Current Duke Appointments & Affiliations
Assistant Professor in Surgery
·
2021 - Present
Surgery, Surgical Sciences,
Surgery
Recent Scholarly Works
Vector-directed immunity and boosting capacity of VRP-srRNA anti-tumor vaccines.
Journal article NPJ Vaccines · March 16, 2026 Self-replicating RNA vaccines delivered by viral replicon particles (VRPs) induce strong immunity, but repeated dosing on short intervals may be limited by vector responses. In patient samples and mice, VRP-srRNA vaccination generated VRP-neutralizing anti ... Full text Link to item CiteCD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity.
Journal article Sci Immunol · December 19, 2025 Tumor antigen vaccination represents an appealing approach for cancer but has failed to materialize as oncologic standard of care. To understand long-term vaccine efficacy, we conducted a retrospective analysis of patients with human epidermal growth recep ... Full text Link to item CiteClinical impact of concurrent autologous adoptive T cells immunotherapy in active COVID-19 infected cancer patients for chemotherapy.
Journal article Infect Agent Cancer · April 9, 2025 BACKGROUND: The concurrent presence of COVID-19 infection in advanced cancer patients has increased the mortality since the compromised immunity was inevitably worsen. The role and clinical impact of autologous adoptive T cell immunotherapy (ACT) designed ... Full text Link to item CiteRecent Grants
Single Cell and Spatial Analysis of Lethal Breast Cancers
ResearchCo Investigator · Awarded by Department of Defense · 2024 - 2028Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory
ResearchCo Investigator · Awarded by Department of Defense · 2021 - 2026Beyond PD1: An immunotherapeutic strategy to stimulate and enable both T-cell and B-cell responses in immunosuppressive and non-mutated metastatic breast cancer
ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2026View All Grants
Education
University of Florida ·
1997
Ph.D.