Aimee Kirsch Zaas | Scholars@Duke

Aimee Kirsch Zaas
Professor of Medicine

Medical education
Genomic applications for diagnosis of infectious diseases
Genomic applications for prediction of infectious diseases

Current Appointments & Affiliations

Professor of Medicine, Medicine, Infectious Diseases, Medicine 2020

Contact Information

2301 Erwin Rd, Box 3182, Durham, NC 27710
Duke Box 3182, DUMC, Durham, NC 27710
aimee.zaas@duke.edu (919) 681-1464

Background
Education, Training, & Certifications
- Fellow in Infectious Diseases, Medicine, Duke University 2003 - 2004
- Fellow in Infectious Diseases, Medicine, Duke University 2001 - 2002
- Medical Resident, Medicine, Johns Hopkins University 1998 - 2001
- M.D., Northwestern University 1998
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2015 - 2020
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2019
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2011 - 2015
- Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2005 - 2010
- Associate in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2004 - 2005
- Instructor, Temporary in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2004
Recognition
In the News
- SEP 19, 2013 CBS News, AP
  
  Blood test can determine whether illness is caused by virus or bacteria
Research
Selected Grants
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG) awarded by National Institutes of Health 2018 - 2023
- Acute Lower Respirator Tract with Lung Ultrasound awarded by Thrasher Research Fund 2018 - 2020
- Bridging the Treatment Gap: Improving Time to Cure of Hepatitis C in North Carolina awarded by American College of Physicians 2018 - 2019
- Learning Health System Research Champion Award awarded by Association of American Medical Colleges 2015 - 2017
- Mid-Career Investigator Award: Preventing and Diagnosing Fungal Disease in Transplantation awarded by National Institutes of Health 2007 - 2013
- Genetic Determinants of A. Fumigatus Susceptibility awarded by National Institutes of Health 2005 - 2009
External Relationships
- UpToDate
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Harris, Rachel, Kyle Covington, Cristin Colford, Nancy Denizard-Thompson, Michael Contarino, Kimberley Evans, Aimee Zaas, M Suzanne Kraemer, and Diana McNeill. “Focusing on Diversity: A Regional Internal Medicine Residency Viewpoint on Underrepresented Minority Support, Retention, and Mentoring.” J Grad Med Educ 13, no. 2 (April 2021): 181–88. https://doi.org/10.4300/JGME-D-20-00729.1.
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  - Simmons, R. P., J. Ortiz, M. Kisielewski, A. Zaas, and K. M. Finn. “Virtual Recruitment: Experiences and Perspectives of Internal Medicine Program Directors.” American Journal of Medicine, January 1, 2021. https://doi.org/10.1016/j.amjmed.2021.10.017.
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  - Windish, D. M., J. S. Catalanotti, A. Zaas, M. Kisielewski, and J. P. Moriarty. “Training in Safe Opioid Prescribing and Treatment of Opioid Use Disorder in Internal Medicine Residencies: a National Survey of Program Directors.” Journal of General Internal Medicine, January 1, 2021. https://doi.org/10.1007/s11606-021-07102-y.
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  - Finn, Kathleen M., Andrew J. Halvorsen, Saima Chaudhry, Sanjay Desai, Denise Dupras, Shalini Reddy, Sandhya Wahi-Gururaj, Lisa Willett, and Aimee K. Zaas. “Does Increased Schedule Flexibility Lead to Change? A National Survey of Program Directors on 2017 Work Hours Requirements.” J Gen Intern Med 35, no. 11 (November 2020): 3205–9. https://doi.org/10.1007/s11606-020-06109-1.
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  - Steinbrink, Julie M., Aimee K. Zaas, Marisol Betancourt, Jennifer L. Modliszewski, David L. Corcoran, and Micah T. McClain. “A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.” Translational Research : The Journal of Laboratory and Clinical Medicine 219 (May 2020): 1–12. https://doi.org/10.1016/j.trsl.2020.02.005.
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  - Finn, Kathleen M., Aimee K. Zaas, Furman S. McDonald, Michael Melfe, Michael Kisielewski, and Lisa L. Willett. “Misinterpretation of the American Board of Internal Medicine Leave Policies for Resident Physicians Around Parental Leave.” Ann Intern Med 172, no. 8 (April 21, 2020): 570–72. https://doi.org/10.7326/M19-2490.
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  - Ryskina, Kira L., Cynthia D. Smith, Vineet M. Arora, Aimee K. Zaas, Andrew J. Halvorsen, Arlene Weissman, and Sandhya Wahi-Gururaj. “Relationship Between Institutional Investment in High-Value Care (HVC) Performance Improvement and Internal Medicine Residents' Perceptions of HVC Training.” Acad Med 93, no. 10 (October 2018): 1517–23. https://doi.org/10.1097/ACM.0000000000002257.
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  - Vidyarthi, Arpana R., Gurpreet Dhaliwal, Bradley Monash, Koin Lon Shum, Joanne Lee, and Aimee K. Zaas. “Hot in the Tropics.” Journal of Hospital Medicine 12, no. 6 (June 2017): 462–66. https://doi.org/10.12788/jhm.2753.
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  - Boggan, Joel C., Aparna Swaminathan, Samantha Thomas, David L. Simel, Aimee K. Zaas, and Jonathan G. Bae. “Improving Timely Resident Follow-Up and Communication of Results in Ambulatory Clinics Utilizing a Web-Based Audit and Feedback Module.” Journal of Graduate Medical Education 9, no. 2 (April 2017): 195–200. https://doi.org/10.4300/jgme-d-16-00460.1.
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  - Elmariah, Hany, Samantha Thomas, Joel C. Boggan, Aimee Zaas, and Jonathan Bae. “The Burden of Burnout.” American Journal of Medical Quality : The Official Journal of the American College of Medical Quality 32, no. 2 (March 2017): 156–62. https://doi.org/10.1177/1062860615625802.
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  - Meade, Lauren B., Kathleen Heist Suddarth, Ronald R. Jones, Aimee K. Zaas, Terry Albanese, Kenji Yamazaki, and Cheryl W. O’Malley. “Patients, Nurses, and Physicians Working Together to Develop a Discharge Entrustable Professional Activity Assessment Tool.” Acad Med 91, no. 10 (October 2016): 1388–91. https://doi.org/10.1097/ACM.0000000000001189.
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  - Dotters-Katz, Sarah, Charles W. Hargett, Aimee K. Zaas, and Lisa G. Criscione-Schreiber. “What motivates residents to teach? The Attitudes in Clinical Teaching study.” Med Educ 50, no. 7 (July 2016): 768–77. https://doi.org/10.1111/medu.13075.
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  - Willett, Lisa L., Andrew J. Halvorsen, Michael Adams, Karen M. Chacko, Saima Chaudhry, Furman S. McDonald, Amy S. Oxentenko, Sara L. Swenson, Aimee Zaas, and Vineet M. Arora. “Factors Associated with Declining Residency Program Pass Rates on the ABIM Certification Examination.” Am J Med 129, no. 7 (July 2016): 759–65. https://doi.org/10.1016/j.amjmed.2016.03.020.
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  - Suddarth, Kathleen Heist, Ronald R. Jones, Cheryl W. O’Malley, David Paje, Kenji Yamazaki, Aimee K. Zaas, and Lauren B. Meade. “Implementation of Milestones-Based Assessment for a Safe and Effective Discharge.” Am J Med 129, no. 6 (June 2016): 640–46. https://doi.org/10.1016/j.amjmed.2016.02.005.
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  - Broderick-Forsgren, Kathleen, Wynn G. Hunter, Ryan D. Schulteis, Wen-Wei Liu, Joel C. Boggan, Poonam Sharma, Steven Thomas, Aimee Zaas, and Jonathan Bae. “Doctor Who? A Quality Improvement Project to Assess and Improve Patients' Knowledge of Their Inpatient Physicians.” J Grad Med Educ 8, no. 2 (May 2016): 197–201. https://doi.org/10.4300/JGME-D-15-00067.1.
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  - Husain, Shahid, Amparo Sole, Barbara D. Alexander, Saima Aslam, Robin Avery, Christian Benden, Eliane M. Billaud, et al. “The 2015 International Society for Heart and Lung Transplantation Guidelines for the management of fungal infections in mechanical circulatory support and cardiothoracic organ transplant recipients: Executive summary.” J Heart Lung Transplant 35, no. 3 (March 2016): 261–82. https://doi.org/10.1016/j.healun.2016.01.007.
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  - Liu, Tzu-Yu, Thomas Burke, Lawrence P. Park, Christopher W. Woods, Aimee K. Zaas, Geoffrey S. Ginsburg, and Alfred O. Hero. “An individualized predictor of health and disease using paired reference and target samples.” Bmc Bioinformatics 17 (January 22, 2016): 47. https://doi.org/10.1186/s12859-016-0889-9.
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  - Tsalik, Ephraim L., Ricardo Henao, Marshall Nichols, Thomas Burke, Emily R. Ko, Micah T. McClain, Lori L. Hudson, et al. “Host gene expression classifiers diagnose acute respiratory illness etiology.” Sci Transl Med 8, no. 322 (January 20, 2016): 322ra11. https://doi.org/10.1126/scitranslmed.aad6873.
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  - McClain, Micah T., Bradly P. Nicholson, Lawrence P. Park, Tzu-Yu Liu, Alfred O. Hero, Ephraim L. Tsalik, Aimee K. Zaas, et al. “A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.” Open Forum Infect Dis 3, no. 1 (January 2016): ofw007. https://doi.org/10.1093/ofid/ofw007.
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  - Tsalik, Ephraim L., Micah McClain, and Aimee K. Zaas. “Moving toward prime time: host signatures for diagnosis of respiratory infections.” J Infect Dis 212, no. 2 (July 15, 2015): 173–75. https://doi.org/10.1093/infdis/jiv032.
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  - Rose, Jason J., Deepak Voora, Derek D. Cyr, Joseph E. Lucas, Aimee K. Zaas, Christopher W. Woods, L Kristin Newby, William E. Kraus, and Geoffrey S. Ginsburg. “Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.” Plos One 10, no. 7 (2015): e0132259. https://doi.org/10.1371/journal.pone.0132259.
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  - Zaas, Aimee K., Bronwen H. Garner, Ephraim L. Tsalik, Thomas Burke, Christopher W. Woods, and Geoffrey S. Ginsburg. “The current epidemiology and clinical decisions surrounding acute respiratory infections.” Trends Mol Med 20, no. 10 (October 2014): 579–88. https://doi.org/10.1016/j.molmed.2014.08.001.
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  - Boggan, Joel C., George Cheely, Bimal R. Shah, Randy Heffelfinger, Deanna Springall, Samantha M. Thomas, Aimee Zaas, and Jonathan Bae. “A Novel Approach to Practice-Based Learning and Improvement Using a Web-Based Audit and Feedback Module.” J Grad Med Educ 6, no. 3 (September 2014): 541–46. https://doi.org/10.4300/JGME-D-14-00016.1.
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  - Kraft, Bryan D., Claude A. Piantadosi, Ashlee M. Benjamin, Joseph E. Lucas, Aimee K. Zaas, Marisol Betancourt-Quiroz, Christopher W. Woods, et al. “Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.” Am J Respir Cell Mol Biol 50, no. 5 (May 2014): 995–1004. https://doi.org/10.1165/rcmb.2013-0340OC.
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  - Xing, Z., B. Nicholson, M. Jimenez, T. Veldman, L. Hudson, J. Lucas, D. Dunson, et al. “Bayesian modeling of temporal properties of infectious disease in a college student population.” Journal of Applied Statistics 41, no. 6 (January 1, 2014): 1358–82. https://doi.org/10.1080/02664763.2013.870138.
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  - McClain, Micah T., Lawrence P. Park, Bradly Nicholson, Timothy Veldman, Aimee K. Zaas, Ron Turner, Robert Lambkin-Williams, Anthony S. Gilbert, Geoffrey S. Ginsburg, and Christopher W. Woods. “Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections.” J Clin Virol 58, no. 4 (December 2013): 689–95. https://doi.org/10.1016/j.jcv.2013.09.015.
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  - Zaas, Aimee K., Thomas Burke, Minhua Chen, Micah McClain, Bradly Nicholson, Timothy Veldman, Ephraim L. Tsalik, et al. “A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.” Sci Transl Med 5, no. 203 (September 18, 2013): 203ra126. https://doi.org/10.1126/scitranslmed.3006280.
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  - Meade, Lauren B., Kelly J. Caverzagie, Susan R. Swing, Ron R. Jones, Cheryl W. O’Malley, Kenji Yamazaki, and Aimee K. Zaas. “Playing with curricular milestones in the educational sandbox: Q-sort results from an internal medicine educational collaborative.” Acad Med 88, no. 8 (August 2013): 1142–48. https://doi.org/10.1097/ACM.0b013e31829a3967.
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  - Wang, Hsin-Neng, Andrew M. Fales, Aimee K. Zaas, Christopher W. Woods, Thomas Burke, Geoffrey S. Ginsburg, and Tuan Vo-Dinh. “Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics.” Anal Chim Acta 786 (July 5, 2013): 153–58. https://doi.org/10.1016/j.aca.2013.05.017.
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  - Desai, Sanjay V., Aimee Zaas, and Joel T. Katz. “Professionalism in graduate medical education.” Jama 309, no. 11 (March 20, 2013): 1110–11. https://doi.org/10.1001/jama.2013.1672.
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  - Bazot, Cécile, Nicolas Dobigeon, Jean-Yves Tourneret, Aimee K. Zaas, Geoffrey S. Ginsburg, and Alfred O. Hero. “Unsupervised Bayesian linear unmixing of gene expression microarrays.” Bmc Bioinformatics 14 (March 19, 2013): 99. https://doi.org/10.1186/1471-2105-14-99.
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  - Ahn, Sun Hee, Ephraim L. Tsalik, Derek D. Cyr, Yurong Zhang, Jennifer C. van Velkinburgh, Raymond J. Langley, Seth W. Glickman, et al. “Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.” Plos One 8, no. 1 (2013): e48979. https://doi.org/10.1371/journal.pone.0048979.
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  - Xing, Z., B. Nicholson, M. Jimenez, T. Veldman, L. Hudson, J. Lucas, D. Dunson, et al. “Bayesian modeling of temporal properties of infectious disease in a college student population.” Journal of Applied Statistics, 2013.
  - Woods, Christopher W., Micah T. McClain, Minhua Chen, Aimee K. Zaas, Bradly P. Nicholson, Jay Varkey, Timothy Veldman, et al. “A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.” Plos One 8, no. 1 (2013): e52198. https://doi.org/10.1371/journal.pone.0052198.
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  - Biggs, H. M., S. M. Chudgar, C. D. Pfeiffer, K. R. Rice, A. K. Zaas, and C. R. Wolfe. “Disseminated Mycobacterium immunogenum infection presenting with septic shock and skin lesions in a renal transplant recipient.” Transpl Infect Dis 14, no. 4 (August 2012): 415–21. https://doi.org/10.1111/j.1399-3062.2012.00730.x.
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  - Carin, Lawrence, Alfred Hero, Joseph Lucas, David Dunson, Minhua Chen, Ricardo Heñao, Arnau Tibau-Puig, Aimee Zaas, Christopher W. Woods, and Geoffrey S. Ginsburg. “High-Dimensional Longitudinal Genomic Data: An analysis used for monitoring viral infections.” Ieee Signal Process Mag 29, no. 1 (January 1, 2012): 108–23. https://doi.org/10.1109/MSP.2011.943009.
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  - Hanson, Kimberly E., Christopher D. Pfeiffer, Erika D. Lease, Alfred H. Balch, Aimee K. Zaas, John R. Perfect, and Barbara D. Alexander. “β-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: a randomized pilot study.” Plos One 7, no. 8 (2012): e42282. https://doi.org/10.1371/journal.pone.0042282.
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  - Shapiro, Rebecca S., Aimee K. Zaas, Marisol Betancourt-Quiroz, John R. Perfect, and Leah E. Cowen. “The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance.” Plos One 7, no. 9 (2012): e44734. https://doi.org/10.1371/journal.pone.0044734.
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  - Peltz, Gary, Aimee K. Zaas, Ming Zheng, Norma V. Solis, Mason X. Zhang, Hong-Hsing Liu, Yajing Hu, et al. “Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection.” Infect Immun 79, no. 11 (November 2011): 4472–79. https://doi.org/10.1128/IAI.05666-11.
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  - Huang, Yongsheng, Aimee K. Zaas, Arvind Rao, Nicolas Dobigeon, Peter J. Woolf, Timothy Veldman, N Christine Øien, et al. “Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.” Plos Genet 7, no. 8 (August 2011): e1002234. https://doi.org/10.1371/journal.pgen.1002234.
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  - Chen, Minhua, David Carlson, Aimee Zaas, Christopher W. Woods, Geoffrey S. Ginsburg, Alfred Hero, Joseph Lucas, and Lawrence Carin. “Detection of viruses via statistical gene expression analysis.” Ieee Trans Biomed Eng 58, no. 3 (March 2011): 468–79. https://doi.org/10.1109/TBME.2010.2059702.
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  - Chen, Minhua, Aimee Zaas, Christopher Woods, Geoffrey S. Ginsburg, Joseph Lucas, David Dunson, and Lawrence Carin. “Predicting Viral Infection From High-Dimensional Biomarker Trajectories.” J Am Stat Assoc 106, no. 496 (January 1, 2011): 1259–79. https://doi.org/10.1198/jasa.2011.ap10611.
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  - Puig, A. T., A. Wiesel, A. K. Zaas, C. W. Woods, G. S. Ginsburg, G. Fleury, and A. O. Hero. “Order-preserving factor analysis-application to longitudinal gene expression.” Ieee Transactions on Signal Processing 59, no. 9 (January 1, 2011): 4447–58. https://doi.org/10.1109/TSP.2011.2157146.
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  - Puig, A. T., A. Wiesel, A. Zaas, G. S. Ginsburg, G. Fleury, and A. O. Hero. “Order-preserving factor discovery from misaligned data.” 2010 Ieee Sensor Array and Multichannel Signal Processing Workshop, Sam 2010, December 20, 2010, 209–12. https://doi.org/10.1109/SAM.2010.5606736.
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  - Chen, Bo, Minhua Chen, John Paisley, Aimee Zaas, Christopher Woods, Geoffrey S. Ginsburg, Alfred Hero, Joseph Lucas, David Dunson, and Lawrence Carin. “Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies.” Bmc Bioinformatics 11 (November 9, 2010): 552. https://doi.org/10.1186/1471-2105-11-552.
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  - Paisley, J., A. Zaas, C. W. Woods, G. S. Ginsburg, and L. Carin. “A stick-breaking construction of the beta process.” Icml 2010 Proceedings, 27th International Conference on Machine Learning, September 17, 2010, 847–54.
  - Ahn, Sun-Hee, Hitesh Deshmukh, Nicole Johnson, Lindsay G. Cowell, Thomas H. Rude, William K. Scott, Charlotte L. Nelson, et al. “Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.” Plos Pathog 6, no. 9 (September 2, 2010): e1001088. https://doi.org/10.1371/journal.ppat.1001088.
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  - LaFayette, Shantelle L., Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Marisol Betancourt-Quiroz, AA Leslie Gunatilaka, John R. Perfect, and Leah E. Cowen. “PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.” Plos Pathog 6, no. 8 (August 26, 2010): e1001069. https://doi.org/10.1371/journal.ppat.1001069.
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  - Pfeiffer, Christopher D., Guillermo Garcia-Effron, Aimee K. Zaas, John R. Perfect, David S. Perlin, and Barbara D. Alexander. “Breakthrough invasive candidiasis in patients on micafungin.” J Clin Microbiol 48, no. 7 (July 2010): 2373–80. https://doi.org/10.1128/JCM.02390-09.
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  - Zaas, Aimee K., Hamza Aziz, Joseph Lucas, John R. Perfect, and Geoffrey S. Ginsburg. “Blood gene expression signatures predict invasive candidiasis.” Sci Transl Med 2, no. 21 (March 3, 2010): 21ra17. https://doi.org/10.1126/scitranslmed.3000715.
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  - Zaas, A. K., M. Chen, A. O. Hero, J. Lucas, L. Carin, and G. S. Ginsburg. “Response: Improving Development of the Molecular Signature for Diagnosis of Acute Respiratory Viral Infections.” Cell Host and Microbe 7, no. 2 (February 18, 2010): 102. https://doi.org/10.1016/j.chom.2010.02.002.
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  - Zaas, Aimee K., Minhua Chen, Jay Varkey, Timothy Veldman, Alfred O. Hero, Joseph Lucas, Yongsheng Huang, et al. “Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.” Cell Host Microbe 6, no. 3 (September 17, 2009): 207–17. https://doi.org/10.1016/j.chom.2009.07.006.
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  - Singh, Sheena D., Nicole Robbins, Aimee K. Zaas, Wiley A. Schell, John R. Perfect, and Leah E. Cowen. “Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.” Plos Pathog 5, no. 7 (July 2009): e1000532. https://doi.org/10.1371/journal.ppat.1000532.
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  - Shapiro, Rebecca S., Priya Uppuluri, Aimee K. Zaas, Cathy Collins, Heather Senn, John R. Perfect, Joseph Heitman, and Leah E. Cowen. “Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling.” Curr Biol 19, no. 8 (April 28, 2009): 621–29. https://doi.org/10.1016/j.cub.2009.03.017.
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  - Cowen, Leah E., Sheena D. Singh, Julia R. Köhler, Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Hamza Aziz, et al. “Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.” Proc Natl Acad Sci U S A 106, no. 8 (February 24, 2009): 2818–23. https://doi.org/10.1073/pnas.0813394106.
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  - Baddley, J. W., J. R. Perfect, R. A. Oster, R. A. Larsen, G. A. Pankey, H. Henderson, D. W. Haas, et al. “Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease.” Eur J Clin Microbiol Infect Dis 27, no. 10 (October 2008): 937–43. https://doi.org/10.1007/s10096-008-0529-z.
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  - Zaas, Aimee K. “Echinocandins: a wealth of choice--how clinically different are they?” Curr Opin Infect Dis 21, no. 4 (August 2008): 426–32. https://doi.org/10.1097/QCO.0b013e328307c79c.
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  - Zaas, Aimee K., Guochun Liao, Jason W. Chien, Clarice Weinberg, David Shore, Steven S. Giles, Kieren A. Marr, et al. “Plasminogen alleles influence susceptibility to invasive aspergillosis.” Plos Genet 4, no. 6 (June 20, 2008): e1000101. https://doi.org/10.1371/journal.pgen.1000101.
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  - Garantziotis, Stavros, John W. Hollingsworth, Aimee K. Zaas, and David A. Schwartz. “The effect of toll-like receptors and toll-like receptor genetics in human disease.” Annu Rev Med 59 (2008): 343–59. https://doi.org/10.1146/annurev.med.59.061206.112455.
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  - Giles, Steven S., Aimee K. Zaas, Mike F. Reidy, John R. Perfect, and Jo Rae Wright. “Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms.” Plos One 2, no. 12 (December 26, 2007): e1370. https://doi.org/10.1371/journal.pone.0001370.
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  - Reddy, Anita J., Aimee K. Zaas, Kimberly E. Hanson, and Scott M. Palmer. “A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome.” J Heart Lung Transplant 26, no. 12 (December 2007): 1286–92. https://doi.org/10.1016/j.healun.2007.09.012.
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  - Hollingsworth, J. W., S. Shofer, and A. Zaas. “Successful treatment of Ochroconis gallopavum infection in an immunocompetent host.” Infection 35, no. 5 (October 2007): 367–69. https://doi.org/10.1007/s15010-007-6054-7.
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  - Zaas, A. K., and J. R. Perfect. “Pulmonary fungal infections: Making the diagnosis.” Infections in Medicine 24, no. 4 (April 1, 2007): 156–68.
  - Dodds Ashley, E. S., A. K. Zaas, A. F. Fang, B. Damle, and J. R. Perfect. “Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets.” Antimicrob Agents Chemother 51, no. 3 (March 2007): 877–80. https://doi.org/10.1128/AAC.01263-06.
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  - Aziz, Hamza, Aimee Zaas, and Geoffrey S. Ginsburg. “Peripheral blood gene expression profiling for cardiovascular disease assessment.” Genomic Med 1, no. 3–4 (2007): 105–12. https://doi.org/10.1007/s11568-008-9017-x.
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  - Zaas, Aimee K., Elizabeth S. Dodds Ashley, Barbara D. Alexander, Melissa D. Johnson, and John R. Perfect. “Caspofungin for invasive candidiasis at a tertiary care medical center.” Am J Med 119, no. 11 (November 2006): 993.e1-993.e6. https://doi.org/10.1016/j.amjmed.2006.02.029.
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  - Zaas, Aimee K. “Host genetics affect susceptibility to invasive aspergillosis.” Med Mycol 44, no. Supplement_1 (September 1, 2006): S55–60. https://doi.org/10.1080/13693780600865481.
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  - Zaas, A. K., and B. D. Alexander. “Galactomannan and advances in fungal diagnostics.” Current Opinion in Organ Transplantation 10, no. 4 (December 1, 2005): 307–11. https://doi.org/10.1097/01.mot.0000187102.18780.b0.
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  - Steinbach, William J., John R. Perfect, Christopher H. Cabell, Vance G. Fowler, G Ralph Corey, Jennifer S. Li, Aimee K. Zaas, and Daniel K. Benjamin. “A meta-analysis of medical versus surgical therapy for Candida endocarditis.” J Infect 51, no. 3 (October 2005): 230–47. https://doi.org/10.1016/j.jinf.2004.10.016.
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  - Zaas, Aimee K., and Barbara D. Alexander. “Echinocandins: role in antifungal therapy, 2005.” Expert Opin Pharmacother 6, no. 10 (August 2005): 1657–68. https://doi.org/10.1517/14656566.6.10.1657.
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  - Zaas, Aimee K., and David A. Schwartz. “Innate immunity and the lung: defense at the interface between host and environment.” Trends Cardiovasc Med 15, no. 6 (August 2005): 195–202. https://doi.org/10.1016/j.tcm.2005.07.001.
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  - Zaas, Aimee K., and William J. Steinbach. “Micafungin: the US perspective.” Expert Rev Anti Infect Ther 3, no. 2 (April 2005): 183–90. https://doi.org/10.1586/14787210.3.2.183.
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  - Zaas, Aimee K., and Barbara D. Alexander. “New developments in the diagnosis and treatment of infections in lung transplant recipients.” Respir Care Clin N Am 10, no. 4 (December 2004): 531–47. https://doi.org/10.1016/j.rcc.2004.06.001.
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  - Steinbach, William J., Daniel K. Benjamin, Scott A. Trasi, Jackie L. Miller, Wiley A. Schell, Aimee K. Zaas, W Michael Foster, and John R. Perfect. “Value of an inhalational model of invasive aspergillosis.” Med Mycol 42, no. 5 (October 2004): 417–25. https://doi.org/10.1080/13693780410001712034.
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  - Steinbach, W. J., and A. K. Zaas. “Newer animal models of Aspergillus and Candida infections.” Drug Discovery Today: Disease Models 1, no. 1 (January 1, 2004): 87–93. https://doi.org/10.1016/j.ddmod.2004.03.001.
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  - Zaas, Aimee K., Molly Boyce, Wiley Schell, Barbara Alexander Lodge, Jackie L. Miller, and John R. Perfect. “Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates.” J Clin Microbiol 41, no. 11 (November 2003): 5233–35. https://doi.org/10.1128/JCM.41.11.5233-5235.2003.
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  - Toonkel, Rebecca, and Aimee Zaas. “Cases from the Osler Medical Service at Johns Hopkins University.” Am J Med 115, no. 6 (October 15, 2003): 497–500. https://doi.org/10.1016/j.amjmed.2003.08.005.
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  - Zaas, A. K., and J. R. Perfect. “Pulmonary fungal infections: Making the diagnosis.” Journal of Respiratory Diseases 24, no. 10 (October 1, 2003): 433–44.
  - Piccini, Jonathan, and Aimee Zaas. “Cases from the Osler Medical Service at Johns Hopkins University. Diffuse colonic angiodysplasia with chronic iron deficiency anemia.” Am J Med 115, no. 3 (August 15, 2003): 245–48. https://doi.org/10.1016/s0002-9343(03)00369-3.
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  - Piccini, Jonathan, and Aimee Zaas. “Cases from the Osler Medical Service at Johns Hopkins University. Digitalis toxicity with bidirectional ventricular tachycardia.” Am J Med 115, no. 1 (July 2003): 70–71. https://doi.org/10.1016/s0002-9343(03)00331-0.
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  - Passaretti, Catherine, and Aimee Zaas. “Cases from the Osler medical service at Johns Hopkins University.” Am J Med 114, no. 7 (May 2003): 613–16. https://doi.org/10.1016/s0002-9343(03)00162-1.
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  - McGirt, Matthew J., Aimee Zaas, Herbert E. Fuchs, Timothy M. George, Keith Kaye, and Daniel J. Sexton. “Risk factors for pediatric ventriculoperitoneal shunt infection and predictors of infectious pathogens.” Clin Infect Dis 36, no. 7 (April 1, 2003): 858–62. https://doi.org/10.1086/368191.
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  - Grow, Robert W., and Aimee Zaas. “Cases from the Osler Medical Service at Johns Hopkins University.” Am J Med 114, no. 2 (February 1, 2003): 153–55. https://doi.org/10.1016/s0002-9343(03)00009-3.
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  - Le, Dung, and Aimee Zaas. “Cases from the Osler Medical Service at Johns Hopkins University. Left atrial myxoma.” Am J Med 113, no. 8 (December 1, 2002): 694–96. https://doi.org/10.1016/s0002-9343(02)01442-0.
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  - Zaas, Aimee K., Xiaoyan Song, Pamela Tucker, and Trish M. Perl. “Risk factors for development of vancomycin-resistant enterococcal bloodstream infection in patients with cancer who are colonized with vancomycin-resistant enterococci.” Clin Infect Dis 35, no. 10 (November 15, 2002): 1139–46. https://doi.org/10.1086/342904.
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  - Zaas, A., P. Scheel, A. Venbrux, and D. B. Hellmann. “Large artery vasculitis following recombinant hepatitis B vaccination: 2 cases.” J Rheumatol 28, no. 5 (May 2001): 1116–20.
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  - Zaas, A. K., X. Y. Song, T. M. Perl, and P. C. Tucker. “Nosocomial vancomycin-resistant enterococcal blood stream infection (VRE-BSI) development in oncology patients colonized with vancomycin-resistant Enterococci(VRE-C).” Clinical Infectious Diseases 31, no. 1 (July 1, 2000): 278–278.
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  - Campbell, Elizabeth A., Matthew J. Crowley, Benjamin J. Powers, Linda L. Sanders, Maren K. Olsen, Susanne Danus, Diana B. McNeill, and Aimee K. Zaas. “Diabetes Quality of Care Before and After Implementation of a Resident Clinic Practice Partnership System.” Am J Med Qual 32, no. 1 (n.d.): 66–72. https://doi.org/10.1177/1062860615615210.
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- Book Sections
  - Steinbach, W. J. “Clinical aspects of the genus aspergillus.” In The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods, 359–75, 2007. https://doi.org/10.1201/9781420008517.
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- Conference Papers
  - Boggan, Joel C., Vaishali A. Patel, and Aimee K. Zaas. “A BLAST FROM THE PAST: RESIDENT AND FACULTY ATTITUDES WITH RE-INSTITUTION OF 24+4-HOUR CALL AT ONE MEDICAL CENTER.” In Journal of General Internal Medicine, 30:S482–S482. SPRINGER, 2015.
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  - Willett, Lisa L., Andrew J. Halvorsen, Michael Adams, Vineet M. Arora, Karen Chacko, Furman S. McDonald, Amy Oxentenko, Sara L. Swenson, Aimee K. Zaas, and Saima Chaudhry. “DECLINING PASS RATES OF THE AMERICAN BOARD OF INTERNAL MEDICINE CERTIFICATION EXAMINATION: PROGRAM DIRECTORS' PERSPECTIVES.” In Journal of General Internal Medicine, 30:S131–32. SPRINGER, 2015.
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  - Meade, Lauren B., Kathleen A. Heist, Ron Jones, Cheryl O’Malley, Kenji Yamazaki, and Aimee K. Zaas. “A SAFE AND EFFECTIVE DISCHARGE CURRICULUM IMPLEMENTED IN ELEVEN INTERNAL MEDICINE PROGRAMS OF THE EDUCATIONAL RESEARCH OUTCOMES COLLABORATIVE.” In Journal of General Internal Medicine, 30:S486–S486. SPRINGER, 2015.
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  - Cho, Alex H., Mark Dakkak, Adia K. Ross, Wei Duan-Porter, Lynn Bowlby, Daniella A. Zipkin, Lawrence Greenblatt, et al. “REDESIGNTNG A RESIDENT CONTINUITY CLINIC TO PROVIDE EFFECTIVE POPULATION HEALTH MANAGEMENT.” In Journal of General Internal Medicine, 29:S494–S494. SPRINGER, 2014.
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Teaching & Mentoring
Recent Courses
- MGM 293: Research Independent Study I 2021
- MGM 293: Research Independent Study I 2020

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