Akankshi Munjal

Journal Article Development · January 1, 2025 During inner ear semicircular canal morphogenesis in zebrafish, patterned canal-genesis zones express genes for extracellular matrix component synthesis. These include hyaluronan and the hyaluronan-binding chondroitin sulfate proteoglycan Versican, which a ... Full text Link to item Cite

Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis.

Journal Article bioRxiv · May 8, 2024 During inner ear semicircular canal morphogenesis in zebrafish, patterned canal-genesis zones express genes for extracellular matrix component synthesis. These include hyaluronan and the hyaluronan-binding chondroitin sulfate proteoglycan Versican, which a ... Full text Link to item Cite

Hydrostatic pressure as a driver of cell and tissue morphogenesis.

Journal Article Semin Cell Dev Biol · November 2022 Morphogenesis, the process by which tissues develop into functional shapes, requires coordinated mechanical forces. Most current literature ascribes contractile forces derived from actomyosin networks as the major driver of tissue morphogenesis. Recent wor ... Full text Link to item Cite

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.

Journal Article Cell · December 22, 2021 How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that convent ... Full text Link to item Cite

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis

Preprint · 2020 Full text Cite

Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.

Journal Article Nat Commun · October 24, 2017 Tissue remodeling requires cell shape changes associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the hydrodynamics of actomyosin as a confined active elastomer with turnover of its components. Our treatment is adapted to de ... Full text Link to item Cite

Modular activation of Rho1 by GPCR signalling imparts polarized myosin II activation during morphogenesis.

Journal Article Nat Cell Biol · March 2016 Polarized cell shape changes during tissue morphogenesis arise by controlling the subcellular distribution of myosin II. For instance, during Drosophila melanogaster gastrulation, apical constriction and cell intercalation are mediated by medial-apical myo ... Full text Link to item Cite

A self-organized biomechanical network drives shape changes during tissue morphogenesis.

Journal Article Nature · August 20, 2015 Tissue morphogenesis is orchestrated by cell shape changes. Forces required to power these changes are generated by non-muscle myosin II (MyoII) motor proteins pulling filamentous actin (F-actin). Actomyosin networks undergo cycles of assembly and disassem ... Full text Link to item Cite

Actomyosin networks and tissue morphogenesis.

Journal Article Development · May 2014 Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcell ... Full text Link to item Cite