https://orcid.org/0000-0002-4287-9741
Overview
Education and Training
Postdoctoral Research Associate, UNC-Chapel Hill, 01/2013-02/2017
PhD, Molecular Cancer Biology, Duke University, 2012
BS, Biology, Wake Forest University, 2007
Postdoctoral Research Associate, UNC-Chapel Hill, 01/2013-02/2017
PhD, Molecular Cancer Biology, Duke University, 2012
BS, Biology, Wake Forest University, 2007
Current Duke Appointments & Affiliations
Research Program Leader, Sr
Medicine,
Clinical Science Departments
Recent Scholarly Works
Spatially resolved transcriptomics in human brain metastases identifies macrophage-tumor interactions associated with survival.
Journal article iScience · August 21, 2026 Despite advances in treatment approaches, the mean survival for patients with brain metastases remains poor. The incidence of brain metastases continues to rise, and there remains a need to identify novel therapeutics targeting mechanisms critical for brai ... Full text Link to item CiteInterleukin-34-Induced Arg1+ Macrophages Play a Key Role in Breast Cancer Brain Metastasis.
Journal article Cancer Res Commun · June 1, 2026 UNLABELLED: Brain metastases occur in up to 40% of patients with stage IV breast cancer, and the cerebellum is a common site for metastases in HER2-positive breast cancer. We developed a syngeneic, immunocompetent mouse model of breast cancer brain metasta ... Full text Link to item CiteQuantitative HER2 tissue and plasma profiling predicts the activity of trastuzumab deruxtecan for breast cancer.
Journal article NPJ Precis Oncol · March 13, 2026 Trastuzumab deruxtecan (T-DXd) is commonly used for treating metastatic breast cancer (MBC); however, traditional HER2 immunohistochemistry has largely failed to predict T-DXd activity. We reviewed survival outcomes and tested the reliability of multiple H ... Full text Link to item CiteRecent Grants
CNS PATTERN: CNS Progression After Targeted Therapy and Effect of Radiation in NSCLC
FellowshipData Manager · Awarded by Lung Cancer Initiative of North Carolina · 2025 - 2027Breast Cancer Brain Metastases: Integrating Immunogenomic and Phenotypic Vulnerabilities to Improve Outcomes
ResearchProject Planner · Awarded by Department of Defense · 2025 - 2027Ancestry-related RNA splicing and immune expression in metastatic breast cancer
ResearchResearch Associate · Awarded by Susan G. Komen Breast Cancer Foundation · 2022 - 2026View All Grants