OBJECTIVES: Obesity is associated with an increased risk of heart failure (HF). Among patients presenting with acute HF, however, differences in clinical characteristics, treatment regimens, and short-term prognosis of varying weights are largely unknown, ... Full text Link to item Cite

Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon.

Journal Article Horm Res · 2008 BACKGROUND: Congenital hyperinsulinism (CHI) is characterized by severe hypoglycemia caused by dysregulated insulin secretion. The long-term outcome is dependent on prevention of hypoglycemic episodes to avoid the high risk of permanent brain damage. Sever ... Full text Link to item Cite

Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.

Journal Article J Clin Endocrinol Metab · December 2007 OBJECTIVES: Focal lesions in infants with congenital hyperinsulinism (HI) represent areas of adenomatosis that express a paternally derived ATP-sensitive potassium channel mutation due to embryonic loss of heterozygosity for the maternal 11p region. This s ... Full text Link to item Cite

Congenital hyperinsulinism - a review of the disorder and a discussion of the anesthesia management.

Journal Article Paediatr Anaesth · July 2007 Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infants and children. In most affected infants, CHI is caused by a specific genetic defect that results in the altered expression of pancreatic beta cells causing unreg ... Full text Link to item Cite

Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.

Journal Article Genes Dev · April 1, 2007 The failure to expand functional pancreatic beta-cell mass in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing beta-cells is the principle mechanism for beta-cell expansi ... Full text Link to item Cite

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

Journal Article Mol Endocrinol · March 2007 Recent advances in functional genomics afford the opportunity to interrogate the expression profiles of thousands of genes simultaneously and examine the function of these genes in a high-throughput manner. In this study, we describe a rational and efficie ... Full text Link to item Cite

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.

Journal Article J Pediatr · February 2007 OBJECTIVES: To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism. STUDY DESIGN: Twenty-four infants with hyper ... Full text Link to item Cite

Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism.

Journal Article J Pediatr Surg · January 2007 Congenital hyperinsulinism (HI) exists in 2 histologic forms, focal and diffuse, and rarely has been attributed to lesions in ectopic pancreatic tissue. The ability to distinguish focal from diffuse HI and locate focal lesions has been difficult, thus limi ... Full text Link to item Cite

PTU-associated vasculitis in a girl with Turner Syndrome and Graves' disease.

Journal Article Pediatr Emerg Care · January 2006 Palpable purpura is a concerning clinical finding in pediatric patients and can have many causes, including infectious and autoimmune processes. A rare cause, drug-induced vasculitis, may result from the production of antineutrophil cytoplasmic antibodies ... Full text Link to item Cite