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Rebecca Koch

Assistant Professor of Pediatrics
Pediatrics, Medical Genetics
DUMC Box 103857, 905 LaSalle St. GSRB1, Durham, NC 27710

Overview


Rebecca Koch, PhD, RDN is a translational researcher and registered dietitian. Prior to joining Duke as an Assistant Professor of Pediatrics in the Division of Medical Genetics, she received a BS in Dietetics from the University of Florida, PhD in Nutritional Sciences from the University of Georgia, and completed a postdoc in Medical Genetics at Duke University. Her current research includes defining the natural history, pathophysiology, and factors related to treatments for inherited metabolic disorders, with a focus on glycogen storage disease.

Current Appointments & Affiliations


Assistant Professor of Pediatrics · 2024 - Present Pediatrics, Medical Genetics, Pediatrics

Recent Publications


Optimizing clinical outcomes: The journey of twins with CRIM-negative infantile-onset Pompe disease on high-dose enzyme replacement therapy and immunomodulation.

Journal Article Mol Genet Metab Rep · December 2024 Infantile-onset Pompe disease (IOPD) is caused by a deficiency in the enzyme acid alpha-glucosidase (GAA). It is characterized by severe and progressive hypertrophic cardiomyopathy and muscle weakness with death in the first 2 years of life if left untreat ... Full text Link to item Cite

Progressive liver disease and dysregulated glycogen metabolism in murine GSD IX γ2 models human disease.

Journal Article Mol Genet Metab · December 2024 Hepatic glycogen storage disease type IX γ2 (GSD IX γ2) is a severe, liver-specific subtype of GSD IX. While all patients with hepatic GSD IX present with similar symptoms, over 95 % of patients with GSD IX γ2 progress to liver fibrosis and cirrhosis. Desp ... Full text Link to item Cite
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Recent Grants


GYS2 knockdown on liver disease in hepatic GSD

ResearchPrincipal Investigator · Awarded by Alnylam Pharmaceuticals · 2025 - 2026

GSD Ib Natural History Study

ResearchProject Manager · Awarded by Sophie's Hope Foundation · 2023 - 2025

Defining the clinical characteristics for clinical trial endpoints of GSD VI and IX

ResearchPostdoctoral Associate · Awarded by Kriya Therapeutics · 2022 - 2024

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Education, Training & Certifications


University of Georgia · 2021 Ph.D.
University of Florida · 2017 B.S.