Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Dundee (United Kingdom) 2009
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2020
• Research
• 

  Selected Grants

  • Methods to Test the Role of Age-related Lifestyle and Vaginal Microenvironment Changes and the Prevention, Treatment, and Progression of Genitourinary Syndrome of Menopause awarded by University of Maryland, Baltimore 2021 - 2026
  • Efficacy of immunization with 4C-MenB in preventing experimental urethral infection with Neisseria gonorrhoeae awarded by University of North Carolina - Chapel Hill 2021 - 2026
  • Proteomics-Driven Reverse Vaccinology for Gonorrhea awarded by Oregon State University 2022 - 2023
  • VTEU Task D Option 1 Protocol FY.2015.A4D14.0033 awarded by National Institutes of Health 2015 - 2022
  • CIVICS Component A - Option 2 awarded by National Institutes of Health 2019 - 2022
  • Human Thymus Core (Core C) awarded by The University of Texas MD Anderson Cancer Center 2020 - 2022
  • Virology Core awarded by Boston Children's Hospital 2021 - 2022
  • Radiation Survival Cohort - Immune Monitoring Core awarded by Wake Forest University Health Sciences 2020 - 2022
  • Emerging Infectious Diseases - Coordination Center awarded by Research Triangle Institute International 2020 - 2022
  • Experimental Human Infection with Isogenic Mutants of Neisseria gonorrhoeae awarded by University of North Carolina - Chapel Hill 2015 - 2022
  • Gonorrhea Vaccine Cooperative Research Center (GV-CRC); Core C: Host Response Monitoring awarded by Henry M. Jackson Foundation 2019 - 2022
  • Cytokine monitoring for Macrogenics trial CP-MGD014-01, Part 2 awarded by MacroGenics, Inc. 2021
  • METHODS TO TEST LIFESTYLE, VAGINAL MICROENVIRONMENT, AND GENITOURINARY SYMPTOMS ACROSS MENOPAUSE TRANSITION awarded by University of Maryland 2020 - 2021
  • Macrogenics Cytokine Profiling Subcontract awarded by MacroGenics, Inc. 2018 - 2020
  • Core C: Monitoring Host Response awarded by Henry M. Jackson Foundation 2014 - 2020
  • Novel nanoparticle platform for antiviral vaccine and therapeutics awarded by University of North Carolina - Chapel Hill 2014 - 2020
  • Biomarker analysis of vaginal lavage samples awarded by University of Maryland, Baltimore 2019
  • Exploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory awarded by National Institutes of Health 2015
  • Metabolic Control of T Cell Subsets and Pyruvate Dehydrogenase Kinase as a Target in Inflammatory Bowel Disease awarded by Kenneth Rainin Foundation 2013 - 2014
• 

  External Relationships

  • Oregon State University
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Matthias, Kathryn A., Kristie L. Connolly, Afrin A. Begum, Ann E. Jerse, Andrew N. Macintyre, Gregory D. Sempowski, and Margaret C. Bash. “Meningococcal Detoxified Outer Membrane Vesicle Vaccines Enhance Gonococcal Clearance in a Murine Infection Model.” J Infect Dis 225, no. 4 (February 15, 2022): 650–60. https://doi.org/10.1093/infdis/jiab450.
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    • Huang, Ying, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, et al. “Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.” Front Immunol 13 (2022): 751296. https://doi.org/10.3389/fimmu.2022.751296.
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    • Tuddenham, Susan, Christina A. Stennett, Richard A. Cone, Jacques Ravel, Andrew N. Macintyre, Khalil G. Ghanem, Xin He, and Rebecca M. Brotman. “Vaginal cytokine profile and microbiota before and after lubricant use compared with condomless vaginal sex: a preliminary observational study.” Bmc Infect Dis 21, no. 1 (September 18, 2021): 973. https://doi.org/10.1186/s12879-021-06512-x.
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    • Macintyre, Andrew N., Matthew J. French, Brittany R. Sanders, Kristina J. Riebe, Ivo D. Shterev, Kevin Wiehe, Bhavna Hora, et al. “Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.” Adv Radiat Oncol 6, no. 5 (September 2021): 100677. https://doi.org/10.1016/j.adro.2021.100677.
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    • Connolly, Kristie L., Michelle Pilligua-Lucas, Carolina Gomez, Allison C. Costenoble-Caherty, Anthony Soc, Knashka Underwood, Andrew N. Macintyre, Gregory D. Sempowski, and Ann E. Jerse. “Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection.” J Infect Dis 224, no. 12 Suppl 2 (August 16, 2021): S152–60. https://doi.org/10.1093/infdis/jiab211.
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    • Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.
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    • Eichenberger, Emily M., Felicia Ruffin, Michael Dagher, Reginald Lerebours, Sin-Ho Jung, Batu Sharma-Kuinkel, Andrew N. Macintyre, et al. “Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.” Am J Transplant 21, no. 6 (June 2021): 2113–22. https://doi.org/10.1111/ajt.16388.
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    • Hale, Laura P., Lynn Cheatham, Andrew N. Macintyre, Bonnie LaFleur, Brittany Sanders, Jesse Troy, Joanne Kurtzberg, and Gregory D. Sempowski. “T cell-depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution.” Geroscience 43, no. 3 (June 2021): 1369–82. https://doi.org/10.1007/s11357-020-00301-1.
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    • Lovett, Angela, Arlene C. Seña, Andrew N. Macintyre, Gregory D. Sempowski, Joseph A. Duncan, and Andreea Waltmann. “Cervicovaginal Microbiota Predicts Neisseria gonorrhoeae Clinical Presentation.” Front Microbiol 12 (2021): 790531. https://doi.org/10.3389/fmicb.2021.790531.
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    • Thornlow, Dana N., Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, and Aaron G. Schmidt. “Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization.” Front Immunol 12 (2021): 737973. https://doi.org/10.3389/fimmu.2021.737973.
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    • Leduc, Isabelle, Kristie L. Connolly, Afrin Begum, Knashka Underwood, Stephen Darnell, William M. Shafer, Jacqueline T. Balthazar, et al. “The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.” Plos Pathog 16, no. 12 (December 2020): e1008602. https://doi.org/10.1371/journal.ppat.1008602.
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    • Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.” Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.
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    • Michalson, Kristofer T., Andrew N. Macintyre, Gregory D. Sempowski, J Daniel Bourland, Timothy D. Howard, Gregory A. Hawkins, Gregory O. Dugan, J Mark Cline, and Thomas C. Register. “Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.” Radiat Res 192, no. 2 (August 2019): 121–34. https://doi.org/10.1667/RR15310.1.
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    • Sinclair, Linda V., Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L. Hukelmann, Andrew N. Macintyre, Xiaojing Liu, et al. “Antigen receptor control of methionine metabolism in T cells.” Elife 8 (March 27, 2019). https://doi.org/10.7554/eLife.44210.
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    • Collier, Michael A., Robert D. Junkins, Matthew D. Gallovic, Brandon M. Johnson, Monica M. Johnson, Andrew N. Macintyre, Gregory D. Sempowski, Eric M. Bachelder, Jenny P-Y Ting, and Kristy M. Ainslie. “Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.” Mol Pharm 15, no. 11 (November 5, 2018): 4933–46. https://doi.org/10.1021/acs.molpharmaceut.8b00579.
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    • Kishton, Rigel J., Carson E. Barnes, Amanda G. Nichols, Sivan Cohen, Valerie A. Gerriets, Peter J. Siska, Andrew N. Macintyre, et al. “AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.” Cell Metab 23, no. 4 (April 12, 2016): 649–62. https://doi.org/10.1016/j.cmet.2016.03.008.
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    • Ho, Ping-Chih, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, et al. “Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.” Cell 162, no. 6 (September 10, 2015): 1217–28. https://doi.org/10.1016/j.cell.2015.08.012.
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    • Gerriets, Valerie A., Rigel J. Kishton, Amanda G. Nichols, Andrew N. Macintyre, Makoto Inoue, Olga Ilkayeva, Peter S. Winter, et al. “Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.” J Clin Invest 125, no. 1 (January 2015): 194–207. https://doi.org/10.1172/JCI76012.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death & Disease 5, no. 11 (November 2014): e1516-. https://doi.org/10.1038/cddis.2014.493.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (October 16, 2014): e1470. https://doi.org/10.1038/cddis.2014.431.
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    • Macintyre, Andrew N., Valerie A. Gerriets, Amanda G. Nichols, Ryan D. Michalek, Michael C. Rudolph, Divino Deoliveira, Steven M. Anderson, et al. “The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.” Cell Metab 20, no. 1 (July 1, 2014): 61–72. https://doi.org/10.1016/j.cmet.2014.05.004.
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    • Freemerman, Alex J., Amy R. Johnson, Gina N. Sacks, J Justin Milner, Erin L. Kirk, Melissa A. Troester, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Jeffery C. Rathmell, and Liza Makowski. “Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.” J Biol Chem 289, no. 11 (March 14, 2014): 7884–96. https://doi.org/10.1074/jbc.M113.522037.
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    • Cao, Yilin, Jeffrey C. Rathmell, and Andrew N. Macintyre. “Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.” Plos One 9, no. 8 (2014): e104104. https://doi.org/10.1371/journal.pone.0104104.
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    • Liu, T., R. J. Kishton, A. N. Macintyre, V. A. Gerriets, H. Xiang, X. Liu, E. D. Abel, D. Rizzieri, J. W. Locasale, and J. C. Rathmell. “Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.” Cell Death Dis 5 (2014): e1516. https://doi.org/10.1038/cddis.2014.493.
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    • Kurokawa, Manabu, Takahiro Ito, Chih-Sheng Yang, Chen Zhao, Andrew N. Macintyre, David A. Rizzieri, Jeffrey C. Rathmell, Michael W. Deininger, Tannishtha Reya, and Sally Kornbluth. “Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.” Proc Natl Acad Sci U S A 110, no. 6 (February 5, 2013): 2300–2305. https://doi.org/10.1073/pnas.1206551110.
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    • Macintyre, Andrew N., and Jeffrey C. Rathmell. “Activated lymphocytes as a metabolic model for carcinogenesis.” Cancer Metab 1, no. 1 (January 23, 2013): 5. https://doi.org/10.1186/2049-3002-1-5.
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    • Coloff, Jonathan L., Andrew N. Macintyre, Amanda G. Nichols, Tingyu Liu, Catherine A. Gallo, David R. Plas, and Jeffrey C. Rathmell. “Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.” Cancer Res 71, no. 15 (August 1, 2011): 5204–13. https://doi.org/10.1158/0008-5472.CAN-10-4531.
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    • Macintyre, Andrew N., and Jeffrey C. Rathmell. “PKM2 and the tricky balance of growth and energy in cancer.” Mol Cell 42, no. 6 (June 24, 2011): 713–14. https://doi.org/10.1016/j.molcel.2011.06.003.
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    • Altman, B. J., S. R. Jacobs, E. F. Mason, R. D. Michalek, A. N. MacIntyre, J. L. Coloff, O. Ilkayeva, W. Jia, Y. -. W. He, and J. C. Rathmell. “Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.” Oncogene 30, no. 16 (April 21, 2011): 1855–67. https://doi.org/10.1038/onc.2010.561.
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    • Michalek, Ryan D., Valerie A. Gerriets, Sarah R. Jacobs, Andrew N. Macintyre, Nancie J. MacIver, Emily F. Mason, Sarah A. Sullivan, Amanda G. Nichols, and Jeffrey C. Rathmell. “Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.” J Immunol 186, no. 6 (March 15, 2011): 3299–3303. https://doi.org/10.4049/jimmunol.1003613.
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    • Macintyre, Andrew N., David Finlay, Gavin Preston, Linda V. Sinclair, Caryll M. Waugh, Peter Tamas, Carmen Feijoo, Klaus Okkenhaug, and Doreen A. Cantrell. “Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.” Immunity 34, no. 2 (February 25, 2011): 224–36. https://doi.org/10.1016/j.immuni.2011.01.012.
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    • Tamás, Peter, Andrew Macintyre, David Finlay, Rosemary Clarke, Carmen Feijoo-Carnero, Alan Ashworth, and Doreen Cantrell. “LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.” Eur J Immunol 40, no. 1 (January 2010): 242–53. https://doi.org/10.1002/eji.200939677.
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    • Chen, Ting, Shannon Hogan, Greg Conley, Csaba Pazmany, Qi-Long Wu, Gary L. McNeil, Gary Bassill, et al. “Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A.” Biol Chem 388, no. 5 (May 2007): 507–12. https://doi.org/10.1515/BC.2007.058.
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    • Stefan, Eduard, Burkhard Wiesner, George S. Baillie, Rustam Mollajew, Volker Henn, Dorothea Lorenz, Jens Furkert, et al. “Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.” J Am Soc Nephrol 18, no. 1 (January 2007): 199–212. https://doi.org/10.1681/ASN.2006020132.
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  • Datasets

    • Hale, Laura, Jesse Troy, Brittany Sanders, Lynn Cheatham, Andrew Macintyre, Joanne Kurtzberg, Bonnie LaFleur, and Gregory Sempowski. “Data and Code from: T Cell-Depleted Cultured Pediatric Thymus Tissue as a Model for Some Aspects of Human Age-Related Thymus Involution,” January 4, 2021. https://doi.org/10.7924/r47d2xg50.
       Data Access

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