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Alex Gunn

House Staff
Medicine

Selected Publications


Sacubitril/valsartan versus valsartan initiation in patients naïve to renin-angiotensin system inhibitors: Insights from PARAGLIDE-HF.

Conference Eur J Heart Fail · January 10, 2025 AIMS: Whether prior treatment with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) modifies efficacy and safety of sacubitril/valsartan (Sac/Val) in patients with heart failure (HF) and ejection fraction (EF) >40% is ... Full text Link to item Cite

Carbon emissions and air pollution savings among telehealth visits for cardiology appointments.

Journal Article Am Heart J Plus · September 2024 BACKGROUND: Climate change has been associated with adverse cardiovascular health, prompting interest in climate mitigation strategies while improving access for cardiovascular patients. We estimated greenhouse gas and air pollution savings from telehealth ... Full text Link to item Cite

Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devices

Journal Article JTCVS Open · June 1, 2024 Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation betw ... Full text Cite

Costs of care and financial hardship among patients with heart failure.

Journal Article Am Heart J · March 2024 With the implementation of new therapies, more patients are living with heart failure (HF) as a chronic condition. Alongside these advances, out-of-pocket (OOP) medical costs have increased, and patients experience significant financial burden. Despite inc ... Full text Link to item Cite

Medullary thyroid cancer with RET V804M mutation: more indolent than expected?

Journal Article Surgery · January 2023 BACKGROUND: Significant genotype-phenotype variability among multiple endocrine neoplasia type 2A patients with a RET V804M mutation has been reported. METHODS: Patients with a RET V804M mutation treated at a single center were identified (January 1996-Dec ... Full text Link to item Cite

Guideline Adherence and Practice Patterns in the Management of Medullary Thyroid Cancer.

Journal Article J Surg Res · January 2023 INTRODUCTION: Little is known about nationwide practice patterns for the management medullary thyroid cancer (MTC) in relation to the 2015 American Thyroid Association guidelines and their impact on survival. METHODS: Using the Surveillance, Epidemiology, ... Full text Link to item Cite

Implementation of an educational intervention to improve medical student cost awareness: a prospective cohort study.

Journal Article BMC medical education · January 2023 BackgroundIn the context of rising healthcare costs, formal education on treatment-related financial hardship is lacking in many medical schools, leaving future physicians undereducated and unprepared to engage in high-value care.MethodWe ... Full text Cite

Tumor marker response to SARS-CoV-2 infection among patients with cancer.

Journal Article Cancer Med · July 2022 BACKGROUND: Inflammatory responses from benign conditions can cause non-cancer-related elevations in tumor markers. The severe acute respiratory coronavirus 2 (SARS-CoV-2) induces a distinct viral inflammatory response, resulting in coronavirus disease 201 ... Full text Link to item Cite

Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease.

Journal Article Thyroid · January 2022 Background: Graves' disease accounts for ∼80% of all cases of hyperthyroidism and is associated with significant morbidity and decreased quality of life. Understanding the association of total thyroidectomy with patient-reported quality-of-life and thyroid ... Full text Link to item Cite

Navigating the high costs of cancer care: opportunities for patient engagement.

Journal Article Future Oncol · October 2021 Over the past decade, the financial burden of cancer care on patients and their families has garnered increased attention. Many of the potential solutions have focused on system-level interventions such as adopting value-based payment models and negotiatin ... Full text Link to item Cite

Assessing the use of low value oncology care following the release of Choosing Wisely guidelines.

Conference Journal of Clinical Oncology · May 20, 2021 e18861 Background: Low -value care contributes to the high costs of cancer treatment. Almost a decade has passed since the American Society of Clinical Oncology (ASCO) Choosing Wisely campaign identified costly diagnostic testing ... Full text Cite

Recurrent Laryngeal Nerve Injury After Thyroid Surgery: An Analysis of 11,370 Patients.

Journal Article J Surg Res · November 2020 BACKGROUND: Recurrent laryngeal nerve (RLN) injury is a well-known, potentially serious complication of thyroid surgery. We investigated factors associated with RLN injury during thyroid surgery using a multi-institutional data set. MATERIALS AND METHODS: ... Full text Link to item Cite

Developing new health technologies for neglected diseases: A pipeline portfolio review and cost model

Journal Article Gates Open Research · January 1, 2020 Background: Funding for neglected disease product development fell from 2009-2015, other than a brief injection of Ebola funding. One impediment to mobilizing resources is a lack of information on product candidates, the estimated costs to move them throug ... Full text Cite

Analysis of the health product pipeline for poverty-related and neglected diseases using the Portfolio-to-Impact (P2I) modeling tool.

Journal Article F1000Research · January 2020 Background: To estimate how much additional funding is needed for poverty-related and neglected disease (PRND) product development and to target new resources effectively, policymakers need updated information on the development pipeline and estimat ... Full text Cite

Pipeline analysis of a vaccine candidate portfolio for diseases of poverty using the Portfolio-To-Impact modelling tool.

Journal Article F1000Research · January 2019 Background: The Portfolio-To-Impact (P2I) P2I model is a recently developed product portfolio tool that enables users to estimate the funding needs to move a portfolio of candidate health products, such as vaccines and drugs, along the product devel ... Full text Cite

The Emergency Department as an Opportunity for Naloxone Distribution.

Journal Article The western journal of emergency medicine · November 2018 IntroductionSubstance use disorders, including opioid use disorders, are a major public health concern in the United States. Between 2005 and 2014, the rate of opioid-related emergency department (ED) visits nearly doubled, from 89.1 per 100,000 p ... Full text Open Access Cite

Developing new health technologies for neglected diseases: a pipeline portfolio review and cost model.

Journal Article Gates open research · January 2018 Background: Funding for neglected disease product development fell from 2009-2015, other than a brief injection of Ebola funding. One impediment to mobilizing resources is a lack of information on product candidates, the estimated costs to move them ... Full text Cite

Funding global health product R&D: the Portfolio-To-Impact Model (P2I), a new tool for modelling the impact of different research portfolios.

Journal Article Gates open research · January 2018 Background: The Portfolio-To-Impact (P2I) Model is a novel tool, developed to estimate minimum funding needs to accelerate health product development from late stage preclinical study to phase III clinical trials, and to visualize potential product ... Full text Cite

Fear of Movement and Associated Factors Among Adults With Symptomatic Knee Osteoarthritis.

Journal Article Arthritis Care Res (Hoboken) · December 2017 OBJECTIVE: To examine the frequency of and factors associated with fear of movement (FOM) among patients with symptomatic knee osteoarthritis (KOA), using the new Brief Fear of Movement (BFOM) measure. METHODS: Participants (n = 350) enrolled in a clinical ... Full text Link to item Cite

Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice.

Journal Article Reproduction (Cambridge, England) · December 2016 Primordial follicles dictate a female's reproductive life span and therefore are central to fertility preservation for both endangered species and individuals with fertility-threatening conditions. Ovarian tissue containing primordial follicles can be cryo ... Full text Cite

Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial.

Journal Article BMC Musculoskelet Disord · August 23, 2016 BACKGROUND: African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has been limited engagement of African Ame ... Full text Link to item Cite

Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods.

Journal Article Journal of adolescent and young adult oncology · December 2015 PurposeFertility preservation in a pediatric and teen female population is challenging because standard technologies of egg and embryo freezing may not be possible due to premenarcheal status. Ovarian tissue cryopreservation (OTC) with the intent ... Full text Cite

Physical therapy vs. internet-based exercise training (PATH-IN) for patients with knee osteoarthritis: study protocol of a randomized controlled trial.

Journal Article BMC Musculoskelet Disord · September 28, 2015 BACKGROUND: Physical activity improves pain and function among individuals with knee osteoarthritis (OA), but most people with this condition are inactive. Physical therapists play a key role in helping people with knee OA to increase appropriate physical ... Full text Link to item Cite