Alexandra Stefanovic | Scholars@Duke

Alexandra Stefanovic
Associate Professor of Medicine

I am convinced that caring for patients with malignant hematologic diseases requires not only up-to-date medical knowledge, but also an understanding of the individual patient's needs and circumstances. I encourage patients to take an active role in their treatment and recovery and I work with them to develop an individualized treatment plan that includes the most advanced therapies available today. My practice focuses primarily on disorders of the lymphatic system (Hodgkin and non-Hodgkin lymphoma and chronic lymphocytic leukemia). As an integral part of my clinical activities, I am dedicated to teaching young physicians at all levels of training and educating the next generation of hematologists.

Current Research Interests

My research focuses on lymphomas and related disorders through clinical trials and collaborative research projects. It is my goal to provide patients, whenever possible, access to carefully selected clinical trials with novel therapies that may help them live longer or improve their quality of life.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2021

Contact Information

Box 3961 Med Ctr, Durham, NC 27710
Hematologic Malignancies, Suite 5000, Durham, NC 27705
alexandra.stefanovic@duke.edu (919) 668-1000
Duke Health Profile
Duke Medicine Profile

Background
Education, Training, & Certifications
- Fellowship in Hematology/Oncology, Jackson Memorial Hospital 2005 - 2008
- Internal Medicine Residency, Western Pennsylvania Hospital 2002 - 2005
- M.D., University of Cologne, Faculty of Medicine (Germany) 1999
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2018 - 2020
- Instructor in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017 - 2018
Academic Positions Outside Duke
- Assistant Professor of Medicine, University of Miami. 2008 - 2017
Expertise
Subject Headings
Global Scholarship
- Expertise
  - Germany (Country)
  - United States of America (Country)
- Research
  - United States of America (Country)
- Teaching
  - United States of America (Country)
Research
External Relationships
- Curio Science LLC
- Envision Communications
- J Reckner Associates, Inc.
- MJH Healthcare holdings
- Putnam Associates LLC
- Sermo
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Alderuccio, Juan Pablo, Luca Arcaini, Marcus P. Watkins, Anne W. Beaven, Geoffrey Shouse, Narendranath Epperla, Michele Spina, et al. “An international analysis evaluating frontline bendamustine with rituximab in extranodal marginal zone lymphoma.” Blood Adv 6, no. 7 (April 12, 2022): 2035–44. https://doi.org/10.1182/bloodadvances.2021006844.
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  - Wonnaparhown, Alex, Alexandra Stefanovic, Patricia Lugar, and Haley P. Hostetler. “Acquired angioedema in B cell lymphoproliferative disease: A retrospective case series.” Clin Exp Immunol 206, no. 3 (December 2021): 378–83. https://doi.org/10.1111/cei.13667.
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  - Go, Ronald S., Eric Jacobsen, Robert Baiocchi, Ilia Buhtoiarov, Erin B. Butler, Patrick K. Campbell, Don W. Coulter, et al. “Histiocytic Neoplasms, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.” J Natl Compr Canc Netw 19, no. 11 (November 2021): 1277–1303. https://doi.org/10.6004/jnccn.2021.0053.
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  - Sung, Anthony D., Shekeab Jauhari, Sharareh Siamakpour-Reihani, Arati V. Rao, Janet Staats, Cliburn Chan, Everett Meyer, et al. “Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects.” Am J Hematol 95, no. 6 (June 2020): 662–71. https://doi.org/10.1002/ajh.25781.
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  - Kelsey, Chris R., Endi Wang, Alexandra Stefanovic, and Meenal Kheterpal. “Radiation therapy for primary cutaneous γδ T-cell lymphoma: Case report and literature review.” Jaad Case Rep 5, no. 7 (July 2019): 582–86. https://doi.org/10.1016/j.jdcr.2019.05.002.
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  - Lee, Jessica W., Leonard R. Prosnitz, Alexandra Stefanovic, and Chris R. Kelsey. “Are Higher Doses of Consolidation Radiation Therapy Necessary in Diffuse Large B-cell Lymphoma Involving Osseous Sites?” Adv Radiat Oncol 4, no. 3 (July 2019): 507–12. https://doi.org/10.1016/j.adro.2019.03.010.
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  - Kelly, Kevin R., Jonathan W. Friedberg, Steven I. Park, Kevin McDonagh, John Hayslip, Daniel Persky, Jia Ruan, et al. “Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma.” Clin Cancer Res 24, no. 24 (December 15, 2018): 6150–59. https://doi.org/10.1158/1078-0432.CCR-18-0286.
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  - Alderuccio, Juan Pablo, Alexandra Stefanovic, Daniel Dammrich, Jennifer R. Chapman, Francisco Vega, Gennaro Selvaggi, Andreas Tzakis, and Izidore S. Lossos. “Decreased survival in hepatitis C patients with monomorphic post-transplant lymphoproliferative disorder after liver transplantation treated with frontline immunochemotherapy.” Leuk Lymphoma 59, no. 9 (September 2018): 2096–2104. https://doi.org/10.1080/10428194.2017.1413187.
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  - Dejman, Adriana, Seyed Navid Alavi, David B. Thomas, Alexandra Stefanovic, Arif Asif, and Ali Nayer. “The potential role of complements in cocaine-induced thrombotic microangiopathy.” Clin Kidney J 11, no. 1 (February 2018): 26–28. https://doi.org/10.1093/ckj/sfx061.
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  - Hosein, Peter J., Jose D. Sandoval-Sus, Deborah Goodman, Alexandra Gomez Arteaga, Isildinha Reis, James Hoffman, Alexandra Stefanovic, Joseph D. Rosenblatt, and Izidore S. Lossos. “Updated survival analysis of two sequential prospective trials of R-MACLO-IVAM followed by maintenance for newly diagnosed mantle cell lymphoma.” Am J Hematol 90, no. 6 (June 2015): E111–16. https://doi.org/10.1002/ajh.23996.
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  - Lossos, Izidore S., Jesus C. Fabregas, Tulay Koru-Sengul, Feng Miao, Deborah Goodman, Aldo N. Serafini, Peter J. Hosein, Alexandra Stefanovic, Joseph D. Rosenblatt, and James E. Hoffman. “Phase II study of (90)Y Ibritumomab tiuxetan (Zevalin) in patients with previously untreated marginal zone lymphoma.” Leuk Lymphoma 56, no. 6 (June 2015): 1750–55. https://doi.org/10.3109/10428194.2014.975801.
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  - Talebi, Tony N., Alexandra Stefanovic, Jaime Merchan, Eric Lian, and Orlando Silva. “Sunitinib-induced microangiopathic hemolytic anemia with fatal outcome.” Am J Ther 19, no. 4 (July 2012): e143–45. https://doi.org/10.1097/MJT.0b013e3181eefe8b.
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  - Joo, Sun Hyung, Zeki Acun, Alexandra Stefanovic, Clifford R. Blieden, Offiong F. Ikpatt, and Jang Moon. “Post-transplant lymphoproliferative disorder presented as small bowel intussusception in adult liver transplant patient.” J Korean Surg Soc 82, no. 1 (January 2012): 50–53. https://doi.org/10.4174/jkss.2012.82.1.50.
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  - Talebi, Tony, Gustavo Fernandez-Castro, Alberto J. Montero, Alexandra Stefanovic, and Eric Lian. “A case of severe thrombotic thrombocytopenic purpura with concomitant Legionella pneumonia: review of pathogenesis and treatment.” Am J Ther 18, no. 5 (September 2011): e180–85. https://doi.org/10.1097/MJT.0b013e3181d1b4a1.
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  - Bayraktar, Soley, Ulas D. Bayraktar, Alexandra Stefanovic, and Izidore S. Lossos. “Primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT): single institution experience in a large cohort of patients.” Br J Haematol 152, no. 1 (January 2011): 72–80. https://doi.org/10.1111/j.1365-2141.2010.08429.x.
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  - Bayraktar, Soley, Ulas D. Bayraktar, Juan C. Ramos, Alexandra Stefanovic, and Izidore S. Lossos. “Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors.” J Neurooncol 101, no. 2 (January 2011): 257–65. https://doi.org/10.1007/s11060-010-0252-3.
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  - Hansra, Damien, Naomi Montague, Alexandra Stefanovic, Ikechukwu Akunyili, Arash Harzand, Yasodha Natkunam, Margarita de la Ossa, Gerald E. Byrne, and Izidore S. Lossos. “Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics.” Am J Clin Pathol 134, no. 5 (November 2010): 710–19. https://doi.org/10.1309/AJCPJH6KEUSECQLU.
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  - Bayraktar, Soley, Alexandra Stefanovic, Naomi Montague, Janet Davis, Timothy Murray, and Izidore S. Lossos. “Central nervous system manifestations of marginal zone B-cell lymphoma.” Ann Hematol 89, no. 10 (October 2010): 1003–9. https://doi.org/10.1007/s00277-010-0976-3.
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  - Stefanovic, Alexandra, Janet Davis, Timothy Murray, Arnold Markoe, and Izidore S. Lossos. “Treatment of isolated primary intraocular lymphoma with high-dose methotrexate-based chemotherapy and binocular radiation therapy: a single-institution experience.” Br J Haematol 151, no. 1 (October 2010): 103–6. https://doi.org/10.1111/j.1365-2141.2010.08321.x.
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  - Stefanovic, Alexandra, and Izidore S. Lossos. “Primary testicular lymphoma: the site matters.” Leuk Lymphoma 51, no. 7 (July 2010): 1159–60. https://doi.org/10.3109/10428194.2010.481067.
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  - Stefanovic, Alexandra, and Izidore S. Lossos. “Rare PTCLs: treatment lagging behind pathobiologic advances.” Oncology (Williston Park) 24, no. 1 (January 2010): 101–2.
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  - Stefanovic, Alexandra, and Izidore S. Lossos. “Extranodal marginal zone lymphoma of the ocular adnexa.” Blood 114, no. 3 (July 16, 2009): 501–10. https://doi.org/10.1182/blood-2008-12-195453.
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  - Escalón, M. P., A. Stefanovic, A. Venkatraman, D. Pereira, E. S. Santos, M. Goodman, J. J. Byrnes, and H. F. Fernandez. “Autologous transplantation for relapsed non-Hodgkin's lymphoma using intravenous busulfan and cyclophosphamide as conditioning regimen: a single center experience.” Bone Marrow Transplant 44, no. 2 (July 2009): 89–96. https://doi.org/10.1038/bmt.2008.429.
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  - Kalkanis, Dimitrios, Alexandra Stefanovic, Fabio Paes, Maricer P. Escalon, Aldo Serafini, and Izidore S. Lossos. “[18F]-fluorodeoxyglucose positron emission tomography combined with computed tomography detection of asymptomatic late pulmonary toxicity in patients with non-Hodgkin lymphoma treated with rituximab-containing chemotherapy.” Leuk Lymphoma 50, no. 6 (June 2009): 904–11. https://doi.org/10.1080/10428190902919200.
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  - Stefanovic, A., and I. S. Lossos. “Response: Variability in the prevalence of Chlamydophila psittaci infection in patients with OAML.” Blood 114, no. 16 (January 1, 2009): 3499–3500. https://doi.org/10.1182/blood-2009-08-235929.
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  - Stefanovic, Alexandra, Daniel Morgensztern, Thomas Fong, and Izidore S. Lossos. “Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database.” Leuk Lymphoma 49, no. 7 (July 2008): 1311–20. https://doi.org/10.1080/10428190802064933.
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  - Baldus, S. E., C. Wickenhauser, E. Dittmar, A. Stefanovic, and J. Thiele. “Visualization of carbohydrate-binding molecules expressed by myelomono- and erythropoietic cells derived from human bone marrow: an immunoenzymatic double-staining study.” Histochem J 32, no. 1 (January 2000): 27–32. https://doi.org/10.1023/a:1003954111600.
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  - Baldus, S. E., C. Wickenhauser, A. Stefanovic, B. Schmitz, J. Thiele, and R. Fischer. “Enrichment of human bone marrow mononuclear phagocytes and characterization of macrophage subpopulations by immunoenzymatic double staining.” Histochem J 30, no. 4 (April 1998): 285–91. https://doi.org/10.1023/a:1003268008228.
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- Conference Papers
  - Alderuccio, Juan Pablo, Anne W. Beaven, Geoffrey Shouse, Narendranath Epperla, Alexandra Stefanovic, Pallawi Torka, Jorge J. Castillo, et al. “Frontline Bendamustine and Rituximab in Extranodal Marginal Zone Lymphoma: An International Analysis.” In Blood, 136:2–3. American Society of Hematology, 2020. https://doi.org/10.1182/blood-2020-137620.
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  - Saul, Eduardo Edelman, Amrita Desai, Jennifer Chapman, Lazaros J. Lekakis, Alexandra Stefanovic, and Agustin Pimentel. “Adult lymphoma-associated hemophagocytic lymphohistiocytosis: A clinical case series in a predominantly Hispanic cohort from the University of Miami/Jackson Memorial Hospital.” In Journal of Clinical Oncology, Vol. 38, 2020.
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  - Alderuccio, Juan, Alexandra Stefanovic, Daniel Dammrich, Jennifer Chapman, Francisco Vega, Andreas Tzakis, and Izidore Lossos. “Single-Center Experience of Post-Transplant Lymphoproliferative Disorder after Liver Transplantation Treated with Immunochemotherapy.” In Clinical Lymphoma Myeloma and Leukemia, 17:S368–S368. Elsevier BV, 2017. https://doi.org/10.1016/j.clml.2017.07.206.
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  - Fabregas, Jesus C., James E. Hoffman, Tulay Koru-Sengul, Miao Feng, Deborah Goodman, Aldo Serafini, Peter J. Hosein, Alexandra Stefanovic, Joseph D. Rosenblatt, and Izidore S. Lossos. “Phase II study of (90)y Ibritumomab Tiuxetan (Zevalin) in Patients with Previously Untreated Marginal Zone Lymphoma.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.
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  - Deutsch, Yehuda E., Daniel J. Dammrich, Jesus C. Fabregas, Agustin Pimentel, Alexandra Stefanovic, and James E. Hoffman. “Clinical Experience Of Lenalidomide Plus Low Dose Dexamethasone As First-Line Therapy For Multiple Myeloma At a Large County Hospital Caring For An Indigent Population.” In Blood, 122:5399–5399. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.5399.5399.
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  - Kelly, Kevin R., Daniel O. Persky, Daruka Mahadevan, Thomas P. Miller, Soham D. Puvvada, Kevin McDonagh, John Hayslip, et al. “Phase 1 Study Of Investigational Agent MLN8237 (Alisertib) + Rituximab ± Vincristine In Patients (Pts) With Relapsed/Refractory (Rel/Ref) Aggressive B-Cell Lymphomas.” In Blood, 122:3027–3027. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.3027.3027.
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  - Sandoval-Sus, Jose D., Peter J. Hosein, Deborah Goodman, Alexandra Stefanovic, Joseph D. Rosenblatt, and Izidore S. Lossos. “Updated Analysis of a Prospective Phase II Trial of R-MACLO-IVAM Followed by Maintenance for Mantle Cell Lymphoma.” In Blood, 120:1622–1622. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.1622.1622.
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  - Stefanovic, Alexandra, Daniel Dammrich, Andreas Tzakis, and Izidore S. Lossos. “Post-Transplant Lymphoproliferative Disease In Liver Transplant Recipients: A Single Institution Experience.” In Blood, 116:731–731. AMER SOC HEMATOLOGY, 2010.
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  - Bayraktar, S., U. D. Bayraktar, A. Stefanovic, and I. S. Lossos. “Primary CNS lymphoma in HIV-positive and -negative patients: Comparison of clinical characteristics, outcome, and prognostic factors.” In Journal of Clinical Oncology, 28:e12502–e12502. American Society of Clinical Oncology (ASCO), 2010. https://doi.org/10.1200/jco.2010.28.15_suppl.e12502.
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  - Stefanovic, A., D. M. Hansra, N. Montague, I. Akunyili, A. Harzand, Y. Natkunam, M. de la Ossa, G. E. Byrne, and I. S. Lossos. “Oral and extraoral plasmablastic lymphoma: Similarities and differences in clinicopathological characteristics.” In Journal of Clinical Oncology, 28:e18539–e18539. American Society of Clinical Oncology (ASCO), 2010. https://doi.org/10.1200/jco.2010.28.15_suppl.e18539.
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  - Stefanovic, A., D. Morgensztern, T. H. Fong, and I. S. Lossos. “Pulmonary marginal zone lymphoma: A single center experience and review of the SEER database.” In Journal of Clinical Oncology, 26:19508–19508. American Society of Clinical Oncology (ASCO), 2008. https://doi.org/10.1200/jco.2008.26.15_suppl.19508.
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  - Stefanovic, A., M. P. Escalon, D. L. Pereira, E. S. Santos, M. Goodman, J. J. Byrnes, and H. F. Fernandez. “Autologous transplantation for relapsed non-Hodgkin lymphoma using intravenous busulfan and cyclophosphamide as conditioning regimen: A single center experience.” In Journal of Clinical Oncology, Vol. 25. AMER SOC CLINICAL ONCOLOGY, 2007.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Academic Positions Outside Duke

Subject Headings

Global Scholarship

Expertise

Research

Teaching

External Relationships

Selected Publications

Academic Articles

Conference Papers