Andrew Neil Macintyre
Assistant Professor in Medicine
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2021
Contact Information
- Box 103020, Rm 1033 Ghrb, 909 S. Lasalle St., Durham, NC 27710
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a.n.macintyre@duke.edu
(919) 668-4704
- Background
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Education, Training, & Certifications
- Ph.D., University of Dundee (United Kingdom) 2009
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Duke Appointment History
- Assistant Professor of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2020
- Research
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Selected Grants
- VTEU Task D Option 1 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
- CIVICS Component A - Option 1 awarded by National Institutes of Health 2019 - 2021
- METHODS TO TEST LIFESTYLE, VAGINAL MICROENVIRONMENT, AND GENITOURINARY SYMPTOMS ACROSS MENOPAUSE TRANSITION awarded by University of Maryland 2020 - 2021
- Human Thymus Core (Core C) awarded by The University of Texas MD Anderson Cancer Center 2020 - 2021
- Radiation Survival Cohort - Immune Monitoring Core awarded by Wake Forest University Health Sciences 2020 - 2021
- Virology Core awarded by Boston Children's Hospital 2017 - 2021
- Emerging Infectious Diseases - Coordination Center awarded by Research Triangle Institute International 2020 - 2021
- Experimental Human Infection with Isogenic Mutants of Neisseria gonorrhoeae awarded by University of North Carolina - Chapel Hill 2015 - 2021
- Gonorrhea Vaccine Cooperative Research Center (GV-CRC); Core C: Host Response Monitoring awarded by Henry M. Jackson Foundation 2019 - 2021
- Macrogenics Cytokine Profiling Subcontract awarded by MacroGenics, Inc. 2018 - 2020
- Core C: Monitoring Host Response awarded by Henry M. Jackson Foundation 2014 - 2020
- Novel nanoparticle platform for antiviral vaccine and therapeutics awarded by University of North Carolina - Chapel Hill 2014 - 2020
- Biomarker analysis of vaginal lavage samples awarded by University of Maryland, Baltimore 2019
- Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory awarded by National Institutes of Health 2015
- Metabolic Control of T Cell Subsets and Pyruvate Dehydrogenase Kinase as a Target in Inflammatory Bowel Disease awarded by Kenneth Rainin Foundation 2013 - 2014
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hale, Laura P., Lynn Cheatham, Andrew N. Macintyre, Bonnie LaFleur, Brittany Sanders, Jesse Troy, Joanne Kurtzberg, and Gregory D. Sempowski. “T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.” Geroscience, January 9, 2021. https://doi.org/10.1007/s11357-020-00301-1.Full Text Link to Item
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Leduc, Isabelle, Kristie L. Connolly, Afrin Begum, Knashka Underwood, Stephen Darnell, William M. Shafer, Jacqueline T. Balthazar, et al. “The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.” Plos Pathog 16, no. 12 (December 2020): e1008602. https://doi.org/10.1371/journal.ppat.1008602.Full Text Link to Item
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Eichenberger, Emily M., Felicia Ruffin, Michael Dagher, Reginald Lerebours, Sin-Ho Jung, Batu Sharma-Kuinkel, Andrew N. Macintyre, et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.” Am J Transplant, October 31, 2020. https://doi.org/10.1111/ajt.16388.Full Text Link to Item
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Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.Full Text Link to Item
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Michalson, Kristofer T., Andrew N. Macintyre, Gregory D. Sempowski, J Daniel Bourland, Timothy D. Howard, Gregory A. Hawkins, Gregory O. Dugan, J Mark Cline, and Thomas C. Register. “Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.” Radiat Res 192, no. 2 (August 2019): 121–34. https://doi.org/10.1667/RR15310.1.Full Text Link to Item
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Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells.” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.Full Text Link to Item
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Collier, Michael A., Robert D. Junkins, Matthew D. Gallovic, Brandon M. Johnson, Monica M. Johnson, Andrew N. Macintyre, Gregory D. Sempowski, Eric M. Bachelder, Jenny P-Y Ting, and Kristy M. Ainslie. “Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.” Mol Pharm 15, no. 11 (November 5, 2018): 4933–46. https://doi.org/10.1021/acs.molpharmaceut.8b00579.Full Text Link to Item
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Kishton, Rigel J., Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, et al. “AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.” Cell Metab 23, no. 4 (April 12, 2016): 649–62. https://doi.org/10.1016/j.cmet.2016.03.008.Full Text Link to Item
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Ho, Ping-Chih, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, et al. “Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.” Cell 162, no. 6 (September 10, 2015): 1217–28. https://doi.org/10.1016/j.cell.2015.08.012.Full Text Link to Item
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Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.Full Text Open Access Copy Link to Item
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Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death & Disease 5, no. 11 (November 2014): e1516-. https://doi.org/10.1038/cddis.2014.493.Full Text
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Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (October 16, 2014): e1470. https://doi.org/10.1038/cddis.2014.431.Full Text Link to Item
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Macintyre, Andrew N., Valerie A. Gerriets, Amanda G. Nichols, Ryan D. Michalek, Michael C. Rudolph, Divino Deoliveira, Steven M. Anderson, et al. “The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.” Cell Metab 20, no. 1 (July 1, 2014): 61–72. https://doi.org/10.1016/j.cmet.2014.05.004.Full Text Link to Item
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Freemerman, Alex J., Amy R. Johnson, Gina N. Sacks, J Justin Milner, Erin L. Kirk, Melissa A. Troester, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Jeffery C. Rathmell, and Liza Makowski. “Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.” J Biol Chem 289, no. 11 (March 14, 2014): 7884–96. https://doi.org/10.1074/jbc.M113.522037.Full Text Link to Item
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Cao, Yilin, Jeffrey C. Rathmell, and Andrew N. Macintyre. “Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.” Plos One 9, no. 8 (2014): e104104. https://doi.org/10.1371/journal.pone.0104104.Full Text Link to Item
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Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (2014): e1516. https://doi.org/10.1038/cddis.2014.493.Full Text Link to Item
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Kurokawa, Manabu, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N. Macintyre, David A. Rizzieri, Jeffrey C. Rathmell, Michael W. Deininger, Tannishtha Reya, and Sally Kornbluth. “Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.” Proc Natl Acad Sci U S A 110, no. 6 (February 5, 2013): 2300–2305. https://doi.org/10.1073/pnas.1206551110.Full Text Open Access Copy Link to Item
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Macintyre, Andrew N., and Jeffrey C. Rathmell. “Activated lymphocytes as a metabolic model for carcinogenesis.” Cancer Metab 1, no. 1 (January 23, 2013): 5. https://doi.org/10.1186/2049-3002-1-5.Full Text Link to Item
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Coloff, Jonathan L., Andrew N. Macintyre, Amanda G. Nichols, Tingyu Liu, Catherine A. Gallo, David R. Plas, and Jeffrey C. Rathmell. “Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.” Cancer Res 71, no. 15 (August 1, 2011): 5204–13. https://doi.org/10.1158/0008-5472.CAN-10-4531.Full Text Link to Item
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Macintyre, Andrew N., and Jeffrey C. Rathmell. “PKM2 and the tricky balance of growth and energy in cancer.” Mol Cell 42, no. 6 (June 24, 2011): 713–14. https://doi.org/10.1016/j.molcel.2011.06.003.Full Text Link to Item
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Altman, B. J., S. R. Jacobs, E. F. Mason, R. D. Michalek, A. N. MacIntyre, J. L. Coloff, O. Ilkayeva, W. Jia, Y. -. W. He, and J. C. Rathmell. “Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.” Oncogene 30, no. 16 (April 21, 2011): 1855–67. https://doi.org/10.1038/onc.2010.561.Full Text Link to Item
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Michalek, Ryan D., Valerie A. Gerriets, Sarah R. Jacobs, Andrew N. Macintyre, Nancie J. MacIver, Emily F. Mason, Sarah A. Sullivan, Amanda G. Nichols, and Jeffrey C. Rathmell. “Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.” J Immunol 186, no. 6 (March 15, 2011): 3299–3303. https://doi.org/10.4049/jimmunol.1003613.Full Text Open Access Copy Link to Item
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Macintyre, Andrew N., David Finlay, Gavin Preston, Linda V. Sinclair, Caryll M. Waugh, Peter Tamas, Carmen Feijoo, Klaus Okkenhaug, and Doreen A. Cantrell. “Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.” Immunity 34, no. 2 (February 25, 2011): 224–36. https://doi.org/10.1016/j.immuni.2011.01.012.Full Text Link to Item
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Tamás, Peter, Andrew Macintyre, David Finlay, Rosemary Clarke, Carmen Feijoo-Carnero, Alan Ashworth, and Doreen Cantrell. “LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.” Eur J Immunol 40, no. 1 (January 2010): 242–53. https://doi.org/10.1002/eji.200939677.Full Text Link to Item
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Chen, Ting, Shannon Hogan, Greg Conley, Csaba Pazmany, Qi-Long Wu, Gary L. McNeil, Gary Bassill, et al. “Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A.” Biol Chem 388, no. 5 (May 2007): 507–12. https://doi.org/10.1515/BC.2007.058.Full Text Link to Item
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Stefan, Eduard, Burkhard Wiesner, George S. Baillie, Rustam Mollajew, Volker Henn, Dorothea Lorenz, Jens Furkert, et al. “Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.” J Am Soc Nephrol 18, no. 1 (January 2007): 199–212. https://doi.org/10.1681/ASN.2006020132.Full Text Link to Item
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Datasets
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LaFleur, Bonnie, Andrew N. Macintyre, Joanne Kurtzberg, Gregory D. Sempowski, Laura P. Hale, Brittany Sanders, Jesse Troy, and Lynn Cheatham. “Data and Code from: T Cell-Depleted Cultured Pediatric Thymus Tissue as a Model for Some Aspects of Human Age-Related Thymus Involution,” January 4, 2021. https://doi.org/10.7924/r47d2xg50.Data Access
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