Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Staff Fellow, Endocrinology, National Institutes of Health 1988 - 1989
  • Resident, Medicine, University of Chicago 1982 - 1985
  • M.D., Johns Hopkins University 1982
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2010 - 2016
  • Instructor, Temporary in the Department of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition, Medicine 2009
• Recognition
• 

  In the News

  • NOV 18, 2015

    Research yields potential treatment approach for glycogen storage disease

  • AUG 19, 2013

    Coffee and Tea May Contribute to a Healthy Liver

  • AUG 19, 2013

    CTV News

    Coffee and tea may protect your liver
• Research
• 

  Selected Grants

  • Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease awarded by National Institutes of Health 2014 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Yen, PM. "Thyroid Disorders." In Principles of Ambulatory Medicine: Seventh Edition, 1336-1366. March 27, 2012.

  • Journal Articles

    • Singh, BK, Sinha, RA, Ohba, K, and Yen, PM. "Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy." Molecular and cellular endocrinology 458 (December 2017): 160-168.  Full Text
    • Farah, BL, Landau, DJ, Wu, Y, Sinha, RA, Loh, A, Bay, B-H, Koeberl, DD, and Yen, PM. "Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia." Molecular genetics and metabolism 122, no. 3 (November 2017): 95-98.  Full Text
    • Wang, M-E, Singh, BK, Hsu, M-C, Huang, C, Yen, PM, Wu, L-S, Jong, D-S, and Chiu, C-H. "Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy." Scientific reports 7, no. 1 (October 25, 2017): 13999-.  Full Text
    • Flamant, F, Cheng, S-Y, Hollenberg, AN, Moeller, LC, Samarut, J, Wondisford, FE, Yen, PM, and Refetoff, S. "Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature." Endocrinology 158, no. 7 (July 2017): 2052-2057.  Full Text
    • Ohba, K, Sinha, RA, Singh, BK, Iannucci, LF, Zhou, J, Kovalik, J-P, Liao, X-H, Refetoff, S, Sng, JCG, Leow, MK-S, and Yen, PM. "Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model." Thyroid : official journal of the American Thyroid Association 27, no. 6 (June 2017): 852-860.  Full Text
    • Iannucci, LF, Cioffi, F, Senese, R, Goglia, F, Lanni, A, Yen, PM, and Sinha, RA. "Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet." Scientific reports 7, no. 1 (May 17, 2017): 2023-.  Full Text
    • Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Lim, A, Hirayama, M, Landau, DJ, Bay, BH, Koeberl, DD, and Yen, PM. "Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)." Scientific reports 7 (March 20, 2017): 44408-.  Full Text
    • Zhou, J, Chong, SY, Lim, A, Singh, BK, Sinha, RA, Salmon, AB, and Yen, PM. "Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging." Aging 9, no. 2 (February 26, 2017): 583-599.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis." Endocrine reviews 38, no. 1 (February 2017): 69-102. (Review)  Full Text
    • Iannucci, LF, Sun, J, Singh, BK, Zhou, J, Kaddai, VA, Lanni, A, Yen, PM, and Sinha, RA. "Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467]." Biochemical and biophysical research communications 482, no. 4 (January 2017): 1517-.  Full Text
    • Sinha, RA, Singh, BK, Zhou, J, Xie, S, Farah, BL, Lesmana, R, Ohba, K, Tripathi, M, Ghosh, S, Hollenberg, AN, and Yen, PM. "Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells." Autophagy 13, no. 1 (January 2017): 169-186.  Full Text
    • Tripathi, M, Zhang, CW, Singh, BK, Sinha, RA, Moe, KT, DeSilva, DA, and Yen, PM. "Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation." Cell death & disease 7, no. 12 (December 8, 2016): e2513-.  Full Text
    • Iannucci, LF, Sun, J, Singh, BK, Zhou, J, Kaddai, VA, Lanni, A, Yen, PM, and Sinha, RA. "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells." Biochemical and biophysical research communications 480, no. 3 (November 2016): 461-467.  Full Text
    • Chng, C-L, Lim, AYY, Tan, HC, Kovalik, J-P, Tham, KW, Bee, YM, Lim, W, Acharyya, S, Lai, OF, Chong, MF-F, and Yen, PM. "Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease." Thyroid : official journal of the American Thyroid Association 26, no. 10 (October 2016): 1422-1430.  Full Text
    • Lim, A, Zhou, J, Sinha, RA, Singh, BK, Ghosh, S, Lim, K-H, Chow, PK-H, Woon, ECY, and Yen, PM. "Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity." Biochemical and biophysical research communications 479, no. 3 (October 2016): 476-481.  Full Text
    • Yen, PM. "TSHβv-A New Bone to Pick." Endocrinology 157, no. 9 (September 2016): 3402-3404.  Full Text
    • Ohba, K, Leow, MK-S, Singh, BK, Sinha, RA, Lesmana, R, Liao, X-H, Ghosh, S, Refetoff, S, Sng, JCG, and Yen, PM. "Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice." Endocrinology 157, no. 4 (April 2016): 1660-1672.  Full Text
    • Farah, BL, Landau, DJ, Sinha, RA, Brooks, ED, Wu, Y, Fung, SYS, Tanaka, T, Hirayama, M, Bay, B-H, Koeberl, DD, and Yen, PM. "Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency." Journal of hepatology 64, no. 2 (February 2016): 370-379.  Full Text
    • Lesmana, R, Sinha, RA, Singh, BK, Zhou, J, Ohba, K, Wu, Y, Yau, WWY, Bay, B-H, and Yen, PM. "Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle." Endocrinology 157, no. 1 (January 2016): 23-38.  Full Text
    • Singh, BK, Sinha, RA, Zhou, J, Tripathi, M, Ohba, K, Wang, M-E, Astapova, I, Ghosh, S, Hollenberg, AN, Gauthier, K, and Yen, PM. "Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition." The Journal of biological chemistry 291, no. 1 (January 2016): 198-214.  Full Text
    • Sinha, RA, and Yen, PM. "Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD." Cell & Bioscience 6 (January 2016): 46-. (Review)  Full Text
    • Yen, PM. "Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease." Best practice & research. Clinical endocrinology & metabolism 29, no. 4 (August 2015): 517-528. (Review)  Full Text
    • Zhou, J, Yong, W-P, Yap, CS, Vijayaraghavan, A, Sinha, RA, Singh, BK, Xiu, S, Manesh, S, Ngo, A, Lim, A, Ang, C, Xie, C, Wong, FY, Lin, SJ, Wan, WK, Tan, IB, Flotow, H, Tan, P, Lim, K-H, Yen, PM, and Goh, LK. "An integrative approach identified genes associated with drug response in gastric cancer." Carcinogenesis 36, no. 4 (April 2015): 441-451.  Full Text
    • Sinha, RA, Singh, BK, Zhou, J, Wu, Y, Farah, BL, Ohba, K, Lesmana, R, Gooding, J, Bay, B-H, and Yen, PM. "Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling." Autophagy 11, no. 8 (January 2015): 1341-1357.  Full Text
    • Yen, PM. "Unliganded TRs regulate growth and developmental timing during early embryogenesis: evidence for a dual function mechanism of TR action." Cell & Bioscience 5, no. 1 (2015): 8-8.  Full Text
    • Yen, PM. "Unliganded TRs regulate growth and developmental timing during early embryogenesis: Evidence for a dual function mechanism of TR action." Cell and Bioscience (2015).  Full Text
    • Aw, DKL, Sinha, RA, Tan, HC, Loh, LM, Salvatore, D, and Yen, PM. "Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism." The Journal of clinical endocrinology and metabolism 99, no. 11 (November 2014): 3965-3971.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism." Trends in endocrinology and metabolism: TEM 25, no. 10 (October 2014): 538-545. (Review)  Full Text
    • Aw, DKL, Sinha, RA, Xie, SY, and Yen, PM. "Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells." Biochemical and biophysical research communications 447, no. 4 (May 2014): 569-573.  Full Text
    • Farah, BL, Madden, L, Li, S, Nance, S, Bird, A, Bursac, N, Yen, PM, Young, SP, and Koeberl, DD. "Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, no. 5 (May 2014): 2272-2280.  Full Text  Open Access Copy
    • Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, B-H, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology 59, no. 4 (April 2014): 1366-1380.  Full Text  Link to Item
    • Refetoff, S, Bassett, JHD, Beck-Peccoz, P, Bernal, J, Brent, G, Chatterjee, K, De Groot, LJ, Dumitrescu, AM, Jameson, JL, Kopp, PA, Murata, Y, Persani, L, Samarut, J, Weiss, RE, Williams, GR, and Yen, PM. "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism." Thyroid : official journal of the American Thyroid Association 24, no. 3 (March 4, 2014): 407-409.  Full Text
    • Refetoff, S, Bassett, JHD, Beck-Peccoz, P, Bernal, J, Brent, G, Chatterjee, K, De Groot, LJ, Dumitrescu, AM, Jameson, JL, Kopp, PA, Murata, Y, Persani, L, Samarut, J, Weiss, RE, Williams, GR, and Yen, PM. "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism." The Journal of clinical endocrinology and metabolism 99, no. 3 (March 2014): 768-770.  Full Text
    • Zhou, J, Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Bay, B-H, Yang, CS, and Yen, PM. "Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance." PloS one 9, no. 1 (January 29, 2014): e87161-.  Full Text
    • Farah, BL, Sinha, RA, Wu, Y, Singh, BK, Zhou, J, Bay, B-H, and Yen, PM. "β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver." PloS one 9, no. 6 (January 2014): e98155-.  Full Text
    • Sinha, RA, Farah, BL, Singh, BK, Siddique, MM, Li, Y, Wu, Y, Ilkayeva, OR, Gooding, J, Ching, J, Zhou, J, Martinez, L, Xie, S, Bay, BH, Summers, SA, Newgard, CB, and Yen, PM. "Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice." Hepatology 59, no. 4 (January 1, 2014): 1366-1380.  Full Text
    • Sinha, RA, Singh, BK, and Yen, PM. "Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism." Trends in Endocrinology and Metabolism 25, no. 10 (January 1, 2014): 538-545. (Review)  Full Text
    • Xie, S, Sinha, RA, Singh, BK, Li, GD, Han, W, and Yen, PM. "Resveratrol induces insulin gene expression in mouse pancreatic α-cells. (Published online)" Cell Biosci 3, no. 1 (December 13, 2013): 47-.  Full Text  Link to Item
    • Yap, CS, Sinha, RA, Ota, S, Katsuki, M, and Yen, PM. "Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells." Biochemical and Biophysical Research Communications 440, no. 4 (November 1, 2013): 635-639.  Full Text
    • Yap, CS, Sinha, RA, Ota, S, Katsuki, M, and Yen, PM. "Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells." Biochem Biophys Res Commun 440, no. 4 (November 1, 2013): 635-639.  Full Text  Link to Item
    • Singh, BK, Sinha, RA, Zhou, J, Xie, SY, You, S-H, Gauthier, K, and Yen, PM. "FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes." J Biol Chem 288, no. 42 (October 18, 2013): 30365-30372.  Full Text  Link to Item
    • Wang, G, Cao, X, Lai, S, Luo, X, Feng, Y, Xia, X, Yen, PM, Gong, J, and Hu, J. "PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA." Mol Cancer Ther 12, no. 10 (October 2013): 2100-2109.  Full Text  Link to Item
    • Zhou, J, Chen, GB, Tang, YC, Sinha, RA, Wu, Y, Yap, CS, Wang, G, Hu, J, Xia, X, Tan, P, Goh, LK, and Yen, PM. "Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. (Published online)" BMC Med Genomics 5 (August 9, 2012): 34-.  Full Text  Link to Item
    • Sinha, RA, You, S-H, Zhou, J, Siddique, MM, Bay, B-H, Zhu, X, Privalsky, ML, Cheng, S-Y, Stevens, RD, Summers, SA, Newgard, CB, Lazar, MA, and Yen, PM. "Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy." J Clin Invest 122, no. 7 (July 2012): 2428-2438.  Full Text  Link to Item
    • Duntas, L, Amino, N, Hay, I, McDermott, M, Peeters, R, Vaismann, M, Ward, L, Williams, G, Jr, TOLSL, and Yen, P. "Thyroid disorders, noncommunicable diseases that gravely impact public health: A commentary and statement by the advisory board of the world thyroid federation." Thyroid 22, no. 6 (2012): 566-567.  Full Text
    • Voss, TC, Schiltz, RL, Sung, M-H, Yen, PM, Stamatoyannopoulos, JA, Biddie, SC, Johnson, TA, Miranda, TB, John, S, and Hager, GL. "Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism." Cell 146, no. 4 (2011): 544-554.  Full Text
    • Culhane, JC, Wang, D, Yen, PM, and Cole, PA. "Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors." Journal of the American Chemical Society 132, no. 9 (2010): 3164-3176.  Full Text
    • Wang, D, Xia, X, Weiss, RE, Refetoff, S, and Yen, PM. "Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHα promoter." PLoS ONE 5, no. 3 (2010).  Full Text
    • Sabet, A, and Yen, PM. "Thyroid hormone action." Clinical Management of Thyroid Disease (2009): 43-56.  Full Text
    • Wang, D, Xia, X, Liu, Y, Oetting, A, Walker, RL, Zhu, Y, Meltzer, P, Cole, PA, Shi, Y-B, and Yen, PM. "Negative regulation of tshα target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation." Molecular Endocrinology 23, no. 5 (2009): 600-609.  Full Text
    • Hu, J, Xia, X, Cheng, A, Wang, G, Luo, X, Reed, MF, Fojo, T, Oetting, A, Gong, J, and Yen, PM. "A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: A novel cancer therapy." Molecular Cancer Therapeutics 7, no. 12 (2008): 3719-3728.  Full Text
    • Yen, PM. "Waterboarding is not torture: a physician's response." The Lancet 371, no. 9627 (2008): 1838--.  Full Text
    • Harvey, CB, Bassett, JHD, Maruvada, P, Yen, PM, and Williams, GR. "The rat thyroid hormone receptor (TR) Δβ3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions." Endocrinology 148, no. 4 (2007): 1764-1773.  Full Text
    • Oetting, A, and Yen, PM. "New insights into thyroid hormone action." Best Practice and Research in Clinical Endocrinology and Metabolism 21, no. 2 (2007): 193-208.  Full Text
    • Liu, Y, Xia, X, Fondell, JD, and Yen, PM. "Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation." Molecular Endocrinology 20, no. 3 (2006): 483-490.  Full Text
    • Yen, PM, Ando, S, Feng, X, Liu, Y, Maruvada, P, and Xia, X. "Thyroid hormone action at the cellular, genomic and target gene levels." Molecular and Cellular Endocrinology 246, no. 1-2 (2006): 121-127.  Full Text
    • Yen, PM. "Thyroid hormones and 3,5-diiodothyropropionic acid: New keys for new locks." Endocrinology 147, no. 4 (2006): 1598-1601.  Full Text
    • Liu, Y, Ando, S, Xia, X, Yao, R, Kim, M, Fondell, J, and Yen, PM. "p62, a TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T₃-mediated transcription." Molecular Endocrinology 19, no. 4 (2005): 879-884.  Full Text
    • Shepshelovich, J, Goldstein-Magal, L, Globerson, A, Yen, PM, Rotman-Pikielny, P, and Hirschberg, K. "Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin." Journal of Cell Science 118, no. 8 (2005): 1577-1586.  Full Text
    • Yen, PM. "Editorial: Studying hormonal regulation by microarrays: Distinguishing the trees from the forest." Journal of Clinical Endocrinology and Metabolism 90, no. 2 (2005): 1241-1242.  Full Text
    • Jimenez, C, Moran, SA, Sereti, I, Wynne, S, Yen, PM, Falloon, J, Jr, RTD, and Sarlis, NJ. "Graves' disease after interleukin-2 therapy in a patient with human immunodeficiency virus infection." Thyroid 14, no. 12 (2004): 1097-1102.  Full Text
    • Maruvada, P, Dmitrieva, NI, East-Palmer, J, and Yen, PM. "Cell Cycle-dependent Expression of Thyroid Hormone Receptor-β Is a Mechanism for Variable Hormone Sensitivity." Molecular Biology of the Cell 15, no. 4 (2004): 1895-1903.  Full Text
    • Maruvada, P, Baumann, CT, Hager, GL, and Yen, PM. "Dynamic shuttling and intranuclear mobility of nuclear hormone receptors." Journal of Biological Chemistry 278, no. 14 (2003): 12425-12432.  Full Text
    • Poguet, A-L, Legrand, C, Feng, X, Yen, PM, Meltzer, P, Samarut, J, and Flamant, F. "Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum." Developmental Biology 254, no. 2 (2003): 188-199.  Full Text
    • Saunier, B, Triyatni, M, Ulianich, L, Maruvada, P, Yen, P, and Kohn, LD. "Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes." Journal of Virology 77, no. 1 (2003): 546-559.  Full Text
    • Yen, PM, Feng, X, Flamant, F, Chen, Y, Walker, RL, Weiss, RE, Chassande, O, Samarut, J, Refetoff, S, and Meltzer, PS. "Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice." EMBO Reports 4, no. 6 (2003): 581-587.  Full Text
    • Yen, PM, and Cheng, SY. "Germline and somatic thyroid hormone receptor mutations in man." Journal of Endocrinological Investigation 26, no. 8 (2003): 780-787.
    • Yen, PM. "Molecular basis of resistance to thyroid hormone." Trends in Endocrinology and Metabolism 14, no. 7 (2003): 327-333.  Full Text
    • Feng, X, Meltzer, P, and Yen, PM. "Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray." Methods in molecular biology (Clifton, N.J.) 202 (2002): 31-54.
    • Parikh, S, Ando, S, Schneider, A, Skarulis, MC, Sarlis, NJ, and Yen, PM. "Resistance to thyroid hormone in a patient without thyroid hormone receptor mutations." Thyroid 12, no. 1 (2002): 81-86.
    • Rotman-Pikielny, P, Hirschberg, K, Maruvada, P, Suzuki, K, Royaux, IE, Green, ED, Kohn, LD, Lippincott-Schwartz, J, and Yen, PM. "Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome." Human Molecular Genetics 11, no. 21 (2002): 2625-2633.
    • Ando, S, Sarlis, NJ, Krishnan, J, Feng, X, Refetoff, S, Zhang, MQ, Oldfield, EH, and Yen, PM. "Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance." Molecular Endocrinology 15, no. 9 (2001): 1529-1538.  Full Text
    • Ando, S, Sarlis, NJ, Oldfield, EH, and Yen, PM. "Somatic mutation of TRβ can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor." Journal of Clinical Endocrinology and Metabolism 86, no. 11 (2001): 5572-5576.  Full Text
    • Baumann, CT, Ma, H, Wolford, R, Reyes, JC, Maruvada, P, Lim, C, Yen, PM, Stallcup, MR, and Hager, GL. "The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome." Molecular Endocrinology 15, no. 4 (2001): 485-500.  Full Text
    • Baumann, CT, Maruvada, P, Hager, GL, and Yen, PM. "Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors: Multiple protein interactions are required for nuclear retention." Journal of Biological Chemistry 276, no. 14 (2001): 11237-11245.  Full Text
    • Feng, X, Jiang, Y, Meltzer, P, and Yen, PM. "Transgenic Targeting of a Dominant Negative Corepressor to Liver Blocks Basal Repression by Thyroid Hormone Receptor and Increases Cell Proliferation." Journal of Biological Chemistry 276, no. 18 (2001): 15066-15072.
    • Phillips, SA, Rotman-Pikielny, P, Lazar, J, Ando, S, Hauser, P, Skarulis, MC, Brucker-Davis, F, and Yen, PM. "Clinical case seminar: Extreme thyroid hormone resistance in a patient with a novel truncated TR mutant." Journal of Clinical Endocrinology and Metabolism 86, no. 11 (2001): 5142-5147.  Full Text
    • Uwaifo, GI, Remaley, AT, Stene, M, Reynolds, JC, Yen, PM, Snider, RH, Becker, KL, and Sarlis, NJ. "A case of spurious hypercalcitoninemia: A cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia." Journal of Endocrinological Investigation 24, no. 5 (2001): 361-369.
    • Yen, PM. "Physiological and molecular basis of Thyroid hormone action." Physiological Reviews 81, no. 3 (2001): 1097-1142.
    • Feng, X, Jiang, Y, Meltzer, P, and Yen, PM. "Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray." Molecular Endocrinology 14, no. 7 (2000): 947-955.  Full Text
    • Rotman-Pikielny, P, Reynolds, JC, Barker, WC, Yen, PM, Skarulis, MC, and Sarlis, NJ. "Recombinant human thyrotropin for the diagnosis and treatment of a highly functional metastatic struma ovarii." Journal of Clinical Endocrinology and Metabolism 85, no. 1 (2000): 237-244.  Full Text
    • Yen, PM. "Thyrotropin Receptor Mutations in Thyroid Diseases." Reviews in Endocrine and Metabolic Disorders 1, no. 1-2 (2000): 123-129.
    • Duncan, KG, Jumper, MD, Ribeiro, RCJ, Bailey, KR, Yen, PM, Sugawara, A, Patel, A, Stern, R, Chin, WW, Baxter, JD, and Schwartz, DM. "Human trabecular meshwork cells as a thyroid hormone target tissue: Presence of functional thyroid hormone receptors." Graefe's Archive for Clinical and Experimental Ophthalmology 237, no. 3 (1999): 231-240.  Full Text
    • Koibuchi, N, Liu, Y, Fukuda, H, Takeshita, A, Yen, PM, and Chin, WW. "RORα augments thyroid hormone receptor-mediated transcriptional activation." Endocrinology 140, no. 3 (1999): 1356-1364.
    • Lee, H-J, and Yen, PM. "Recent advances in understanding thyroid hormone receptor coregulators." Journal of Biomedical Science 6, no. 2 (1999): 71-78.
    • Sasaki, S, Lesoon-Wood, LA, Dey, A, Kuwata, T, Weintraub, BD, Humphrey, G, Yang, W-M, Seto, E, Yen, PM, Howard, BH, and Ozato, K. "Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin β gene." EMBO Journal 18, no. 19 (1999): 5389-5398.  Full Text
    • Liu, Y, Takeshita, A, Misiti, S, Chin, WW, and Yen, PM. "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors." Endocrinology 139, no. 10 (1998): 4197-4204.
    • Liu, Y, Takeshita, A, Nagaya, T, Baniahmad, A, Chin, WW, and Yen, PM. "An inhibitory region of the DNA binding domain of thyroid hormone receptor blocks hormone-dependent transactivation." Molecular Endocrinology 12, no. 1 (1998): 34-44.  Full Text
    • Misiti, S, Schomburg, L, Yen, PM, and Chin, WW. "Expression and hormonal regulation of coactivator and corepressor genes." Endocrinology 139, no. 5 (1998): 2493-2500.
    • Nagaya, T, Murata, Y, Yamaguchi, S, Nomura, Y, Ohmori, S, Fujieda, M, Katunuma, N, Yen, PM, Chin, WW, and Seo, H. "Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor α by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action." Journal of Biological Chemistry 273, no. 50 (1998): 33166-33173.  Full Text
    • Takeshita, A, Yen, PM, Ikeda, M, Cardona, GR, Liu, Y, Koibuchi, N, Norwitz, ER, and Chin, WW. "Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1." Journal of Biological Chemistry 273, no. 34 (1998): 21554-21562.  Full Text
    • Blange, I, Drvota, V, Yen, PM, and Sylven, C. "Species differences in cardiac thyroid hormone receptor isoforms protein abundance." Biological and Pharmaceutical Bulletin 20, no. 11 (1997): 1123-1126.
    • Lin, H-Y, Yen, PM, Davis, FB, and Davis, PJ. "Protein synthesis-dependent potentiation by thyroxine of antiviral activity of interferon-γ." American Journal of Physiology - Cell Physiology 273, no. 4 42-4 (1997): C1225-C1232.
    • Sanno, N, Sugawara, A, Teramoto, A, Abe, Y, Yen, PM, Chin, WW, and Osamura, RY. "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas." Neuroendocrinology 65, no. 4 (1997): 299-306.
    • Scott, REM, Wu-Peng, XS, Yen, PM, Chin, WW, and Pfaff, DW. "Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: A comparison with the vitellogenin A2 consensus ERE." Molecular Endocrinology 11, no. 11 (1997): 1581-1592.  Full Text
    • Yen, PM, Liu, Y, Palvimo, JJ, Trifiro, M, Whang, J, Pinsky, L, Janne, OA, and Chin, WW. "Erratum: Mutant and wild type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription (Molecular Endocrinology (1997) 11 (162-171))." Molecular Endocrinology 11, no. 3 (1997): 391-392.
    • Yen, PM, Liu, Y, Palvimo, JJ, Trifiro, M, Whang, J, Pinsky, L, Jänne, OA, and Chin, WW. "Mutant and wild-type androgen receptors exhibit cross-talk on androgen- , glucocorticoid-, and progesterone-mediated transcription." Molecular Endocrinology 11, no. 2 (1997): 162-171.  Full Text
    • Allain, TJ, Yen, PM, Flanagan, AM, and Mcgregor, AM. "The isoform-specific expression of the tri-iodothyronine receptor in osteoblasts and osteoclasts." European Journal of Clinical Investigation 26, no. 5 (1996): 418-425.
    • Chin, WW, and Yen, PM. "T3 or not T3--the slings and arrows of outrageous TR function." Endocrinology 137, no. 2 (1996): 387-388.
    • Lin, H-Y, Davis, FB, Yen, PM, and Davis, PJ. "Milrinone mimics thyroid hormone potentiation of the antiviral activity of human interferon-γ in hela cells." Journal of Investigative Medicine 44, no. 3 (1996): 261a-.
    • Shalev, A, Siegrist-Kaiser, CA, Yen, PM, Wahli, W, Burger, AG, Chin, WW, and Meier, CA. "The peroxisome proliferator-activated receptor α is a phosphoprotein: Regulation by insulin." Endocrinology 137, no. 10 (1996): 4499-4502.  Full Text
    • Takeshita, A, Yen, PM, Misiti, S, Cardona, GR, Liu, Y, and Chin, WW. "Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator." Endocrinology 137, no. 8 (1996): 3594-3597.  Full Text
    • Yen, PM, Liu, Y, Sugawara, A, and Chin, WW. "Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity." Journal of Biological Chemistry 271, no. 18 (1996): 10910-10916.  Full Text
    • Zhu, Y-S, Yen, PM, Chin, WW, and Pfaff, DW. "Estrogen and thyroid hormone interaction on regulation of gene expression." Proceedings of the National Academy of Sciences of the United States of America 93, no. 22 (1996): 12587-12592.  Full Text
    • Hayashi, Y, Weiss, RE, Sarne, DH, Yen, PM, Sunthornthepvarakul, T, Marcocci, C, Chin, WW, and Refetoff, S. "Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-β receptors?." Journal of Clinical Endocrinology and Metabolism 80, no. 11 (1995): 3246-3256.
    • Sugawara, A, Yen, PM, Qi, Y, Lechan, RM, and Chin, WW. "Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland." Endocrinology 136, no. 4 (1995): 1766-1774.
    • Yen, PM, Sugawara, A, Liu, Y, Whang, J, and Chin, WW. "Factors that enhance Escherichia coli-expressed TRβ binding to T₃ and DNA." Thyroid 5, no. 4 (1995): 309-313.
    • Yen, PM, Wilcox, EC, Hayashi, Y, Refetoff, S, and Chin, WW. "Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-β mutants." Endocrinology 136, no. 7 (1995): 2845-2851.
    • Yen, PM, Wilcox, EC, and Chin, WW. "Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors." Endocrinology 136, no. 2 (1995): 440-445.
    • Sugawara, A, Yen, PM, and Chin, WW. "9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors." Endocrinology 135, no. 5 (November 1994): 1956-1962.  Full Text
    • Yen, PM, and Chin, WW. "Molecular mechanisms of dominant negative activity by nuclear hormone receptors." Molecular endocrinology (Baltimore, Md.) 8, no. 11 (November 1994): 1450-1454. (Review)  Full Text
    • Yen, PM, Brubaker, JH, Apriletti, JW, Baxter, JD, and Chin, WW. "Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation." Endocrinology 134, no. 3 (March 1994): 1075-1081.  Full Text
    • Leonard, JL, Farwell, AP, Yen, PM, Chin, WW, and Stula, M. "Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells." Endocrinology 135, no. 2 (January 1, 1994): 548-555.  Full Text
    • Leonard, JL, Farwell, AP, Yen, PM, Chin, WW, and Stula, M. "Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells." Endocrinology 135, no. 2 (1994): 548-555.  Full Text
    • Ribeiro, JCJ, Apriletti, JW, Yen, PM, Chin, WW, and Baxter, JD. "Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid x receptor-related factor." Endocrinology 135, no. 5 (January 1, 1994): 2076-2085.  Full Text
    • Ribeiro, RCJ, Apriletti, JW, Yen, PM, Chin, WW, and Baxter, JD. "Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor." Endocrinology 135, no. 5 (1994): 2076-2085.  Full Text
    • Suen, C-S, Yen, PM, and Chin, WW. "In vitro transcriptional studies of the roles of the thyroid hormone (T₃) response elements and minimal promoters in T₃-stimulated gene transcription." Journal of Biological Chemistry 269, no. 2 (1994): 1314-1322.
    • Sugawara, A, Yen, PM, Apriletti, JW, Ribeiro, RCJ, Sacks, DB, Baxter, JD, and Chin, WW. "Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA." Journal of Biological Chemistry 269, no. 1 (1994): 433-437.
    • Sugawara, A, Yen, PM, and Chin, WW. "9-cis retinoic acid regulation of rat growth hormone gene expression: Potential roles of multiple nuclear hormone receptors." Endocrinology 135, no. 5 (1994): 1956-1962.  Full Text
    • Yen, PM, Brubaker, JH, Apriletti, JW, Baxter, JD, and Chin, WW. "Roles of 3,5,3′-Triiodothyronine and Deoxyribonucleic Acid Binding on Thyroid Hormone Receptor Complex Formation." Endocrinology 134, no. 3 (1994): 1075-1081.  Full Text
    • Yen, PM, Ikeda, M, Brubaker, JH, Forgione, M, Sugawara, A, and Chin, WW. "Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA." Journal of Biological Chemistry 269, no. 2 (1994): 903-909.
    • Yen, PM, Ikeda, M, Wilcox, EC, Brubaker, JH, Spanjaard, RA, Sugawara, A, and Chin, WW. "Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity." Journal of Biological Chemistry 269, no. 17 (1994): 12704-12709.
    • Yen, PM, and Chin, WW. "Molecular mechanisms of dominant negative activity by nuclear hormone receptors." Molecular Endocrinology 8, no. 11 (1994): 1450-1454.  Full Text
    • Yen, PM, and Chin, WW. "New advances in understanding the molecular mechanisms of thyroid hormone action." Trends in Endocrinology and Metabolism 5, no. 2 (1994): 65-72.  Full Text
    • Sugawara, A, Yen, PM, Darling, DS, and Chin, WW. "Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors." Endocrinology 133, no. 3 (September 1993): 965-971.  Full Text
    • Darling, DS, Carter, RL, Yen, PM, Welborn, JM, Chin, WW, and Umeda, PK. "Different dimerization activities of α and β thyroid hormone receptor isoforms." Journal of Biological Chemistry 268, no. 14 (1993): 10221-10227.
    • Miyashita, Y, Miller, M, Yen, PM, Harmon, JM, Hanover, JA, and Jr, SSS. "Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport." Journal of Steroid Biochemistry and Molecular Biology 46, no. 3 (1993): 309-320.  Full Text
    • Sugawara, A, Yen, PM, Darling, DS, and Chin, WW. "Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors." Endocrinology 133, no. 3 (1993): 965-971.  Full Text
    • Yen, PM, Spanjaard, RA, Sugawara, A, Darling, DS, Nguyen, VP, and Chin, WW. "Orientation and spacing of half-sites differentially affect T3-receptor (TR) monomer, homodimer, and heterodimer binding to thyroid hormone response elements." Endocrine 1, no. 6 (1993): 461-466.
    • Yen, PM, Sugawara, A, Forgione, M, Spanjaard, RA, Macchia, E, Cheng, S-Y, and Chin, WW. "Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization." Molecular and Cellular Endocrinology 97, no. 1-2 (1993): 93-99.  Full Text
    • Yen, PM, Sunday, ME, Darling, DS, and Chin, WW. "Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries." Endocrinology 130, no. 3 (March 1992): 1539-1546.  Full Text  Link to Item
    • Yen, PM, Darling, DS, Carter, RL, Forgione, M, Umeda, PK, and Chin, WW. "Triiodothyronine (T₃) decreases binding to DNA by T₃-receptor homodimers but not receptor-auxiliary protein heterodimers." Journal of Biological Chemistry 267, no. 6 (1992): 3565-3568.
    • Yen, PM, Sugawara, A, Refetoff, S, and Chin, WW. "New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone." Journal of Clinical Investigation 90, no. 5 (1992): 1825-1831.  Full Text
    • Yen, PM, Sugawara, A, and Chin, WW. "Triiodothyronine (T₃) differentially affects T₃-receptor/retinoic acid receptor and T₃-receptor/retinoid X receptor heterodimer binding to DNA." Journal of Biological Chemistry 267, no. 32 (1992): 23248-23252.
    • Yen, PM, Darling, DS, and Chin, WW. "Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements." Endocrinology 129, no. 6 (1991): 3331-3336.
    • Yen, PM, and Jr, SSS. "Evidence against posttranslational glycosylation of rat glucocorticoid receptors." Receptor 1, no. 3 (1991): 191-205.
    • Jr, SSS, Mercier, L, Miller, NR, Miller, PA, Oshima, H, Sistare, FD, Thompson, EB, Wasner, G, and Yen, PM. "Differential modulation of gene induction by glucocorticoids and antiglucocorticoids in rat hepatoma tissue culture cells." Cancer Research 49, no. 8 SUPPL. (1989): 2244s-2252s.
    • Urda, LA, Yen, PM, Jr, SSS, and Harmon, JM. "Region-specific antiglucocorticoid receptor antibodies selectively recognize the activated form of the ligand-occupied receptor and inhibit the binding of activated complexes to deoxyribonucleic acid." Molecular Endocrinology 3, no. 2 (1989): 251-260.
    • Yen, PM, and Jr, AHT. "Short chain fatty acids increase prolactin and growth hormone production and alter cell morphology in the GH₃ strain of rat pituitary cells." Endocrinology 109, no. 1 (1981): 17-22.
    • Dannies, PS, Yen, PM, and Jr, AHT. "Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells." Endocrinology 101, no. 4 (1977): 1151-1156.

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