Journal ArticleVaccine · September 17, 2024
BACKGROUND: One of the goals of the President's Cancer Panel was to maximize access to human papillomavirus (HPV) vaccination through expansion of alternative settings for receiving the vaccine, such as in public health settings, schools, and pharmacies. M ...
Full textLink to itemCite
Journal ArticleInt J Radiat Oncol Biol Phys · April 1, 2024
PURPOSE: Despite aggressive multimodal treatment that typically includes definitive or adjuvant radiation therapy (RT), locoregional recurrence rates approach 50% for patients with locally advanced human papillomavirus (HPV)-negative head and neck squamous ...
Full textLink to itemCite
Journal ArticleJAMA Otolaryngol Head Neck Surg · October 1, 2023
IMPORTANCE: The US Food and Drug Administration approved immune checkpoint inhibitors (immunotherapy) for select cases of head and neck squamous cell carcinoma (HNSCC) in 2016. However, it is unclear whether there are clinical or sociodemographic differenc ...
Full textLink to itemCite
Journal ArticleCurrent Otorhinolaryngology Reports · September 1, 2023
Purpose of Review: The goal of this article is to serve as a resource for those seeking to identify targets for structural change to advance DEI in otolaryngology. Recent Findings: Best practices exist to advance DEI and can be modeled within otolaryngolog ...
Full textCite
Journal ArticleOtolaryngol Clin North Am · April 2023
The Department of Veterans Affairs Laryngeal Cancer Study propelled the combination of chemotherapy and radiation therapy to the forefront of strategies used for the management of locally advanced laryngeal cancer. The organ preservation rate was 84%. Howe ...
Full textLink to itemCite
Journal ArticleAm J Pathol · February 2023
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease where, in advanced stages, clinical and pathologic stages do not correlate with outcome. Molecular and genomic biomarkers for HNSCC classification have shown promise for prognostic an ...
Full textOpen AccessLink to itemCite
Journal ArticleHum Vaccin Immunother · December 30, 2022
It is unclear how the COVID-19 pandemic impacted human papillomavirus (HPV) vaccine uptake and which sociodemographic groups may have been most impacted. We aimed to assess differences in HPV vaccine uptake (initiation and completion) before and during the ...
Full textLink to itemCite
Journal ArticleAm J Pathol · September 2022
The tumor microenvironment (TME) plays an important role in the progression of head and neck squamous cell carcinoma (HNSCC). Currently, pathologic assessment of TME is nonstandardized and subject to observer bias. Genome-wide transcriptomic approaches to ...
Full textLink to itemCite
Journal ArticleJAMA Otolaryngol Head Neck Surg · February 1, 2022
IMPORTANCE: Approximately 1 in 5 new patients with head and neck cancer (HNC) in the US belong to racial and ethnic minority groups, but their survival rates are worse than White individuals. However, because most studies compare Black vs White patients, l ...
Full textLink to itemCite
Journal ArticleCurrent Opinion in Physiology · October 1, 2021
In recent years, the human oral microbiome has emerged as a significant target of interest and research focus because of the role microbiota in oral cavity may play in the progression, diagnosis, and treatment of diseases. Home to an abundant and distinct ...
Full textCite
Journal ArticleJ Crohns Colitis · August 2, 2021
BACKGROUND AND AIMS: Little is known about the presence and function of tissue-resident mesenchymal stem cells [MtSCs] within the gastrointestinal mucosa in health and inflammatory bowel disease [IBD]. The contribution of MtSCs to the generation of inflamm ...
Full textLink to itemCite
Journal ArticleFrontiers in Oncology · April 28, 2020
Desmoplasia, a hallmark of a head and neck cancer, has both biologic and physiologic effects on cancer progression and chemotherapeutic response. Mesenchymal stem/stromal cells (MSCs), also known as mesenchymal stromal progenitor cells, have been shown to ...
Full textCite
Journal ArticleOperative Techniques in Otolaryngology - Head and Neck Surgery · June 1, 2019
The pectoralis major myocutaneous flap has enjoyed a long history of over 40 years utilization to reconstruct a variety of head and neck defects. Despite the attractiveness, feasibility and success rates of free tissue transfer, the role of the pectoralis ...
Full textCite
Journal ArticleClin Otolaryngol · April 2017
OBJECTIVES: To demonstrate the feasibility and efficacy of the Google Glass as a tool to improve patient satisfaction and patient-physician communication for otolaryngology residents in the outpatient clinic setting. The primary outcome of the study was to ...
Full textLink to itemCite
Journal ArticleJ Transl Med · December 8, 2016
BACKGROUND: The robust desmoplasia associated with head and neck squamous cell carcinoma (HNSCC) suggests that the tumor microenvironment may be an important component in the pathophysiology of this cancer. Moreover, the high recurrence rate and poor clini ...
Full textLink to itemCite
Journal ArticleInt J Cancer · April 15, 2016
IL-6 is a pleiotropic cytokine increased in CRC and known to directly promote tumor growth. Colonic myofibroblasts/fibroblasts (CMFs or stromal cells) are CD90(+) innate immune cells representing up to 30% of normal colonic mucosal lamina propria cells. Th ...
Full textLink to itemCite
Journal ArticleRare Tumors · June 25, 2014
While there is an intimate anatomical and embryological relationship between the inferior parathyroid gland and thymus, concurrent pathology is rare. Three cases have been reported in the literature of a parathyroid adenoma in conjunction with a thymoma. W ...
Full textCite
Journal ArticleEar Nose Throat J · July 2013
We conducted a retrospective case review at a tertiary academic medical center for the complications of pneumolabyrinth with pneumocephalus and subcutaneous emphysema after surgery for middle ear and cochlear implants. Charts of 76 cochlear implant and 2 m ...
Full textLink to itemCite
ConferenceHead Neck · January 2013
BACKGROUND: The purpose of this study was to report the incidence of venous thromboembolism (VTE) in patients with head and neck cancer after surgery. METHODS: This was a single-institution, retrospective cohort: 134 patients underwent resection and simult ...
Full textLink to itemCite
Journal ArticleLaryngoscope · December 2012
OBJECTIVES/HYPOTHESIS: To determine if melanoma cells secrete chemotactic factors that result in the migration of multipotent stem cells. STUDY DESIGN: In vitro cell culture. METHODS: Chemotaxis and invasion of human mesenchymal stem cells (hMSCs) was dete ...
Full textLink to itemCite
Journal ArticleOtolaryngol Head Neck Surg · March 2011
OBJECTIVE: In the setting of known facial nerve sacrifice or injury, patients require precautions to prevent exposure keratitis and the morbidity that follows. One recommended treatment is surgical placement of a gold weight with or without lateral tarsal ...
Full textLink to itemCite
ConferenceLaryngoscope · October 1, 2010
Educational Objective: At the conclusion of this presentation, the participants should be able to describe the various presentations of a thyroglossal duct cyst (TGDC), to expand their differential diagnosis of a midline neck mass with dysphagia, acute voi ...
Full textCite
Journal ArticleEar Nose Throat J · September 2009
We conducted a randomized, controlled, double-blind, prospective study to evaluate the effect of intraoperative bupivacaine injection on postoperative pain control following Bovie cautery-assisted tonsillectomy in 26 adults. Sixteen patients were injected ...
Link to itemCite
Journal ArticleLaryngoscope · April 2009
OBJECTIVES: To investigate the utility of positron-emission tomography/computed tomography (PET-CT) in identifying distant metastatic disease in patients with suspected recurrent head and neck squamous cell cancer (HNSCC). STUDY DESIGN: Retrospective analy ...
Full textLink to itemCite
Journal ArticleLaryngoscope · April 2008
OBJECTIVES: To investigate the utility of positron-emission tomography-computed tomography (PET-CT) in identifying distant metastatic disease in patients with previously untreated head and neck squamous cell cancer (HNSCC) prior to definitive treatment. MA ...
Full textLink to itemCite
Journal ArticleArch Otolaryngol Head Neck Surg · December 2007
OBJECTIVE: To determine the feasibility of the combined use of laryngeal nerve monitoring and minimally invasive thyroid surgery. DESIGN: Prospective, nonrandomized analysis of single-surgeon experience. SETTING: Academic institution. PATIENTS: Consecutive ...
Full textLink to itemCite
Journal ArticleLaryngoscope · November 2007
OBJECTIVES: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism. METHODS: Retrospective evaluation of consecutive patients undergoing m ...
Full textLink to itemCite
Journal ArticleProc Natl Acad Sci U S A · February 22, 2005
Increased intestinal permeability has been observed in numerous human autoimmune diseases, including type-1 diabetes (T1D) and its' animal model, the BB-wor diabetic prone rat. We have recently described zonulin, a protein that regulates intercellular tigh ...
Full textLink to itemCite
Journal ArticleJ Gene Med · 2002
BACKGROUND: Nuclease activity present within respiratory tissues contributes to the rapid clearance of injected DNA and therefore may reduce the transfection activity of directly injected transgenes. Most gene transfer technologies transduce or transfect m ...
Full textLink to itemCite
ConferenceJournal of Investigative Medicine · January 1, 1999
Zonula occludnes toxin (Zot) is a protein elaborated by Vibrio Cholerae that modulates the opening of intercellular tight jucntions (tj). The mechanism by which Zot modulates tj involves rearrangement of the cytoskeleton with resultant polymerization of ac ...
Cite