Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Staff Fellow, Endocrinology, National Institutes of Health 1988 - 1989
  • Resident, Medicine, University of Chicago 1982 - 1985
  • M.D., Johns Hopkins University 1982
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2010 - 2016
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2009
• Recognition
• 

  In the News

  • NOV 18, 2015

    Research yields potential treatment approach for glycogen storage disease

  • AUG 19, 2013

    Coffee and Tea May Contribute to a Healthy Liver

  • AUG 19, 2013

    CTV News

    Coffee and tea may protect your liver
• Research
• 

  Selected Grants

  • Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease awarded by National Institutes of Health 2014 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Waskowicz, LR, Zhou, J, Landau, DJ, Brooks, ED, Lim, A, Yavarow, ZA, Kudo, T, Zhang, H, Wu, Y, Grant, S, Young, SP, Huat, BB, Yen, PM, and Koeberl, DD. "Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia." Human Molecular Genetics 28, no. 1 (January 2019): 143-154.  Full Text
    • Yau, WW, Singh, BK, Lesmana, R, Zhou, J, Sinha, RA, Wong, KA, Wu, Y, Bay, B-H, Sugii, S, Sun, L, and Yen, PM. "Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy." Autophagy 15, no. 1 (January 2019): 131-150.  Full Text
    • Singh, BK, Sinha, RA, and Yen, PM. "Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone." International Journal of Molecular Sciences 19, no. 10 (October 22, 2018). (Review)  Full Text
    • Cheong, A, Low, JJA, Lim, A, Yen, PM, and Woon, ECY. "A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N 6-methyladenosine demethylase activity in cells." Chemical Science 9, no. 36 (September 2018): 7174-7185.  Full Text
    • Bruinstroop, E, Dalan, R, Cao, Y, Bee, YM, Chandran, K, Cho, LW, Soh, SB, Teo, EK, Toh, S-A, Leow, MKS, Sinha, RA, Sadananthan, SA, Michael, N, Stapleton, HM, Leung, C, Angus, PW, Patel, SK, Burrell, LM, Lim, SC, Sum, CF, Velan, SS, and Yen, PM. "Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD." The Journal of Clinical Endocrinology and Metabolism 103, no. 7 (July 2018): 2698-2706.  Full Text
    • Singh, BK, Sinha, RA, Tripathi, M, Mendoza, A, Ohba, K, Sy, JAC, Xie, SY, Zhou, J, Ho, JP, Chang, C-Y, Wu, Y, Giguère, V, Bay, B-H, Vanacker, J-M, Ghosh, S, Gauthier, K, Hollenberg, AN, McDonnell, DP, and Yen, PM. "Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function." Science Signaling 11, no. 536 (June 26, 2018).  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Direct effects of thyroid hormones on hepatic lipid metabolism." Nature Reviews. Endocrinology 14, no. 5 (May 2018): 259-269. (Review)  Full Text
    • Zhou, J, Sinha, RA, Lesmana, R, Yau, WWY, and Yen, PM. "Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro." Methods in Molecular Biology (Clifton, N.J.) 1801 (January 2018): 111-122.  Full Text
    • Singh, BK, Sinha, RA, Ohba, K, and Yen, PM. "Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy." Molecular and Cellular Endocrinology 458 (December 2017): 160-168. (Review)  Full Text
    • Farah, BL, Landau, DJ, Wu, Y, Sinha, RA, Loh, A, Bay, B-H, Koeberl, DD, and Yen, PM. "Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia." Molecular Genetics and Metabolism 122, no. 3 (November 2017): 95-98.  Full Text
    • Wang, M-E, Singh, BK, Hsu, M-C, Huang, C, Yen, PM, Wu, L-S, Jong, D-S, and Chiu, C-H. "Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy." Scientific Reports 7, no. 1 (October 25, 2017): 13999-null.  Full Text
    • Flamant, F, Cheng, S-Y, Hollenberg, AN, Moeller, LC, Samarut, J, Wondisford, FE, Yen, PM, and Refetoff, S. "Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature." Endocrinology 158, no. 7 (July 2017): 2052-2057.  Full Text
    • Ohba, K, Sinha, RA, Singh, BK, Iannucci, LF, Zhou, J, Kovalik, J-P, Liao, X-H, Refetoff, S, Sng, JCG, Leow, MK-S, and Yen, PM. "Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model." Thyroid : Official Journal of the American Thyroid Association 27, no. 6 (June 2017): 852-860.  Full Text
    • Iannucci, LF, Cioffi, F, Senese, R, Goglia, F, Lanni, A, Yen, PM, and Sinha, RA. "Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet." Scientific Reports 7, no. 1 (May 17, 2017): 2023-null.  Full Text
    • Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Lim, A, Hirayama, M, Landau, DJ, Bay, BH, Koeberl, DD, and Yen, PM. "Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)." Scientific Reports 7 (March 20, 2017): 44408-null.  Full Text
    • Zhou, J, Chong, SY, Lim, A, Singh, BK, Sinha, RA, Salmon, AB, and Yen, PM. "Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging." Aging 9, no. 2 (February 26, 2017): 583-599.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis." Endocrine reviews 38, no. 1 (February 2017): 69-102. (Review)  Full Text
    • Butler, MS, Roshan-Moniri, M, Hsing, M, Lau, D, Kim, A, Yen, P, Mroczek, M, Nouri, M, Lien, S, Cilies, PA, Dalal, K, Yau, C, Ghaidi, F, Guo, Y, Yamazaki, T, Lawn, S, Gleave, ME, Gregory-Evans, CY, McIntosh, LP, Cox, ME, Rennie, PS, and Cherkasov, A. "Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer." Oncotarget 8, no. 26 (January 1, 2017): 42438-42454.  Full Text
    • Iannucci, LF, Sun, J, Singh, BK, Zhou, J, Kaddai, VA, Lanni, A, Yen, PM, and Sinha, RA. "Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467]." Biochemical and biophysical research communications 482, no. 4 (January 2017): 1517-.  Full Text
    • Sinha, RA, Singh, BK, Zhou, J, Xie, S, Farah, BL, Lesmana, R, Ohba, K, Tripathi, M, Ghosh, S, Hollenberg, AN, and Yen, PM. "Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells." Autophagy 13, no. 1 (January 2017): 169-186.  Full Text
    • Tripathi, M, Zhang, CW, Singh, BK, Sinha, RA, Moe, KT, DeSilva, DA, and Yen, PM. "Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation." Cell Death & Disease 7, no. 12 (December 8, 2016): e2513-null.  Full Text
    • Iannucci, LF, Sun, J, Singh, BK, Zhou, J, Kaddai, VA, Lanni, A, Yen, PM, and Sinha, RA. "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells." Biochemical and Biophysical Research Communications 480, no. 3 (November 2016): 461-467.  Full Text
    • Chng, C-L, Lim, AYY, Tan, HC, Kovalik, J-P, Tham, KW, Bee, YM, Lim, W, Acharyya, S, Lai, OF, Chong, MF-F, and Yen, PM. "Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease." Thyroid : Official Journal of the American Thyroid Association 26, no. 10 (October 2016): 1422-1430.  Full Text
    • Lim, A, Zhou, J, Sinha, RA, Singh, BK, Ghosh, S, Lim, K-H, Chow, PK-H, Woon, ECY, and Yen, PM. "Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity." Biochemical and Biophysical Research Communications 479, no. 3 (October 2016): 476-481.  Full Text
    • Yen, PM. "TSHβv-A New Bone to Pick." Endocrinology 157, no. 9 (September 2016): 3402-3404.  Full Text
    • Ohba, K, Leow, MK-S, Singh, BK, Sinha, RA, Lesmana, R, Liao, X-H, Ghosh, S, Refetoff, S, Sng, JCG, and Yen, PM. "Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice." Endocrinology 157, no. 4 (April 2016): 1660-1672.  Full Text
    • Farah, BL, Landau, DJ, Sinha, RA, Brooks, ED, Wu, Y, Fung, SYS, Tanaka, T, Hirayama, M, Bay, B-H, Koeberl, DD, and Yen, PM. "Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency." Journal of Hepatology 64, no. 2 (February 2016): 370-379.  Full Text
    • Lesmana, R, Sinha, RA, Singh, BK, Zhou, J, Ohba, K, Wu, Y, Yau, WWY, Bay, B-H, and Yen, PM. "Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle." Endocrinology 157, no. 1 (January 2016): 23-38.  Full Text
    • Singh, BK, Sinha, RA, Zhou, J, Tripathi, M, Ohba, K, Wang, M-E, Astapova, I, Ghosh, S, Hollenberg, AN, Gauthier, K, and Yen, PM. "Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition." The Journal of Biological Chemistry 291, no. 1 (January 2016): 198-214.  Full Text
    • Sinha, RA, and Yen, PM. "Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD." Cell & Bioscience 6 (January 2016): 46-. (Review)  Full Text
    • Yen, PM. "Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease." Best practice & research. Clinical endocrinology & metabolism 29, no. 4 (August 2015): 517-528. (Review)  Full Text
    • Zhou, J, Yong, W-P, Yap, CS, Vijayaraghavan, A, Sinha, RA, Singh, BK, Xiu, S, Manesh, S, Ngo, A, Lim, A, Ang, C, Xie, C, Wong, FY, Lin, SJ, Wan, WK, Tan, IB, Flotow, H, Tan, P, Lim, K-H, Yen, PM, and Goh, LK. "An integrative approach identified genes associated with drug response in gastric cancer." Carcinogenesis 36, no. 4 (April 2015): 441-451.  Full Text
    • Yen, PM. "Unliganded TRs regulate growth and developmental timing during early embryogenesis: Evidence for a dual function mechanism of TR action." Cell and Bioscience 5, no. 1 (March 2, 2015).  Full Text
    • Sinha, RA, Singh, BK, Zhou, J, Wu, Y, Farah, BL, Ohba, K, Lesmana, R, Gooding, J, Bay, B-H, and Yen, PM. "Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling." Autophagy 11, no. 8 (January 2015): 1341-1357.  Full Text
    • Yen, PM. "Unliganded TRs regulate growth and developmental timing during early embryogenesis: Evidence for a dual function mechanism of TR action." Cell and Bioscience (2015).  Full Text
    • Aw, DKL, Sinha, RA, Tan, HC, Loh, LM, Salvatore, D, and Yen, PM. "Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism." The Journal of clinical endocrinology and metabolism 99, no. 11 (November 2014): 3965-3971.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism." Trends in Endocrinology and Metabolism: Tem 25, no. 10 (October 2014): 538-545. (Review)  Full Text
    • Aw, DKL, Sinha, RA, Xie, SY, and Yen, PM. "Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells." Biochemical and biophysical research communications 447, no. 4 (May 2014): 569-573.  Full Text
    • Farah, BL, Madden, L, Li, S, Nance, S, Bird, A, Bursac, N, Yen, PM, Young, SP, and Koeberl, DD. "Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 2272-2280.  Full Text  Open Access Copy
    • Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, B-H, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology (Baltimore, Md.) 59, no. 4 (April 2014): 1366-1380.  Full Text
    • Refetoff, S, Bassett, JHD, Beck-Peccoz, P, Bernal, J, Brent, G, Chatterjee, K, De Groot, LJ, Dumitrescu, AM, Jameson, JL, Kopp, PA, Murata, Y, Persani, L, Samarut, J, Weiss, RE, Williams, GR, and Yen, PM. "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism." Thyroid : Official Journal of the American Thyroid Association 24, no. 3 (March 4, 2014): 407-409.  Full Text
    • Refetoff, S, Bassett, JHD, Beck-Peccoz, P, Bernal, J, Brent, G, Chatterjee, K, De Groot, LJ, Dumitrescu, AM, Jameson, JL, Kopp, PA, Murata, Y, Persani, L, Samarut, J, Weiss, RE, Williams, GR, and Yen, PM. "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism." The Journal of clinical endocrinology and metabolism 99, no. 3 (March 2014): 768-770.  Full Text
    • Zhou, J, Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Bay, B-H, Yang, CS, and Yen, PM. "Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance." Plos One 9, no. 1 (January 29, 2014): e87161-null.  Full Text
    • Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Zhou, J, Bay, B-H, and Yen, PM. "β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver." Plos One 9, no. 6 (January 2014): e98155-null.  Full Text
    • Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, BH, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology 59, no. 4 (January 1, 2014): 1366-1380.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism." Trends in Endocrinology and Metabolism 25, no. 10 (January 1, 2014): 538-545. (Review)  Full Text
    • Xie, S, Sinha, RA, Singh, BK, Li, GD, Han, W, and Yen, PM. "Resveratrol induces insulin gene expression in mouse pancreatic α-cells." Cell & Bioscience 3, no. 1 (December 13, 2013): 47-null.  Full Text
    • Yap, CS, Sinha, RA, Ota, S, Katsuki, M, and Yen, PM. "Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells." Biochemical and Biophysical Research Communications 440, no. 4 (November 1, 2013): 635-639.  Full Text
    • Yap, CS, Sinha, RA, Ota, S, Katsuki, M, and Yen, PM. "Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells." Biochem Biophys Res Commun 440, no. 4 (November 1, 2013): 635-639.  Full Text  Link to Item
    • Singh, BK, Sinha, RA, Zhou, J, Xie, SY, You, S-H, Gauthier, K, and Yen, PM. "FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes." The Journal of Biological Chemistry 288, no. 42 (October 2013): 30365-30372.  Full Text
    • Wang, G, Cao, X, Lai, S, Luo, X, Feng, Y, Xia, X, Yen, PM, Gong, J, and Hu, J. "PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA." Molecular Cancer Therapeutics 12, no. 10 (October 2013): 2100-2109.  Full Text
    • Zhou, J, Chen, GB, Tang, YC, Sinha, RA, Wu, Y, Yap, CS, Wang, G, Hu, J, Xia, X, Tan, P, Goh, LK, and Yen, PM. "Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. (Published online)" BMC Med Genomics 5 (August 9, 2012): 34-.  Full Text  Link to Item
    • Sinha, RA, You, S-H, Zhou, J, Siddique, MM, Bay, B-H, Zhu, X, Privalsky, ML, Cheng, S-Y, Stevens, RD, Summers, SA, Newgard, CB, Lazar, MA, and Yen, PM. "Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy." The Journal of Clinical Investigation 122, no. 7 (July 2012): 2428-2438.  Full Text
    • Duntas, L, Amino, N, Hay, I, McDermott, M, Peeters, R, Vaismann, M, Ward, L, Williams, G, Jr, TOLSL, and Yen, P. "Thyroid disorders, noncommunicable diseases that gravely impact public health: A commentary and statement by the advisory board of the world thyroid federation." Thyroid 22, no. 6 (2012): 566-567.  Full Text
    • Voss, TC, Schiltz, RL, Sung, M-H, Yen, PM, Stamatoyannopoulos, JA, Biddie, SC, Johnson, TA, Miranda, TB, John, S, and Hager, GL. "Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism." Cell 146, no. 4 (August 11, 2011): 544-554.  Full Text
    • Culhane, JC, Wang, D, Yen, PM, and Cole, PA. "Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors." Journal of the American Chemical Society 132, no. 9 (2010): 3164-3176.  Full Text
    • Wang, D, Xia, X, Weiss, RE, Refetoff, S, and Yen, PM. "Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHα promoter." PLoS ONE 5, no. 3 (2010).  Full Text
    • Sabet, A, and Yen, PM. "Thyroid hormone action." (December 1, 2009): 43-56. (Chapter)  Full Text
    • Wang, D, Xia, X, Liu, Y, Oetting, A, Walker, RL, Zhu, Y, Meltzer, P, Cole, PA, Shi, Y-B, and Yen, PM. "Negative regulation of tshα target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation." Molecular Endocrinology 23, no. 5 (2009): 600-609.  Full Text
    • Hu, J, Xia, X, Cheng, A, Wang, G, Luo, X, Reed, MF, Fojo, T, Oetting, A, Gong, J, and Yen, PM. "A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: A novel cancer therapy." Molecular Cancer Therapeutics 7, no. 12 (2008): 3719-3728.  Full Text
    • Yen, PM. "Waterboarding is not torture: a physician's response." The Lancet 371, no. 9627 (2008): 1838--.  Full Text
    • Harvey, CB, Bassett, JHD, Maruvada, P, Yen, PM, and Williams, GR. "The rat thyroid hormone receptor (TR) Δβ3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions." Endocrinology 148, no. 4 (2007): 1764-1773.  Full Text
    • Oetting, A, and Yen, PM. "New insights into thyroid hormone action." Best Practice and Research in Clinical Endocrinology and Metabolism 21, no. 2 (2007): 193-208.  Full Text
    • Yen, PM, Ando, S, Feng, X, Liu, Y, Maruvada, P, and Xia, X. "Thyroid hormone action at the cellular, genomic and target gene levels." Molecular and Cellular Endocrinology 246, no. 1-2 (February 2006): 121-127. (Review)  Full Text
    • Liu, Y, Xia, X, Fondell, JD, and Yen, PM. "Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation." Molecular Endocrinology 20, no. 3 (2006): 483-490.  Full Text
    • Yen, PM. "Thyroid hormones and 3,5-diiodothyropropionic acid: New keys for new locks." Endocrinology 147, no. 4 (2006): 1598-1601.  Full Text
    • Shepshelovich, J, Goldstein-Magal, L, Globerson, A, Yen, PM, Rotman-Pikielny, P, and Hirschberg, K. "Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin." Journal of Cell Science 118, no. Pt 8 (April 2005): 1577-1586.  Full Text
    • Liu, Y, Ando, S, Xia, X, Yao, R, Kim, M, Fondell, J, and Yen, PM. "p62, a TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T₃-mediated transcription." Molecular Endocrinology 19, no. 4 (2005): 879-884.  Full Text
    • Yen, PM. "Editorial: Studying hormonal regulation by microarrays: Distinguishing the trees from the forest." Journal of Clinical Endocrinology and Metabolism 90, no. 2 (2005): 1241-1242.  Full Text
    • Maruvada, P, Dmitrieva, NI, East-Palmer, J, and Yen, PM. "Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity." Molecular Biology of the Cell 15, no. 4 (April 2004): 1895-1903.  Full Text
    • Jimenez, C, Moran, SA, Sereti, I, Wynne, S, Yen, PM, Falloon, J, Jr, RTD, and Sarlis, NJ. "Graves' disease after interleukin-2 therapy in a patient with human immunodeficiency virus infection." Thyroid 14, no. 12 (2004): 1097-1102.  Full Text
    • Yen, PM, Feng, X, Flamant, F, Chen, Y, Walker, RL, Weiss, RE, Chassande, O, Samarut, J, Refetoff, S, and Meltzer, PS. "Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice." Embo Reports 4, no. 6 (June 2003): 581-587.  Full Text
    • Maruvada, P, Baumann, CT, Hager, GL, and Yen, PM. "Dynamic shuttling and intranuclear mobility of nuclear hormone receptors." The Journal of Biological Chemistry 278, no. 14 (April 2003): 12425-12432.  Full Text
    • Poguet, A-L, Legrand, C, Feng, X, Yen, PM, Meltzer, P, Samarut, J, and Flamant, F. "Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum." Developmental Biology 254, no. 2 (February 2003): 188-199.  Full Text
    • Saunier, B, Triyatni, M, Ulianich, L, Maruvada, P, Yen, P, and Kohn, LD. "Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes." Journal of Virology 77, no. 1 (January 2003): 546-559.  Full Text
    • Yen, PM, and Cheng, SY. "Germline and somatic thyroid hormone receptor mutations in man." Journal of Endocrinological Investigation 26, no. 8 (2003): 780-787.
    • Yen, PM. "Molecular basis of resistance to thyroid hormone." Trends in Endocrinology and Metabolism 14, no. 7 (2003): 327-333.  Full Text
    • Rotman-Pikielny, P, Hirschberg, K, Maruvada, P, Suzuki, K, Royaux, IE, Green, ED, Kohn, LD, Lippincott-Schwartz, J, and Yen, PM. "Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome." Human Molecular Genetics 11, no. 21 (October 2002): 2625-2633.  Full Text
    • Feng, X, Meltzer, P, and Yen, PM. "Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray." Methods in molecular biology (Clifton, N.J.) 202 (2002): 31-54.
    • Parikh, S, Ando, S, Schneider, A, Skarulis, MC, Sarlis, NJ, and Yen, PM. "Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations." Thyroid 12, no. 1 (2002): 81-86.
    • Ando, S, Sarlis, NJ, Oldfield, EH, and Yen, PM. "Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor." The Journal of Clinical Endocrinology and Metabolism 86, no. 11 (November 2001): 5572-5576.  Full Text
    • Phillips, SA, Rotman-Pikielny, P, Lazar, J, Ando, S, Hauser, P, Skarulis, MC, Brucker-Davis, F, and Yen, PM. "Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant." The Journal of Clinical Endocrinology and Metabolism 86, no. 11 (November 2001): 5142-5147.  Full Text
    • Ando, S, Sarlis, NJ, Krishnan, J, Feng, X, Refetoff, S, Zhang, MQ, Oldfield, EH, and Yen, PM. "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance." Molecular Endocrinology (Baltimore, Md.) 15, no. 9 (September 2001): 1529-1538.  Full Text
    • Yen, PM. "Physiological and molecular basis of thyroid hormone action." Physiological Reviews 81, no. 3 (July 2001): 1097-1142. (Review)  Full Text
    • Baumann, CT, Ma, H, Wolford, R, Reyes, JC, Maruvada, P, Lim, C, Yen, PM, Stallcup, MR, and Hager, GL. "The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome." Molecular Endocrinology (Baltimore, Md.) 15, no. 4 (April 2001): 485-500.  Full Text
    • Baumann, CT, Maruvada, P, Hager, GL, and Yen, PM. "Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors: Multiple protein interactions are required for nuclear retention." Journal of Biological Chemistry 276, no. 14 (2001): 11237-11245.  Full Text
    • Feng, X, Jiang, Y, Meltzer, P, and Yen, PM. "Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation." Journal of Biological Chemistry 276, no. 18 (2001): 15066-15072.
    • Uwaifo, GI, Remaley, AT, Stene, M, Reynolds, JC, Yen, PM, Snider, RH, Becker, KL, and Sarlis, NJ. "A case of spurious hypercalcitoninemia: A cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia." Journal of Endocrinological Investigation 24, no. 5 (2001): 361-369.
    • Feng, X, Jiang, Y, Meltzer, P, and Yen, PM. "Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray." Molecular Endocrinology (Baltimore, Md.) 14, no. 7 (July 2000): 947-955.  Full Text
    • Rotman-Pikielny, P, Reynolds, JC, Barker, WC, Yen, PM, Skarulis, MC, and Sarlis, NJ. "Recombinant human thyrotropin for the diagnosis and treatment of a highly functional metastatic struma ovarii." The Journal of Clinical Endocrinology and Metabolism 85, no. 1 (January 2000): 237-244.  Full Text
    • Yen, PM. "Thyrotropin Receptor Mutations in Thyroid Diseases." Reviews in Endocrine and Metabolic Disorders 1, no. 1-2 (2000): 123-129.
    • Koibuchi, N, Liu, Y, Fukuda, H, Takeshita, A, Yen, PM, and Chin, WW. "ROR alpha augments thyroid hormone receptor-mediated transcriptional activation." Endocrinology 140, no. 3 (March 1999): 1356-1364.  Full Text
    • Lee, H, and Yen, PM. "Recent advances in understanding thyroid hormone receptor coregulators." Journal of Biomedical Science 6, no. 2 (March 1999): 71-78. (Review)  Full Text
    • Duncan, KG, Jumper, MD, Ribeiro, RCJ, Bailey, KR, Yen, PM, Sugawara, A, Patel, A, Stern, R, Chin, WW, Baxter, JD, and Schwartz, DM. "Human trabecular meshwork cells as a thyroid hormone target tissue: Presence of functional thyroid hormone receptors." Graefe's Archive for Clinical and Experimental Ophthalmology 237, no. 3 (1999): 231-240.  Full Text
    • Sasaki, S, Lesoon-Wood, LA, Dey, A, Kuwata, T, Weintraub, BD, Humphrey, G, Yang, W-M, Seto, E, Yen, PM, Howard, BH, and Ozato, K. "Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin β gene." EMBO Journal 18, no. 19 (1999): 5389-5398.  Full Text
    • Liu, Y, Takeshita, A, Misiti, S, Chin, WW, and Yen, PM. "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors." Endocrinology 139, no. 10 (October 1998): 4197-4204.  Full Text
    • Misiti, S, Schomburg, L, Yen, PM, and Chin, WW. "Expression and hormonal regulation of coactivator and corepressor genes." Endocrinology 139, no. 5 (May 1998): 2493-2500.  Full Text
    • Liu, Y, Takeshita, A, Nagaya, T, Baniahmad, A, Chin, WW, and Yen, PM. "An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation." Molecular Endocrinology (Baltimore, Md.) 12, no. 1 (January 1998): 34-44.  Full Text
    • Nagaya, T, Murata, Y, Yamaguchi, S, Nomura, Y, Ohmori, S, Fujieda, M, Katunuma, N, Yen, PM, Chin, WW, and Seo, H. "Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor α by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action." Journal of Biological Chemistry 273, no. 50 (1998): 33166-33173.  Full Text
    • Takeshita, A, Yen, PM, Ikeda, M, Cardona, GR, Liu, Y, Koibuchi, N, Norwitz, ER, and Chin, WW. "Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1." Journal of Biological Chemistry 273, no. 34 (1998): 21554-21562.  Full Text
    • Lin, HY, Yen, PM, Davis, FB, and Davis, PJ. "Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-gamma." The American Journal of Physiology 273, no. 4 Pt 1 (October 1997): C1225-C1232.
    • Scott, RE, Wu-Peng, XS, Yen, PM, Chin, WW, and Pfaff, DW. "Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE." Molecular Endocrinology (Baltimore, Md.) 11, no. 11 (October 1997): 1581-1592.  Full Text
    • Yen, PM, Liu, Y, Palvimo, JJ, Trifiro, M, Whang, J, Pinsky, L, Jänne, OA, and Chin, WW. "Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription." Molecular Endocrinology (Baltimore, Md.) 11, no. 2 (February 1997): 162-171.  Full Text
    • Blange, I, Drvota, V, Yen, PM, and Sylven, C. "Species differences in cardiac thyroid hormone receptor isoforms protein abundance." Biological and Pharmaceutical Bulletin 20, no. 11 (1997): 1123-1126.
    • Sanno, N, Sugawara, A, Teramoto, A, Abe, Y, Yen, PM, Chin, WW, and Osamura, RY. "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas." Neuroendocrinology 65, no. 4 (1997): 299-306.
    • Yen, PM, Liu, Y, Palvimo, JJ, Trifiro, M, Whang, J, Pinsky, L, Janne, OA, and Chin, WW. "Erratum: Mutant and wild type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription (Molecular Endocrinology (1997) 11 (162-171))." Molecular Endocrinology 11, no. 3 (January 1, 1997): 391-392.
    • Shalev, A, Siegrist-Kaiser, CA, Yen, PM, Wahli, W, Burger, AG, Chin, WW, and Meier, CA. "The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin." Endocrinology 137, no. 10 (October 1996): 4499-4502.  Full Text
    • Takeshita, A, Yen, PM, Misiti, S, Cardona, GR, Liu, Y, and Chin, WW. "Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator." Endocrinology 137, no. 8 (August 1996): 3594-3597.  Full Text
    • Chin, WW, and Yen, PM. "T3 or not T3--the slings and arrows of outrageous TR function." Endocrinology 137, no. 2 (February 1996): 387-388. (Review)  Full Text
    • Allain, TJ, Yen, PM, Flanagan, AM, and Mcgregor, AM. "The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts." European Journal of Clinical Investigation 26, no. 5 (1996): 418-425.
    • Lin, HY, Davis, FB, Yen, PM, and Davis, PJ. "Milrinone mimics thyroid hormone potentiation of the antiviral activity of human interferon-γ in hela cells." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
    • Yen, PM, Liu, Y, Sugawara, A, and Chin, WW. "Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity." Journal of Biological Chemistry 271, no. 18 (1996): 10910-10916.  Full Text
    • Zhu, Y-S, Yen, PM, Chin, WW, and Pfaff, DW. "Estrogen and thyroid hormone interaction on regulation of gene expression." Proceedings of the National Academy of Sciences of the United States of America 93, no. 22 (1996): 12587-12592.  Full Text
    • Hayashi, Y, Weiss, RE, Sarne, DH, Yen, PM, Sunthornthepvarakul, T, Marcocci, C, Chin, WW, and Refetoff, S. "Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors?." The Journal of Clinical Endocrinology and Metabolism 80, no. 11 (November 1995): 3246-3256.  Full Text
    • Yen, PM, Wilcox, EC, Hayashi, Y, Refetoff, S, and Chin, WW. "Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants." Endocrinology 136, no. 7 (July 1995): 2845-2851.  Full Text
    • Sugawara, A, Yen, PM, Qi, Y, Lechan, RM, and Chin, WW. "Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland." Endocrinology 136, no. 4 (April 1995): 1766-1774.  Full Text
    • Yen, PM, Wilcox, EC, and Chin, WW. "Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors." Endocrinology 136, no. 2 (February 1995): 440-445.  Full Text
    • Yen, PM, Sugawara, A, Liu, Y, Whang, J, and Chin, WW. "Factors that enhance Escherichia coli-expressed TRβ binding to T₃ and DNA." Thyroid 5, no. 4 (1995): 309-313.
    • Ribeiro, RC, Apriletti, JW, Yen, PM, Chin, WW, and Baxter, JD. "Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor." Endocrinology 135, no. 5 (November 1994): 2076-2085.  Full Text
    • Sugawara, A, Yen, PM, and Chin, WW. "9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors." Endocrinology 135, no. 5 (November 1994): 1956-1962.  Full Text
    • Sugawara, A. "9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors." Endocrinology 135, no. 5 (November 1, 1994): 1956-1962.  Full Text
    • Yen, PM, and Chin, WW. "Molecular mechanisms of dominant negative activity by nuclear hormone receptors." Molecular Endocrinology (Baltimore, Md.) 8, no. 11 (November 1994): 1450-1454. (Review)  Full Text
    • Yen, PM. "Molecular mechanisms of dominant negative activity by nuclear hormone receptors." Molecular Endocrinology 8, no. 11 (November 1, 1994): 1450-1454.  Full Text
    • Leonard, JL, Farwell, AP, Yen, PM, Chin, WW, and Stula, M. "Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells." Endocrinology 135, no. 2 (August 1994): 548-555.  Full Text
    • Yen, PM, Brubaker, JH, Apriletti, JW, Baxter, JD, and Chin, WW. "Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation." Endocrinology 134, no. 3 (March 1994): 1075-1081.  Full Text
    • Yen, PM. "Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation." Endocrinology 134, no. 3 (March 1, 1994): 1075-1081.  Full Text
    • Leonard, JL, Farwell, AP, Yen, PM, Chin, WW, and Stula, M. "Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells." Endocrinology 135, no. 2 (January 1, 1994): 548-555.  Full Text
    • Ribeiro, JCJ, Apriletti, JW, Yen, PM, Chin, WW, and Baxter, JD. "Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid x receptor-related factor." Endocrinology 135, no. 5 (January 1, 1994): 2076-2085.  Full Text
    • Suen, C-S, Yen, PM, and Chin, WW. "In vitro transcriptional studies of the roles of the thyroid hormone (T₃) response elements and minimal promoters in T₃-stimulated gene transcription." Journal of Biological Chemistry 269, no. 2 (1994): 1314-1322.
    • Sugawara, A, Yen, PM, Apriletti, JW, Ribeiro, RCJ, Sacks, DB, Baxter, JD, and Chin, WW. "Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA." Journal of Biological Chemistry 269, no. 1 (1994): 433-437.
    • Yen, PM, Ikeda, M, Brubaker, JH, Forgione, M, Sugawara, A, and Chin, WW. "Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA." Journal of Biological Chemistry 269, no. 2 (1994): 903-909.
    • Yen, PM, Ikeda, M, Wilcox, EC, Brubaker, JH, Spanjaard, RA, Sugawara, A, and Chin, WW. "Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity." Journal of Biological Chemistry 269, no. 17 (1994): 12704-12709.
    • Yen, PM, and Chin, WW. "New advances in understanding the molecular mechanisms of thyroid hormone action." Trends in Endocrinology and Metabolism 5, no. 2 (January 1, 1994): 65-72. (Review)  Full Text
    • Sugawara, A, Yen, PM, Darling, DS, and Chin, WW. "Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors." Endocrinology 133, no. 3 (September 1993): 965-971.  Full Text
    • Sugawara, A. "Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X- receptors." Endocrinology 133, no. 3 (September 1, 1993): 965-971.  Full Text
    • Darling, DS, Carter, RL, Yen, PM, Welborn, JM, Chin, WW, and Umeda, PK. "Different dimerization activities of α and β thyroid hormone receptor isoforms." Journal of Biological Chemistry 268, no. 14 (1993): 10221-10227.
    • Miyashita, Y, Miller, M, Yen, PM, Harmon, JM, Hanover, JA, and Jr, SSS. "Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport." Journal of Steroid Biochemistry and Molecular Biology 46, no. 3 (1993): 309-320.  Full Text
    • Yen, PM, Spanjaard, RA, Sugawara, A, Darling, DS, Nguyen, VP, and Chin, WW. "Orientation and spacing of half-sites differentially affect T3-receptor (TR) monomer, homodimer, and heterodimer binding to thyroid hormone response elements." Endocrine 1, no. 6 (1993): 461-466.
    • Yen, PM, Sugawara, A, Forgione, M, Spanjaard, RA, Macchia, E, Cheng, S-Y, and Chin, WW. "Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization." Molecular and Cellular Endocrinology 97, no. 1-2 (1993): 93-99.  Full Text
    • Yen, PM, Sugawara, A, Refetoff, S, and Chin, WW. "New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone." The Journal of Clinical Investigation 90, no. 5 (November 1992): 1825-1831.  Full Text
    • Yen, PM, Sugawara, A, and Chin, WW. "Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA." The Journal of Biological Chemistry 267, no. 32 (November 1992): 23248-23252.
    • Yen, PM, Sunday, ME, Darling, DS, and Chin, WW. "Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries." Endocrinology 130, no. 3 (March 1992): 1539-1546.  Full Text
    • Yen, PM, Darling, DS, Carter, RL, Forgione, M, Umeda, PK, and Chin, WW. "Triiodothyronine (T₃) decreases binding to DNA by T₃-receptor homodimers but not receptor-auxiliary protein heterodimers." Journal of Biological Chemistry 267, no. 6 (1992): 3565-3568.
    • Yen, PM, Darling, DS, and Chin, WW. "Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements." Endocrinology 129, no. 6 (1991): 3331-3336.
    • Yen, PM, and Jr, SSS. "Evidence against posttranslational glycosylation of rat glucocorticoid receptors." Receptor 1, no. 3 (1991): 191-205.
    • Jr, SSS, Mercier, L, Miller, NR, Miller, PA, Oshima, H, Sistare, FD, Thompson, EB, Wasner, G, and Yen, PM. "Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells." Cancer Research 49, no. 8 SUPPL. (1989): 2244s-2252s.
    • Urda, LA, Yen, PM, Jr, SSS, and Harmon, JM. "Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid." Molecular Endocrinology 3, no. 2 (1989): 251-260.
    • Yen, PM, and Jr, AHT. "Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH₃ strain of rat pituitary cells." Endocrinology 109, no. 1 (1981): 17-22.
    • Dannies, PS, Yen, PM, and Jr, AHT. "Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells." Endocrinology 101, no. 4 (1977): 1151-1156.

  • Book Sections

    • Yen, PM. "Thyroid Disorders." In Principles of Ambulatory Medicine: Seventh Edition, 1336-1366. March 27, 2012.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.