Scholars@Duke
Paula Bernice Cechmanek

Paula Bernice Cechmanek

Instructor B in the Department of Biology
Biology
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Selected Publications

Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development

Journal Article Cell Communication and Signaling · August 19, 2022 AbstractBackgroundDuring development a pool of precursors form a heart with atrial and ventricular chambers that exhibit distinct transcriptional and elec ... Full text Cite

Retinal Pigment Epithelium and Neural Retinal Progenitors Interact via Semaphorin 6D to Facilitate Optic Cup Morphogenesis

Journal Article eneuro · May 2021 AbstractCell movement propels embryonic tissues to acquire shapes required for mature function. The movements are driven both by acto-myosin signaling and by cells interacting with the extracellular matrix (ECM). Unknown is ... Full text Cite

Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms.

Journal Article Developmental dynamics : an official publication of the American Association of Anatomists · August 2017 BackgroundThe retinal pigment epithelium (RPE) is a specialized monolayer of epithelial cells that forms a tight barrier surrounding the neural retina. RPE cells are indispensable for mature photoreceptor renewal and survival, yet how the initial ... Full text Cite

Rho kinase is required to prevent retinal axons from entering the contralateral optic nerve.

Journal Article Molecular and cellular neurosciences · November 2015 To grow out to contact target neurons an axon uses its distal tip, the growth cone, as a sensor of molecular cues that help the axon make appropriate guidance decisions at a series of choice points along the journey. In the developing visual system, the ax ... Full text Cite

Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion.

Journal Article Development (Cambridge, England) · June 2014 Organs are generated from collections of cells that coalesce and remain together as they undergo a series of choreographed movements to give the organ its final shape. We know little about the cellular and molecular mechanisms that regulate tissue cohesion ... Full text Cite

Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · January 2010 Axons are guided to their targets by molecular cues expressed in their environment. How is the presence of these cues regulated? Although some evidence indicates that morphogens establish guidance cue expression as part of their role in patterning tissues, ... Full text Cite