Amanda M. Buch

Conference Proceedings of Machine Learning Research · January 1, 2024 AI-enabled precision medicine promises a transformational improvement in healthcare outcomes. However, training on biomedical data presents significant challenges as they are often high dimensional, clustered, and of limited sample size. To overcome these ... Cite

Gene-brain-behavior mechanisms underlying autism spectrum disorder: implications for precision psychiatry.

Journal Article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · January 2024 Full text Cite

Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder.

Journal Article Nature neuroscience · April 2023 The mechanisms underlying phenotypic heterogeneity in autism spectrum disorder (ASD) are not well understood. Using a large neuroimaging dataset, we identified three latent dimensions of functional brain network connectivity that predicted individual diffe ... Full text Cite

Gabrb3 is required for the functional integration of pyramidal neuron subtypes in the somatosensory cortex.

Journal Article Neuron · January 2023 Dysfunction of gamma-aminobutyric acid (GABA)ergic circuits is strongly associated with neurodevelopmental disorders. However, it is unclear how genetic predispositions impact circuit assembly. Using in vivo two-photon and widefield calcium imaging in deve ... Full text Cite

Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics.

Journal Article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · January 2021 Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a unitary disease entity, encompassing a broad spectrum of psychopathology arising from distinct pathophysiological mechanisms. Motivated by a need to advance our understandi ... Full text Cite