Recent Publications
Early U.S. Heart Transplant Experience With Normothermic Regional Perfusion Following Donation After Circulatory Death.
Journal Article JACC Heart Fail · December 2024 BACKGROUND: Heart transplantation following donation after circulatory death (DCD HT) has short-term survival outcomes comparable to donation after brain death and has led to a significant increase in transplantation volume. The U.S. experience with the no ... Full text Link to item CiteCapsid-mediated control of adeno-associated viral transcription determines host range.
Journal Article Cell Rep · March 26, 2024 Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By swapping the VP1 ... Full text Link to item CiteRepurposing CRISPR-Cas13 systems for robust mRNA trans-splicing.
Journal Article Nat Commun · March 14, 2024 Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been utilized for site-targeted single base edits, demethylation, RNA cleavage or knockdown and alternative splicing. However, ... Full text Link to item CiteRecent Grants
Evaluation of adeno-associated viral (AAV) mediated gene replacement therapy as a therapeutic option for SLC25A4 deficiency
FellowshipPI-Fellow · Awarded by National Heart, Lung, and Blood Institute · 2023 - 2025View All Grants