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Amy Lynn McNulty

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery
DUMC Box 3093, Durham, NC 27710
355A MSRB1, Durham, NC 27710

Overview


The McNulty Lab is working to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury. In order to accomplish this, we are working in three main areas.  1) We are working to understand the pathways that are activated by normal and injurious mechanical loading of cartilage and meniscus and how these mechanotransduction pathways are altered during aging, injury, and tissue degeneration. A greater understanding of alterations in mechanosensitive signaling mechanisms with aging and injury will likely reveal potential targets to promote tissue repair and prevent tissue degeneration and osteoarthritis development. 2) We are developing meniscus tissue engineered constructs that will be utilized to repair and replace meniscus tissue lost due to injury and surgical resection.  3)  We are focusing on the biological and biomechanical changes that occur in the joint following meniscus injury and how these may contribute to osteoarthritis development.   

Current Appointments & Affiliations


Associate Professor in Orthopaedic Surgery · 2022 - Present Orthopaedic Surgery, Clinical Science Departments
Associate Professor in the Department of Pathology · 2019 - Present Pathology, Clinical Science Departments
Associate Professor of Biomedical Engineering · 2022 - Present Biomedical Engineering, Pratt School of Engineering
Associate Research Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Regeneration Next Initiative, Basic Science Departments

Education, Training & Certifications


Duke University · 2005 Ph.D.