Alexandra Badea
Associate Professor in Radiology
I have a joint appointment in Radiology and Neurology and my research focuses on neurological conditions like Alzheimer’s disease. I work on imaging and analysis to provide a comprehensive characterization of the brain. MRI is particularly suitable for brain imaging, and diffusion tensor imaging is an important tool for studying brain microstructure, and the connectivity amongst gray matter regions.
I am interested in image segmentation, morphometry and shape analysis, as well as in integrating information from MRI with genetics, and behavior. Our approaches target: 1) phenotyping the neuroanatomy using imaging; 2) uncovering the link between structural and functional changes, the genetic bases, and environmental factors. I am interested in generating methods and tools for comprehensive phenotyping.
We use high-performance cluster computing to accelerate our image analysis. We use compressed sensing image reconstruction, and process large image arrays using deformable registration, perform segmentation based on multiple image contrasts including diffusion tensor imaging, as well as voxel, and graph analysis for connectomics.
At BIAC my efforts focus on developing multivariate biomarkers and identifying vulnerable networks based on genetic risk for Alzheimer's disease.
My enthusiasm comes from the possibility to extend from single to integrative multivariate and network based analyses to obtain a comprehensive picture of normal development and aging, stages of disease, and the effects of treatments. I am working on multivariate image analysis and predictive modeling approaches to help better understand early biomarkers for human disease indirectly through mouse models, as well as directly in human studies.
I am dedicated to supporting an increase in female presence in STEM fields, and love working with students. The Bass Connections teams involve undergraduate students in research, providing them the opportunity to do independent research studies and get involved with the community. These students have for example takes classes such as:
BME 394: Projects in Biomedical Engineering (GE)
BME 493: Projects in Biomedical Engineering (GE)
ECE 899: Special Readings in Electrical Engineering
NEUROSCI 493: Research Independent Study 1
Current Research Interests
Current Appointments & Affiliations
- Associate Professor in Radiology, Radiology, Clinical Science Departments 2021
- Associate Professor in the Department of Neurology, Neurology, Behavioral Neurology, Neurology 2021
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2017
- Member of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2018
Contact Information
- Box 3302 Duke University Medic, Durham, NC 27710
- Center for in Vivo Microscopy, Room 139 Bryan Research Building, Durham, NC 27710
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alexandra.badea@duke.edu
(919) 684-7654
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See my Duke Radiology Page - Click Here
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See my Duke University School of Medicine Page - Click Here
- Background
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Education, Training, & Certifications
- Ph.D., University of Patras (Greece) 2003
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Previous Appointments & Affiliations
- Associate Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2018 - 2021
- Associate Professor in Radiology, Radiology, Clinical Science Departments 2018 - 2020
- Associate Professor in Radiology, Radiology, Clinical Science Departments 2017 - 2018
- Assistant Professor of Radiology, Radiology, Clinical Science Departments 2011 - 2017
- Medical Instructor in the Department of Radiology, Radiology, Clinical Science Departments 2010
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Leadership & Clinical Positions at Duke
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Bass Connections Team Leader - with Dr Christina Williams
REU mentor
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Bass Connections Team Leader - with Dr Christina Williams
- Recognition
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In the News
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NOV 2, 2021 Bass Connections
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- Research
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Selected Grants
- Brain networks in mouse models of aging awarded by National Institutes of Health 2019 - 2024
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2019 - 2024
- Cardiac photon counting CT and its application in studying interactions between Alzheimer's and heart disease awarded by National Institutes of Health 2021 - 2024
- The Duke Pre-Clinical Research Resources for Quantitative Imaging Biomarkers awarded by National Institutes of Health 2017 - 2022
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2021
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2020
- Gender and APOE genotype interact to alter immune regulated metabolism in AD awarded by National Institutes of Health 2017 - 2019
- Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
- Immune regulated amino acid pathways in Alzheimer's Disease awarded by National Institutes of Health 2016 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
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External Relationships
- Elsevier
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Mahzarnia, Ali, Jacques A. Stout, Robert J. Anderson, Hae Sol Moon, Zay Yar Han, Kate Beck, Jeffrey N. Browndyke, et al. “Identifying vulnerable brain networks associated with Alzheimer's disease risk.” Cereb Cortex, November 1, 2022. https://doi.org/10.1093/cercor/bhac419.Full Text Link to Item
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Moon, Hae Sol, Lindsay Heffron, Ali Mahzarnia, Barnabas Obeng-Gyasi, Matthew Holbrook, Cristian T. Badea, Wuwei Feng, and Alexandra Badea. “Automated multimodal segmentation of acute ischemic stroke lesions on clinical MR images.” Magn Reson Imaging 92 (October 2022): 45–57. https://doi.org/10.1016/j.mri.2022.06.001.Full Text Link to Item
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Badea, Alexandra, Didong Li, Andrei R. Niculescu, Robert J. Anderson, Jacques A. Stout, Christina L. Williams, Carol A. Colton, Nobuyo Maeda, and David B. Dunson. “Absolute Winding Number Differentiates Mouse Spatial Navigation Strategies With Genetic Risk for Alzheimer's Disease.” Front Neurosci 16 (2022): 848654. https://doi.org/10.3389/fnins.2022.848654.Full Text Link to Item
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Badea, Alexandra, Didong Li, Andrei R. Niculescu, Robert J. Anderson, Jacques A. Stout, Christina L. Williams, Carol A. Colton, Nobuyo Maeda, and David B. Dunson. “Corrigendum: Absolute winding number differentiates mouse spatial navigation strategies with genetic risk for Alzheimer's disease.” Front Neurosci 16 (2022): 1070425. https://doi.org/10.3389/fnins.2022.1070425.Full Text Link to Item
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Nair, K Saidas, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, et al. “GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.” Nat Commun 12, no. 1 (August 12, 2021): 4877. https://doi.org/10.1038/s41467-021-25181-7.Full Text Link to Item
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Bryan, Jordan, Arpita Mandan, Gauri Kamat, W Kirby Gottschalk, Alexandra Badea, Kendra J. Adams, J Will Thompson, et al. “Likelihood ratio statistics for gene set enrichment in Alzheimer's disease pathways.” Alzheimers Dement 17, no. 4 (April 2021): 561–73. https://doi.org/10.1002/alz.12223.Full Text Link to Item
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Badea, Alexandra, Robert Schmalzigaug, Woojoo Kim, Pamela Bonner, Umer Ahmed, G Allan Johnson, Gary Cofer, et al. “Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging.” Magn Reson Imaging 76 (February 2021): 26–38. https://doi.org/10.1016/j.mri.2020.09.023.Full Text Link to Item
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Zhuang, Jie, David J. Madden, Priscila Cunha, Alexandra Badea, Simon W. Davis, Guy G. Potter, Eleonora M. Lad, et al. “Cerebral white matter connectivity, cognition, and age-related macular degeneration.” Neuroimage Clin 30 (2021): 102594. https://doi.org/10.1016/j.nicl.2021.102594.Full Text Open Access Copy Link to Item
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Slosky, Lauren M., Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.” Cell 181, no. 6 (June 11, 2020): 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053.Full Text Link to Item
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Anderson, Robert J., Christopher M. Long, Evan D. Calabrese, Scott H. Robertson, G Allan Johnson, Gary P. Cofer, Richard J. O’Brien, and Alexandra Badea. “Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions.” Front Phys 8 (April 2020). https://doi.org/10.3389/fphy.2020.00088.Full Text Link to Item
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Holbrook, M. D., S. J. Blocker, Y. M. Mowery, A. Badea, Y. Qi, E. S. Xu, D. G. Kirsch, G. A. Johnson, and C. T. Badea. “MRI-Based Deep Learning Segmentation and Radiomics of Sarcoma in Mice.” Tomography 6, no. 1 (March 2020): 23–33. https://doi.org/10.18383/j.tom.2019.00021.Full Text Open Access Copy Link to Item
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Lorenzo, Damaris N., Alexandra Badea, Ruobo Zhou, Peter J. Mohler, Xiaowei Zhuang, and Vann Bennett. “βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.” Proc Natl Acad Sci U S A 116, no. 31 (July 30, 2019): 15686–95. https://doi.org/10.1073/pnas.1820649116.Full Text Link to Item
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Yang, Rui, Kathryn K. Walder-Christensen, Namsoo Kim, Danwei Wu, Damaris N. Lorenzo, Alexandra Badea, Yong-Hui Jiang, Henry H. Yin, William C. Wetsel, and Vann Bennett. “ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.” Proc Natl Acad Sci U S A 116, no. 30 (July 23, 2019): 15262–71. https://doi.org/10.1073/pnas.1904348116.Full Text Link to Item
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Anderson, Robert J., James J. Cook, Natalie Delpratt, John C. Nouls, Bin Gu, James O. McNamara, Brian B. Avants, G Allan Johnson, and Alexandra Badea. “Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework.” Neuroinformatics 17, no. 3 (July 2019): 451–72. https://doi.org/10.1007/s12021-018-9410-0.Full Text Link to Item
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Badea, Alexandra, Natalie A. Delpratt, R. J. Anderson, Russell Dibb, Yi Qi, Hongjiang Wei, Chunlei Liu, William C. Wetsel, Brian B. Avants, and Carol Colton. “Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.” Magn Reson Imaging 60 (July 2019): 52–67. https://doi.org/10.1016/j.mri.2019.03.022.Full Text Link to Item
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Tange, Runze, Michael Ketcha, Alexandra Badea, Evan D. Calabrese, Daniel S. Margulies, Joshua T. Vogelstein, Carey E. Priebe, and Daniel L. Sussman. “Connectome Smoothing via Low-Rank Approximations.” Ieee Trans Med Imaging 38, no. 6 (June 2019): 1446–56. https://doi.org/10.1109/TMI.2018.2885968.Full Text Link to Item
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Nouls, John C., Rohan S. Virgincar, Alexander G. Culbert, Nathann Morand, Dana W. Bobbert, Anne D. Yoder, Robert S. Schopler, et al. “Applications of 3D printing in small animal magnetic resonance imaging.” J Med Imaging (Bellingham) 6, no. 2 (April 2019): 021605. https://doi.org/10.1117/1.JMI.6.2.021605.Full Text Link to Item
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Badea, Alexandra, Kwan L. Ng, Robert J. Anderson, Jiangyang Zhang, Michael I. Miller, and Richard J. O’Brien. “Magnetic resonance imaging of mouse brain networks plasticity following motor learning.” Plos One 14, no. 5 (2019): e0216596. https://doi.org/10.1371/journal.pone.0216596.Full Text Link to Item
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Badea, Alexandra, Wenlin Wu, Jordan Shuff, Michele Wang, Robert J. Anderson, Yi Qi, G Allan Johnson, et al. “Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer's Disease.” Front Neuroinform 13 (2019): 72. https://doi.org/10.3389/fninf.2019.00072.Full Text Link to Item
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Wang, Nian, Robert J. Anderson, Alexandra Badea, Gary Cofer, Russell Dibb, Yi Qi, and G Allan Johnson. “Whole mouse brain structural connectomics using magnetic resonance histology.” Brain Struct Funct 223, no. 9 (December 2018): 4323–35. https://doi.org/10.1007/s00429-018-1750-x.Full Text Link to Item
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Nouls, John C., Alexandra Badea, Robert B. J. Anderson, Gary P. Cofer, and G. Allan Johnson. “Diffusion tensor imaging using multiple coils for mouse brain connectomics.” Nmr Biomed 31, no. 6 (June 2018): e3921. https://doi.org/10.1002/nbm.3921.Full Text Link to Item
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Badea, Alexandra, Alaa Kamnaksh, Robert J. Anderson, Evan Calabrese, Joseph B. Long, and Denes V. Agoston. “Repeated mild blast exposure in young adult rats results in dynamic and persistent microstructural changes in the brain.” Neuroimage Clin 18 (2018): 60–73. https://doi.org/10.1016/j.nicl.2018.01.007.Full Text Link to Item
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Graña, Gilberto David, Kendall A. Hutson, Alexandra Badea, Andrew Pappa, William Scott, and Douglas C. Fitzpatrick. “The organization of frequency and binaural cues in the gerbil inferior colliculus.” J Comp Neurol 525, no. 9 (June 15, 2017): 2050–74. https://doi.org/10.1002/cne.24155.Full Text Link to Item
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Anderson, Robert J., James J. Cook, Natalie A. Delpratt, John C. Nouls, Bin Gu, James O. McNamara, Brian B. Avants, G Allan Johnson, and Alexandra Badea. “An HPC Pipeline with Validation Framework for Small Animal Multivariate Brain Analysis (SAMBA).” Corr abs/1709.10483 (2017).
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Badea, Alexandra, Lauren Kane, Robert J. Anderson, Yi Qi, Mark Foster, Gary P. Cofer, Neil Medvitz, et al. “The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease.” Neuroimage 142 (November 15, 2016): 498–511. https://doi.org/10.1016/j.neuroimage.2016.08.014.Full Text Link to Item
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Bhagat, Srishti L., Sunny Qiu, Zachary F. Caffall, Yehong Wan, Yuanji Pan, Ramona M. Rodriguiz, William C. Wetsel, Alexandra Badea, Ute Hochgeschwender, and Nicole Calakos. “Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models.” Neurobiol Dis 93 (September 2016): 137–45. https://doi.org/10.1016/j.nbd.2016.05.003.Full Text Link to Item
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Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.” Nat Commun 7 (May 10, 2016): 11459. https://doi.org/10.1038/ncomms11459.Full Text Open Access Copy Link to Item
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Calabrese, Evan, Alexandra Badea, Gary Cofer, Yi Qi, and G Allan Johnson. “A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.” Cereb Cortex 25, no. 11 (November 2015): 4628–37. https://doi.org/10.1093/cercor/bhv121.Full Text Open Access Copy Link to Item
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Calabrese, Evan, Alexandra Badea, Christopher L. Coe, Gabriele R. Lubach, Yundi Shi, Martin A. Styner, and G Allan Johnson. “A diffusion tensor MRI atlas of the postmortem rhesus macaque brain.” Neuroimage 117 (August 15, 2015): 408–16. https://doi.org/10.1016/j.neuroimage.2015.05.072.Full Text Link to Item
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Borg, Jana Schaich, Mai-Anh Vu, Cristian Badea, Alexandra Badea, G Allan Johnson, and Kafui Dzirasa. “Localization of Metal Electrodes in the Intact Rat Brain Using Registration of 3D Microcomputed Tomography Images to a Magnetic Resonance Histology Atlas.” Eneuro 2, no. 4 (2015). https://doi.org/10.1523/ENEURO.0017-15.2015.Full Text Open Access Copy Link to Item
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Lorenzo, Damaris Nadia, Alexandra Badea, Jonathan Davis, Janell Hostettler, Jiang He, Guisheng Zhong, Xiaowei Zhuang, and Vann Bennett. “A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.” J Cell Biol 207, no. 6 (December 22, 2014): 735–52. https://doi.org/10.1083/jcb.201407063.Full Text Link to Item
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Calabrese, Evan, Alexandra Badea, Christopher L. Coe, Gabriele R. Lubach, Martin A. Styner, and G Allan Johnson. “Investigating the tradeoffs between spatial resolution and diffusion sampling for brain mapping with diffusion tractography: time well spent?” Hum Brain Mapp 35, no. 11 (November 2014): 5667–85. https://doi.org/10.1002/hbm.22578.Full Text Link to Item
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Johnson, G Allan, Evan Calabrese, Peter B. Little, Laurence Hedlund, Yi Qi, and Alexandra Badea. “Quantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology.” Neurotoxicology 42 (May 2014): 12–23. https://doi.org/10.1016/j.neuro.2014.02.009.Full Text Open Access Copy Link to Item
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Ashbrook, David G., Anna Delprato, Claudia Grellmann, Marieke Klein, Richard Wetzel, Rupert W. Overall, and Alexandra Badea. “Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus.” Front Neurosci 8 (2014): 418. https://doi.org/10.3389/fnins.2014.00418.Full Text Link to Item
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Clark, D., A. Badea, G. A. Johnson, and C. T. Badea. “Constructing a 4D murine cardiac micro-CT atlas for automated segmentation and phenotyping applications.” Progress in Biomedical Optics and Imaging Proceedings of Spie 8669 (June 3, 2013). https://doi.org/10.1117/12.2007043.Full Text
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Calabrese, Evan, Alexandra Badea, Charles Watson, and G Allan Johnson. “A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability.” Neuroimage 71 (May 1, 2013): 196–206. https://doi.org/10.1016/j.neuroimage.2013.01.017.Full Text Link to Item
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Badea, Alexandra, and G Allan Johnson. “Magnetic resonance microscopy.” Stud Health Technol Inform 185 (2013): 153–84.Link to Item
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Johnson, G Allan, Alexandra Badea, Evan Calabrese, Chunlei Liu, and Luke Xie. “Magnetic resonance histology: cool images- but who cares?” Toxicology Letters 221 (2013): S50–S50. https://doi.org/10.1016/j.toxlet.2013.06.183.Full Text Link to Item
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Badea, Alexandra, Sally Gewalt, Brian B. Avants, James J. Cook, and G Allan Johnson. “Quantitative mouse brain phenotyping based on single and multispectral MR protocols.” Neuroimage 63, no. 3 (November 15, 2012): 1633–45. https://doi.org/10.1016/j.neuroimage.2012.07.021.Full Text Link to Item
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Clark, Darin, Alexandra Badea, Yilin Liu, G Allan Johnson, and Cristian T. Badea. “Registration-based segmentation of murine 4D cardiac micro-CT data using symmetric normalization.” Phys Med Biol 57, no. 19 (October 7, 2012): 6125–45. https://doi.org/10.1088/0031-9155/57/19/6125.Full Text Link to Item
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Driehuys, B., J. Nouls, A. Badea, E. Bucholz, K. Ghaghada, A. Petiet, and L. W. Hedlund. “Small animal imaging with magnetic resonance microscopy.” Ilar Journal 53, no. 1 (September 11, 2012): 35–53.
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Johnson, G Allan, Evan Calabrese, Alexandra Badea, George Paxinos, and Charles Watson. “A multidimensional magnetic resonance histology atlas of the Wistar rat brain.” Neuroimage 62, no. 3 (September 2012): 1848–56. https://doi.org/10.1016/j.neuroimage.2012.05.041.Full Text Link to Item
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Wu, Teresa, Min Hyeok Bae, Min Zhang, Rong Pan, and Alexandra Badea. “A prior feature SVM-MRF based method for mouse brain segmentation.” Neuroimage 59, no. 3 (February 1, 2012): 2298–2306. https://doi.org/10.1016/j.neuroimage.2011.09.053.Full Text Link to Item
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Badea, Alexandra, and G Allan Johnson. “Magnetic resonance microscopy.” Anal Cell Pathol (Amst) 35, no. 4 (2012): 205–27. https://doi.org/10.3233/ACP-2011-0050.Full Text Open Access Copy Link to Item
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Poot, Martin, Alexandra Badea, Robert W. Williams, and Martien J. Kas. “Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes.” Plos One 6, no. 5 (May 4, 2011): e18612. https://doi.org/10.1371/journal.pone.0018612.Full Text Link to Item
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Bowden, Douglas M., G Allan Johnson, Laszlo Zaborsky, William D. K. Green, Eider Moore, Alexandra Badea, Mark F. Dubach, and Fred L. Bookstein. “A symmetrical Waxholm canonical mouse brain for NeuroMaps.” J Neurosci Methods 195, no. 2 (February 15, 2011): 170–75. https://doi.org/10.1016/j.jneumeth.2010.11.028.Full Text Link to Item
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Johnson, G Allan, Alexandra Badea, and Yi Jiang. “Quantitative neuromorphometry using magnetic resonance histology.” Toxicol Pathol 39, no. 1 (January 2011): 85–91. https://doi.org/10.1177/0192623310389622.Full Text Link to Item
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Johnson, G Allan, Alexandra Badea, Jeffrey Brandenburg, Gary Cofer, Boma Fubara, Song Liu, and Jonathan Nissanov. “Waxholm space: an image-based reference for coordinating mouse brain research.” Neuroimage 53, no. 2 (November 1, 2010): 365–72. https://doi.org/10.1016/j.neuroimage.2010.06.067.Full Text Link to Item
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Badea, Alexandra, G Allan Johnson, and Joanna L. Jankowsky. “Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease.” Neuroimage 50, no. 2 (April 1, 2010): 416–27. https://doi.org/10.1016/j.neuroimage.2009.12.070.Full Text Link to Item
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Badea, Alexandra, G Allan Johnson, and Robert W. Williams. “Genetic dissection of the mouse CNS using magnetic resonance microscopy.” Curr Opin Neurol 22, no. 4 (August 2009): 379–86. https://doi.org/10.1097/WCO.0b013e32832d9b86.Full Text Link to Item
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Bae, Min Hyeok, Rong Pan, Teresa Wu, and Alexandra Badea. “Automated segmentation of mouse brain images using extended MRF.” Neuroimage 46, no. 3 (July 1, 2009): 717–25. https://doi.org/10.1016/j.neuroimage.2009.02.012.Full Text Link to Item
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Badea, A., G. A. Johnson, and R. W. Williams. “Genetic dissection of the mouse brain using high-field magnetic resonance microscopy.” Neuroimage 45, no. 4 (May 1, 2009): 1067–79. https://doi.org/10.1016/j.neuroimage.2009.01.021.Full Text Link to Item
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Johnson, Allan G., Alexandra Badea, J. Brandenberg, Pablo Burstein, Carl Gustafson, S. Liu, and Jonathan Nissanov. “Waxholm Space: Target Volumes for a Standard Coordinate System for the Mouse Brain.” Frontiers in Neuroinformatics 3 (2009). https://doi.org/10.3389/conf.neuro.11.2009.08.004.Full Text
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Driehuys, Bastiaan, John Nouls, Alexandra Badea, Elizabeth Bucholz, Ketan Ghaghada, Alexandra Petiet, and Laurence W. Hedlund. “Small animal imaging with magnetic resonance microscopy.” Ilar J 49, no. 1 (2008): 35–53. https://doi.org/10.1093/ilar.49.1.35.Full Text Link to Item
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Sharief, Anjum A., Alexandra Badea, Anders M. Dale, and G Allan Johnson. “Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy.” Neuroimage 39, no. 1 (January 1, 2008): 136–45. https://doi.org/10.1016/j.neuroimage.2007.08.028.Full Text Link to Item
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Badea, A., A. A. Ali-Sharief, and G. A. Johnson. “Morphometric analysis of the C57BL/6J mouse brain.” Neuroimage 37, no. 3 (September 1, 2007): 683–93. https://doi.org/10.1016/j.neuroimage.2007.05.046.Full Text Link to Item
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Johnson, G Allan, Anjum Ali-Sharief, Alexandra Badea, Jeffrey Brandenburg, Gary Cofer, Boma Fubara, Sally Gewalt, Laurence W. Hedlund, and Lucy Upchurch. “High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology.” Neuroimage 37, no. 1 (August 1, 2007): 82–89. https://doi.org/10.1016/j.neuroimage.2007.05.013.Full Text Link to Item
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Badea, Alexandra, Peter J. Nicholls, G Allan Johnson, and William C. Wetsel. “Neuroanatomical phenotypes in the reeler mouse.” Neuroimage 34, no. 4 (February 15, 2007): 1363–74. https://doi.org/10.1016/j.neuroimage.2006.09.053.Full Text Link to Item
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Ali, Anjum A., Anders M. Dale, Alexandra Badea, and G Allan Johnson. “Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain.” Neuroimage 27, no. 2 (August 15, 2005): 425–35. https://doi.org/10.1016/j.neuroimage.2005.04.017.Full Text Link to Item
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Badea, Alexandra, George K. Kostopoulos, and Andreas A. Ioannides. “Surface visualization of electromagnetic brain activity.” J Neurosci Methods 127, no. 2 (August 15, 2003): 137–47. https://doi.org/10.1016/s0165-0270(03)00100-6.Full Text Link to Item
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Conference Papers
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Allphin, A. J., D. P. Clark, A. Badea, and C. T. Badea. “Anatomical and functional cardiac PCCT imaging pipeline for characterization of Apolipoprotein E mouse models.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 12036, 2022. https://doi.org/10.1117/12.2611806.Full Text
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Holbrook, M. D., S. J. Blocker, Y. Mowery, A. Badea, Y. Qi, D. G. Kirsch, and C. T. Badea. “MRI-based radiomics of sarcomas in the preclinical arm of a Co-clinical trial.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 11317, 2020. https://doi.org/10.1117/12.2549628.Full Text
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Nair, Saidas, Chitrangda Srivastava, Swanand Koli, Hong Soon Kang, Yien-Ming Kuo, Helene Choquet, Alexandra Badea, Eric Jorgenson, and Anton Jetten. “Kruppel-like zinc finger transcription factor GLIS1 regulates intraocular pressure by maintaining trabecular meshwork function.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.Link to Item
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Johnson, G. A., R. J. Anderson, J. J. Cook, C. Long, and A. Badea. “Image-processing pipelines: Applications in magnetic resonance histology.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 9784, 2016. https://doi.org/10.1117/12.2203525.Full Text
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Lorenzo, D. N., A. Badea, G. Johnson, and V. Bennett. “An ankyrin-B/beta-2 spectrin-based mechanism regulates axonal organelle transport and axonal growth.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.Link to Item
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Lorenzo, D. N., A. Badea, J. Davis, J. D. Hostettler, J. He, G. Zhong, X. Zhuang, and V. Bennett. “A PIK3C3/Ankyrin-B/Dynactin pathway promotes axonal growth and multi-organelle transport.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.Link to Item
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Johnson, G Allan, Alexandra Badea, Evan Calabrese, Chunlei Liu, and Luke Xie. “Magnetic resonance histology—Applications in toxicology.” In Toxicology Letters, 229:S31–32. Elsevier BV, 2014. https://doi.org/10.1016/j.toxlet.2014.06.148.Full Text
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Bowsher, J. E., H. Yuan, L. W. Hedlund, T. G. Turkington, G. Akabani, A. Badea, W. C. Kurylo, et al. “Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors.” In Ieee Nuclear Science Symposium Conference Record, 4:2488–92, 2004.
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Preprints
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Stout, Jacques A., Rui Dai, Robert J. Anderson, Scott Cousins, Jie Zhuang, Eleonora M. Lad, Diane Whitaker, et al. “Age-related Macular Degeneration is associated with faster rates of structural brain changes and widespread differences in connectivity.” Cold Spring Harbor Laboratory, July 20, 2022. https://doi.org/10.1101/2022.07.19.500546.Full Text
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Badea, Alexandra, Didong Li, Andrei R. Niculescu, Robert J. Anderson, Jacques A. Stout, Christina L. Williams, Carol A. Colton, Nobuyo Maeda, and David B. Dunson. “Absolute Winding Number Differentiates Spatial Navigation Strategies with Genetic Risk for Alzheimer's Disease.” Cold Spring Harbor Laboratory, February 8, 2022. https://doi.org/10.1101/2022.02.04.479128.Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 494: Projects in Biomedical Engineering (GE) 2023
- BME 791: Graduate Independent Study 2023
- BRAINSOC 395T: Bass Connections in Brain & Society Research Team 2023
- BRAINSOC 396T: Bass Connections in Brain & Society Research Team 2023
- BRAINSOC 397T: Bass Connections in Brain & Society Research Team 2023
- BRAINSOC 398T: Bass Connections in Brain & Society Research Team 2023
- BRAINSOC 795T: Bass Connections in Brain & Society Research Team 2023
- BRAINSOC 796T: Bass Connections in Brain & Society Research Team 2023
- BME 493: Projects in Biomedical Engineering (GE) 2022
- BME 494: Projects in Biomedical Engineering (GE) 2022
- BRAINSOC 395-1: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2022
- BRAINSOC 395: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2022
- BRAINSOC 395T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 396-1: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2022
- BRAINSOC 396T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 397-1: Bass Connections in Brain and Society 3: Interdisciplinary Team Projects 2022
- BRAINSOC 397T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 398-1: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2022
- BRAINSOC 398: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2022
- BRAINSOC 398T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 795T: Bass Connections in Brain & Society Research Team 2022
- BRAINSOC 796T: Bass Connections in Brain & Society Research Team 2022
- EGR 393: Research Projects in Engineering 2022
- NEUROSCI 494: Research Independent Study 2 2022
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 494: Projects in Biomedical Engineering (GE) 2021
- BRAINSOC 395-1: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2021
- BRAINSOC 395: Bass Connections in Brain and Society: Interdisciplinary Team Projects 2021
- BRAINSOC 395T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 396-1: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2021
- BRAINSOC 396: Bass Connections in Brain and Society 2: Interdisciplinary Team Projects 2021
- BRAINSOC 396T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 397-1: Bass Connections in Brain and Society 3: Interdisciplinary Team Projects 2021
- BRAINSOC 397: Bass Connections in Brain and Society 3: Interdisciplinary Team Projects 2021
- BRAINSOC 397T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 398-1: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2021
- BRAINSOC 398: Bass Connections in Brain and Society 4: Interdisciplinary Team Projects 2021
- BRAINSOC 398T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 795T: Bass Connections in Brain & Society Research Team 2021
- BRAINSOC 796T: Bass Connections in Brain & Society Research Team 2021
- MEDPHY 791: Independent Study in Medical Physics 2021
- NEUROSCI 493: Research Independent Study 1 2021
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Teaching Activities
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NEUROSCI Research Independent Study
NEUROSCI 493
NEUROSCI 494
NEUROSCI 495
NEUROSCI 496
BME 393
BME 394
ECE 898
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- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
- Bass Connections Team Leader. Alzheimer's Disease: Exercise Therapy and Brain Networks. 2021 - 2023 2021 - 2023
- Bass Connections Team Leader. Exercise Therapy and Brain Networks: Implications for Alzheimer's Disease. 2020 - 2021 2020 - 2021
- Bass Connections Team Leader. Exercise Therapy and Brain Networks: Implications for Alzheimer's Disease. 2019 - 2020 2019 - 2020
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