https://orcid.org/0000-0002-5297-0207
Overview
Andrew Macintyre, PhD, directs the Immunology Unit within the Duke Regional Biocontainment Laboratory. The Macintyre lab team designs and performs assays to quantify immune reconstitution and immune responses. The lab specializes in multiplex cytokine arrays, flow cytometry, high-throughput ELISAs, qRT-PCR, and other molecular tests.
The assays his team develops and runs support research into biodefense and critical public health challenges. Long-running collaborative projects include the evaluation of radiation countermeasures and the development of vaccines for influenza, gonorrhea, SARS-CoV2, and other pathogens.
Current Appointments & Affiliations
Associate Professor in Medicine
·
2024 - Present
Medicine, Duke Human Vaccine Institute,
Medicine
Member of the Duke Human Vaccine Institute
·
2024 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Reconstitution of thymopoiesis via implantation of cryopreserved cultured thymus tissue into athymic recipients.
Journal Article Am J Transplant · March 2026 Implantation of cultured allogeneic thymus tissue (CTTI) into athymic human recipients generates functional recipient-derived naïve T cells that are tolerant to the donor. Currently, CTTI is always performed with 12 to 21 days of thymus procurement to avoi ... Full text Link to item CitePresentation of hemagglutinin on adjuvant-bearing self-assembling peptide nanofibers increases heterologous responses against influenza.
Journal Article Acta Biomater · January 2026 Influenza presents a global threat representing hundreds of thousands of deaths each year worldwide, yet influenza vaccines currently do not offer full protection against infection and must be updated each year to account for antigenic drift. Subunit vacci ... Full text Link to item CiteCoordinated changes in stromal and hematopoietic cells that define the perinatal to juvenile transition in the mouse thymus.
Journal Article Cell Rep · December 23, 2025 Perinatal T cells have distinctive phenotypes and functions that may be due in part to age-associated features of stromal cells in the perinatal thymus. We identify age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hemat ... Full text Link to item CiteRecent Grants
External Quality Assurance Program Oversight Laboratory (EQAPOL)
ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2031Center for immunological Interventions against Gonorrhea (CIIG) - Core B
ResearchPrincipal Investigator · Awarded by Henry M. Jackson Foundation · 2025 - 2030Thymic and peripheral aspects of T cell aging and rejuvenation: Human Target Verification and Thymic Function Core (Core C)
ResearchInvestigator · Awarded by University of Arizona · 2023 - 2028View All Grants
Education
University of Dundee (United Kingdom) ·
2009
Ph.D.