Overview
Andrew Macintyre, PhD, directs the Immunology Unit within the Duke Regional Biocontainment Laboratory. The Macintyre lab team designs and performs assays to quantify immune reconstitution and immune responses. The lab specializes in multiplex cytokine arrays, flow cytometry, high-throughput ELISAs, qRT-PCR, and other molecular tests.
The assays his team develops and runs support research into biodefense and critical public health challenges. Long-running collaborative projects include the evaluation of radiation countermeasures and the development of vaccines for influenza, gonorrhea, SARS-CoV2, and other pathogens.
Current Appointments & Affiliations
Associate Professor in Medicine
·
2024 - Present
Medicine, Duke Human Vaccine Institute,
Medicine
Member of the Duke Human Vaccine Institute
·
2024 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model
Journal Article npj Vaccines · December 1, 2024 Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed, whole-cell vaccine has been stymied by coincident epitope destruction during inactivation. Here, we presen ... Full text CiteSpatiotemporal Control of Immune Responses with Nucleic Acid Cocktail Vaccine
Journal Article Advanced Therapeutics · November 1, 2024 Nucleic acid vaccines play important roles in the prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigates a cocktail app ... Full text CiteDevelopment and Validation of Multiplex Assays for Mouse and Human IgG and IgA to Neisseria gonorrhoeae Antigens.
Journal Article J Infect Dis · October 16, 2024 There is an urgent need for vaccines against Neisseria gonorrhoeae, the causative agent of gonorrhea. Vaccination with an outer membrane vesicle-based Neisseria meningitidis vaccine provides some protection from N. gonorrhoeae; however, the mechanisms unde ... Full text Link to item CiteRecent Grants
External Quality Assurance Program Oversight Laboratory (EQAPOL)
ResearchInvestigator · Awarded by National Institutes of Health · 2024 - 2031Thymic and peripheral aspects of T cell aging and rejuvenation: Human Target Verification and Thymic Function Core (Core C)
ResearchInvestigator · Awarded by University of Arizona · 2023 - 2028Radiation Survival Cohort - Immune Monitoring Core
ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2020 - 2027View All Grants
Education, Training & Certifications
University of Dundee (United Kingdom) ·
2009
Ph.D.