Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellowship, Feinberg Cardiovascular Research Institute, Northwestern University 2013 - 2014
  • Postdoctoral Fellowship, Department Of Medical Biochemistry, Tohoku University (Japan) 2012 - 2013
  • Ph.D., Tohoku University (Japan) 2012
  • M.D., Shimane University (Japan) 2004
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  Previous Appointments & Affiliations

  • Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2017 - 2019
• 

  Academic Positions Outside Duke

  • Research assistant professor, Northwestern University. 2015 - 2017
• Recognition
• 

  In the News

  • NOV 15, 2022

    Duke Health News

    Protected From a Form of Cell Death, Women are More Resilient to Kidney Disease
• Research
• 

  Selected Grants

  • Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair - R01 awarded by National Institutes of Health 2023 - 2028
  • Tissue-Specific Regulation and Effects of CYP24A1 awarded by National Institutes of Health 2023 - 2027
  • R01: Targeting Renal Tubular Epithelial Progenitors in AKI to CKD transition awarded by National Institutes of Health 2020 - 2025
  • Targeting anti-ferroptotic pathways to prevent the AKI-to-CKD transition awarded by  American Heart Association 2020 - 2021
  • Elucidating molecular mechanisms of maladaptive renal repair awarded by Northwestern University 2020 - 2021
  • Harnessing Antioxidative Stress Pathways in Renal Epithelial Progenitors to Prevent AKI-to-CKD Transition awarded by ASN Foundation for Kidney Research 2019 - 2020
  • Molecular Mechanisms of Cardiac Injury Induced by FGF23 in the Settings of High Phosphate Diet and CKD awarded by Northwestern University 2016 - 2020
• 

  External Relationships

  • Variant Bio
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Privratsky, Jamie R., Shintaro Ide, Yanting Chen, Hiroki Kitai, Jiafa Ren, Helene Fradin, Xiaohan Lu, Tomokazu Souma, and Steven D. Crowley. “A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury.” Kidney Int 103, no. 3 (March 2023): 514–28. https://doi.org/10.1016/j.kint.2022.10.008.
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    • Ide, Shintaro, Kana Ide, Koki Abe, Yoshihiko Kobayashi, Hiroki Kitai, Jennifer McKey, Sarah A. Strausser, et al. “Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.” Cell Rep 41, no. 6 (November 8, 2022): 111610. https://doi.org/10.1016/j.celrep.2022.111610.
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    • Finer, Gal, Yoshiro Maezawa, Shintaro Ide, Tuncer Onay, Tomokazu Souma, Rizaldy Scott, Xiaoyan Liang, et al. “Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling.” Kidney360 3, no. 7 (July 28, 2022): 1228–41. https://doi.org/10.34067/KID.0005572021.
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    • Lu, Xiaohan, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P. Rudemiller, Shintaro Ide, Tomokazu Souma, and Steven D. Crowley. “Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell-Mediated T Cell Activation.” Hypertension 79, no. 6 (June 2022): 1227–36. https://doi.org/10.1161/HYPERTENSIONAHA.121.18734.
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    • Ide, Kana, and Tomokazu Souma. “In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice.” Curr Protoc 2, no. 4 (April 2022): e413. https://doi.org/10.1002/cpz1.413.
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    • Ren, Jiafa, Yuemei Xu, Xiaohan Lu, Liming Wang, Shintaro Ide, Gentzon Hall, Tomokazu Souma, Jamie R. Privratsky, Robert F. Spurney, and Steven D. Crowley. “Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration.” Jci Insight 6, no. 15 (August 9, 2021). https://doi.org/10.1172/jci.insight.148109.
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    • Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah A. Strausser, Koki Abe, Savannah Herbek, Lori L. O’Brien, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.” Elife 10 (July 19, 2021). https://doi.org/10.7554/eLife.68603.
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    • Herbek, Savannah, Daniel L. Edmonston, and Tomokazu Souma. “Hypoxia signaling in renal pericytes-is it safe to activate?” Kidney Int 99, no. 6 (June 2021): 1267–69. https://doi.org/10.1016/j.kint.2021.02.014.
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    • Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah Strausser, Savannah Herbek, Lori O’Brien, Steven Crowley, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair,” 2021. https://doi.org/10.1101/2021.03.23.436661.
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    • Young, Terri L., Kristina N. Whisenhunt, Jing Jin, Sarah M. LaMartina, Sean M. Martin, Tomokazu Souma, Vachiranee Limviphuvadh, et al. “SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma.” Invest Ophthalmol Vis Sci 61, no. 12 (October 1, 2020): 6. https://doi.org/10.1167/iovs.61.12.6.
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    • Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A. Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.” Elife 9 (April 17, 2020). https://doi.org/10.7554/eLife.51756.
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    • Yahara, Yasuhito, Tomasa Barrientos, Yuning J. Tang, Vijitha Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, et al. “Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair.” Nat Cell Biol 22, no. 1 (January 2020): 49–59. https://doi.org/10.1038/s41556-019-0437-8.
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    • Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah Strausser, Anisha Watwe, Jamie Pivratsky, Steven Crowley, Mari Shinohara, Benjamin Alman, and Tomokazu Souma. “Yolk-Sac-Derived Macrophages Progressively Expand in the Mouse Kidney with Age,” October 21, 2019. https://doi.org/10.1101/811927.
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    • Thomson, Benjamin R., Isabel A. Carota, Tomokazu Souma, Saily Soman, Dietmar Vestweber, and Susan E. Quaggin. “Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma.” Elife 8 (October 17, 2019). https://doi.org/10.7554/eLife.48474.
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    • Taylor, Ashlee, Christopher Yanucil, John Musgrove, Melody Shi, Shintaro Ide, Tomokazu Souma, Christian Faul, Myles Wolf, and Alexander Grabner. “FGFR4 does not contribute to progression of chronic kidney disease.” Sci Rep 9, no. 1 (October 1, 2019): 14023. https://doi.org/10.1038/s41598-019-50669-0.
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    • Carota, Isabel A., Yael Kenig-Kozlovsky, Tuncer Onay, Rizaldy Scott, Benjamin R. Thomson, Tomokazu Souma, Christina S. Bartlett, et al. “Targeting VE-PTP phosphatase protects the kidney from diabetic injury.” J Exp Med 216, no. 4 (April 1, 2019): 936–49. https://doi.org/10.1084/jem.20180009.
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    • Ide, Shintaro, Gal Finer, Yoshiro Maezawa, Tuncer Onay, Tomokazu Souma, Rizaldy Scott, Kana Ide, et al. “Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.” J Am Soc Nephrol 29, no. 12 (December 2018): 2795–2808. https://doi.org/10.1681/ASN.2017121278.
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    • Stanifer, John W., Heather M. Stapleton, Tomokazu Souma, Ashley Wittmer, Xinlu Zhao, and L Ebony Boulware. “Perfluorinated Chemicals as Emerging Environmental Threats to Kidney Health: A Scoping Review.” Clin J Am Soc Nephrol 13, no. 10 (October 8, 2018): 1479–92. https://doi.org/10.2215/CJN.04670418.
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    • Liu, Pan, Jan Wysocki, Tomokazu Souma, Minghao Ye, Veronica Ramirez, Bisheng Zhou, Lisa D. Wilsbacher, Susan E. Quaggin, Daniel Batlle, and Jing Jin. “Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation.” Kidney Int 94, no. 1 (July 2018): 114–25. https://doi.org/10.1016/j.kint.2018.01.029.
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    • Strausser, Sarah A., Daisuke Nakano, and Tomokazu Souma. “Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response.” Curr Opin Nephrol Hypertens 27, no. 4 (July 2018): 314–22. https://doi.org/10.1097/MNH.0000000000000424.
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    • Souma, Tomokazu, Benjamin R. Thomson, Stefan Heinen, Isabel Anna Carota, Shinji Yamaguchi, Tuncer Onay, Pan Liu, et al. “Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.” Proc Natl Acad Sci U S A 115, no. 6 (February 6, 2018): 1298–1303. https://doi.org/10.1073/pnas.1714446115.
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    • Thomson, Benjamin R., Tomokazu Souma, Stuart W. Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M. Siggs, Liang Feng, et al. “Angiopoietin-1 is required for Schlemm's canal development in mice and humans.” J Clin Invest 127, no. 12 (December 1, 2017): 4421–36. https://doi.org/10.1172/JCI95545.
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    • Liu, Pan, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, and Jing Jin. “Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation.” J Vis Exp, no. 127 (September 6, 2017). https://doi.org/10.3791/56278.
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    • Nezu, Masahiro, Tomokazu Souma, Lei Yu, Hiroki Sekine, Nobuyuki Takahashi, Andrew Zu-Sern Wei, Sadayoshi Ito, et al. “Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.” Sci Signal 10, no. 479 (May 16, 2017). https://doi.org/10.1126/scisignal.aam5711.
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    • Liu, Pan, Jan Wysocki, Peter Serfozo, Minghao Ye, Tomokazu Souma, Daniel Batlle, and Jing Jin. “A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13.” Sci Rep 7 (April 5, 2017): 45473. https://doi.org/10.1038/srep45473.
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    • Nezu, Masahiro, Tomokazu Souma, Lei Yu, Takafumi Suzuki, Daisuke Saigusa, Sadayoshi Ito, Norio Suzuki, and Masayuki Yamamoto. “Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.” Kidney Int 91, no. 2 (February 2017): 387–401. https://doi.org/10.1016/j.kint.2016.08.023.
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    • Liu, Pan, Tomokazu Souma, Andrew Zu-Sern Wei, Xueying Xie, Xunrong Luo, and Jing Jin. “A Novel Method for Anti-HLA Antibody Detection Using Personalized Peptide Arrays.” Transplant Direct 2, no. 11 (November 2016): e109. https://doi.org/10.1097/TXD.0000000000000619.
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    • Souma, Tomokazu, Stuart W. Tompson, Benjamin R. Thomson, Owen M. Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, et al. “Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.” J Clin Invest 126, no. 7 (July 1, 2016): 2575–87. https://doi.org/10.1172/JCI85830.
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    • Souma, Tomokazu, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, et al. “Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.” J Am Soc Nephrol 27, no. 2 (February 2016): 428–38. https://doi.org/10.1681/ASN.2014121184.
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    • Tojo, Yutaka, Hiroki Sekine, Ikuo Hirano, Xiaoqing Pan, Tomokazu Souma, Tadayuki Tsujita, Shin-ichi Kawaguchi, et al. “Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.” Mol Cell Biol 35, no. 15 (August 2015): 2658–72. https://doi.org/10.1128/MCB.00161-15.
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    • Macosko, Evan Z., Anindita Basu, Rahul Satija, James Nemesh, Karthik Shekhar, Melissa Goldman, Itay Tirosh, et al. “Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.” Cell 161, no. 5 (May 21, 2015): 1202–14. https://doi.org/10.1016/j.cell.2015.05.002.
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    • Souma, T., and N. Suzuki. “Renal fibrosis and anemia.” Japanese Journal of Nephrology 57, no. 7 (January 1, 2015): 1193–99.
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    • Souma, Tomokazu, and Norio Suzuki. “[Renal fibrosis and anemia].” Nihon Jinzo Gakkai Shi 57, no. 7 (2015): 1193–99.
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    • Souma, Tomokazu, Norio Suzuki, and Masayuki Yamamoto. “Renal erythropoietin-producing cells in health and disease.” Front Physiol 6 (2015): 167. https://doi.org/10.3389/fphys.2015.00167.
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    • Nezu, Masahiro, Tomokazu Souma, and Masayuki Yamamoto. “[Renal erythropoietin-producing cells and kidney disease].” Nihon Rinsho 72, no. 9 (September 2014): 1691–1700.
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    • Yu, Lei, Takashi Moriguchi, Tomokazu Souma, Jun Takai, Hironori Satoh, Naoki Morito, James Douglas Engel, and Masayuki Yamamoto. “GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.” Mol Cell Biol 34, no. 11 (June 2014): 1929–41. https://doi.org/10.1128/MCB.01659-13.
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    • Souma, Tomokazu, Shun Yamazaki, Takashi Moriguchi, Norio Suzuki, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, et al. “Plasticity of renal erythropoietin-producing cells governs fibrosis.” J Am Soc Nephrol 24, no. 10 (October 2013): 1599–1616. https://doi.org/10.1681/ASN.2013010030.
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    • Akiyama, Yasutoshi, Koichi Kikuchi, Daisuke Saigusa, Takehiro Suzuki, Yoichi Takeuchi, Eikan Mishima, Yasuaki Yamamoto, et al. “Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3.” Plos One 8, no. 7 (2013): e66518. https://doi.org/10.1371/journal.pone.0066518.
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    • Yamazaki, Shun, Tomokazu Souma, Ikuo Hirano, Xiaoqing Pan, Naoko Minegishi, Norio Suzuki, and Masayuki Yamamoto. “A mouse model of adult-onset anaemia due to erythropoietin deficiency.” Nat Commun 4 (2013): 1950. https://doi.org/10.1038/ncomms2950.
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    • Ainoya, Keiko, Takashi Moriguchi, Shin’ya Ohmori, Tomokazu Souma, Jun Takai, Masanobu Morita, Kelly J. Chandler, et al. “UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.” Mol Cell Biol 32, no. 12 (June 2012): 2312–22. https://doi.org/10.1128/MCB.06699-11.
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    • Xue, Mingzhan, Naila Rabbani, Hiroshi Momiji, Precious Imbasi, M Maqsud Anwar, Neil Kitteringham, B Kevin Park, et al. “Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.” Biochem J 443, no. 1 (April 1, 2012): 213–22. https://doi.org/10.1042/BJ20111648.
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    • Souma, Tomokazu, Michiaki Abe, Takashi Moriguchi, Jun Takai, Noriko Yanagisawa-Miyazawa, Eisuke Shibata, Yasutoshi Akiyama, et al. “Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells.” J Am Soc Nephrol 22, no. 4 (April 2011): 635–48. https://doi.org/10.1681/ASN.2009111130.
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    • Abe, Michiaki, Takafumi Toyohara, Akiko Ishii, Takehiro Suzuki, Naoya Noguchi, Yasutoshi Akiyama, Hiromi O. Shiwaku, et al. “The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides.” Drug Metab Pharmacokinet 25, no. 3 (2010): 274–82. https://doi.org/10.2133/dmpk.25.274.
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    • Miyazawa, Noriko, Michiaki Abe, Tomokazu Souma, Masayuki Tanemoto, Takaaki Abe, Masaaki Nakayama, and Sadayoshi Ito. “Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.” Free Radic Res 44, no. 1 (January 2010): 101–7. https://doi.org/10.3109/10715760903321788.
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    • Toyohara, Takafumi, Takehiro Suzuki, Ryo Morimoto, Yasutoshi Akiyama, Tomokazu Souma, Hiromi O. Shiwaku, Yoichi Takeuchi, et al. “SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.” J Am Soc Nephrol 20, no. 12 (December 2009): 2546–55. https://doi.org/10.1681/ASN.2009070696.
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    • Bockenhauer, D., M. Cruwys, R. Kleta, L. F. Halperin, P. Wildgoose, T. Souma, N. Nukiwa, et al. “Antenatal Bartter's syndrome: why is this not a lethal condition?” Qjm 101, no. 12 (December 2008): 927–42. https://doi.org/10.1093/qjmed/hcn119.
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  • Conference Papers

    • Tompson, Stuart William, Kristina Whisenhunt, Sarah M. LaMartina, Sean M. Martin, Tomokazu Souma, Vachiranee Limviphuvadh, Jing Jin, et al. “SVEP1 as a genetic modifier of TEK-related primary congenital glaucoma.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.
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