Scholars@Duke
Teng Su

Teng Su

Assistant Professor in Medicine
Medicine, Cardiology
teng.su@duke.edu
213 Research Drive, CARL Building Room 250, Durham, NC 27710

Selected Publications

Exosome-eluting stents for vascular healing after ischaemic injury.

Journal Article Nat Biomed Eng · October 2021 Drug-eluting stents implanted after ischaemic injury reduce the proliferation of endothelial cells and vascular smooth muscle cells and thus neointimal hyperplasia. However, the eluted drug also slows down the re-endothelialization process, delays arterial ... Full text Open Access Link to item Cite

Platelet membrane and stem cell exosome hybrid enhances cellular uptake and targeting to heart injury.

Journal Article Nano Today · August 2021 Exosomes from mesenchymal stem cells have been largely studied as therapeutics to treat myocardial infarctions. However, exosomes injected for therapeutic purposes face a number of challenges, including competition from exosomes already in circulation, and ... Full text Open Access Link to item Cite

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs.

Journal Article ACS Biomater Sci Eng · November 9, 2020 Featured Publication The vascularized cardiac patch strategy is promising for ischemic heart repair after myocardial infarction (MI), but current fabrication processes are quite complicated. Vascularized cardiac patches that can promote concurrent restoration of both the myoca ... Full text Open Access Link to item Cite

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling.

Journal Article Sci Adv · July 2020 Featured Publication The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon cu ... Full text Open Access Link to item Cite

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.

Journal Article Sci Transl Med · April 8, 2020 Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with cells to create cardiac patches that ... Full text Open Access Link to item Cite

Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair.

Journal Article Sci Adv · February 2020 An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates further heart injury and promotes adverse cardiac remodeling. Interleukin-1β (IL-1β) plays a central role in the sterile inflammatory response that results from A ... Full text Open Access Link to item Cite

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs.

Journal Article Theranostics · 2020 Cancer is the second leading cause of death worldwide and patients are in urgent need of therapies that can effectively target cancer with minimal off-target side effects. Exosomes are extracellular nano-shuttles that facilitate intercellular communication ... Full text Open Access Link to item Cite

Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine.

Journal Article Curr Stem Cell Res Ther · 2020 Exosomes and biomimetic nanoparticles have great potential to develop into a wide-scale therapeutic platform within the regenerative medicine industry. Exosomes, a subgroup of EVs with diameter ranging from 30-100 nm, have recently gained attention as an i ... Full text Open Access Link to item Cite

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging.

Journal Article ACS Nano · October 22, 2019 Featured Publication Human dermal fibroblasts (HDFs), the main cell population of the dermis, gradually lose their ability to produce collagen and renew intercellular matrix with aging. One clinical application for the autologous trans-dermis injection of HDFs that has been ap ... Full text Open Access Link to item Cite

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

Journal Article Advanced Therapeutics · October 1, 2019 Featured Publication Bone marrow stem cells (BMSCs) are a promising strategy for cardiac regenerative therapy for myocardial infarction (MI). However, cell transplantation has to overcome a number of hurdles, such as cell quality control, clinical practicality, low cell retent ... Full text Open Access Cite

Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.

Journal Article J Cell Sci · September 9, 2019 Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how ... Full text Open Access Link to item Cite

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome.

Journal Article Adv Healthc Mater · July 2019 Stem cell therapies have made strides toward the efficacious treatment of injured endometrium and the prevention of intrauterine adhesions, or Asherman's syndrome (AS). Despite this progress, they are limited by their risk of tumor formation, low engraftme ... Full text Open Access Link to item Cite

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.

Journal Article J Clin Invest · April 29, 2019 Featured Publication Exosomes, as functional paracrine units of therapeutic cells, can partially reproduce the reparative properties of their parental cells. The constitution of exosomes, as well as their biological activity, largely depends on the cells that secrete them. We ... Full text Open Access Link to item Cite

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells.

Journal Article Nano Lett · March 13, 2019 Stem cell therapies have shown promise in treating acute and chronic ischemic heart disease. However, current therapies are limited by the low retention and poor integration of injected cells in the injured tissue. Taking advantage of the natural infarct-h ... Full text Open Access Link to item Cite

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.

Journal Article Adv Funct Mater · January 24, 2019 Featured Publication Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. ... Full text Open Access Link to item Cite

Antibody-armed platelets for regenerative targeting of endogenous stem cells

Conference Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019 Statement of Purpose: Stem cell therapy has been shown the most cutting-edge therapies in acute and chronic ischemic heart disease. However, current therapies are limited by the low efficiency of retention and integration of injected cells in the injured t ... Cite

Human dermal fibroblast spheroids combined with platelets rich plasma promote skin remodeling in a skin wrinkle model of aged nude mice

Conference Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019 Statement of Purpose: Dermal fibroblasts (DFs) are resident mesenchymal cells that produce collagen and other extracellular matrix proteins. Cultured autologous dermal fibroblasts are believed to reduce wrinkle formation and promote skin rejuvenation. One ... Cite

Cardiac stromal cell/platelet-inspired nanoparticles for targeted heart repair

Conference Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019 Statement of Purpose: The development of stem cell-derived biomimetics as therapeutic biologics has the potential to revolutionize cardiovascular regenerative medicine.1 Here, we report on developing a cardiac stromal cell/platelet-inspired nanoparticle (S ... Cite

Intravenous application of bispecific antibody for cardiac regenerative therapy after heart ischemia/reperfusion injury

Conference Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019 Statement of Purpose: Stem cell therapy, which makes use of cellular paracrine secretions, is a promising strategy for therapeutic heart regeneration. In the last decade, scientists have been using biomaterial and bioengineering approaches to deliver diffe ... Cite

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair.

Journal Article ACS Nano · December 26, 2018 Stem cell therapy is one of the promising strategies for the treatment of ischemic heart disease. However, the clinical application of stem cells transplantation is limited by low cell engraftment in the infarcted myocardium. Taking advantage of pretargeti ... Full text Open Access Link to item Cite

Cardiac cell-integrated microneedle patch for treating myocardial infarction.

Journal Article Sci Adv · November 2018 Featured Publication We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based heart regeneration, cells are currently delivered to the heart via direct mus ... Full text Open Access Link to item Cite

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction.

Journal Article ACS Appl Mater Interfaces · October 3, 2018 Featured Publication Cardiac stem cell (CSC) therapy has shown preclinical and clinical evidence for ischemic heart repair but is limited by low cellular engraftment and survival after transplantation. Previous versions of the cardiac patch strategy improve stem cell engraftme ... Full text Open Access Link to item Cite

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.

Journal Article ACS Nano · July 24, 2018 Featured Publication Acute liver failure is a critical condition characterized by global hepatocyte death and often time needs a liver transplantation. Such treatment is largely limited by donor organ shortage. Stem cell therapy offers a promising option to patients with acute ... Full text Open Access Link to item Cite

Targeted repair of heart injury by stem cells fused with platelet nanovesicles.

Journal Article Nat Biomed Eng · 2018 Featured Publication Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhanc ... Full text Open Access Link to item Cite

Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.

Journal Article ACS Macro Lett · November 15, 2016 Featured Publication Inspired by the delicate architecture of hyaline articular cartilage, we report on a biomimetic polymer hydrogel that incorporates strong intermolecular hydrogen bonding between urethane-urethane linkages as well as urethane-ester linkages. The resultant h ... Full text Open Access Link to item Cite

Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for Pathological Responsive Ultrasound Imaging and T2-Weighted Magnetic Resonance Imaging.

Journal Article ACS Nano · June 23, 2015 Featured Publication A dual-enzyme-loaded multifunctional hybrid nanogel probe (SPIO@GCS/acryl/biotin-CAT/SOD-gel, or SGC) has been developed for dual-modality pathological responsive ultrasound (US) imaging and enhanced T2-weighted magnetic resonance (MR) imaging. This probe ... Full text Open Access Link to item Cite

Hydrogel-coated enzyme electrodes formed by GOx-mediated polymerization for glucose detecting

Journal Article RSC Advances · January 1, 2015 This communication reports the mild fabrication of a hydrogel-coated enzyme electrode for glucose detecting with high sensitivity (35.19 μA mM-1 cm-2) and robust stability. ... Full text Open Access Cite

Microgels formed by enzyme-mediated polymerization in reverse micelles with tunable activity and high stability

Journal Article RSC Advances · January 1, 2015 Featured Publication This communication describes the preparation of microgels via enzyme-triggered inverse emulsion polymerization, which provides an effective method for immobilizing enzymes with tunable catalytic performance and high stability. ... Full text Open Access Cite

Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents.

Journal Article Biomaterials · 2015 This work described a proof of concept study of hybrid nanogel-based magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb. as SGM, for highly efficient, pH-responsive T1 and T2 dual-mode magnetic resonance imaging (MRI). SGM have been synt ... Full text Open Access Link to item Cite

Dual enzymatic formation of hybrid hydrogels with supramolecular-polymeric networks.

Journal Article Chem Commun (Camb) · November 28, 2014 Featured Publication This communication describes a mild construction of hybrid hydrogels with supramolecular-polymeric networks via a dual enzymatic reaction. ... Full text Open Access Link to item Cite

Magnetic nanocomposite hydrogel prepared by ZnO-initiated photopolymerization for La (III) adsorption.

Journal Article ACS Appl Mater Interfaces · November 26, 2014 Featured Publication Here, we provide an effective method to fabricate magnetic ZnO clay nanocomposite hydrogel via the photopolymerization. The inorganic components endow the hydrogel with high mechanical strength, while the organic copolymers exhibit good adsorption capacity ... Full text Open Access Link to item Cite

Glucose oxidase triggers gelation of N-hydroxyimide-heparin conjugates to form enzyme-responsive hydrogels for cell-specific drug delivery

Journal Article Chemical Science · November 1, 2014 Featured Publication A new strategy for creating enzyme-responsive hydrogels by employing an N-hydroxyimide-heparin conjugate, designed to act as both an enzyme-mediated radical initiator and an enzyme-sensitive therapeutic carrier, is described. A novel enzyme-mediated redox ... Full text Open Access Cite

Tough nanocomposite ionogel-based actuator exhibits robust performance.

Journal Article Sci Rep · October 20, 2014 Ionogel electrolytes can be fabricated for electrochemical actuators with many desirable advantages, including direct low-voltage control in air, high electrochemical and thermal stability, and complete silence during actuation. However, the demands for ac ... Full text Open Access Link to item Cite

Nanocomposite gels via in situ photoinitiation and disassembly of TiOTiO₂-clay composites with polymers applied as UV protective films.

Journal Article ACS Appl Mater Interfaces · February 12, 2014 We report a facile solution polymerized approach to prepare nanocomposite hydrogels. The electrostatic assembly of positive TiO2 nanoparticles with negative clay nanosheets obtained TiO2-clay composite particles, which was disassembled by the solution poly ... Full text Open Access Link to item Cite

Functional elastic hydrogel as recyclable membrane for the adsorption and degradation of methylene blue.

Journal Article PLoS One · 2014 Developing the application of high-strength hydrogels has gained much attention in the fields of medical, pharmacy, and pollutant removal due to their versatility and stimulus-responsive properties. In this presentation, a high-strength freestanding elasti ... Full text Open Access Link to item Cite

Thermal responsive microgels as recyclable carriers to immobilize active proteins with enhanced nonaqueous biocatalytic performance.

Journal Article Chem Commun (Camb) · December 14, 2013 Featured Publication We describe the preparation of a thermoresponsive microgel, which can non-covalently immobilize active proteins with enhanced biocatalytic performance in organic solvents and easy reusability due to the porous microstructure and temperature responsive prop ... Full text Open Access Link to item Cite

BSA-rGO nanocomposite hydrogel formed by UV polymerization and in situ reduction applied as biosensor electrode.

Journal Article J Mater Chem B · October 28, 2013 This communication demonstrates a convenient strategy to prepare a tough BSA-rGO hydrogel electrode via photopolymerization, which is demonstrated to be a highly effective H2O2 biosensor electrode with low detection concentration and high sensing sensitivi ... Full text Open Access Link to item Cite

HRP-mediated polymerization forms tough nanocomposite hydrogels with high biocatalytic performance.

Journal Article Chem Commun (Camb) · September 21, 2013 Featured Publication This communication describes the mild and quick construction of tough nanocomposite hydrogels via a horseradish peroxidase-mediated radical polymerization for effectively immobilizing enzymes to attain high catalytic performance in various solvents. ... Full text Open Access Link to item Cite

Fluorinated siloxane-containing waterborne polyurethaneureas with excellent hemocompatibility, waterproof and mechanical properties

Journal Article European Polymer Journal · March 1, 2010 Featured Publication Two series of polyurethaneurea (PUU) aqueous dispersions consisting of fluorinated siloxane segments were prepared from a high-molecular-weight (Mn = 8361) α,ω-dihydroxypoly[(3,3,3-trifluoropropyl)methylsiloxane] (PTFPMS), dimethylolpropionic acid, isophor ... Full text Cite

Preparation and properties of waterborne interpenetrating polymer networks composed of polyurethaneurea and graft vinyl ester resin

Journal Article Journal of Applied Polymer Science · October 15, 2009 Featured Publication Various waterborne interpenetrating polymer networks (IPNs) composed of polyurethaneurea (PUU) and graft vinyl ester resin were prepared from polyester polyol, dimethylolpropionic acid, isophorone di-isocyanate, ethylenediamine and a well-defined graft vin ... Full text Cite

Preparation and properties of well-defined waterborne polyurethaneurea with fluorinated siloxane units in hard or soft segments

Journal Article Journal of Polymer Science, Part A: Polymer Chemistry · November 1, 2007 Featured Publication Two series of well-defined polyurethaneurea (PUU) aqueous dispersions consisting of fluorinated siloxane units in the hard and the soft segments, respectively, were prepared from polyester polyol, α,ω- dihydroxypory[(3,3,3-trifluoropropyl) methylsiloxane] ... Full text Cite

Preparation and properties of waterborne polyurethaneurea consisting of fluorinated siloxane units

Journal Article Journal of Polymer Science, Part A: Polymer Chemistry · May 15, 2006 Featured Publication A series of polyurethaneurea (PUTJ) aqueous dispersions were prepared via a prepolymer process from polyester polyol, α,ω-dihydroxypoly[(3,3,3- trifluoropropyl) methylsiloxane] (PTFPMS), dimethylolpropionic acid, isophorone diisocyanate, and ethylenediamin ... Full text Cite

Preparation and properties of waterborne polyurethaneurea consisting of α, ω-dihydroxypoly [(3,3,3-trifluoropropyl) methylsiloxane] units

Conference "New Century, New Materials and New Life" - Proceedings of 2005 International Conference on Advanced Fibers and Polymer Materials, ICAFPM 2005 · January 1, 2005 Featured Publication A series of polyurethaneurea (PUU) aqueous dispersions modified with α, ω-dihydroxypoly [(3, 3, 3-trifluoropropyl) methylsiloxane] (PTFPMS) were prepared. These anionic-type aqueous dispersions were stable at ambient temperature and showed excellent high-t ... Cite

Study on enzymatic treatment of biological slime in industrial circulating water

Journal Article Zhongguo Jishui Paishui/China Water & Wastewater · August 1, 2002 Cite