https://orcid.org/0000-0002-5575-0509
Overview
Since joining the Integrative Immunobiology department, the lab has set out to gain a deeper understanding of how tissue cues affect immune and glial cell behavior. The lab is particularly focused on how tissue damage and inflammation shape T cell and glial cell function in the context of neuroinflammation. An additional line of research probes how the cellular ontogeny of T cells contributes to the layered immune system in adulthood.
Lab homepage
Lab homepage
Current Duke Appointments & Affiliations
Assistant Professor in Integrative Immunobiology
·
2022 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.
Journal article Clin Cancer Res · February 17, 2026 PURPOSE: Exhaustion represents a collection of programmed T-cell differentiation states and an important mode of T-cell dysfunction. T-cell progression from progenitor to terminal exhaustion is associated with upregulation of the transcription factor thymo ... Full text Link to item CiteNovel Roles for IL-1R Family Members in Neuroinflammation
Conference JOURNAL OF NEUROCHEMISTRY · July 2025 Link to item CitePrecursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.
Journal article J Exp Med · October 7, 2024 Upon antigenic stimulation, naïve CD4+ T cells can give rise to phenotypically distinct effector T helper cells and long-lived memory T cells. We computationally reconstructed the in vivo trajectory of CD4+ T cell differentiation during a type I inflammato ... Full text Link to item CiteRecent Grants
Contributions of neonatal-origin CD4 T cells to immunity and tissue function
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Genetics and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031View All Grants
Education
The Scripps Research Institute ·
2010
Ph.D.