Scholars@Duke
Alev Brigande

Selected Publications

Mesolimbic exendin-4 attenuates reward salience evoked by neuropeptide Y and ghrelin.

Journal Article Behavioural brain research · February 2023 In the present study, we investigated the effects of the glucagon-like peptide-1 (GLP-1) agonist exendin-4 (Ex-4) on the stimulatory action of neuropeptide Y (NPY) and ghrelin. These effects were examined in relation to operant responding for palatable foo ... Full text Cite

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats.

Journal Article Developmental psychobiology · March 2022 A growing body of evidence links prenatal and early postnatal acetaminophen (APAP) exposure to atypical development of brain and behavior. In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposu ... Full text Cite

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction.

Journal Article Nucleic acids research · May 2020 Disabling hearing loss impacts ∼466 million individuals worldwide with 34 million children affected. Gene and pharmacotherapeutic strategies to rescue auditory function in mouse models of human deafness are most effective when administered before hearing o ... Full text Cite