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Alexandra Thomas

Professor of Medicine
Medicine, Medical Oncology
40 Duke Medicine Circle, Clinic 2-2, Durham, NC 27710
40 Duke Medicine Circle, Clinic 2-2, Durham, NC 27710

Current Appointments & Affiliations


Professor of Medicine · 2024 - Present Medicine, Medical Oncology, Medicine
Member of the Duke Cancer Institute · 2024 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published March 10, 2025
Targeted Therapies Improve Outcomes for Some Breast Cancers

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Recent Publications


Evolving incidence patterns for locally advanced operable breast cancer by receptor status: SEER 2010-2021.

Journal Article NPJ Breast Cancer · November 13, 2025 Tumor biologic risk has replaced anatomic disease burden for guiding chemotherapy use in HR-positive, early-stage breast cancer. Recent surgical trials support less frequent axillary lymph node dissection, potentially impacting incidence of N2-3 diagnoses. ... Full text Link to item Cite

Multi-receptor targeted therapy of breast cancer and brain metastases with a novel QUAD-drug conjugate.

Journal Article Breast Cancer Res · October 27, 2025 BACKGROUND: Identifying treatments for triple-negative breast cancer (TNBC) remains a critical medical need. We have found that Interleukin 13 receptor alpha 2 (IL-13RA2), EphA2, EphA3 and EphB2 receptors are over-expressed collectively in majority of pati ... Full text Link to item Cite
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Recent Grants


A Pragmatic Phase II Trial of Chemotherapy +/- Tocilizumab for Metastatic Triple Negative and ER-low Breast Cancers

Clinical TrialPrincipal Investigator · Awarded by Indiana University · 2025 - 2030

I-SPY 2 Trial: Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis 2

Clinical TrialPrincipal Investigator · Awarded by Quantum Leap Healthcare Collaborative · 2025 - 2030

A single shot therapy will accelerate the elimination of breast cancer

ResearchResearch Professional · Awarded by United States Army Medical Research Acquisition Activity · 2024 - 2028

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Education, Training & Certifications


Johns Hopkins University, School of Medicine · 1995 M.D.