Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Yale University School of Medicine 1999
  • Ph.D., Yale University 1999
• 

  Duke Appointment History

  • Associate Director of the Center for Cognitive Neuroscience, Center for Cognitive Neuroscience, Duke Institute for Brain Sciences 2015 - 2018
  • Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2007 - 2017
  • Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2008 - 2017
  • Assistant Professor in the Department of Psychology & Neuroscience, Psychology and Neuroscience, Trinity College of Arts & Sciences 2011 - 2017
• Recognition
• 

  In the News

  • AUG 17, 2018

    Duke Institute for Brain Sciences

    Adcock to Direct Center for Cognitive Neuroscience

  • MAR 4, 2016

    NPR

    Could you hack your brain to get more motivated?

  • MAR 2, 2016

    Self-Motivation Can Help Tune Your Brain

  • JUN 26, 2015

    Allen Song Named Interim Director of Brain Institute

  • OCT 29, 2013

    WUNC Radio

    How a sugar pill can treat mental illness
• 

  Awards & Honors

  • Sloan Research Fellowship-Neuroscience. Alfred P. Sloan Foundation. 2008
• Research
• 

  Selected Grants

  • Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
  • Longitudinal Investigation of the Neurobiological Underpinnings of Risk Behavior in ADHD throughout the Adolescent Transition: The Key Role of Cognitive Control and Motivation Network Development awarded by University of North Carolina - Chapel Hill 2019 - 2024
  • Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
  • Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • Targeting reward dysfunction as a mechanism to improve smoking cessation awarded by National Institutes of Health 2016 - 2021
  • Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD) awarded by National Institutes of Health 2017 - 2020
  • Modeling the Neurobehavioral Basis of Extrinsic and Volitional Motivation in ADHD awarded by National Institutes of Health 2017 - 2020
  • Modeling the Neurobehavioral Basis of Extrinsic and Volitional Motivation in ADHD awarded by National Institutes of Health 2017 - 2020
  • Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use awarded by National Institutes of Health 2014 - 2020
  • Increasing Motivation in ADHD Via Self-activation of VTA awarded by National Institutes of Health 2016 - 2020
  • Characterizing Neural Mechanisms of Cognitive Control awarded by National Institutes of Health 2010 - 2019
  • Instructed Activation of the Human Dopaminergic Midbrain Using Real-Time fMRI in Nicotine-Dependent Individuals 2016 - 2019
  • Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
  • Connectivity of the Dopaminergic Midbrain During Learned Regulation of Intrinsic Motivation awarded by Canadian Institutes of Health Research 2014 - 2017
  • BRAIN EAGER: Bayesian Models of Translational Neural Networks: Motivation and Reward awarded by  National Science Foundation 2014 - 2017
  • Acute and chronic nicotine modulation of reinforcement learning awarded by National Institutes of Health 2013 - 2017
  • A Compute Cluster for Brain Imaging and Analysis awarded by National Institutes of Health 2016 - 2017
  • Motivated Memory as Therapeutic Target awarded by National Institutes of Health 2011 - 2017
  • Instructed Activation of the Human Dopaminergic Midbrain using Real-Time fMRI awarded by National Institutes of Health 2014 - 2016
  • Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
  • Brain Imaging Studies of Negative Reinforcement in Humans awarded by National Institutes of Health 2009 - 2015
  • From Phenotype to Mechanism: Mapping the Pathways underlying Risky Choice awarded by National Institutes of Health 2009 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Duffy, Korrina A., Bruce Luber, R Alison Adcock, and Tanya L. Chartrand. “Enhancing activation in the right temporoparietal junction using theta-burst stimulation: Disambiguating between two hypotheses of top-down control of behavioral mimicry..” Plos One 14, no. 1 (2019). https://doi.org/10.1371/journal.pone.0211279.
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    • Wang, Chenhao, Jimmy Lee, New Fei Ho, Joseph K. W. Lim, Joann S. Poh, Gurpreet Rekhi, Ranga Krishnan, et al. “Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study..” Cereb Cortex 28, no. 12 (December 1, 2018): 4234–43. https://doi.org/10.1093/cercor/bhx278.
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    • Chiew, Kimberly S., Jordan Hashemi, Lee K. Gans, Laura Lerebours, Nathaniel J. Clement, Mai-Anh T. Vu, Guillermo Sapiro, Nicole E. Heller, and R Alison Adcock. “Motivational valence alters memory formation without altering exploration of a real-life spatial environment..” Plos One 13, no. 3 (2018). https://doi.org/10.1371/journal.pone.0193506.
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    • Dickerson, Kathryn, and R Alison Adcock. “Motivation and Memory.” Stevens’ Handbook of Experimental Psychology and Cognitive Neuroscience, 2018. https://doi.org/10.1002/9781119170174.epcn107.
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    • Horne, Alexandra J., Kimberly S. Chiew, Jie Zhuang, Linda K. George, R Alison Adcock, Guy G. Potter, Eleonora M. Lad, et al. “Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study..” J Aging Res 2018 (2018). https://doi.org/10.1155/2018/4930385.
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    • MacDuffie, Katherine E., Jeff MacInnes, Kathryn C. Dickerson, Kari M. Eddington, Timothy J. Strauman, and R Alison Adcock. “Single session real-time fMRI neurofeedback has a lasting impact on cognitive behavioral therapy strategies..” Neuroimage Clin 19 (2018): 868–75. https://doi.org/10.1016/j.nicl.2018.06.009.
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    • Scult, Matthew A., Annchen R. Knodt, Jamie L. Hanson, Minyoung Ryoo, R Alison Adcock, Ahmad R. Hariri, and Timothy J. Strauman. “Individual differences in regulatory focus predict neural response to reward..” Soc Neurosci 12, no. 4 (August 2017): 419–29. https://doi.org/10.1080/17470919.2016.1178170.
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    • Ho, New Fei, Daphne J. Holt, Mike Cheung, Juan Eugenio Iglesias, Alex Goh, Mingyuan Wang, Joseph Kw Lim, et al. “Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study..” Neuropsychopharmacology 42, no. 6 (May 2017): 1361–70. https://doi.org/10.1038/npp.2017.5.
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    • Murty, Vishnu P., Ian C. Ballard, and R Alison Adcock. “Hippocampus and Prefrontal Cortex Predict Distinct Timescales of Activation in the Human Ventral Tegmental Area..” Cereb Cortex 27, no. 2 (February 1, 2017): 1660–69. https://doi.org/10.1093/cercor/bhw005.
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    • Murty, Vishnu P., Alexa Tompary, R Alison Adcock, and Lila Davachi. “Selectivity in Postencoding Connectivity with High-Level Visual Cortex Is Associated with Reward-Motivated Memory..” J Neurosci 37, no. 3 (January 18, 2017): 537–45. https://doi.org/10.1523/JNEUROSCI.4032-15.2016.
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    • Murty, Vishnu P., Alexa Tompary, R Alison Adcock, and Lila Davachi. “Selectivity in post-encoding connectivity with high-level visual cortex is associated with reward-motivated memory..” J Neurosci, December 5, 2016. https://doi.org/10.1523/JNEUROSCI.4032-15.2016.
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    • Murty, Vishnu P., Kevin S. LaBar, and R Alison Adcock. “Distinct medial temporal networks encode surprise during motivation by reward versus punishment..” Neurobiol Learn Mem 134 Pt A (October 2016): 55–64. https://doi.org/10.1016/j.nlm.2016.01.018.
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    • Wang, C., F. Ji, Z. Hong, J. S. Poh, R. Krishnan, J. Lee, G. Rekhi, et al. “Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study..” Psychol Med 46, no. 13 (October 2016): 2771–83. https://doi.org/10.1017/S0033291716001410.
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    • MacInnes, Jeff J., Kathryn C. Dickerson, Nan-Kuei Chen, and R Alison Adcock. “Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation..” Neuron 89, no. 6 (March 16, 2016): 1331–42. https://doi.org/10.1016/j.neuron.2016.02.002.
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    • McClernon, F Joseph, Cynthia A. Conklin, Rachel V. Kozink, R Alison Adcock, Maggie M. Sweitzer, Merideth A. Addicott, Ying-hui Chou, Nan-kuei Chen, Matthew B. Hallyburton, and Anthony M. DeVito. “Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence..” Neuropsychopharmacology 41, no. 3 (February 2016): 877–85. https://doi.org/10.1038/npp.2015.214.
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    • Chiew, Kimberly S., Jessica K. Stanek, and R Alison Adcock. “Reward Anticipation Dynamics during Cognitive Control and Episodic Encoding: Implications for Dopamine..” Front Hum Neurosci 10 (2016). https://doi.org/10.3389/fnhum.2016.00555.
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    • Klauser, Paul, Juan Zhou, Joseph K. W. Lim, Joann S. Poh, Hui Zheng, Han Ying Tng, Ranga Krishnan, et al. “Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study..” Schizophr Bull 41, no. 6 (November 2015): 1285–93. https://doi.org/10.1093/schbul/sbv012.
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    • Murty, Vishnu P., Maheen Shermohammed, David V. Smith, R McKell Carter, Scott A. Huettel, and R Alison Adcock. “Resting state networks distinguish human ventral tegmental area from substantia nigra..” Neuroimage 100 (October 15, 2014): 580–89. https://doi.org/10.1016/j.neuroimage.2014.06.047.
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    • Murty, Vishnu P., and R Alison Adcock. “Enriched encoding: reward motivation organizes cortical networks for hippocampal detection of unexpected events..” Cereb Cortex 24, no. 8 (August 2014): 2160–68. https://doi.org/10.1093/cercor/bht063.
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    • Kollins, Scott H., and R Alison Adcock. “ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence..” Prog Neuropsychopharmacol Biol Psychiatry 52 (July 3, 2014): 70–78. https://doi.org/10.1016/j.pnpbp.2014.02.002.
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    • Dandash, Orwa, Alex Fornito, Jimmy Lee, Richard S. E. Keefe, Michael W. L. Chee, R Alison Adcock, Christos Pantelis, Stephen J. Wood, and Ben J. Harrison. “Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis..” Schizophr Bull 40, no. 4 (July 2014): 904–13. https://doi.org/10.1093/schbul/sbt093.
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    • Braver, Todd S., Marie K. Krug, Kimberly S. Chiew, Wouter Kool, J Andrew Westbrook, Nathan J. Clement, R Alison Adcock, et al. “Mechanisms of motivation-cognition interaction: challenges and opportunities..” Cogn Affect Behav Neurosci 14, no. 2 (June 2014): 443–72. https://doi.org/10.3758/s13415-014-0300-0.
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    • Clark, Kait, Matthew S. Cain, R Alison Adcock, and Stephen R. Mitroff. “Context matters: the structure of task goals affects accuracy in multiple-target visual search..” Appl Ergon 45, no. 3 (May 2014): 528–33. https://doi.org/10.1016/j.apergo.2013.07.008.
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    • Yaakub, Siti N., Kavitha Dorairaj, Joann S. Poh, Christopher L. Asplund, Ranga Krishnan, Jimmy Lee, Richard S. E. Keefe, R Alison Adcock, Stephen J. Wood, and Michael W. L. Chee. “Preserved working memory and altered brain activation in persons at risk for psychosis..” Am J Psychiatry 170, no. 11 (November 2013): 1297–1307. https://doi.org/10.1176/appi.ajp.2013.12081135.
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    • Libertus, Klaus, Jennifer Gibson, Nadia Z. Hidayatallah, Jane Hirtle, R Alison Adcock, and Amy Needham. “Size matters: how age and reaching experiences shape infants' preferences for different sized objects..” Infant Behav Dev 36, no. 2 (April 2013): 189–98. https://doi.org/10.1016/j.infbeh.2013.01.006.
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    • Murty, Vishnu P., Ian C. Ballard, Katherine E. Macduffie, Ruth M. Krebs, and R Alison Adcock. “Hippocampal networks habituate as novelty accumulates..” Learn Mem 20, no. 4 (March 19, 2013): 229–35. https://doi.org/10.1101/lm.029728.112.
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    • Murty, Vishnu P., Kevin S. Labar, and R Alison Adcock. “Threat of punishment motivates memory encoding via amygdala, not midbrain, interactions with the medial temporal lobe..” J Neurosci 32, no. 26 (June 27, 2012): 8969–76. https://doi.org/10.1523/JNEUROSCI.0094-12.2012.
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    • Ballard, Ian C., Vishnu P. Murty, R McKell Carter, Jeffrey J. MacInnes, Scott A. Huettel, and R Alison Adcock. “Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior..” J Neurosci 31, no. 28 (July 13, 2011): 10340–46. https://doi.org/10.1523/JNEUROSCI.0895-11.2011.
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    • Whitford, T. J., D. H. Mathalon, M. E. Shenton, B. J. Roach, R. Bammer, R. A. Adcock, S. Bouix, et al. “Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia..” Psychol Med 41, no. 5 (May 2011): 959–69. https://doi.org/10.1017/S0033291710001376.
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    • Murty, Vishnu P., Maureen Ritchey, R Alison Adcock, and Kevin S. LaBar. “Reprint of: fMRI studies of successful emotional memory encoding: a quantitative meta-analysis..” Neuropsychologia 49, no. 4 (March 2011): 695–705. https://doi.org/10.1016/j.neuropsychologia.2011.02.031.
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    • Murty, Vishnu P., Kevin S. LaBar, Derek A. Hamilton, and R Alison Adcock. “Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory..” Learn Mem 18, no. 11 (2011): 712–17. https://doi.org/10.1101/lm.023549.111.
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    • Murty, Vishnu P., Maureen Ritchey, R Alison Adcock, and Kevin S. LaBar. “fMRI studies of successful emotional memory encoding: A quantitative meta-analysis..” Neuropsychologia 48, no. 12 (October 2010): 3459–69. https://doi.org/10.1016/j.neuropsychologia.2010.07.030.
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    • Shohamy, Daphna, and R Alison Adcock. “Dopamine and adaptive memory..” Trends Cogn Sci 14, no. 10 (October 2010): 464–72. https://doi.org/10.1016/j.tics.2010.08.002.
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    • Han, Sanghoon, Scott A. Huettel, Ana Raposo, R Alison Adcock, and Ian G. Dobbins. “Functional significance of striatal responses during episodic decisions: recovery or goal attainment?.” J Neurosci 30, no. 13 (March 31, 2010): 4767–75. https://doi.org/10.1523/JNEUROSCI.3077-09.2010.
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    • Dale, Corby L., Anne M. Findlay, R Alison Adcock, Mary Vertinski, Melissa Fisher, Alexander Genevsky, Stephanie Aldebot, et al. “Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects..” Int J Psychophysiol 75, no. 2 (February 2010): 183–93. https://doi.org/10.1016/j.ijpsycho.2009.10.009.
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    • Adcock, R Alison, Corby Dale, Melissa Fisher, Stephanie Aldebot, Alexander Genevsky, Gregory V. Simpson, Srikantan Nagarajan, and Sophia Vinogradov. “When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia..” Schizophr Bull 35, no. 6 (November 2009): 1132–41. https://doi.org/10.1093/schbul/sbp068.
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    • Carter, R McKell, Jeff J. Macinnes, Scott A. Huettel, and R Alison Adcock. “Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses..” Front Behav Neurosci 3 (2009). https://doi.org/10.3389/neuro.08.021.2009.
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    • Adcock, R Alison, Arul Thangavel, Susan Whitfield-Gabrieli, Brian Knutson, and John D. E. Gabrieli. “Reward-motivated learning: mesolimbic activation precedes memory formation..” Neuron 50, no. 3 (May 4, 2006): 507–17. https://doi.org/10.1016/j.neuron.2006.03.036.
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    • Knutson, Brian, and R Alison Adcock. “Remembrance of rewards past..” Neuron 45, no. 3 (February 3, 2005): 331–32. https://doi.org/10.1016/j.neuron.2005.01.020.
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    • Adcock, R. A., R. T. Constable, J. C. Gore, and P. S. Goldman-Rakic. “Functional neuroanatomy of executive processes involved in dual-task performance..” Proc Natl Acad Sci U S A 97, no. 7 (March 28, 2000): 3567–72. https://doi.org/10.1073/pnas.060588897.
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    • Lane, J. D., R. A. Adcock, and R. E. Burnett. “Respiratory sinus arrhythmia and cardiovascular responses to stress..” Psychophysiology 29, no. 4 (July 1992): 461–70. https://doi.org/10.1111/j.1469-8986.1992.tb01720.x.
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    • Lane, J. D., R. A. Adcock, R. B. Williams, and C. M. Kuhn. “Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption..” Psychosom Med 52, no. 3 (May 1990): 320–36. https://doi.org/10.1097/00006842-199005000-00006.
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  • Book Sections

    • Murty, V. P., and R. A. Adcock. “Distinct medial temporal lobe network states as neural contexts for motivated memory formation.” In The Hippocampus from Cells to Systems: Structure, Connectivity, and Functional Contributions to Memory and Flexible Cognition, 467–501, 2017. https://doi.org/10.1007/978-3-319-50406-3_15.
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  • Conference Papers

    • Adcock, R Alison, Jeffrey MacInnes, Vishnu Murty, Ian Ballard, Siow Ann Chong, Mythily Subramaniam, Richard Keefe, et al. “DORSOLATERAL PREFRONTAL CORTEX DRIVES MESOLIMBIC DOPAMINERGIC REGIONS DURING MOTIVATED BEHAVIOR: INSIGHTS FROM DYNAMIC CAUSAL MODELING AND FMRI IN AT-RISK ADOLESCENTS.” In Schizophrenia Research, 153:S38–S38. ELSEVIER SCIENCE BV, 2014.
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    • Clement, Nathan, and R Alison Adcock. “MOVE FASTER TO LEARN BETTER: EXPLORATION SPEED IMPACTS LEARNING ABOUT OBJECTS AND THEIR LOCATIONS.” In Journal of Cognitive Neuroscience, 79–80. MIT PRESS, 2013.
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    • Murty, Vishnu, Kevin LaBar, and R Alison Adcock. “THE ACTIVE AVOIDANCE OF THREAT ENHANCES NEURAL SENSITIVITY TO EXPECTANCY VIOLATION..” In Journal of Cognitive Neuroscience, 183–183. MIT PRESS, 2013.
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    • Sumner, Elizabeth, Kristin Duffy, and R Alison Adcock. “DOPAMINERGIC MODULATION OF REWARD-MOTIVATED MEMORY.” In Journal of Cognitive Neuroscience, 227–28. MIT PRESS, 2013.
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    • Johnson, Elizabeth B., Jessica Wilson, Joann Poh, Siti Yaakub, Kavitha Dorairaj, Attillio Rapisarda, Michael Chee, et al. “Midbrain Modulation of Hippocampus Dependent Learning in Singaporeans at Ultra High Risk for the Development of Schizophrenia.” In Biological Psychiatry, 71:254S-254S. ELSEVIER SCIENCE INC, 2012.
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    • Murty, Vishnu P., Siow A. Chong, Mythily Subramaniam, Richard Keefe, Michael Kraus, Joann Poh, Kavitha Dorairaj, Jamie Thong, Yioe L. Bong, and R Alison Adcock. “Amygdala Reactivity in Singaporeans at Ultra High Risk for the Development of Schizophrenia.” In Biological Psychiatry, 69:235S-235S. ELSEVIER SCIENCE INC, 2011.
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    • Johnson, Elizabeth B., and R Alison Adcock. “Generalized Enhancement of Episodic Memory by Prior Reward Experience.” In Biological Psychiatry, 67:85S-85S. ELSEVIER SCIENCE INC, 2010.
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• Teaching & Mentoring
• 

  Recent Courses

  • NEUROBIO 393: Research Independent Study 2019
  • NEUROBIO 793: Research in Neurobiology 2019
  • NEUROSCI 150: Research Practicum 2019
  • NEUROSCI 755: Interdisciplinary Program in Cognitive Neuroscience (IPCN) Independent Research Rotation 2019
  • PSY 394: Research Independent Study 2019
  • PSY 493: Research Independent Study 2019
  • NEUROSCI 493: Research Independent Study 1 2018
  • NEUROSCI 494: Research Independent Study 2 2018
  • NEUROSCI 495: Research Independent Study 3 2017
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Faculty Team Member . The Construction of Memory at Duke and in Durham: Using Memory Studies. August 2016 - May 2017  2016 - 2017
  • Bass Connections Faculty Team Member. The Construction of Memory at Duke and in Durham: Using Memory Studies. August 2016 - May 2017  2016 - 2017

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