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Amit Patel

Associate Professor of Medicine
Medicine, Gastroenterology
DUMC Box 3913, Durham, NC 27710
Duke University, Division of Gastroenterology, Durham, NC 27710

Selected Publications


Ineffective esophageal motility is associated with diabetes mellitus end organ complications.

Journal Article Neurogastroenterol Motil · June 14, 2024 BACKGROUND: Diabetes Mellitus (DM) is known to induce a wide range of harmful effects on several organs, notably leading to ineffective esophageal motility (IEM). However, the relationship between DM and IEM is not fully elucidated. We aimed to determine t ... Full text Link to item Cite

Heartburn Relief Is the Major Unmet Need for Drug Development in Gastroesophageal Reflux Disease: Threshold Value Analysis.

Journal Article Clin Gastroenterol Hepatol · February 16, 2024 BACKGROUND AND AIMS: Heartburn symptoms contribute to healthcare-seeking among patients with gastroesophageal reflux disease (GERD). Despite clinical guidance, management is often dictated by insurance restrictions. Several potassium-competitive acid block ... Full text Link to item Cite

Evaluation of the Potential Utility of an Artificial Intelligence Chatbot in Gastroesophageal Reflux Disease Management.

Journal Article Am J Gastroenterol · December 1, 2023 INTRODUCTION: Artificial intelligence chatbots could serve as an information resource for patients and a tool for clinicians. Their ability to respond appropriately to questions regarding gastroesophageal reflux disease is unknown. METHODS: Twenty-three pr ... Full text Link to item Cite

The Impact of Gastroparesis on Medical Therapy for Gastroesophageal Reflux Disease (GERD)

Journal Article Foregut: The Journal of the American Foregut Society · November 6, 2023 Symptoms suspicious for gastroesophageal reflux disease (GERD) represent frequent indications for medical presentation, as do symptoms potentially compatible with delayed gastric emptying. In this clinical setting, care must be taken to characteri ... Full text Cite

Optimizing the Management Algorithm for Heartburn in General Gastroenterology: Cost-Effectiveness and Cost-Minimization Analysis.

Journal Article Clin Gastroenterol Hepatol · September 7, 2023 BACKGROUND AND AIMS: Heartburn is the most common symptom seen in gastroenterology practice. We aimed to optimize cost-effective evaluation and management of heartburn. METHODS: We developed a decision analytic model from insurer and patient perspectives c ... Full text Link to item Cite

Gastroesophageal Reflux Disease.

Chapter · September 2023 Symptoms potentially attributable to gastroesophageal reflux disease are among those most commonly reported to primary care providers in the outpatient setting. In this review, we discuss clinical approaches to the evaluation and management of these sympto ... Full text Link to item Cite

The role of magnetic sphincter augmentation in the gastroesophageal reflux disease treatment pathway: the gastroenterology perspective.

Journal Article Dis Esophagus · June 15, 2023 Featured Publication Magnetic sphincter augmentation (MSA) is a surgical intervention for well-characterized gastroesophageal reflux disease (GERD), where the esophagogastric junction barrier is augmented using a bracelet of magnetized titanium beads. MSA could be an attractiv ... Full text Link to item Cite

Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD).

Journal Article Dig Dis Sci · June 2023 In our present clinical paradigm, patient symptoms and presentation in the setting of traditional findings from endoscopy (erosive esophagitis, Barrett's esophagus, reflux-mediated stenosis), esophageal high-resolution manometry, and/or ambulatory reflux m ... Full text Link to item Cite

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.

Journal Article Gastroenterology · June 2023 INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College ... Full text Link to item Cite

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.

Journal Article Am J Gastroenterol · June 1, 2023 INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College ... Full text Link to item Cite

Potassium-Competitive Acid Blockers: Present and Potential Utility in the Armamentarium for Acid Peptic Disorders.

Journal Article Gastroenterol Hepatol (N Y) · December 2022 Potassium-competitive acid blockers (PCABs) such as vonoprazan represent a novel class of acid suppressants that show tremendous promise to enhance care of acid peptic disorders. PCAB characteristics distinct from those of proton pump inhibitors-such as ac ... Link to item Cite

Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation.

Journal Article Dis Esophagus · May 10, 2022 BACKGROUND: Upper endoscopy (EGD) is frequently performed in patients with esophageal complaints following anti-reflux surgery such as fundoplication. Endoscopic evaluation of fundoplication wrap integrity can be challenging. Our primary aim in this pilot ... Full text Link to item Cite

Postbariatric surgery esophageal dysmotility

Chapter · January 1, 2022 The burgeoning obesity epidemic has fostered increased innovation and utilization of bariatric surgical interventions. These include adjustable gastric banding, sleeve gastrectomy, Roux-en-Y gastric bypass, and biliopancreatic diversion-duodenal switch, as ... Full text Cite

Esophageal dysbiosis and esophageal motility disorders

Chapter · January 1, 2022 The esophageal microbiome is an emerging field of investigation. Better understanding of the relationships between the esophageal microbiome and esophageal motility disorders may impact clinical management and facilitate further understanding of esophageal ... Full text Cite

Ineffective esophageal motility is associated with diabetes mellitus end organ complications.

Journal Article Neurogastroenterol Motil · June 14, 2024 BACKGROUND: Diabetes Mellitus (DM) is known to induce a wide range of harmful effects on several organs, notably leading to ineffective esophageal motility (IEM). However, the relationship between DM and IEM is not fully elucidated. We aimed to determine t ... Full text Link to item Cite

Heartburn Relief Is the Major Unmet Need for Drug Development in Gastroesophageal Reflux Disease: Threshold Value Analysis.

Journal Article Clin Gastroenterol Hepatol · February 16, 2024 BACKGROUND AND AIMS: Heartburn symptoms contribute to healthcare-seeking among patients with gastroesophageal reflux disease (GERD). Despite clinical guidance, management is often dictated by insurance restrictions. Several potassium-competitive acid block ... Full text Link to item Cite

Evaluation of the Potential Utility of an Artificial Intelligence Chatbot in Gastroesophageal Reflux Disease Management.

Journal Article Am J Gastroenterol · December 1, 2023 INTRODUCTION: Artificial intelligence chatbots could serve as an information resource for patients and a tool for clinicians. Their ability to respond appropriately to questions regarding gastroesophageal reflux disease is unknown. METHODS: Twenty-three pr ... Full text Link to item Cite

The Impact of Gastroparesis on Medical Therapy for Gastroesophageal Reflux Disease (GERD)

Journal Article Foregut: The Journal of the American Foregut Society · November 6, 2023 Symptoms suspicious for gastroesophageal reflux disease (GERD) represent frequent indications for medical presentation, as do symptoms potentially compatible with delayed gastric emptying. In this clinical setting, care must be taken to characteri ... Full text Cite

Optimizing the Management Algorithm for Heartburn in General Gastroenterology: Cost-Effectiveness and Cost-Minimization Analysis.

Journal Article Clin Gastroenterol Hepatol · September 7, 2023 BACKGROUND AND AIMS: Heartburn is the most common symptom seen in gastroenterology practice. We aimed to optimize cost-effective evaluation and management of heartburn. METHODS: We developed a decision analytic model from insurer and patient perspectives c ... Full text Link to item Cite

Gastroesophageal Reflux Disease.

Chapter · September 2023 Symptoms potentially attributable to gastroesophageal reflux disease are among those most commonly reported to primary care providers in the outpatient setting. In this review, we discuss clinical approaches to the evaluation and management of these sympto ... Full text Link to item Cite

The role of magnetic sphincter augmentation in the gastroesophageal reflux disease treatment pathway: the gastroenterology perspective.

Journal Article Dis Esophagus · June 15, 2023 Featured Publication Magnetic sphincter augmentation (MSA) is a surgical intervention for well-characterized gastroesophageal reflux disease (GERD), where the esophagogastric junction barrier is augmented using a bracelet of magnetized titanium beads. MSA could be an attractiv ... Full text Link to item Cite

Novel Diagnostic Techniques in the Evaluation of Gastroesophageal Reflux Disease (GERD).

Journal Article Dig Dis Sci · June 2023 In our present clinical paradigm, patient symptoms and presentation in the setting of traditional findings from endoscopy (erosive esophagitis, Barrett's esophagus, reflux-mediated stenosis), esophageal high-resolution manometry, and/or ambulatory reflux m ... Full text Link to item Cite

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.

Journal Article Gastroenterology · June 2023 INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College ... Full text Link to item Cite

American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation.

Journal Article Am J Gastroenterol · June 1, 2023 INTRODUCTION: Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College ... Full text Link to item Cite

Potassium-Competitive Acid Blockers: Present and Potential Utility in the Armamentarium for Acid Peptic Disorders.

Journal Article Gastroenterol Hepatol (N Y) · December 2022 Potassium-competitive acid blockers (PCABs) such as vonoprazan represent a novel class of acid suppressants that show tremendous promise to enhance care of acid peptic disorders. PCAB characteristics distinct from those of proton pump inhibitors-such as ac ... Link to item Cite

Variability in endoscopic assessment of Nissen fundoplication wrap integrity and hiatus herniation.

Journal Article Dis Esophagus · May 10, 2022 BACKGROUND: Upper endoscopy (EGD) is frequently performed in patients with esophageal complaints following anti-reflux surgery such as fundoplication. Endoscopic evaluation of fundoplication wrap integrity can be challenging. Our primary aim in this pilot ... Full text Link to item Cite

Postbariatric surgery esophageal dysmotility

Chapter · January 1, 2022 The burgeoning obesity epidemic has fostered increased innovation and utilization of bariatric surgical interventions. These include adjustable gastric banding, sleeve gastrectomy, Roux-en-Y gastric bypass, and biliopancreatic diversion-duodenal switch, as ... Full text Cite

Esophageal dysbiosis and esophageal motility disorders

Chapter · January 1, 2022 The esophageal microbiome is an emerging field of investigation. Better understanding of the relationships between the esophageal microbiome and esophageal motility disorders may impact clinical management and facilitate further understanding of esophageal ... Full text Cite

Reply.

Journal Article Gastroenterology · July 2021 Full text Link to item Cite

Diagnosis and Management of Refractory Gastroesophageal Reflux Disease.

Journal Article Gastroenterol Hepatol (N Y) · July 2021 Featured Publication In up to half of patients with symptoms suspected to stem from gastroesophageal reflux disease (GERD), these symptoms persist despite treatment with daily proton pump inhibitor (PPI) therapy. The symptoms may be characterized as typical (eg, heartburn or r ... Link to item Cite

Reply.

Journal Article Gastroenterology · June 2021 Full text Link to item Cite

The Clinical Utility of Provocative Maneuvers at Esophageal High-resolution Manometry (HRM).

Journal Article J Clin Gastroenterol · February 1, 2021 Featured Publication Esophageal high-resolution manometry (HRM) assesses esophageal motor function and is indicated both for evaluation of esophageal symptoms and before antireflux interventions. HRM studies are interpreted and esophageal motor diagnoses made according to the ... Full text Link to item Cite

Artificial intelligence automates and augments baseline impedance measurements from pH-impedance studies in gastroesophageal reflux disease.

Journal Article J Gastroenterol · January 2021 BACKGROUND: Artificial intelligence (AI) has potential to streamline interpretation of pH-impedance studies. In this exploratory observational cohort study, we determined feasibility of automated AI extraction of baseline impedance (AIBI) and evaluated cli ... Full text Link to item Cite

Esophageal contractile segment impedance from high-resolution impedance manometry correlates with mean nocturnal baseline impedance and acid exposure time from 24-hour pH-impedance monitoring.

Journal Article Dis Esophagus · December 7, 2020 Featured Publication Esophageal baseline impedance (BI) acquired during esophageal contraction (contractile segment impedance [CSI]) is proposed to improve BI accuracy in gastroesophageal reflux disease (GERD). We evaluated associations between CSI and conventional and novel G ... Full text Link to item Cite

Recommendations for Follow-up Colonoscopy After Polypectomy.

Journal Article JAMA · December 1, 2020 Featured Publication Full text Link to item Cite

Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring.

Journal Article J Neurogastroenterol Motil · September 30, 2020 Featured Publication BACKGROUND/AIMS: Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar between acquisition me ... Full text Link to item Cite

Esophageal Functional Lumen Imaging Probe (FLIP): How Can FLIP Enhance Your Clinical Practice?

Journal Article Dig Dis Sci · September 2020 Featured Publication Recent innovations in esophageal diagnostic testing have enhanced gastroenterology clinical practice by facilitating more nuanced and advanced evaluation of esophageal symptoms. Among these pivotal advances is the FDA-approved functional lumen imaging prob ... Full text Link to item Cite

ACG Clinical Guidelines: Clinical Use of Esophageal Physiologic Testing.

Journal Article Am J Gastroenterol · September 2020 Featured Publication Esophageal symptoms are common and may indicate the presence of gastroesophageal reflux disease (GERD), structural processes, motor dysfunction, behavioral conditions, or functional disorders. Esophageal physiologic tests are often performed when initial e ... Full text Link to item Cite

Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility.

Journal Article Clin Gastroenterol Hepatol · July 2020 BACKGROUND & AIMS: Esophageal motor disorders (EMD) and pathologic reflux are often identified in obese individuals, but it is not clear how obesity contributes to these symptoms. We examined the relationships among symptom burden, EMD, acid exposure time ... Full text Link to item Cite

Mean Nocturnal Baseline Impedance Correlates With Symptom Outcome When Acid Exposure Time Is Inconclusive on Esophageal Reflux Monitoring.

Journal Article Clin Gastroenterol Hepatol · March 2020 BACKGROUND & AIMS: Abnormal acid exposure time (AET) is associated with good outcomes of symptoms from antireflux therapy. Low esophageal mean nocturnal baseline impedance (MNBI) is an additional marker of reflux disease. We aimed to evaluate the value of ... Full text Link to item Cite

Dysphagia in a 34-Year-Old Woman.

Journal Article JAMA · February 18, 2020 Featured Publication Full text Link to item Cite

The Utility of Esophageal Motility Testing in Gastroesophageal Reflux Disease (GERD).

Journal Article Curr Gastroenterol Rep · July 10, 2019 PURPOSE OF REVIEW: Here, we discuss how esophageal motor testing plays important roles in patients with suspected gastroesophageal reflux disease (GERD). In addition to guiding appropriate placement of catheters for ambulatory reflux monitoring, esophageal ... Full text Link to item Cite

Screening for Barrett's Esophagus: Balancing Clinical Value and Cost-effectiveness.

Journal Article J Neurogastroenterol Motil · April 30, 2019 Featured Publication In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia ... Full text Link to item Cite

Utility of Esophageal High-Resolution Manometry in Clinical Practice: First, Do HRM.

Journal Article Dig Dis Sci · December 2018 Esophageal high-resolution manometry (HRM) has advanced the understanding of esophageal motor function and the ability to diagnose and manage disorders of esophageal motility. In this review, we describe the indications for and the technical performance of ... Full text Link to item Cite

Esophageal High-Resolution Manometry in Gastroesophageal Reflux Disease.

Journal Article JAMA · September 25, 2018 Featured Publication Full text Link to item Cite

Curriculum for neurogastroenterology and motility training: A report from the joint ANMS-ESNM task force.

Journal Article Neurogastroenterol Motil · September 2018 Although neurogastroenterology and motility (NGM) disorders are some of the most frequent disorders encountered by practicing gastroenterologists, a structured competency-based training curriculum developed by NGM experts is lacking. The American Neurogast ... Full text Link to item Cite

A diagnosis of eosinophilic esophagitis is associated with increased life insurance premiums.

Journal Article Dis Esophagus · August 1, 2018 Eosinophilic esophagitis (EoE) is a chronic disease that can be diagnosed at any age, but is not associated with malignancy and does not shorten lifespan. It remains unknown whether an EoE diagnosis affects insurability or insurance premium costs. We there ... Full text Link to item Cite

Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.

Journal Article J Neurogastroenterol Motil · July 30, 2018 BACKGROUND/AIMS: Breaks in the peristaltic contour on esophageal high-resolution manometry (HRM) may be associated with bolus retention in the esophagus. We evaluated the relationship between peristaltic breaks and esophageal symptoms, reflux exposure, and ... Full text Link to item Cite

Gastroesophageal Reflux Monitoring.

Journal Article JAMA · March 27, 2018 Featured Publication Full text Link to item Cite

Genetic risk factors for perception of symptoms in GERD: an observational cohort study.

Journal Article Aliment Pharmacol Ther · January 2018 Featured Publication BACKGROUND: Genetic polymorphisms in G-protein beta-3 subunit (GNβ3) and beta-2 adrenergic receptor (ADRB2) are associated with pain and gut hypersensitivity, which can overlap with gastroesophageal reflux disease (GERD). AIM: To evaluate relationships bet ... Full text Link to item Cite

Upper esophageal sphincter (UES) metrics on high-resolution manometry (HRM) differentiate achalasia subtypes.

Journal Article Neurogastroenterol Motil · December 2017 BACKGROUND: The upper esophageal sphincter (UES) reflexively responds to bolus presence within the esophageal lumen, therefore UES metrics can vary in achalasia. METHODS: Within consecutive patients undergoing esophageal high-resolution manometry (HRM), 30 ... Full text Link to item Cite

Comparison of motor diagnoses by Chicago Classification versions 2.0 and 3.0 on esophageal high-resolution manometry.

Journal Article Neurogastroenterol Motil · July 2017 Featured Publication BACKGROUND: The Chicago Classification (CC) uses high-resolution manometry (HRM) software tools to designate esophageal motor diagnoses. We evaluated changes in diagnostic designations between two CC versions, and determined motor patterns not identified b ... Full text Link to item Cite

Elevated intrabolus pressure identifies obstructive processes when integrated relaxation pressure is normal on esophageal high-resolution manometry.

Journal Article Am J Physiol Gastrointest Liver Physiol · July 1, 2017 Elevated integrated relaxation pressure (IRP) on esophageal high-resolution manometry (HRM) identifies obstructive processes at the esophagogastric junction (EGJ). Our aim was to determine whether intrabolus pressure (IBP) can identify structural EGJ proce ... Full text Link to item Cite

Cover Image

Journal Article Neurogastroenterology & Motility · July 2017 Full text Cite

Impact of symptom burden and health-related quality of life (HRQOL) on esophageal motor diagnoses.

Journal Article Neurogastroenterol Motil · April 2017 BACKGROUND: High-resolution manometry (HRM) categorizes esophageal motor processes into specific Chicago Classification (CC) diagnoses, but the clinical impact of these motor diagnoses on symptom burden remain unclear. METHODS: Two hundred and eleven subje ... Full text Link to item Cite

The learning curve for interpretation of oesophageal high-resolution manometry: a prospective interventional cohort study.

Journal Article Aliment Pharmacol Ther · January 2017 BACKGROUND: High-resolution manometry has become the preferred choice of oesophagologists for oesophageal motor assessment, but the learning curve among trainees remains unclear. AIM: To determine the learning curve of high-resolution manometry interpretat ... Full text Link to item Cite

Comparison of two high-resolution manometry software systems in evaluating esophageal motor function.

Journal Article Neurogastroenterol Motil · December 2016 BACKGROUND: High-resolution manometry (HRM) utilizes software tools to diagnose esophageal motor disorders. Performance of these software metrics could be affected by averaging and by software characteristics of different manufacturers. METHODS: High-resol ... Full text Link to item Cite

How to Optimally Apply Impedance in the Evaluation of Esophageal Dysmotility.

Journal Article Curr Gastroenterol Rep · November 2016 The utilization of impedance technology has enhanced our understanding and assessment of esophageal dysmotility. Esophageal high-resolution manometry (HRM) catheters incorporated with multiple impedance electrodes help assess esophageal bolus transit, and ... Full text Link to item Cite

Loss of Peristaltic Reserve, Determined by Multiple Rapid Swallows, Is the Most Frequent Esophageal Motility Abnormality in Patients With Systemic Sclerosis.

Journal Article Clin Gastroenterol Hepatol · October 2016 We assessed peristaltic reserve using multiple rapid swallows (MRS) during esophageal high-resolution manometry (HRM) of 111 patients with systemic sclerosis (89 women; ages, 42-64 y). We performed a retrospective analysis of HRM studies that included MRS ... Full text Link to item Cite

Interrogation of esophagogastric junction barrier function using the esophagogastric junction contractile integral: an observational cohort study.

Journal Article Dis Esophagus · October 2016 The esophagogastric junction contractile integral (EGJ-CI), designed similar to distal contractile integral (DCI), has been proposed as a metric to evaluate EGJ barrier function. We determined normative values and evaluated EGJ-CI in predicting esophageal ... Full text Link to item Cite

Distal mean nocturnal baseline impedance on pH-impedance monitoring predicts reflux burden and symptomatic outcome in gastro-oesophageal reflux disease.

Journal Article Aliment Pharmacol Ther · October 2016 Featured Publication BACKGROUND: Mean nocturnal baseline impedance (MNBI), a novel pH-impedance metric, may be a surrogate marker of reflux burden. AIM: To assess the predictive value of MNBI on symptomatic outcomes after anti-reflux therapy. METHODS: In this prospective obser ... Full text Link to item Cite

Prevalence, characteristics, and treatment outcomes of reflux hypersensitivity detected on pH-impedance monitoring.

Journal Article Neurogastroenterol Motil · September 2016 BACKGROUND: Positive symptom association probability (SAP) with physiologic esophageal acid exposure time (AET) on pH-impedance monitoring defines reflux hypersensitivity (RH), a correlate of acid sensitivity on pH monitoring. We evaluated prevalence, clin ... Full text Link to item Cite

Esophagogastric junction contractile integral (EGJ-CI) quantifies changes in EGJ barrier function with surgical intervention.

Journal Article Neurogastroenterol Motil · May 2016 BACKGROUND: Esophagogastric junction contractile integral (EGJ-CI) assesses EGJ barrier function on esophageal high resolution manometry (HRM). We assessed EGJ-CI values in achalasia and gastroesophageal reflux disease (GERD) to determine if postoperative ... Full text Link to item Cite

GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation.

Journal Article Neurogastroenterol Motil · April 2016 Featured Publication BACKGROUND: Combinations of reflux parameters (acid exposure time, AET; symptom association probability, SAP) on pH-impedance monitoring describe varying confidence in reflux evidence. We compared outcomes between phenotypes with distinct pre-identified re ... Full text Link to item Cite

Ineffective esophageal motility phenotypes following fundoplication in gastroesophageal reflux disease.

Journal Article Neurogastroenterol Motil · February 2016 BACKGROUND: Ineffective esophageal motility (IEM) is associated with reflux disease, but its natural history is unclear. We evaluated patients undergoing repeat esophageal high resolution manometry (HRM) for symptomatic presentations after antireflux surge ... Full text Link to item Cite

Achalasia symptom response after Heller myotomy segregated by high-resolution manometry subtypes.

Journal Article J Gastroenterol · February 2016 Featured Publication BACKGROUND: Achalasia is classified into three HRM subtypes that predict outcomes from diverse management strategies. We assessed if symptomatic response varied when a single management strategy-Heller myotomy (HM)-is employed. METHODS: Treatment-naive sub ... Full text Link to item Cite

Definitions of gastroesophageal reflux disease (GERD)

Chapter · July 21, 2015 Featured Publication Full text Cite

Cameron lesions in patients with hiatal hernias: prevalence, presentation, and treatment outcome.

Journal Article Dis Esophagus · July 2015 Cameron lesions, as defined by erosions and ulcerations at the diaphragmatic hiatus, are found in the setting of gastrointestinal (GI) bleeding in patients with a hiatus hernia (HH). The study aim was to determine the epidemiology and clinical manifestatio ... Full text Link to item Cite

Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease.

Journal Article Clin Gastroenterol Hepatol · May 2015 Featured Publication BACKGROUND & AIMS: pH-impedance monitoring detects acid and nonacid reflux events, but little is known about which parameters predict outcomes of different management strategies. We evaluated a cohort of medically and surgically managed patients after pH-i ... Full text Link to item Cite

Gastroesophageal reflux disease

Internet Publication · May 2015 Cite

Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms.

Journal Article J Clin Gastroenterol · February 2015 BACKGROUND: Globus is commonly encountered in clinical practice, but high-resolution manometry (HRM) characteristics are incompletely characterized. We evaluated HRM metrics in globus subjects, compared with age-matched and sex-matched dysphagia subjects a ... Full text Link to item Cite

Exaggerated smooth muscle contraction segments on esophageal high-resolution manometry: prevalence and clinical relevance.

Journal Article Neurogastroenterol Motil · February 2015 BACKGROUND: Two smooth muscle contraction segments (S2, S3) on esophageal high-resolution manometry (HRM) demonstrate varying contraction vigor in symptomatic patients. Significance of isolated exaggerated smooth muscle contraction remains unclear. METHODS ... Full text Link to item Cite

Optimizing the high-resolution manometry (HRM) study protocol.

Journal Article Neurogastroenterol Motil · February 2015 Featured Publication BACKGROUND: Intolerance of the esophageal manometry catheter may prolong high-resolution manometry (HRM) studies and increase patient distress. We assessed the impact of obtaining the landmark phase at the end of the study when the patient has acclimatized ... Full text Link to item Cite

Esophageal motor function: technical aspects of manometry.

Journal Article Gastrointest Endosc Clin N Am · October 2014 Featured Publication High-resolution manometry (HRM) has advanced the understanding of esophageal peristaltic mechanisms and has simplified esophageal motor testing. In this article the technical aspects of HRM are addressed, focusing on test protocols, in addition to concerns ... Full text Link to item Cite

Acid-based parameters on pH-impedance testing predict symptom improvement with medical management better than impedance parameters.

Journal Article Am J Gastroenterol · June 2014 Featured Publication OBJECTIVES: pH-impedance testing detects reflux events irrespective of pH, but its value in predicting treatment outcome is unclear. We prospectively evaluated subjects treated medically after pH-impedance testing to determine predictors of symptom improve ... Full text Link to item Cite

Reproducibility patterns of multiple rapid swallows during high resolution esophageal manometry provide insights into esophageal pathophysiology.

Journal Article Neurogastroenterol Motil · May 2014 BACKGROUND: Multiple rapid swallows (MRS) during esophageal high resolution manometry (HRM) assess esophageal neuromuscular integrity by evaluating postdeglutitive inhibition and rebound contraction, but most reports performed only a single MRS sequence. W ... Full text Link to item Cite

Reproducibility of multiple rapid swallows during high resolution manometry (HRM)

Conference NEUROGASTROENTEROLOGY AND MOTILITY · September 1, 2013 Link to item Cite

Sensory neuromodulators in functional nausea and vomiting: predictors of response.

Journal Article Postgrad Med J · March 2013 BACKGROUND: Tricyclic antidepressants (TCAs) are known to benefit subjects with functional nausea and vomiting (FNV), but it is not known if alternate neuromodulators are also beneficial. We retrospectively evaluated outcomes and clinical predictors of res ... Full text Link to item Cite

Cameron's Lesions: Incidence, Presentation and Treatment Outcome

Conference GASTROINTESTINAL ENDOSCOPY · April 1, 2012 Link to item Cite

Amphibian pathogen Batrachochytrium dendrobatidis is inhibited by the cutaneous bacteria of amphibian species

Journal Article EcoHealth · March 1, 2006 Population declines of amphibian species in many parts of the world are associated with a lethal fungal pathogen, Batrachochytrium dendrobatidis. Using laboratory challenge assays, we describe the inhibition of B. dendrobatidis by members of eight genera o ... Full text Cite

Gastrointestinal Diseases

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Gastrointestinal Diseases

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