Current Duke Appointments & Affiliations
Adjunct Associate Professor in the Department of Pathology
·
2021 - Present
Pathology,
Clinical Science Departments
Recent Scholarly Works
Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.
Journal article Cancer Res · December 15, 2025 UNLABELLED: Preinvasive breast cancer, or ductal carcinoma in situ (DCIS), shares many morphologic and genomic features with invasive breast cancer, yet most DCIS tumors remain indolent over decades. In this study, we performed spatial analyses of somatic ... Full text Link to item CiteSingle-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition.
Journal article Cancer Res · June 16, 2025 UNLABELLED: Ductal carcinoma in situ (DCIS) is a risk factor for subsequent invasive breast cancer (IBC). To identify events in DCIS that lead to invasive cancer, we performed single-cell RNA sequencing on DCIS lesions and matched normal breast tissue. Inf ... Full text Link to item CiteEvolutionary measures show that recurrence of DCIS is distinct from progression to breast cancer.
Journal article Breast Cancer Res · March 21, 2025 BACKGROUND: Progression from pre-cancers like ductal carcinoma in situ (DCIS) to invasive disease (cancer) is driven by somatic evolution and is altered by clinical interventions. We hypothesized that genetic and/or phenotypic intra-tumor heterogeneity wou ... Full text Link to item CiteRecent Grants
CaMKK2 inhibition as an approach to increase tumor immunity in breast cancers
ResearchPathologist · Awarded by Department of Defense · 2020 - 2024Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort
ResearchCo Investigator · Awarded by Breast Cancer Research Foundation · 2020 - 2021Culturally appropriate screening and diagnosis of cervical cancer in East Africa
ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2021View All Grants
Education
Duke University, School of Medicine ·
2007
MD./PhD.