Overview
Since joining the Integrative Immunobiology department, the lab has set out to gain a deeper understanding of how tissue cues affect immune and glial cell behavior. The lab is particularly focused on how tissue damage and inflammation shape T cell and glial cell function in the context of neuroinflammation. An additional line of research probes how the cellular ontogeny of T cells contributes to the layered immune system in adulthood.
Lab homepage
Lab homepage
Current Appointments & Affiliations
Assistant Professor in Integrative Immunobiology
·
2022 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity.
Journal Article Clin Cancer Res · November 21, 2025 PURPOSE: Exhaustion represents a collection of programmed T cell differentiation states and an important mode of T cell dysfunction. T cell progression from progenitor to terminal exhaustion is associated with upregulation of the transcription factor TOX. ... Full text Link to item CiteNovel Roles for IL-1R Family Members in Neuroinflammation
Conference JOURNAL OF NEUROCHEMISTRY · 2025 CitePrecursor central memory versus effector cell fate and naïve CD4+ T cell heterogeneity.
Journal Article J Exp Med · October 7, 2024 Upon antigenic stimulation, naïve CD4+ T cells can give rise to phenotypically distinct effector T helper cells and long-lived memory T cells. We computationally reconstructed the in vivo trajectory of CD4+ T cell differentiation during a type I inflammato ... Full text Link to item CiteRecent Grants
Biomaterials strategies to promote functional recovery after ischemic stroke
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2030Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026Origin matters: Decoding how neonatal T cell persistence contributes to health and disease
ResearchPrincipal Investigator · Awarded by G. Harold & Leila Y. Mathers Foundation · 2023 - 2026View All Grants
Education, Training & Certifications
The Scripps Research Institute ·
2010
Ph.D.