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Amanda Van Swearingen

Research Program Leader, Sr
Medicine
232 Baker House, Trent Drive, Box #3381, Durham, NC 27710
20 Sydenham Road, Durham, NC 27713

Overview


Education and Training

Postdoctoral Research Associate, UNC-Chapel Hill, 01/2013-02/2017

PhD, Molecular Cancer Biology, Duke University, 2012

BS, Biology, Wake Forest University, 2007

Current Appointments & Affiliations


Research Program Leader, Sr Medicine, Clinical Science Departments

Recent Publications


A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases.

Journal Article Acta Neuropathol Commun · June 2, 2025 BACKGROUND: Melanoma brain metastases (MBM) have a unique molecular profile compared to extracranial metastases (ECM). Description of the biological features and clinical outcomes of MBM will facilitate the design of rational therapies. METHODS: We examine ... Full text Link to item Cite

Genomic and immune profiling of breast cancer brain metastases.

Journal Article Acta Neuropathol Commun · May 12, 2025 BACKGROUND: Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic ... Full text Link to item Cite

Snord67 promotes breast cancer metastasis by guiding U6 modification and modulating the splicing landscape.

Journal Article Nat Commun · May 2, 2025 Previously considered "housekeeping" genes, small nucleolar RNAs (snoRNAs) are increasingly understood to have wide-ranging functions in cancer, yet their role in metastasis has been less well studied. Here, we identify the snoRNA Snord67 as a regulator of ... Full text Link to item Cite
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Recent Grants


CNS PATTERN: CNS Progression After Targeted Therapy and Effect of Radiation in NSCLC

FellowshipData Manager · Awarded by Lung Cancer Initiative of North Carolina · 2025 - 2026

Breast Cancer Brain Metastases: Integrating Immunogenomic and Phenotypic Vulnerabilities to Improve Outcomes

ResearchProject Planner · Awarded by Department of Defense · 2025 - 2026

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