Journal ArticleGenome biology and evolution · January 2025
Altered regulatory interactions during development likely underlie a large fraction of phenotypic diversity within and between species, yet identifying specific evolutionary changes remains challenging. Analysis of single-cell developmental transcriptomes ...
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Journal ArticleDevelopment (Cambridge, England) · October 2024
Biphasic lifecycles are widespread among animals, but little is known about how the developmental transition between larvae and adults is regulated. Sea urchins are a unique system for studying this phenomenon because of the stark differences between their ...
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Journal ArticleNature ecology & evolution · December 2022
Changes in developmental gene regulatory networks (dGRNs) underlie much of the diversity of life, but the evolutionary mechanisms that operate on regulatory interactions remain poorly understood. Closely related species with extreme phenotypic divergence p ...
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Journal ArticleMethods in molecular biology (Clifton, N.J.) · January 2021
An epithelial-mesenchymal transition (EMT) occurs in almost every metazoan embryo at the time mesoderm begins to differentiate. Several embryos have a long record as models for studying an EMT given that a known population of cells enters the EMT at a know ...
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Journal ArticleGenome biology and evolution · July 2020
Lytechinus variegatus is a camarodont sea urchin found widely throughout the western Atlantic Ocean in a variety of shallow-water marine habitats. Its distribution, abundance, and amenability to developmental perturbation make it a popular model for ecolog ...
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Journal ArticleBMC genomics · May 2020
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BackgroundAdaptive changes in cis-regulatory elements are an essential component of evolution by natural selection. Identifying adaptive and functional noncoding DNA elements throughout the genome is therefore crucial for understanding the relatio ...
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Journal ArticlePeerJ · January 2020
BackgroundThe emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to huma ...
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Journal Article · 2020
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Background The emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to hum ...
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Journal Article · 2020
Here we employed scRNA-seq coupled with computational approaches to examine molecular changes in cells during specification and differentiation. We examined the first 24 hours of development of the sea urchin Lytechinus variegatus ( Lv ) with 18 time point ...
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Journal Article · 2020
Background Pair bonding with a reproductive partner is rare among mammals but is an important feature of human social behavior. Decades of research on monogamous prairie voles ( Microtus ochrogaster ), along with comparative studies using the rela ...
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Journal ArticleGenome Biol Evol · October 1, 2019
Changes in transcriptional regulation are thought to be a major contributor to the evolution of phenotypic traits, but the contribution of changes in chromatin accessibility to the evolution of gene expression remains almost entirely unknown. To address th ...
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Journal ArticleGenome Biol Evol · July 1, 2019
Humans carry a much larger percentage of body fat than other primates. Despite the central role of adipose tissue in metabolism, little is known about the evolution of white adipose tissue in primates. Phenotypic divergence is often caused by genetic diver ...
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Journal ArticleJournal of Avian Biology · June 1, 2019
Populations undergoing range expansions are often faced with novel selective pressures, and to cope with such challenges, populations must either adapt quickly or exhibit phenotypic plasticity. This latter option allows for rapid phenotypic adjustments and ...
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Journal Article · 2019
Humans carry a much larger percentage of body fat than other primates. Despite the central role of adipose tissue in metabolism, little is known about the evolution of white adipose tissue in primates. Phenotypic divergence is often caused by genetic diver ...
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Journal ArticleMolecular ecology · January 2018
Adaptive variation in social behaviour depends upon standing genetic variation, but we know little about how evolutionary forces shape genetic diversity relevant to brain and behaviour. In prairie voles (Microtus ochrogaster), variants at the Avpr1a locus ...
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Journal ArticleFrontiers in neuroscience · January 2017
Social behavior is among the most complex and variable of traits. Despite its diversity, we know little about how genetic and developmental factors interact to shape natural variation in social behavior. This review surveys recent work on individual differ ...
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Journal ArticleMolecular ecology · April 2016
Organisms can adapt to variable environments by using environmental cues to modulate developmental gene expression. In principle, maternal influences can adaptively adjust offspring phenotype when early life and adult environments match, but they may be ma ...
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Journal ArticleScience (New York, N.Y.) · December 2015
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Individual variation in social behavior seems ubiquitous, but we know little about how it relates to brain diversity. Among monogamous prairie voles, levels of vasopressin receptor (encoded by the gene avpr1a) in brain regions related to spatial memory pre ...
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Journal ArticleRevista Colombiana de Entomologia · July 1, 2011
There are two species of the genus Hypothenemus of economical importance in Colombia: H. hampei and H. obscurus. The first is the most destructive insect pest of coffee worldwide, while the latter attacks several crops including macadamia nut and coffee. T ...
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Journal ArticleMemorias do Instituto Oswaldo Cruz · May 2006
Cytogenetics of triatomines have been a valuable biological tool for the study of evolution, taxonomy, and epidemiology of these vectors of Trypanosoma cruzi. Here we present a single microtube protocol that combines micro-centrifugation and micro-spreadin ...
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