Scholars@Duke
Alan Neil Carlson

Alan Neil Carlson

Professor of Ophthalmology
Ophthalmology, Corneal Diseases
alan.carlson@duke.edu
Box 3802 Duec, Durham, NC 27710
Duke Univ Eye Ctr, Durham, NC 27710
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Selected Publications

Evaluation of the Patient and Decision Making in Anterior Lamellar Keratoplasty

Chapter · January 1, 2024 Since the work done by Eduard Zirm in 1905 with the first successful human full-thickness penetrating keratoplasty (PK), 1 there have been several surgeons, including von Hippel, 2 Paufique and Charles, 3 McGhee, Kim, and Wilson, 4 and Anwar, 5 who have in ... Full text Cite

Foreword

Journal Article Mastering Corneal Surgery: Recent Advances and Current Techniques · January 1, 2024 Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center.

Journal Article J Ophthalmic Inflamm Infect · December 2016 BACKGROUND: Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis at a tertiary referral center in the Southe ... Full text Link to item Cite

Eye Bank Graft Preparation for Pre-Descemet's Endothelial Keratoplasty

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

April consultation #5.

Journal Article J Cataract Refract Surg · April 2016 Full text Link to item Cite

Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation: a review.

Journal Article Curr Opin Ophthalmol · July 2015 PURPOSE OF REVIEW: Meibomian gland dysfunction (MGD) is understood to be a highly prevalent, chronic progressive disease and the leading cause of dry eye. All available published peer-reviewed results of the novel vectored thermal pulsation therapy for pat ... Full text Link to item Cite

Textural interface opacity after Descemet-stripping automated endothelial keratoplasty.

Journal Article J Cataract Refract Surg · September 2014 PURPOSE: To describe cases of interface haze, also known as textural interface opacity, after Descemet-stripping automated endothelial keratoplasty (DSAEK). SETTING: Department of Cornea, External Disease, and Refractive Surgery Service, Duke Eye Center, D ... Full text Link to item Cite

Effect of cornea donor graft thickness on the outcome of Descemet stripping automated endothelial keratoplasty surgery.

Journal Article Am J Ophthalmol · November 2013 PURPOSE: To determine whether Descemet stripping automated endothelial keratoplasty (DSAEK) donor cornea graft thickness impacts measurements of best spectacle-corrected visual acuity (BSCVA), refractive error and intraocular pressure (IOP). DESIGN: Retros ... Full text Link to item Cite

Lamellar keratoplasty: a literature review.

Journal Article J Ophthalmol · 2013 The concept of lamellar keratoplasty (LK) is not new. However, newer forms of lamellar keratoplasty techniques have emerged in the last decade or so revolving around the concept of targeted replacement of diseased corneal layers. These include anterior lam ... Full text Link to item Cite

Increased Rates of Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Failure and Dislocation in Glaucomatous Eyes with Aqueous Shunts.

Journal Article J Ophthalmic Vis Res · July 2012 PURPOSE: To investigate the rates of Descemet's stripping automated endothelial keratoplasty (DSAEK) graft dislocation and failure in glaucomatous eyes, including eyes with history of trabeculectomy and/or aqueous shunts. METHODS: A retrospective, case-con ... Link to item Cite

Prevalence of sleep apnea in patients with keratoconus.

Journal Article Cornea · June 2012 PURPOSE: To determine the prevalence of obstructive sleep apnea (OSA) in patients with keratoconus and evaluate the risk of developing OSA in this patient population. METHODS: Three hundred sixty-two patients diagnosed with keratoconus by a single physicia ... Full text Link to item Cite

Dislocation of the donor graft to the posterior segment in descemet stripping automated endothelial keratoplasty.

Journal Article Am J Ophthalmol · April 2012 PURPOSE: To report a series of dislocations of the donor graft into the posterior segment associated with Descemet stripping endothelial keratoplasty (DSAEK) and to identify possible risk factors for dislocation and clinical outcomes. DESIGN: Retrospective ... Full text Link to item Cite

Where are the older patients with keratoconus?

Other Cornea · April 2010 Featured Publication Full text Link to item Cite

Using Intacs corneal implants to treat Ectasia after radial keratotomy

Other Clinical and Surgical Ophthalmology · December 1, 2009 Ectasia after refractive surgery is a major concern for many ophthalmologists. Radial keratotomy (RK) was a popular refractive surgical procedure that used 4 or more deep radial incisions to treat myopia. Although many patients did well after RK, some expe ... Cite

Evaluation of the Patient and Decision Making in Anterior Lamellar Keratoplasty

Chapter · January 1, 2024 Since the work done by Eduard Zirm in 1905 with the first successful human full-thickness penetrating keratoplasty (PK), 1 there have been several surgeons, including von Hippel, 2 Paufique and Charles, 3 McGhee, Kim, and Wilson, 4 and Anwar, 5 who have in ... Full text Cite

Foreword

Journal Article Mastering Corneal Surgery: Recent Advances and Current Techniques · January 1, 2024 Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center.

Journal Article J Ophthalmic Inflamm Infect · December 2016 BACKGROUND: Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis at a tertiary referral center in the Southe ... Full text Link to item Cite

Eye Bank Graft Preparation for Pre-Descemet's Endothelial Keratoplasty

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · September 1, 2016 Link to item Cite

April consultation #5.

Journal Article J Cataract Refract Surg · April 2016 Full text Link to item Cite

Treatment for meibomian gland dysfunction and dry eye symptoms with a single-dose vectored thermal pulsation: a review.

Journal Article Curr Opin Ophthalmol · July 2015 PURPOSE OF REVIEW: Meibomian gland dysfunction (MGD) is understood to be a highly prevalent, chronic progressive disease and the leading cause of dry eye. All available published peer-reviewed results of the novel vectored thermal pulsation therapy for pat ... Full text Link to item Cite

Textural interface opacity after Descemet-stripping automated endothelial keratoplasty.

Journal Article J Cataract Refract Surg · September 2014 PURPOSE: To describe cases of interface haze, also known as textural interface opacity, after Descemet-stripping automated endothelial keratoplasty (DSAEK). SETTING: Department of Cornea, External Disease, and Refractive Surgery Service, Duke Eye Center, D ... Full text Link to item Cite

Effect of cornea donor graft thickness on the outcome of Descemet stripping automated endothelial keratoplasty surgery.

Journal Article Am J Ophthalmol · November 2013 PURPOSE: To determine whether Descemet stripping automated endothelial keratoplasty (DSAEK) donor cornea graft thickness impacts measurements of best spectacle-corrected visual acuity (BSCVA), refractive error and intraocular pressure (IOP). DESIGN: Retros ... Full text Link to item Cite

Lamellar keratoplasty: a literature review.

Journal Article J Ophthalmol · 2013 The concept of lamellar keratoplasty (LK) is not new. However, newer forms of lamellar keratoplasty techniques have emerged in the last decade or so revolving around the concept of targeted replacement of diseased corneal layers. These include anterior lam ... Full text Link to item Cite

Increased Rates of Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Graft Failure and Dislocation in Glaucomatous Eyes with Aqueous Shunts.

Journal Article J Ophthalmic Vis Res · July 2012 PURPOSE: To investigate the rates of Descemet's stripping automated endothelial keratoplasty (DSAEK) graft dislocation and failure in glaucomatous eyes, including eyes with history of trabeculectomy and/or aqueous shunts. METHODS: A retrospective, case-con ... Link to item Cite

Prevalence of sleep apnea in patients with keratoconus.

Journal Article Cornea · June 2012 PURPOSE: To determine the prevalence of obstructive sleep apnea (OSA) in patients with keratoconus and evaluate the risk of developing OSA in this patient population. METHODS: Three hundred sixty-two patients diagnosed with keratoconus by a single physicia ... Full text Link to item Cite

Dislocation of the donor graft to the posterior segment in descemet stripping automated endothelial keratoplasty.

Journal Article Am J Ophthalmol · April 2012 PURPOSE: To report a series of dislocations of the donor graft into the posterior segment associated with Descemet stripping endothelial keratoplasty (DSAEK) and to identify possible risk factors for dislocation and clinical outcomes. DESIGN: Retrospective ... Full text Link to item Cite

Where are the older patients with keratoconus?

Other Cornea · April 2010 Featured Publication Full text Link to item Cite

Using Intacs corneal implants to treat Ectasia after radial keratotomy

Other Clinical and Surgical Ophthalmology · December 1, 2009 Ectasia after refractive surgery is a major concern for many ophthalmologists. Radial keratotomy (RK) was a popular refractive surgical procedure that used 4 or more deep radial incisions to treat myopia. Although many patients did well after RK, some expe ... Cite

Keratoconus.

Other Ophthalmology · October 2009 Featured Publication Full text Link to item Cite

Femtosecond keratectomy for advanced fungal keratitis

Other Techniques in Ophthalmology · June 1, 2009 We report the use of the femtosecond laser (IntraLase FS laser; Advanced Medical Optics, Inc, Santa Ana, Calif) to create a therapeutic lamellar keratectomy to facilitate the treatment of fungal keratitis. Lamellar keratectomy was used to remove infected t ... Full text Cite

Candida glabrata endophthalmitis following penetrating keratoplasty.

Journal Article J Cataract Refract Surg · March 2009 Featured Publication We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and ... Full text Link to item Cite

Using intacs corneal implants to treat ectasia after radial keratotomy

Other Techniques in Ophthalmology · March 1, 2009 Ectasia after refractive surgery is a major concern for many ophthalmologists. Radial keratotomy (RK) was a popular refractive surgical procedure that used 4 or more deep radial incisions to treat myopia. Although many patients did well after RK, some expe ... Full text Cite

Refractive change after descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter.

Journal Article Cornea · January 2009 Featured Publication PURPOSE: The purpose of this study was to evaluate the refractive change after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery and its correlation with graft thickness and diameter. METHODS: We retrospectively analyzed the refractive ... Full text Link to item Cite

Combined fluocinolone acetonide intraocular delivery system insertion, phacoemulsification, and intraocular lens implantation for severe uveitis.

Journal Article Am J Ophthalmol · October 2008 Featured Publication PURPOSE: To determine whether a three-year fluocinolone acetonide sustained drug delivery system can be implanted safely at the same time that phacoemulsification and intraocular lens (IOL) implantation are performed for a visually significant cataract in ... Full text Link to item Cite

Using intacs corneal implants to treat ectasia after radial keratotomy

Other Techniques in Ophthalmology · September 1, 2008 Ectasia after refractive surgery is a major concern for many ophthalmologists. Radial keratotomy (RK) was a popular refractive surgical procedure that used 4 or more deep radial incisions to treat myopia. Although many patients did well after RK, some expe ... Full text Cite

Corneal transplantation using the Descemet's stripping endothelial keratoplasty technique.

Journal Article Expert Rev Pharmacoecon Outcomes Res · April 2007 Featured Publication Descemet's stripping endothelial keratoplasty (DSEK) is a relatively new technique that is rapidly replacing full-thickness procedures for those patients needing corneal transplantation for endothelial dysfunction. Benefits of DSEK include a faster recover ... Full text Link to item Cite

Eyelid disease.

Other Ophthalmology · November 2005 Featured Publication Full text Link to item Cite

Trends in the indications for penetrating keratoplasty, 1980-2001.

Journal Article Cornea · October 2005 Featured Publication PURPOSE: To study the leading indications and changing trends for penetrating keratoplasty (PK) over the past 3 decades. METHODS: This is a retrospective review of 696 cases of PK. The indications for PKs performed at the Duke University Eye Center during ... Full text Link to item Cite

Keratoconus and obesity - A connection?

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2003 Link to item Cite

Outcomes after laser in situ keratomileusis (LASIK) requiring surgical intervention

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2003 Link to item Cite

Severe autoimmune keratitis requiring tectonic keratoplasty

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2003 Link to item Cite

Acute corneal endothelial changes after laser in situ keratomileusis.

Journal Article Cornea · August 2001 PURPOSE: To report the acute effects of laser in situ keratomileusis (LASIK) on the corneal endothelium. METHODS: Twenty eyes of 10 consecutive patients (mean age, 38.1 +/- 10.84 years) underwent bilateral simultaneous LASIK for myopic astigmatism (spheric ... Full text Link to item Cite

Ultrasonographic measurement of induced myopia associated with capsular bag distention syndrome.

Journal Article Ophthalmology · May 2000 OBJECTIVE: To determine the causes of postoperative myopia associated with capsular bag distention syndrome (CBDS) and characterize the associated findings. DESIGN: Prospective, multicenter, nonrandomized, comparative (self-controlled) trial. PARTICIPANTS: ... Full text Link to item Cite

Intraocular lens complications requiring removal or exchange.

Journal Article Surv Ophthalmol · 1998 Intraocular lens (IOL)-related complications are caused primarily by mechanical trauma, inflammatory or infectious complications, or optical problems. Complications may occur at the time of surgery or be the result of an ongoing postoperative process. Mech ... Full text Link to item Cite

Suction cup/contact lens complications following penetrating keratoplasty.

Journal Article CLAO J · January 1998 PURPOSE: Rigid gas permeable (RGP) contact lenses facilitate visual rehabilitation in cases of high or irregular corneal astigmatism following penetrating keratoplasty. A variety of plunger-like suction cup devices are available to assist in the removal of ... Link to item Cite

Three-millimeter versus 6-mm incisions in combined phacoemulsification and trabeculectomy.

Journal Article Ophthalmic Surg Lasers · October 1996 BACKGROUND AND OBJECTIVE: To determine the results of phacoemulsification and combined trabeculectomy in subjects receiving either a 3- or a 6-mm scleral incision. PATIENTS AND METHODS: The authors evaluated consecutive patients who underwent combined phac ... Link to item Cite

Prognostic factors in long-term intraocular pressure control following combined phacoemulsification and trabeculectomy.

Journal Article Acta Ophthalmol Scand · April 1996 We studied 36 consecutive patients who underwent combined phacoemulsification and trabeculectomy to determine prognostic factors associated with intraocular pressure control one year postoperatively. In patients who were either easier (intraocular pressure ... Full text Link to item Cite

Is the sutureless cataract incision a valve for bacterial inoculation?

Journal Article J Cataract Refract Surg · July 1995 Many cataract surgeons perform sutureless surgery to decrease operating time, postoperative astigmatism, and healing time. Anecdotal case reports of postoperative endophthalmitis after sutureless surgery prompted our investigation of this type of wound clo ... Full text Link to item Cite

Effect of cataract extraction on automated fields in chronic open-angle glaucoma.

Journal Article Arch Ophthalmol · July 1995 OBJECTIVE: To evaluate the influence of cataract extraction on the results of visual field testing in chronic open-angle glaucoma. DESIGN: We performed automated perimetry within 6 months before and after phacoemulsification and combined trabeculectomy in ... Full text Link to item Cite

Results of combined phacoemulsification and trabeculectomy in patients with elevated preoperative intraocular pressures.

Journal Article J Glaucoma · June 1995 PURPOSE: We evaluated the results of 17 consecutive patients with high intraocular pressures and visually significant cataracts who underwent combined phacoemulsification and trabeculectomy. METHODS: We individually matched each patient by age, race, and i ... Link to item Cite

Fornix- vs. limbus-based flaps in combined phacoemulsification and trabeculectomy.

Journal Article Doc Ophthalmol · 1994 We studied prospectively the results of limbus-versus fornix-based flaps in patients undergoing combined trabeculectomy and phacoemulsification. We found no significant difference at six months postoperatively in the level of intraocular pressure between t ... Full text Link to item Cite

Results of trabeculectomy combined with phacoemulsification versus trabeculectomy combined with extracapsular cataract extraction in patients with advanced glaucoma.

Journal Article Ophthalmic Surg · 1994 We compared the results of trabeculectomy combined with phacoemulsification (n = 16) with those of trabeculectomy combined with extracapsular cataract extraction (n = 18). There was no significant difference between the two groups in terms of early or chro ... Link to item Cite

Fungal scleritis after cataract surgery. Successful outcome using itraconazole.

Journal Article Cornea · March 1992 Featured Publication We report the development of fungal scleritis in a 53-year-old man after uncomplicated cataract surgery. Histopathology and culture identified the organism as Aspergillus flavus. Clinically, the patient worsened on treatment with oral ketoconazole and topi ... Full text Link to item Cite

A comparison of neodymium: yttrium aluminum garnet and diode laser transscleral cyclophotocoagulation and cyclocryotherapy.

Journal Article Invest Ophthalmol Vis Sci · September 1991 The cyclodestructive effects of cyclocryotherapy and of the neodymium:yttrium aluminum garnet (Nd:YAG) and diode laser transscleral cyclophotocoagulation were investigated in phakic and pseudophakic cadaver eyes using a modified Miyake posterior-view techn ... Link to item Cite

Preparation and study of human eyes obtained postmortem with the Miyake posterior photographic technique.

Journal Article Ophthalmology · June 1990 Featured Publication A modification of the original Miyake technique of posterior photography of human eyes obtained postmortem is presented. A detailed description of globe preparation and equipment is described. Use of modern technology including a high magnification microsc ... Full text Link to item Cite

Endocapsular hypopyon: a clinical sign of localized endophthalmitis.

Journal Article Ophthalmic Surg · March 1990 Featured Publication Chronic intraocular infection following cataract extraction and intraocular lens (IOL) implantation has been documented by several authors. We report a case of chronic, bacterial endophthalmitis that clinically correlates with previous pathologic studies i ... Link to item Cite

Sutured retropupillary posterior chamber intraocular lenses for exchange or secondary implantation. The 12th annual Binkhorst lecture, 1988.

Journal Article Ophthalmology · August 1989 Featured Publication The histopathologic findings of four eyes obtained postmortem with iris-sutured posterior chamber intraocular lenses (PC IOLs) are described. These IOLs were implanted as exchange procedures. In most instances, the loops were not situated in the ciliary su ... Full text Link to item Cite

Infectious complications of modern cataract surgery and intraocular lens implantation.

Other Infect Dis Clin North Am · June 1989 Featured Publication Over one million intraocular lenses are implanted each year during cataract surgery in the United States alone. Despite an impressive overall success rate, infection remains an important postoperative complication. Virtually every microbial organism has th ... Link to item Cite

Endophthalmitis following Nd:YAG laser posterior capsulotomy.

Journal Article Ophthalmic Surg · March 1988 Featured Publication We report the development of Propionibacterium acnes endophthalmitis following Nd:YAG laser posterior capsulotomy. The patient previously underwent uncomplicated extracapsular cataract extraction with intraocular lens insertion and was free of inflammation ... Link to item Cite