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Olga Theresa Gupta

Associate Professor of Pediatrics
Pediatrics, Endocrinology
Box 31242 Med Ctr, Durham, NC 27710
Dept of Pediatrics, Durham, NC 27710

Selected Publications

The Expanding Problem of Regional Adiposity: Revisiting a 1985 Diabetes Classic by Ohlson et al.

Journal Article Diabetes · May 1, 2024 Body fat distribution is a predictor of metabolic health in obesity. In this Classics in Diabetes article, we revisit a 1985 Diabetes article by Swedish investigators Ohlson et al. This work was one of the first prospective population-based studies that es ... Full text Link to item Cite

Internet-based cognitive behavioral therapy intervention for youth with type 1 diabetes and depressive symptoms: a pilot and feasibility study.

Journal Article Mhealth · 2024 Depression is more common in youth with type 1 diabetes (T1D) compared to youth without diabetes. This study aims to assess the efficacy of Competent Adulthood Transition with Cognitive Humanistic and Interpersonal Teaching (CATCH-IT), an internet-based co ... Full text Link to item Cite

Electronic phenotypes to distinguish clinician attention to high body mass index, hypertension, lipid disorders, fatty liver and diabetes in pediatric primary care: Diagnostic accuracy of electronic phenotypes compared to masked comprehensive chart review.

Journal Article Pediatric obesity · October 2023 Background/objectivesElectronic phenotyping is a method of using electronic-health-record (EHR) data to automate identifying a patient/population with a characteristic of interest. This study determines validity of using EHR data of children with ... Full text Cite

The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes.

Journal Article J Pediatr · December 2022 OBJECTIVES: To evaluate the frequency and severity of new cases of youth-onset type 2 diabetes in the US during the first year of the pandemic compared with the mean of the previous 2 years. STUDY DESIGN: Multicenter (n = 24 centers), hospital-based, retro ... Full text Open Access Link to item Cite

Perivascular mesenchymal cells control adipose-tissue macrophage accrual in obesity.

Journal Article Nat Metab · November 2020 Chronic low-grade white adipose tissue (WAT) inflammation is a hallmark of metabolic syndrome in obesity. Here, we demonstrate that a subpopulation of mouse WAT perivascular (PDGFRβ+) cells, termed fibro-inflammatory progenitors (FIPs), activate proinflamm ... Full text Link to item Cite

Impact of insulin reduction on glycemic control in children attending a residential diabetes camp.

Journal Article Pediatr Diabetes · December 2019 BACKGROUND/OBJECTIVES: Children attending diabetes camp are more active, increasing the risk of hypoglycemia. Decreasing initial insulin doses may reduce this risk. The objectives of our study were to compare glycemic control between campers receiving mult ... Full text Link to item Cite

Improving medication adherence in the pediatric population using integrated care of companion animals.

Journal Article Patient Educ Couns · October 2018 Medication non-adherence occurs in more than half of children with chronic conditions. Unfortunately, most strategies for improving adherence have had limited success in the pediatric population highlighting the need for novel interventions that establish ... Full text Link to item Cite

Camp-based multi-component intervention for families of young children with type 1 diabetes: A pilot and feasibility study.

Journal Article Pediatr Diabetes · June 2018 BACKGROUND: Managing type 1 diabetes mellitus (T1DM) in preschool-aged children has unique challenges that can negatively impact glycemic control and parental coping. OBJECTIVE: To evaluate the impact of a camp-based multi-component intervention on glycate ... Full text Link to item Cite

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.

Journal Article Cell Metab · September 13, 2016 "Beige" adipocytes reside in white adipose tissue (WAT) and dissipate energy as heat. Several studies have shown that cold temperature can activate pro-opiomelanocortin-expressing (POMC) neurons and increase sympathetic neuronal tone to regulate WAT beigin ... Full text Link to item Cite

Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?

Journal Article Trends Endocrinol Metab · October 2015 Visceral adiposity and pathological adipose tissue remodeling, a result of overnutrition, are strong predictors of metabolic health in obesity. Factors intrinsic to visceral adipose depots are likely to play a causal role in eliciting the detrimental effec ... Full text Link to item Cite