Overview
Since joining the Integrative Immunobiology department, the lab has set out to gain a deeper understanding of how tissue cues affect immune and glial cell behavior. The lab is particularly focused on how tissue damage and inflammation shape T cell and glial cell function in the context of neuroinflammation. An additional line of research probes how the cellular ontogeny of T cells contributes to the layered immune system in adulthood.
Lab homepage
Lab homepage
Current Appointments & Affiliations
Assistant Professor in Integrative Immunobiology
·
2022 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Precursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.
Journal Article J Exp Med · October 7, 2024 Upon antigenic stimulation, naïve CD4+ T cells can give rise to phenotypically distinct effector T helper cells and long-lived memory T cells. We computationally reconstructed the in vivo trajectory of CD4+ T cell differentiation during a type I inflammato ... Full text Link to item CiteNovel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota.
Journal Article Nature · October 2022 Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical ro ... Full text Link to item CiteT reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation.
Journal Article J Exp Med · February 1, 2021 ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in ... Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Origin matters: Decoding how neonatal T cell persistence contributes to health and disease
ResearchPrincipal Investigator · Awarded by G. Harold & Leila Y. Mathers Foundation · 2023 - 2026T cell/astrocyte fusions as a novel form of trained immunity to infection
ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026View All Grants
Education, Training & Certifications
The Scripps Research Institute ·
2010
Ph.D.