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Amy Claudine Hobeika

Assistant Professor in Surgery
Surgery, Surgical Sciences
Box 2606 Med Ctr, Durham, NC 27710
404A MSRB 1, Research Dr, Durham, NC 27710

Current Appointments & Affiliations


Assistant Professor in Surgery · 2021 - Present Surgery, Surgical Sciences, Surgery

Recent Publications


Clinical impact of concurrent autologous adoptive T cells immunotherapy in active COVID-19 infected cancer patients for chemotherapy.

Journal Article Infect Agent Cancer · April 9, 2025 BACKGROUND: The concurrent presence of COVID-19 infection in advanced cancer patients has increased the mortality since the compromised immunity was inevitably worsen. The role and clinical impact of autologous adoptive T cell immunotherapy (ACT) designed ... Full text Link to item Cite

Vaccines targeting ESR1 activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer.

Journal Article Hum Vaccin Immunother · December 31, 2024 ER+ breast cancers (BC) are characterized by the elevated expression and signaling of estrogen receptor alpha (ESR1), which renders them sensitive to anti-endocrine therapy. While these therapies are clinically effective, prolonged treatment inevitably res ... Full text Link to item Cite

Clinical trials of self-replicating RNA-based cancer vaccines.

Journal Article Cancer Gene Ther · June 2023 Therapeutic cancer vaccines, designed to activate immune effectors against tumor antigens, utilize a number of different platforms for antigen delivery. Among these are messenger RNAs (mRNA), successfully deployed in some prophylactic SARS-CoV2 vaccines. T ... Full text Link to item Cite
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Recent Grants


Single Cell and Spatial Analysis of Lethal Breast Cancers

ResearchCo Investigator · Awarded by Department of Defense · 2024 - 2028

Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory

ResearchCo Investigator · Awarded by Department of Defense · 2021 - 2025

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Education, Training & Certifications


University of Florida · 1997 Ph.D.