Sophia Grace Califano

Assistant Professor in Medicine

Medicine, General Internal Medicine

Sophia.Califano@va.gov

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Selected Publications

Centralizing Telehealth Test-to-Treat Through a Regional Clinical Contact Center: A Veterans Health Administration Pilot.

Journal Article Telemed J E Health · October 2023 Background: This project describes a Veterans Health Administration telehealth pilot to facilitate COVID-19 oral antiviral treatment as part of the national test-to-treat (T2T) strategy. The pilot was operationalized for two pilot VA medical centers by the ... Full text Link to item Cite

Pre-endoscopy coronavirus disease 2019 screening and severe acute respiratory syndrome coronavirus-2 nucleic acid amplification testing in the Veterans Affairs healthcare system: clinical practice patterns, outcomes, and relationship to procedure volume

Journal Article Gastrointestinal Endoscopy · September 2022 Full text Cite

Synergistic premalignant effects of chronic ethanol exposure and insulin receptor substrate-1 overexpression in liver

Journal Article Hepatology Research · August 13, 2008 Aim: Insulin receptor substrate, type 1 (IRS-1) transmits growth and survival signals, and is overexpressed in more than 90% of hepatocellular carcinomas (HCCs). However, experimental overexpression of IRS-1 in the liver was found not to be sufficient to c ... Full text Cite

Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness.

Journal Article J Hepatol · May 2006 BACKGROUND/AIMS: We measured aspartyl (asparaginyl)-beta-hydroxylase (AAH) gene expression in human hepatocelluar carcinoma and surrounding uninvolved liver at both the mRNA and protein level and examined the regulation and function of this enzyme. METHODS ... Full text Link to item Cite

Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma.

Journal Article J Hepatol · November 2005 BACKGROUND/AIMS: The molecular mechanisms of hepatocarcinogenesis remain largely unknown. Previous studies suggest that activation of the Wnt/beta-catenin pathway is important during hepatocyte transformation but the role of Frizzled receptor (FZD) in this ... Full text Link to item Cite

Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver.

Journal Article Hepatology · September 2003 Chronic ethanol consumption can cause sustained hepatocellular injury and inhibit the subsequent regenerative response. These effects of ethanol may be mediated by impaired hepatocyte survival mechanisms. The present study examines the effects of ethanol o ... Full text Link to item Cite