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Trinitia Y Cannon

Associate Professor of Head and Neck Surgery & Communication Sciences
Head & Neck Surgical Oncology
3404 Wake Forest Rd; Suite 202, Raleigh, NC 27609
3404 Wake Forest Road, Suite 202, Raleigh, NC 27609

Selected Publications


Salvage Surgery.

Journal Article Otolaryngol Clin North Am · April 2023 The Department of Veterans Affairs Laryngeal Cancer Study propelled the combination of chemotherapy and radiation therapy to the forefront of strategies used for the management of locally advanced laryngeal cancer. The organ preservation rate was 84%. Howe ... Full text Link to item Cite

Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: A pilot study.

Journal Article Laryngoscope Investig Otolaryngol · February 2023 BACKGROUND: Pharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well-defined understanding of its therapeutic mechanism. We hyp ... Full text Link to item Cite

Differential Outcomes Among Survivors of Head and Neck Cancer Belonging to Racial and Ethnic Minority Groups.

Journal Article JAMA Otolaryngol Head Neck Surg · February 1, 2022 IMPORTANCE: Approximately 1 in 5 new patients with head and neck cancer (HNC) in the US belong to racial and ethnic minority groups, but their survival rates are worse than White individuals. However, because most studies compare Black vs White patients, l ... Full text Link to item Cite

Surgeon Volume and Complications in Lateral Neck Dissection for Squamous Cell Carcinoma: A Multidatabase Analysis.

Journal Article Otolaryngol Head Neck Surg · December 2021 OBJECTIVE: To determine whether annual surgeon volume of lateral neck dissections for squamous cell carcinoma is associated with complication rates. STUDY DESIGN: Retrospective review. SETTING: Two US databases spanning 2000 to 2014. METHODS: Neck dissecti ... Full text Link to item Cite

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula in Patients Who Have Undergone Laryngectomy.

Journal Article JAMA Otolaryngol Head Neck Surg · November 1, 2021 IMPORTANCE: Pharyngocutaneous fistula (PCF) is a serious complication after total laryngectomy. Despite the well-described clinical risk factors for PCF and its association with poor quality of life, there is a paucity of data on the nonclinical factors th ... Full text Link to item Cite

Incidence of occult lymph node metastasis in primary larynx squamous cell carcinoma, by subsite, t classification and neck level: A systematic review

Journal Article Cancers · April 1, 2020 Background: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define the prevalence of occult metastas ... Full text Cite

The cervicofacial flap

Journal Article Operative Techniques in Otolaryngology - Head and Neck Surgery · June 1, 2019 Surgical and traumatic defects of the face present a reconstructive challenge to restore facial symmetry. The cervicofacial flap is a rotational and advancement flap with random blood supply utilized to close moderate- to large-sized defects of the cheek. ... Full text Cite

Ultrasound-Guided Transcutaneous Needle Biopsy of the Base of the Tongue and Floor of the Mouth From a Submental Approach.

Journal Article J Ultrasound Med · May 2016 Limited data exist regarding the feasibility of ultrasound-guided transcutaneous biopsy of the base of the tongue and floor of the mouth. This retrospective study reviewed 8 cases with lesions in the base of the tongue or floor of the mouth that were biops ... Full text Link to item Cite

Cancer of the hypopharynx

Chapter · January 1, 2016 Squamous cell carcinoma of the hypopharynx is relatively uncommon, accounting for about 4% of all head and neck tumors, with approximately 3400 new cases diagnosed annually. However, these tumors are associated with the lowest survival rates when compared ... Full text Cite

Liver function tests: inadequate screening modality for detection of liver metastasis in head and neck carcinoma.

Journal Article Otolaryngol Head Neck Surg · January 2012 OBJECTIVE: Report the prevalence and risk factors of liver metastasis in head and neck squamous cell carcinoma (HNSCC) while evaluating the utility of liver function tests (LFTs) in detection of such metastases. STUDY DESIGN: Case series with chart review. ... Full text Link to item Cite

Oromandibular reconstruction.

Journal Article Clin Anat · January 2012 Mandibular reconstruction is often necessary due to congenital, traumatic, infectious, and following treatment for neoplasms of the region. Mandibular defects following ablative surgery for malignant tumors of the head and neck region impact both form and ... Full text Link to item Cite

Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma.

Journal Article Head Neck · March 2008 BACKGROUND: Muscle wasting and weight loss were observed when carcinomas were induced in a murine model of head and neck squamous cell carcinomas. Our hypothesis was C3H/HeN mice would develop evidence of cachexia when injected with tumor cells METHODS: Ag ... Full text Link to item Cite

Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.

Journal Article Head Neck · January 2008 BACKGROUND: Animal models suggest that cyclooxygenase-2 (COX-2) inhibitors may be beneficial in suppressing cancer cachexia. We investigated the effect of short-course celecoxib on body composition, inflammation, and quality of life (QOL) in patients with ... Full text Link to item Cite

The effect of altered Toll-like receptor 4 signaling on cancer cachexia.

Conference Arch Otolaryngol Head Neck Surg · December 2007 OBJECTIVE: To determine whether mice unable to mount an intact inflammatory response because of a Toll-like receptor (TLR) pathway defect will develop less severe cancer cachexia. DESIGN: Prospective animal study. SETTING: Academic research center. SUBJECT ... Full text Link to item Cite

Comparison of animal models for head and neck cancer cachexia.

Journal Article Laryngoscope · December 2007 OBJECTIVES/HYPOTHESIS: Despite its negative impact on cancer patients, there are few animal models of cancer cachexia. Our hypothesis was that different human cell lines would variably induce cachexia. STUDY DESIGN: Prospective animal study. METHODS: We es ... Full text Link to item Cite

Defining cancer cachexia in head and neck squamous cell carcinoma.

Journal Article Clin Cancer Res · November 15, 2007 PURPOSE: Cancer cachexia is a devastating and understudied illness in patients with head and neck squamous cell carcinoma (HNSCC). The primary objective was to identify clinical characteristics and serum levels of cytokines and cachexia-related factors in ... Full text Link to item Cite

Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology.

Journal Article Head Neck · May 2007 Cancer cachexia is a morbid wasting syndrome common among patients with head and neck cancer. While its clinical manifestations have been well characterized, its pathophysiology remains complex. A comprehensive literature search on cancer cachexia was perf ... Full text Link to item Cite

Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment.

Journal Article Head Neck · April 2007 BACKGROUND: Cancer cachexia is a debilitating, wasting condition that affects many cancer patients, including those with head and neck cancer. The overall incidence of cancer cachexia is quite high for some types of cancer, and cachexia will be the main ca ... Full text Link to item Cite

Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States.

Journal Article Arch Otolaryngol Head Neck Surg · October 2006 OBJECTIVES: To compare the incidence rates of nasopharyngeal carcinoma (NPC) among US black, white, and Asian/Pacific Islander (Asian) populations, with a focus on those diagnosed before age 20 years and between ages 20 and 29 years. Our secondary objectiv ... Full text Link to item Cite

Salvage Surgery.

Journal Article Otolaryngol Clin North Am · April 2023 The Department of Veterans Affairs Laryngeal Cancer Study propelled the combination of chemotherapy and radiation therapy to the forefront of strategies used for the management of locally advanced laryngeal cancer. The organ preservation rate was 84%. Howe ... Full text Link to item Cite

Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: A pilot study.

Journal Article Laryngoscope Investig Otolaryngol · February 2023 BACKGROUND: Pharyngocutaneous fistula (PCF) and salivary leaks are well known complications of head and neck surgery. The medical management of PCF has included the use of octreotide without a well-defined understanding of its therapeutic mechanism. We hyp ... Full text Link to item Cite

Differential Outcomes Among Survivors of Head and Neck Cancer Belonging to Racial and Ethnic Minority Groups.

Journal Article JAMA Otolaryngol Head Neck Surg · February 1, 2022 IMPORTANCE: Approximately 1 in 5 new patients with head and neck cancer (HNC) in the US belong to racial and ethnic minority groups, but their survival rates are worse than White individuals. However, because most studies compare Black vs White patients, l ... Full text Link to item Cite

Surgeon Volume and Complications in Lateral Neck Dissection for Squamous Cell Carcinoma: A Multidatabase Analysis.

Journal Article Otolaryngol Head Neck Surg · December 2021 OBJECTIVE: To determine whether annual surgeon volume of lateral neck dissections for squamous cell carcinoma is associated with complication rates. STUDY DESIGN: Retrospective review. SETTING: Two US databases spanning 2000 to 2014. METHODS: Neck dissecti ... Full text Link to item Cite

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula in Patients Who Have Undergone Laryngectomy.

Journal Article JAMA Otolaryngol Head Neck Surg · November 1, 2021 IMPORTANCE: Pharyngocutaneous fistula (PCF) is a serious complication after total laryngectomy. Despite the well-described clinical risk factors for PCF and its association with poor quality of life, there is a paucity of data on the nonclinical factors th ... Full text Link to item Cite

Incidence of occult lymph node metastasis in primary larynx squamous cell carcinoma, by subsite, t classification and neck level: A systematic review

Journal Article Cancers · April 1, 2020 Background: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define the prevalence of occult metastas ... Full text Cite

The cervicofacial flap

Journal Article Operative Techniques in Otolaryngology - Head and Neck Surgery · June 1, 2019 Surgical and traumatic defects of the face present a reconstructive challenge to restore facial symmetry. The cervicofacial flap is a rotational and advancement flap with random blood supply utilized to close moderate- to large-sized defects of the cheek. ... Full text Cite

Ultrasound-Guided Transcutaneous Needle Biopsy of the Base of the Tongue and Floor of the Mouth From a Submental Approach.

Journal Article J Ultrasound Med · May 2016 Limited data exist regarding the feasibility of ultrasound-guided transcutaneous biopsy of the base of the tongue and floor of the mouth. This retrospective study reviewed 8 cases with lesions in the base of the tongue or floor of the mouth that were biops ... Full text Link to item Cite

Cancer of the hypopharynx

Chapter · January 1, 2016 Squamous cell carcinoma of the hypopharynx is relatively uncommon, accounting for about 4% of all head and neck tumors, with approximately 3400 new cases diagnosed annually. However, these tumors are associated with the lowest survival rates when compared ... Full text Cite

Liver function tests: inadequate screening modality for detection of liver metastasis in head and neck carcinoma.

Journal Article Otolaryngol Head Neck Surg · January 2012 OBJECTIVE: Report the prevalence and risk factors of liver metastasis in head and neck squamous cell carcinoma (HNSCC) while evaluating the utility of liver function tests (LFTs) in detection of such metastases. STUDY DESIGN: Case series with chart review. ... Full text Link to item Cite

Oromandibular reconstruction.

Journal Article Clin Anat · January 2012 Mandibular reconstruction is often necessary due to congenital, traumatic, infectious, and following treatment for neoplasms of the region. Mandibular defects following ablative surgery for malignant tumors of the head and neck region impact both form and ... Full text Link to item Cite

Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma.

Journal Article Head Neck · March 2008 BACKGROUND: Muscle wasting and weight loss were observed when carcinomas were induced in a murine model of head and neck squamous cell carcinomas. Our hypothesis was C3H/HeN mice would develop evidence of cachexia when injected with tumor cells METHODS: Ag ... Full text Link to item Cite

Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.

Journal Article Head Neck · January 2008 BACKGROUND: Animal models suggest that cyclooxygenase-2 (COX-2) inhibitors may be beneficial in suppressing cancer cachexia. We investigated the effect of short-course celecoxib on body composition, inflammation, and quality of life (QOL) in patients with ... Full text Link to item Cite

The effect of altered Toll-like receptor 4 signaling on cancer cachexia.

Conference Arch Otolaryngol Head Neck Surg · December 2007 OBJECTIVE: To determine whether mice unable to mount an intact inflammatory response because of a Toll-like receptor (TLR) pathway defect will develop less severe cancer cachexia. DESIGN: Prospective animal study. SETTING: Academic research center. SUBJECT ... Full text Link to item Cite

Comparison of animal models for head and neck cancer cachexia.

Journal Article Laryngoscope · December 2007 OBJECTIVES/HYPOTHESIS: Despite its negative impact on cancer patients, there are few animal models of cancer cachexia. Our hypothesis was that different human cell lines would variably induce cachexia. STUDY DESIGN: Prospective animal study. METHODS: We es ... Full text Link to item Cite

Defining cancer cachexia in head and neck squamous cell carcinoma.

Journal Article Clin Cancer Res · November 15, 2007 PURPOSE: Cancer cachexia is a devastating and understudied illness in patients with head and neck squamous cell carcinoma (HNSCC). The primary objective was to identify clinical characteristics and serum levels of cytokines and cachexia-related factors in ... Full text Link to item Cite

Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology.

Journal Article Head Neck · May 2007 Cancer cachexia is a morbid wasting syndrome common among patients with head and neck cancer. While its clinical manifestations have been well characterized, its pathophysiology remains complex. A comprehensive literature search on cancer cachexia was perf ... Full text Link to item Cite

Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment.

Journal Article Head Neck · April 2007 BACKGROUND: Cancer cachexia is a debilitating, wasting condition that affects many cancer patients, including those with head and neck cancer. The overall incidence of cancer cachexia is quite high for some types of cancer, and cachexia will be the main ca ... Full text Link to item Cite

Incidence and survival rates for young blacks with nasopharyngeal carcinoma in the United States.

Journal Article Arch Otolaryngol Head Neck Surg · October 2006 OBJECTIVES: To compare the incidence rates of nasopharyngeal carcinoma (NPC) among US black, white, and Asian/Pacific Islander (Asian) populations, with a focus on those diagnosed before age 20 years and between ages 20 and 29 years. Our secondary objectiv ... Full text Link to item Cite

Nasopharyngeal carcinoma in young patients: a systematic review of racial demographics.

Journal Article Laryngoscope · June 2006 OBJECTIVES: To evaluate patients 25 years of age or younger who were treated for nasopharyngeal carcinoma. STUDY DESIGN: Retrospective review, systematic literature review. METHODS: Nasopharyngeal carcinoma (NPC) is rare in the Western world. In people you ... Full text Link to item Cite

High-resolution computed tomography analysis of the greater palatine canal.

Journal Article Am J Rhinol · 2006 BACKGROUND: The greater palatine foramen injection is effective for minimizing bleeding during sinus surgery. The correct depth is important to minimize risk of orbital penetration. This study analyzed the length of the greater palatine canal using high-re ... Full text Link to item Cite