Journal ArticleEndocr Connect · December 14, 2021
Glucocorticoid use is the most common cause of secondary osteoporosis. Poor skeletal health related to glucocorticoid use is thought to involve inhibition of the Wnt/β-catenin signaling pathway, a key pathway in osteoblastogenesis. Sclerostin, a peptide pr ...
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Journal ArticleJ Clin Endocrinol Metab · June 1, 2020
CONTEXT: Complex relationships between aldosterone and calcium homeostasis have been proposed. OBJECTIVE: To disentangle the influence of aldosterone and intravascular volume on calcium physiology. DESIGN: Patient-oriented and epidemiology studies. SETTING ...
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Journal ArticleJ Renin Angiotensin Aldosterone Syst · 2018
BACKGROUND: Prior studies suggest that vitamin D therapy may decrease cardiovascular disease risk in type 2 diabetes (T2DM) by lowering renin-angiotensin system (RAS) activity. However, randomized human intervention studies to evaluate the effect of vitami ...
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Journal ArticleJ Clin Endocrinol Metab · April 1, 2017
CONTEXT: Obesity is associated with poor bone mineralization and quality. Fibroblast growth factor 23 (FGF23) plays an important role in skeletal physiology. OBJECTIVE: To test hypothesis that greater adiposity results in higher FGF23 levels among individu ...
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Journal ArticleInt J Endocrinol · 2017
BACKGROUND: Prior studies suggest that renin-angiotensin-aldosterone system (RAAS) inhibitors decrease parathyroid hormone (PTH) secretion. OBJECTIVE: To evaluate the effect of angiotensin-converting enzyme inhibitors (ACEi) on serum PTH in participants wi ...
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Journal ArticleJ Bone Miner Res · June 2016
Thiazide diuretic (TZ) use is associated with higher bone mineral density, whereas loop diuretic (LD) use is associated with lower bone density and incident fracture. Dihydropyridine-sensitive calcium channels are expressed on parathyroid cells and may pla ...
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Journal ArticleCardiovasc Intervent Radiol · October 2015
Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH ...
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Journal ArticleExpert Opin Drug Metab Toxicol · March 2015
INTRODUCTION: Low trauma fractures due to osteoporosis are a major health concern worldwide. Despite the availability of many therapeutic compounds to reduce fracture risk, osteoporosis remains undertreated and the burden of osteoporotic fractures remains ...
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