Scholars@Duke

• Research
• 

  Selected Grants

  • Immunotherapy to treat Triple Negative Breast Cancer Brain Metastases awarded by University of North Carolina - Chapel Hill 2019 - 2021
  • Gender Differences in Stimulant Action awarded by National Institutes of Health 1998 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Papke, B., S. H. Azam, A. Y. Feng, C. Gutierrez-Ford, H. Huggins, P. S. Pallan, A. E. D. Van Swearingen, et al. “Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA.” Acs Pharmacology and Translational Science 4, no. 2 (April 9, 2021): 703–12. https://doi.org/10.1021/acsptsci.0c00165.
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    • Harrison, Emily B., Alessandro Porrello, Brittany M. Bowman, Adam R. Belanger, Gabriella Yacovone, Salma H. Azam, Ian A. Windham, et al. “A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.” Cancer Research 80, no. 22 (November 2020): 4972–85. https://doi.org/10.1158/0008-5472.can-20-1162.
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    • Valiente, Manuel, Amanda E. D. Van Swearingen, Carey K. Anders, Amos Bairoch, Adrienne Boire, Paula D. Bos, Diana M. Cittelly, et al. “Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines.” Cancer Research 80, no. 20 (October 2020): 4314–23. https://doi.org/10.1158/0008-5472.can-20-0291.
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    • Zimmer, Alexandra S., Amanda E. D. Van Swearingen, and Carey K. Anders. “HER2-positive breast cancer brain metastasis: A new and exciting landscape.” Cancer Reports (Hoboken, N.J.), September 3, 2020, e1274. https://doi.org/10.1002/cnr2.1274.
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    • Sammons, Sarah, Amanda E. D. Van Swearingen, and Carey K. Anders. “Receptor discordance in breast cancer brain metastases: when knowledge is power.” Neuro Oncol 22, no. 8 (August 17, 2020): 1060–61. https://doi.org/10.1093/neuonc/noaa131.
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    • Vinod, Natasha, Duhyeong Hwang, Salma H. Azam, Amanda E. D. Van Swearingen, Elizabeth Wayne, Sloane Christian Fussell, Marina Sokolsky-Papkov, Chad V. Pecot, and Alexander V. Kabanov. “High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma.” Science Advances 6, no. 25 (June 17, 2020): eaba5542. https://doi.org/10.1126/sciadv.aba5542.
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    • Sammons, S., A. E. D. Van Swearingen, and C. K. Anders. “The Promise of Immunotherapy for Breast Cancer Brain Metastases.” Current Breast Cancer Reports 11, no. 4 (December 1, 2019): 241–47. https://doi.org/10.1007/s12609-019-00335-1.
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    • Leslie, Patrick L., Yvonne L. Chao, Yi-Hsuan Tsai, Subrata K. Ghosh, Alessandro Porrello, Amanda E. D. Van Swearingen, Emily B. Harrison, et al. “Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes.” Nature Communications 10, no. 1 (September 13, 2019): 4192. https://doi.org/10.1038/s41467-019-12222-5.
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    • Van Swearingen, Amanda E. D., Marni B. Siegel, Allison M. Deal, Maria J. Sambade, Alan Hoyle, D Neil Hayes, Heejoon Jo, et al. “LCCC 1025: a phase II study of everolimus, trastuzumab, and vinorelbine to treat progressive HER2-positive breast cancer brain metastases.” Breast Cancer Research and Treatment 171, no. 3 (October 2018): 637–48. https://doi.org/10.1007/s10549-018-4852-5.
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    • Siegel, Marni B., Xiaping He, Katherine A. Hoadley, Alan Hoyle, Julia B. Pearce, Amy L. Garrett, Sunil Kumar, et al. “Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.” The Journal of Clinical Investigation 128, no. 4 (April 2018): 1371–83. https://doi.org/10.1172/jci96153.
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    • Nelson, Kimberly J., Arden Perkins, Amanda E. D. Van Swearingen, Steven Hartman, Andrew E. Brereton, Derek Parsonage, Freddie R. Salsbury, P Andrew Karplus, and Leslie B. Poole. “Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.” Antioxidants & Redox Signaling 28, no. 7 (March 2018): 521–36. https://doi.org/10.1089/ars.2016.6922.
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    • McNeill, Robert S., Demitra A. Canoutas, Timothy J. Stuhlmiller, Harshil D. Dhruv, David M. Irvin, Ryan E. Bash, Steven P. Angus, et al. “Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.” Neuro Oncology 19, no. 11 (October 2017): 1469–80. https://doi.org/10.1093/neuonc/nox044.
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    • Van Swearingen, Amanda E. D., Maria J. Sambade, Marni B. Siegel, Shivani Sud, Robert S. McNeill, Samantha M. Bevill, Xin Chen, et al. “Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer.” Neuro Oncology 19, no. 11 (October 2017): 1481–93. https://doi.org/10.1093/neuonc/nox052.
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    • Zagar, Timothy M., Amanda E. D. Van Swearingen, Orit Kaidar-Person, Matthew G. Ewend, and Carey K. Anders. “Multidisciplinary Management of Breast Cancer Brain Metastases.” Oncology (Williston Park, N.Y.) 30, no. 10 (October 2016): 923–33.
    • Sambade, Maria, Allison Deal, Allison Schorzman, J Christopher Luft, Charles Bowerman, Kevin Chu, Olga Karginova, et al. “Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.” Nanomedicine (London, England) 11, no. 15 (August 2016): 1947–55. https://doi.org/10.2217/nnm-2016-0147.
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    • Karginova, Olga, Marni B. Siegel, Amanda E. D. Van Swearingen, Allison M. Deal, Barbara Adamo, Maria J. Sambade, Soha Bazyar, et al. “Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.” Molecular Cancer Therapeutics 14, no. 4 (April 2015): 920–30. https://doi.org/10.1158/1535-7163.mct-14-0474.
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    • Sanchez, Cristina L., Amanda E. D. Van Swearingen, Andrew E. Arrant, Caroline S. Biskup, Cynthia M. Kuhn, and Florian D. Zepf. “Simplified dietary acute tryptophan depletion: effects of a novel amino acid mixture on the neurochemistry of C57BL/6J mice.” Food & Nutrition Research 59 (2015). https://doi.org/10.3402/fnr.v59.27424.
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    • Sánchez, Cristina L., Amanda E. D. Van Swearingen, Andrew E. Arrant, Caroline S. Biskup, Cynthia M. Kuhn, and Florian D. Zepf. “Simplified dietary acute tryptophan depletion: effects of a novel amino acid mixture on the neurochemistry of C57BL/6J mice.” Food Nutr Res 59 (2015): 27424. https://doi.org/10.3402/fnr.v59.27424.
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    • Siegel, Marni B., Amanda E. D. Van Swearingen, and Carey K. Anders. “Approaches for optimal drug development and clinical trial design for breast cancer brain metastasis.” Oncology (Williston Park, N.Y.) 28, no. 7 (July 2014): 579–85.
    • Van Swearingen, Amanda Ed, Marni B. Siegel, and Carey K. Anders. “Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?” Breast Cancer Research : Bcr 16, no. 3 (May 6, 2014): 304. https://doi.org/10.1186/bcr3651.
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    • Sánchez, Cristina L., Amanda E. D. Van Swearingen, Andrew E. Arrant, Cynthia M. Kuhn, and Florian D. Zepf. “Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures.” J Neural Transm (Vienna) 121, no. 2 (February 2014): 153–62. https://doi.org/10.1007/s00702-013-1083-0.
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    • Van Swearingen, Amanda E. D., Cristina L. Sanchez, Suzanne M. Frisbee, Antonia Williams, Q David Walker, Kenneth S. Korach, and Cynthia M. Kuhn. “Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.” Neuropharmacology 72 (September 2013): 236–49. https://doi.org/10.1016/j.neuropharm.2013.04.015.
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    • Van Swearingen, Amanda E. D., Q David Walker, and Cynthia M. Kuhn. “Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice.” Psychopharmacology (Berl) 225, no. 3 (February 2013): 707–18. https://doi.org/10.1007/s00213-012-2860-4.
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    • Walker, Q David, Misha L. Johnson, Amanda E. D. Van Swearingen, Andrew E. Arrant, Joseph M. Caster, and Cynthia M. Kuhn. “Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy.” Neuropharmacology 62, no. 7 (June 2012): 2267–77. https://doi.org/10.1016/j.neuropharm.2012.01.029.
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    • Biskup, Caroline Sarah, Cristina L. Sánchez, Andrew Arrant, Amanda E. D. Van Swearingen, Cynthia Kuhn, and Florian Daniel Zepf. “Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice.” Plos One 7, no. 5 (2012): e35916. https://doi.org/10.1371/journal.pone.0035916.
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    • Johnson, M. L., A. E. Day, C. C. Ho, Q. D. Walker, R. Francis, and C. M. Kuhn. “Androgen decreases dopamine neurone survival in rat midbrain.” J Neuroendocrinol 22, no. 4 (April 2010): 238–47. https://doi.org/10.1111/j.1365-2826.2010.01965.x.
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    • Johnson, M. L., C. C. Ho, A. E. Day, Q. D. Walker, R. Francis, and C. M. Kuhn. “Oestrogen receptors enhance dopamine neurone survival in rat midbrain.” J Neuroendocrinol 22, no. 4 (April 2010): 226–37. https://doi.org/10.1111/j.1365-2826.2010.01964.x.
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    • Altman, Brian J., Jessica A. Wofford, Yuxing Zhao, Jonathan L. Coloff, Emily C. Ferguson, Heather L. Wieman, Amanda E. Day, Olga Ilkayeva, and Jeffrey C. Rathmell. “Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.” Mol Biol Cell 20, no. 4 (February 2009): 1180–91. https://doi.org/10.1091/mbc.e08-08-0829.
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    • Nelson, Kimberly J., Amanda E. Day, Bu-Bing Zeng, S Bruce King, and Leslie B. Poole. “Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pKa values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.” Analytical Biochemistry 375, no. 2 (April 2008): 187–95. https://doi.org/10.1016/j.ab.2007.12.004.
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  • Conference Papers

    • Pecot, C., A. Van Swearingen, and B. Papke. “MA27.06 Therapeutic Silencing of Oncogenic KRAS With a Mutant-Specific Short Interfering RNA.” In Journal of Thoracic Oncology, 13:S456–S456. Elsevier BV, 2018. https://doi.org/10.1016/j.jtho.2018.08.551.
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    • Sambade, Maria, Amanda Van Swearingen, Kaiming Sun, Jing Wang, Kevin Mikule, and Carey K. Anders. “Abstract 2813: Efficacy and pharmacokinetics of niraparib inBRCA-mutant and wild-type intracranial triple negative breast cancer murine models.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2018. https://doi.org/10.1158/1538-7445.am2018-2813.
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    • Swearingen, Amanda ED Van, Maria J. Sambade, Marni B. Siegel, Shivani Sud, Samantha M. Bevill, Brian T. Golitz, Ryan E. Bash, et al. “Abstract A03: Several rational combination kinase inhibitor treatments identified by synthetic lethality screens are efficacious in intracranial triple negative breast cancer models.” In Model Organisms to Identify Synthetic Lethal Interactions. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-8514.synthleth-a03.
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    • Anders, Carey K., Allison Mary Deal, Amanda Elyse Day Van Swearingen, Marni Siegel, David N. Hayes, Heejoon Jo, Paul Little, et al. “LCCC 1025: Phase II study of everolimus, trastuzumab, and vinorelbine for HER2+ breast cancer brain metastases (BCBM).” In Journal of Clinical Oncology, 35:1011–1011. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.1011.
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    • Van Swearingen, Amanda E. D., Maria J. Sambade, Shivani Sud, Brian Golitz, Gary L. Johnson, and Carey K. Anders. “Abstract 3867: Combined PI3K and AURKA inhibition are efficacious in triple-negative breast cancer models.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2016. https://doi.org/10.1158/1538-7445.am2016-3867.
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    • Van Swearingen, Amanda E. D., Marni B. Siegel, Maria J. Sambade, Shivani Sud, Samantha M. Miller, Grace Silva, Ryan E. Bash, et al. “Abstract 2579: Combination therapy with MEK inhibition is efficacious in intracranial triple negative breast cancer models.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-2579.
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    • Swearingen, Amanda ED Van, Marni B. Siegel, Ryan Bash, Brian Golitz, Charlene Santos, David Darr, Joel Parker, Gary L. Johnson, C Ryan Miller, and Carey K. Anders. “Abstract 5449A: PI3K and MEK inhibition in intracranial triple negative breast cancer: Efficacy of BKM120 and AZD6244 in preclinical mouse models.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-5449a.
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    • McNeill, Robert, Amanda Van Swearingen, Ryan Bash, Salma Azam, Demitra Canoutas, Brian Constance, Ralf Schmid, Carey Anders, and C. Miller. “Efficacy of Mono and Dual PI3K and MAPK Inhibition in Glioblastoma and Triple-Negative Breast Cancer Brain Metastasis Models.” In Journal of Neuropathology and Experimental Neurology, 73:587–587. LIPPINCOTT WILLIAMS & WILKINS, 2014.
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    • Nelson, Kimberly J., Derek Parsonage, Amanda E. D. Van Swearingen, Ye Yuan, Freddie R. Salsbury, Andrea Hall, P. Andrew Karplus, and Leslie B. Poole. “Specific Residues in Peroxiredoxins Promote Peroxide Reactivity Through Effects on Cysteine pKa, Transition State Stabilization and Oligomerization.” In Free Radical Biology and Medicine, 53:S151–S151. Elsevier BV, 2012. https://doi.org/10.1016/j.freeradbiomed.2012.10.411.
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