Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Associate, University of Florida 1997 - 1999
  • Ph.D., University of Florida 1997
  • Laboratory Technician, University of Florida 1993 - 1996
  • Teaching Assistant, University of Florida 1993 - 1996
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2011 - 2020
  • Assistant Professor of Surgery, Surgical Oncology, Surgery 2011
  • Assistant Professor of Surgery, Surgery, Clinical Science Departments 2006 - 2010
  • Assistant Research Professor in Surgery, Surgery, Clinical Science Departments 2005 - 2006
• Research
• 

  Selected Grants

  • Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory awarded by Department of Defense 2021 - 2025
  • Beyond PD1: An immunotherapeutic strategy to stimulate and enable both T-cell and B-cell responses in immunosuppressive and non-mutated metastatic breast cancer awarded by Department of Defense 2020 - 2024
  • Detection and Elimination of Oncogenic Signaling Networks in Pre-malignant and Malignant Cells with Magnetic Resonance Imaging awarded by Department of Defense 2012 - 2022
  • Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy awarded by Department of Defense 2012 - 2022
  • A Molecular Framework for Understanding DCIS awarded by Department of Defense 2014 - 2022
  • Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
  • Immunologic Correlates of Effective Immunizations for Cancer Vaccines awarded by National Institutes of Health 2001 - 2006
  • Dexasome Based Immunotherapy of Lung Cancer awarded by National Institutes of Health 2001 - 2004
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Morse, Michael A., Erika J. Crosby, Jeremy Force, Takuya Osada, Amy C. Hobeika, Zachary C. Hartman, Peter Berglund, Jonathan Smith, and H Kim Lyerly. “Clinical trials of self-replicating RNA-based cancer vaccines.” Cancer Gene Ther, February 10, 2023, 1–9. https://doi.org/10.1038/s41417-023-00587-1.
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    • Kaneko, Kensuke, Chaitanya R. Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F. Hughes, et al. “Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers.” J Immunother Cancer 10, no. 9 (September 2022). https://doi.org/10.1136/jitc-2022-004793.
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    • Osada, Takuya, Erika J. Crosby, Kensuke Kaneko, Joshua C. Snyder, Joshua D. Ginzel, Chaitanya R. Acharya, Xiao-Yi Yang, et al. “HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study.” Mol Cancer Ther 21, no. 1 (January 2022): 217–26. https://doi.org/10.1158/1535-7163.MCT-21-0334.
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    • Song, Linan, Shuo Wang, Tong Fang, Xiaoguang Qiu, Xiaoli Wang, Xinna Zhou, Michael A. Morse, et al. “Changes in Peripheral Blood Regulatory T Cells and IL-6 and IL-10 Levels Predict Response of Pediatric Medulloblastoma and Germ Cell Tumors With Residual or Disseminated Disease to Craniospinal Irradiation.” Int J Radiat Oncol Biol Phys 111, no. 2 (October 1, 2021): 479–90. https://doi.org/10.1016/j.ijrobp.2021.04.041.
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    • Yang, Duo, Xiaoli Wang, Xinna Zhou, Jing Zhao, Huabing Yang, Shuo Wang, Michael A. Morse, et al. “Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapy.” Oncoimmunology 10, no. 1 (2021): 1976953. https://doi.org/10.1080/2162402X.2021.1976953.
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    • Crosby, Erika J., Amy C. Hobeika, Donna Niedzwiecki, Christel Rushing, David Hsu, Peter Berglund, Jonathan Smith, et al. “Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio.” J Immunother Cancer 8, no. 2 (November 2020). https://doi.org/10.1136/jitc-2020-001662.
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    • He, Zixuan, Shuo Wang, Guoliang Qiao, Xiaoli Wang, Xinna Zhou, Siyu Zhu, Yanhua Yuan, et al. “Clinical efficacy of intra-cavitary infusions of autologous dendritic cell/cytokine-induced killer cell products for the treatment of refractory malignant pleural effusions and ascites.” Am J Transl Res 12, no. 7 (2020): 3940–52.
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    • Zhou, Xinna, Guoliang Qiao, Jun Ren, Xiaoli Wang, Shuo Wang, Siyu Zhu, Yanhua Yuan, Michael A. Morse, Amy Hobeika, and Herbert Kim Lyerly. “Adoptive immunotherapy with autologous T-cell infusions reduces opioid requirements in advanced cancer patients.” Pain 161, no. 1 (January 2020): 127–34. https://doi.org/10.1097/j.pain.0000000000001702.
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    • Huang, Lefu, Guoliang Qiao, Michael A. Morse, Xiaoli Wang, Xinna Zhou, Jiangping Wu, Amy Hobeika, Jun Ren, and Herbert K. Lyerly. “Predictive significance of T cell subset changes during ex vivo generation of adoptive cellular therapy products for the treatment of advanced non-small cell lung cancer.” Oncol Lett 18, no. 6 (December 2019): 5717–24. https://doi.org/10.3892/ol.2019.10964.
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    • Qiao, Guoliang, Xiaoli Wang, Xinna Zhou, Michael A. Morse, Jiangping Wu, Shuo Wang, Yuguang Song, et al. “Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors.” Int J Hyperthermia 36, no. sup1 (November 2019): 74–82. https://doi.org/10.1080/02656736.2019.1647350.
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    • Lv, Shuzhen, Shuo Wang, Guoliang Qiao, Xiaoli Wang, Xinna Zhou, Fengcai Yan, Yanping Li, et al. “Functional CD3+CD8+PD1- T Cell Accumulation and PD-L1 Expression Increases During Tumor Invasion in DCIS of the Breast.” Clin Breast Cancer 19, no. 5 (October 2019): e617–23. https://doi.org/10.1016/j.clbc.2019.04.001.
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    • Sun, Yuanyuan, Suya Wang, Hainan Yang, Jiangping Wu, Sha Li, Guoliang Qiao, Shuo Wang, et al. “Impact of synchronized anti-PD-1 with Ad-CEA vaccination on inhibition of colon cancer growth.” Immunotherapy 11, no. 11 (August 2019): 953–66. https://doi.org/10.2217/imt-2019-0055.
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    • Zhao, Y., G. Qiao, X. Wang, Y. Song, X. Zhou, N. Jiang, L. Zhou, et al. “Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients' preference-based study (PPPS).” Clin Transl Oncol 21, no. 6 (June 2019): 721–28. https://doi.org/10.1007/s12094-018-1968-3.
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    • Crosby, Erika J., William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, et al. “Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.” Clin Cancer Res 25, no. 9 (May 1, 2019): 2725–36. https://doi.org/10.1158/1078-0432.CCR-18-3102.
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    • Wang, Xiaoli, Shuo Wang, Michael A. Morse, Ni Jiang, Yanjie Zhao, Yuguang Song, Lei Zhou, et al. “Prospective randomized comparative study on rivaroxaban and LMWH for prophylaxis of post-apheresis thrombosis in adoptive T cell immunotherapy cancer patients.” J Thromb Thrombolysis 47, no. 4 (May 2019): 505–11. https://doi.org/10.1007/s11239-019-01844-7.
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    • Qiao, Guoliang, Xiaoli Wang, Lei Zhou, Xinna Zhou, Yuguang Song, Shuo Wang, Lei Zhao, et al. “Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study.” Clin Cancer Res 25, no. 5 (March 1, 2019): 1494–1504. https://doi.org/10.1158/1078-0432.CCR-18-2360.
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    • Osada, Takuya, Zachary C. Hartman, Junping Wei, Gangjun Lei, Amy C. Hobeika, William R. Gwin, Marcio A. Diniz, et al. “Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers.” Breast Cancer Res 20, no. 1 (August 9, 2018): 90. https://doi.org/10.1186/s13058-018-1023-x.
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    • Zhou, Xinna, Guoliang Qiao, Xiaoli Wang, Qingkun Song, Michael A. Morse, Amy Hobeika, William R. Gwin, Jun Ren, and H Kim Lyerly. “CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine.” Cancer Chemother Pharmacol 81, no. 2 (February 2018): 365–72. https://doi.org/10.1007/s00280-017-3500-9.
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    • Song, Qingkun, Jun Ren, Xinna Zhou, Xiaoli Wang, Guohong Song, Amy Hobeika, Yanhua Yuan, and Herbert Kim Lyerly. “Circulating CD8⁺CD28^- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.” Cytotherapy 20, no. 1 (January 2018): 126–33. https://doi.org/10.1016/j.jcyt.2017.08.018.
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    • Osada, Takuya, Kensuke Kaneko, William R. Gwin, Michael A. Morse, Amy Hobeika, Brian W. Pogue, Zachary C. Hartman, Philip F. Hughes, Timothy Haystead, and H Kim Lyerly. “In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior.” Clin Cancer Res 23, no. 24 (December 15, 2017): 7531–42. https://doi.org/10.1158/1078-0432.CCR-17-1453.
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    • Jiang, Ni, Guoliang Qiao, Xiaoli Wang, Michael A. Morse, William R. Gwin, Lei Zhou, Yuguang Song, et al. “Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study.” Clin Cancer Res 23, no. 17 (September 1, 2017): 5066–73. https://doi.org/10.1158/1078-0432.CCR-17-0492.
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    • Osada, Takuya, Michael A. Morse, Amy Hobeika, Marcio A. Diniz, William R. Gwin, Zachary Hartman, Junping Wei, et al. “Vaccination targeting human HER3 alters the phenotype of infiltrating T cells and responses to immune checkpoint inhibition.” Oncoimmunology 6, no. 6 (2017): e1315495. https://doi.org/10.1080/2162402X.2017.1315495.
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    • Ren, Jun, William R. Gwin, Xinna Zhou, Xiaoli Wang, Hongyan Huang, Ni Jiang, Lei Zhou, et al. “Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy.” Oncoimmunology 6, no. 4 (2017): e1264563. https://doi.org/10.1080/2162402X.2016.1264563.
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    • Song, Qing-Kun, Jun Ren, Xin-Na Zhou, Xiao-Li Wang, Guo-Hong Song, Li-Jun Di, Jing Yu, et al. “The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion.” Oncotarget 6, no. 38 (December 1, 2015): 41350–59. https://doi.org/10.18632/oncotarget.5534.
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    • Osada, Takuya, Koji Nagaoka, Masashi Takahara, Xiao Yi Yang, Cong-Xiao Liu, Hongtao Guo, Kingshuk Roy Choudhury, et al. “Precision cancer immunotherapy: optimizing dendritic cell-based strategies to induce tumor antigen-specific T-cell responses against individual patient tumors.” J Immunother 38, no. 4 (May 2015): 155–64. https://doi.org/10.1097/CJI.0000000000000075.
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    • Morse, Michael A., Takuya Osada, Amy Hobeika, Sandip Patel, and H Kim Lyerly. “Biomarkers and correlative endpoints for immunotherapy trials.” Am Soc Clin Oncol Educ Book, 2013. https://doi.org/10.14694/EdBook_AM.2013.33.e287.
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    • Osada, Takuya, Peter Berglund, Michael A. Morse, Bolyn Hubby, Whitney Lewis, Donna Niedzwiecki, Xiao Yi Yang, et al. “Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.” Cancer Immunol Immunother 61, no. 11 (November 2012): 1941–51. https://doi.org/10.1007/s00262-012-1248-y.
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    • Ren, Xiu-Rong, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Wenle Xia, Neil Spector, et al. “Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.” Breast Cancer Res 14, no. 3 (June 7, 2012): R89. https://doi.org/10.1186/bcr3204.
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    • Osada, Takuya, Michael A. Morse, Amy Hobeika, and H Kim Lyerly. “Novel recombinant alphaviral and adenoviral vectors for cancer immunotherapy.” Semin Oncol 39, no. 3 (June 2012): 305–10. https://doi.org/10.1053/j.seminoncol.2012.02.013.
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    • Hamilton, Erika, Kimberly Blackwell, Amy C. Hobeika, Timothy M. Clay, Gloria Broadwater, Xiu-Rong Ren, Wei Chen, et al. “Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected].” J Transl Med 10 (February 10, 2012): 28. https://doi.org/10.1186/1479-5876-10-28.
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    • Morse, M. A., A. Hobeika, D. Serra, K. Aird, M. McKinney, A. Aldrich, T. Clay, et al. “Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.” Cancer Gene Ther 19, no. 1 (January 2012): 30–37. https://doi.org/10.1038/cgt.2011.63.
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    • Hamilton, E. P., A. C. Hobeika, H. K. Lyerly, K. Owzar, G. Rocha, G. G. Kimmick, P. K. Marcom, J. M. Peppercorn, M. A. Morse, and K. L. Blackwell. “P1-13-03: Zoledronic Acid Induces an Immune Response in Breast Cancer Patients through Stimulation of Central Memory and Effector Memory gamma/delta T-Cells.” Cancer Research 71, no. 24_Supplement (December 15, 2011). https://doi.org/10.1158/0008-5472.sabcs11-p1-13-03.
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    • Hartman, Zachary C., Junping Wei, Oliver K. Glass, Hongtao Guo, Gangjun Lei, Xiao-Yi Yang, Takuya Osada, et al. “Increasing vaccine potency through exosome antigen targeting.” Vaccine 29, no. 50 (November 21, 2011): 9361–67. https://doi.org/10.1016/j.vaccine.2011.09.133.
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    • Morse, Michael A., Robert Chapman, John Powderly, Kimberly Blackwell, Tibor Keler, Jennifer Green, Renee Riggs, et al. “Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients.” Clin Cancer Res 17, no. 14 (July 15, 2011): 4844–53. https://doi.org/10.1158/1078-0432.CCR-11-0891.
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    • Morse, Michael A., Angeles A. Secord, Kimberly Blackwell, Amy C. Hobeika, Gomathinayagam Sinnathamby, Takuya Osada, Julie Hafner, et al. “MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T-cell responses against breast and ovarian cancer.” Clin Cancer Res 17, no. 10 (May 15, 2011): 3408–19. https://doi.org/10.1158/1078-0432.CCR-10-2614.
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    • Clay, Timothy M., Takuya Osada, Zachary C. Hartman, Amy Hobeika, Gayathri Devi, Michael A. Morse, and H Kim Lyerly. “Polyclonal immune responses to antigens associated with cancer signaling pathways and new strategies to enhance cancer vaccines.” Immunol Res 49, no. 1–3 (April 2011): 235–47. https://doi.org/10.1007/s12026-010-8186-6.
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    • Sinnathamby, G., J. Zerfass, J. Hafner, P. Block, Z. Nickens, A. Hobeika, A. A. Secord, H. K. Lyerly, M. A. Morse, and R. Philip. “ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.” Clin Exp Immunol 163, no. 3 (March 2011): 324–32. https://doi.org/10.1111/j.1365-2249.2010.04298.x.
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    • Hobeika, Amy C., Michael A. Morse, Takuya Osada, Sharon Peplinski, H Kim Lyerly, and Timothy M. Clay. “Depletion of human regulatory T cells.” Methods Mol Biol 707 (2011): 219–31. https://doi.org/10.1007/978-1-61737-979-6_14.
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    • Morse, Michael A., Amy C. Hobeika, Takuya Osada, Peter Berglund, Bolyn Hubby, Sarah Negri, Donna Niedzwiecki, et al. “An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.” J Clin Invest 120, no. 9 (September 2010): 3234–41. https://doi.org/10.1172/JCI42672.
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    • Morse, Michael A., Junping Wei, Zachary Hartman, Wenle Xia, Xiu-Rong Ren, Gangjun Lei, William T. Barry, et al. “Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo.” Int J Cancer 126, no. 12 (June 15, 2010): 2893–2903. https://doi.org/10.1002/ijc.24995.
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    • Hartman, Zachary C., Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei, Xiao-Yi Yang, Sharon Peplinski, et al. “An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity.” Clin Cancer Res 16, no. 5 (March 1, 2010): 1466–77. https://doi.org/10.1158/1078-0432.CCR-09-2549.
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    • Sun, Baodong, Michael D. Kulis, Sarah P. Young, Amy C. Hobeika, Songtao Li, Andrew Bird, Haoyue Zhang, et al. “Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.” Mol Ther 18, no. 2 (February 2010): 353–60. https://doi.org/10.1038/mt.2009.195.
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    • Osada, T., D. Hsu, S. Hammond, A. Hobeika, G. Devi, T. M. Clay, H. K. Lyerly, and M. A. Morse. “Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody.” Br J Cancer 102, no. 1 (January 5, 2010): 124–33. https://doi.org/10.1038/sj.bjc.6605364.
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    • Morse, Michael A., Amy C. Hobeika, Takuya Osada, Delila Serra, Donna Niedzwiecki, H Kim Lyerly, and Timothy M. Clay. “Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines.” Blood 112, no. 3 (August 1, 2008): 610–18. https://doi.org/10.1182/blood-2008-01-135319.
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    • Hobeika, Ac, T. Osada, D. Serra, S. Peplinski, K. Hanson, Y. Tanaka, D. Niedzwiecki, et al. “Detailed analysis of cytomegalovirus (CMV)-specific T cells expanded for adoptive immunotherapy of CMV infection following allogeneic stem cell transplantation for malignant disease.” Cytotherapy 10, no. 3 (2008): 289–302. https://doi.org/10.1080/14653240801927040.
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    • Morse, Michael, Lee Langer, Alexander Starodub, Amy Hobeika, Timothy Clay, and H Kim Lyerly. “Current immunotherapeutic strategies in colon cancer.” Surg Oncol Clin N Am 16, no. 4 (October 2007): 873–x. https://doi.org/10.1016/j.soc.2007.07.005.
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    • Morse, Michael A., Amy Hobeika, Takuya Osada, Donna Niedzwiecki, Paul Kelly Marcom, Kimberly L. Blackwell, Carey Anders, Gayathri R. Devi, H Kim Lyerly, and Timothy M. Clay. “Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2.” J Transl Med 5 (September 6, 2007): 42. https://doi.org/10.1186/1479-5876-5-42.
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    • Mosca, Paul J., H Kim Lyerly, Timothy M. Clay, and Michael A. Morse. “Dendritic cell vaccines.” Front Biosci 12 (May 1, 2007): 4050–60. https://doi.org/10.2741/2371.
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    • Johnson, Benjamin F., Timothy M. Clay, Amy C. Hobeika, H Kim Lyerly, and Michael A. Morse. “Vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy.” Expert Opin Biol Ther 7, no. 4 (April 2007): 449–60. https://doi.org/10.1517/14712598.7.4.449.
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    • Osada, Takuya, Timothy Clay, Amy Hobeika, H Kim Lyerly, and Michael A. Morse. “NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity.” Cancer Immunol Immunother 55, no. 9 (September 2006): 1122–31. https://doi.org/10.1007/s00262-005-0089-3.
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    • Morse, Michael A., Timothy M. Clay, Amy C. Hobeika, Takuya Osada, Shubi Khan, Stephen Chui, Donna Niedzwiecki, Dennis Panicali, Jeffrey Schlom, and H Kim Lyerly. “Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules.” Clin Cancer Res 11, no. 8 (April 15, 2005): 3017–24. https://doi.org/10.1158/1078-0432.CCR-04-2172.
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    • Morse, Michael A., Jennifer Garst, Takuya Osada, Shubi Khan, Amy Hobeika, Timothy M. Clay, Nancy Valente, et al. “A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer.” J Transl Med 3, no. 1 (February 21, 2005): 9. https://doi.org/10.1186/1479-5876-3-9.
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    • Morse, Michael A., Stephen Chui, Amy Hobeika, H Kim Lyerly, and Timothy Clay. “Recent developments in therapeutic cancer vaccines.” Nat Clin Pract Oncol 2, no. 2 (February 2005): 108–13. https://doi.org/10.1038/ncponc0098.
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    • Hobeika, Amy C., Michael A. Morse, Takuya Osada, Manar Ghanayem, Donna Niedzwiecki, Robert Barrier, H Kim Lyerly, and Timothy M. Clay. “Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis.” J Immunother 28, no. 1 (2005): 63–72. https://doi.org/10.1097/00002371-200501000-00008.
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    • Chui, S., T. M. Clay, P. J. Mosca, A. C. Hobeika, T. Osada, L. Galibert, D. Caron, H. K. Lyerly, and M. A. Morse. “Flt3-ligand as a vaccine adjuvant: Results in a study of Flt3-ligand plus tetanus toxoid immunization.” Journal of Applied Research 4, no. 4 (December 1, 2004): 536–49.
    • Morse, M. A., T. M. Clay, A. C. Hobeika, S. Chui, P. J. Mosca, D. Caron, and H. K. Lyerly. “Active immunotherapy with Flt3-ligand mobilized peripheral blood dendritic cells loaded with carcinoembryonic antigen peptide in patients with metastatic malignancies.” Journal of Applied Research 4, no. 4 (December 1, 2004): 554–69.
    • Chui, S. Y., M. A. Morse, T. Doldo, T. Osada, T. M. Clay, H. K. Lyerly, S. Khan, A. Gattis, and A. C. Hobeika. “Regulatory and effector T cell subsets and dendritic cells in breast cancer.” J Clin Oncol 22, no. 14_suppl (July 15, 2004): 9697.
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    • Morse, Michael A., Smita K. Nair, Paul J. Mosca, Amy C. Hobeika, Timothy M. Clay, Yuping Deng, David Boczkowski, et al. “Immunotherapy with autologous, human dendritic cells transfected with carcinoembryonic antigen mRNA.” Cancer Invest 21, no. 3 (June 2003): 341–49. https://doi.org/10.1081/cnv-120018224.
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    • Morse, Michael A., Timothy M. Clay, Kirsten Colling, Amy Hobeika, Ken Grabstein, Martin A. Cheever, and H Kim Lyerly. “HER2 dendritic cell vaccines.” Clin Breast Cancer 3 Suppl 4 (February 2003): S164–72. https://doi.org/10.3816/cbc.2003.s.007.
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    • Mosca, Paul J., H Kim Lyerly, C Denise Ching, Amy C. Hobeika, Timothy M. Clay, and Michael A. Morse. “Proteomics for monitoring immune responses to cancer vaccines.” Curr Opin Mol Ther 5, no. 1 (February 2003): 39–43.
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    • Mosca, Paul J., Amy C. Hobeika, Kirsten Colling, Timothy M. Clay, Elaine K. Thomas, Dania Caron, H Kim Lyerly, and Michael A. Morse. “Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand.” J Leukoc Biol 72, no. 3 (September 2002): 546–53.
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    • Morse, Michael A., David Rizzieri, Timothy T. Stenzel, Amy C. Hobeika, James J. Vredenburgh, Nelson J. Chao, Timothy M. Clay, Paul J. Mosca, and H Kim Lyerly. “Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants.” J Hematother Stem Cell Res 11, no. 4 (August 2002): 659–68. https://doi.org/10.1089/15258160260194802.
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    • Kominsky, S. L., B. A. Torres, A. C. Hobeika, F. A. Lake, and H. M. Johnson. “Superantigen enhanced protection against a weak tumor-specific melanoma antigen: implications for prophylactic vaccination against cancer.” Int J Cancer 94, no. 6 (December 15, 2001): 834–41. https://doi.org/10.1002/ijc.1551.
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    • Clay, T. M., A. C. Hobeika, P. J. Mosca, H. K. Lyerly, and M. A. Morse. “Assays for monitoring cellular immune responses to active immunotherapy of cancer.” Clin Cancer Res 7, no. 5 (May 2001): 1127–35.
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    • Torres, B. A., A. C. Hobeika, F. A. Lake, H. M. Johnson, and S. L. Kominsky. “Superantigens induce potent and protective immune responses to weak melanoma-specific antigens.” Faseb Journal 15, no. 5 (March 8, 2001): A1201–A1201.
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    • Torres, B. A., S. Kominsky, G. Q. Perrin, A. C. Hobeika, and H. M. Johnson. “Superantigens: the good, the bad, and the ugly.” Exp Biol Med (Maywood) 226, no. 3 (March 2001): 164–76. https://doi.org/10.1177/153537020122600303.
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    • Mosca, P. J., A. C. Hobeika, T. M. Clay, M. A. Morse, and H. K. Lyerly. “Direct detection of cellular immune responses to cancer vaccines.” Surgery 129, no. 3 (March 2001): 248–54. https://doi.org/10.1067/msy.2001.108609.
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    • Morse, M. A., T. M. Clay, A. C. Hobeika, P. J. Mosca, and H. K. Lyerly. “Monitoring cellular immune responses to cancer immunotherapy.” Curr Opin Mol Ther 3, no. 1 (February 2001): 45–52.
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    • Hobeika, A. C., T. M. Clay, P. J. Mosca, H. K. Lyerly, and M. A. Morse. “Quantitating therapeutically relevant T-cell responses to cancer vaccines.” Crit Rev Immunol 21, no. 1–3 (2001): 287–97.
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    • Morse, M. A., S. Nair, M. Fernandez-Casal, Y. Deng, M. St Peter, R. Williams, A. Hobeika, et al. “Preoperative mobilization of circulating dendritic cells by Flt3 ligand administration to patients with metastatic colon cancer.” J Clin Oncol 18, no. 23 (December 1, 2000): 3883–93. https://doi.org/10.1200/JCO.2000.18.23.3883.
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    • Mosca, P. J., A. C. Hobeika, T. M. Clay, S. K. Nair, E. K. Thomas, M. A. Morse, and H. K. Lyerly. “A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment.” Blood 96, no. 10 (November 15, 2000): 3499–3504.
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    • Kominsky, S. L., A. C. Hobeika, F. A. Lake, B. A. Torres, and H. M. Johnson. “Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.” Cancer Res 60, no. 14 (July 15, 2000): 3904–8.
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    • Subramaniam, P. S., P. E. Cruz, A. C. Hobeika, and H. M. Johnson. “Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line.” Oncogene 16, no. 14 (April 9, 1998): 1885–90. https://doi.org/10.1038/sj.onc.1201712.
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    • Hobeika, A. C., and H. M. Johnson. “A neutralizing epitope of the superantigen SEA has agonist activity on T cells.” Biochem Biophys Res Commun 223, no. 3 (June 25, 1996): 565–71. https://doi.org/10.1006/bbrc.1996.0935.
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    • Soos, J. M., P. S. Subramaniam, A. C. Hobeika, J. Schiffenbauer, and H. M. Johnson. “The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity.” J Immunol 155, no. 5 (September 1, 1995): 2747–53.
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    • Soos, J. M., A. C. Hobeika, E. J. Butfiloski, J. Schiffenbauer, and H. M. Johnson. “Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen.” Proc Natl Acad Sci U S A 92, no. 13 (June 20, 1995): 6082–86. https://doi.org/10.1073/pnas.92.13.6082.
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  • Book Sections

    • Hobeika, A. C., M. A. Morse, T. M. Clay, T. Osada, P. J. Mosca, and H. K. Lyerly. “Intracellular Cytokine Assays.” In Measuring Immunity: Basic Biology and Clinical Assessment, 336–40, 2005. https://doi.org/10.1016/B978-012455900-4/50290-7.
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    • Hobeika, A. C., M. A. Morse, T. M. Clay, T. Osada, P. J. Mosca, and H. K. Lyerly. “Intracellular Cytokine Assays.” In Measuring Immunity: Basic Science and Clinical Practice, 336–40, 2004. https://doi.org/10.1016/B978-012455900-4/50290-7.
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  • Other Articles

    • Hamilton, E., K. Blackwell, A. C. Hobeika, T. M. Clay, G. Broadwater, X. R. Ren, W. Chen, et al. “Correction: phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion.” J Transl Med, 2013. https://doi.org/10.1186/1479-5876-11-82.
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    • Hobeika, A. C., T. M. Clay, and M. A. Morse. “Monitoring immunity to cancer vaccines.” Enhancer  Biotherapy of Cancer, December 4, 2006.
    • Morse, M. A., T. M. Clay, A. C. Hobeika, P. J. Mosca, and H. K. Lyerly. “Surrogate markers of response to cancer immunotherapy.” Expert Opin Biol Ther, March 2001. https://doi.org/10.1517/14712598.1.2.153.
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  • Conference Papers

    • Crosby, E. J., W. R. Gwin, S. Chang, H. T. Maecker, V. Lubkov, J. C. Snyder, G. Broadwater, et al. “Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients.” In Cancer Research, Vol. 79. American Association for Cancer Research (AACR), 2019. https://doi.org/10.1158/1538-7445.sabcs18-p2-09-16.
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    • Hobeika, Amy C., Takuya Osada, Teresa Brehm, Xiao Yi Yang, H Kim Lyerly, Michael Morse, and Timothy Clay. “Depletion of regulatory T cells increases the in vivo CEA specific T cell response.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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    • Chui, S. Y., M. A. Morse, T. Doldo, T. Osada, T. M. Clay, H. K. Lyerly, S. Khan, A. Gattis, and A. C. Hobeika. “Regulatory and effector T cell subsets and dendritic cells in breast cancer.” In Journal of Clinical Oncology, 22:884S-884S. AMER SOC CLINICAL ONCOLOGY, 2004.
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    • Colling, K. L., A. C. Hobeika, P. J. Mosca, T. M. Clay, H. K. Lyerly, and M. A. Morse. “Enumerating functionally mature monocyte-derived dendritic cells for use in cancer immunotherapy.” In Blood, 98:851A-851A. AMER SOC HEMATOLOGY, 2001.
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    • Hobeika, A. C., S. Peplinski, M. A. Morse, P. J. Mosca, T. C. Clay, and H. K. Lyerly. “Quantitating antigen specific T cell responses in peripheral blood: A comparison of peptide MHC tetramer, ELISpot and intracellular cytokine analysis.” In Blood, 98:23A-23A. AMER SOC HEMATOLOGY, 2001.
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    • Hobeika, A. C., S. L. Peplinski, T. M. Clay, and H. K. Lyerly. “Quantitating functional CD8+T cell response to viral antigens.” In Faseb Journal, 15:A304–A304. FEDERATION AMER SOC EXP BIOL, 2001.
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    • Morse, M. A., D. Rizzieri, A. C. Hobeika, N. Chao, and H. Kirn Lyerly. “Dendritic cell (DC) reconstitution after nonmyeloablative allogeneic stem cell transplants.” In Blood, Vol. 96, 2000.
    • Morse, M. A., D. Rizzieri, A. C. Hobeika, N. Chao, and H. K. Lyerly. “Dendritic cell (DC) reconstitution after non-myeloablative allogeneic stem cell transplants.” In Blood, 96:305B-305B. AMER SOC HEMATOLOGY, 2000.
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    • Mosca, P. J., A. C. Hobeika, T. M. Clay, S. K. Nair, E. K. Thomas, D. A. Caron, H. K. Lyerly, and M. A. Morse. “Multiple signals are required for IL-12 production by Flt-3 ligand mobilized dendritic cells.” In Blood, 96:295A-295A. AMER SOC HEMATOLOGY, 2000.
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    • Hobeika, A. C., W. Etienne, H. M. Johnson, and P. S. Subramaniam. “IFN gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis.” In Faseb Journal, 13:A610–A610. FEDERATION AMER SOC EXP BIOL, 1999.
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    • Hobeika, A. C., W. Etienne, P. E. Cruz, P. S. Subramaniam, and H. M. Johnson. “IFN gamma induction of p21(WAF1) in prostate cancer cells: Role in cell cycle and cell phenotype.” In Faseb Journal, 12:A283–A283. FEDERATION AMER SOC EXP BIOL, 1998.
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    • Hobeika, A. C., W. Etienne, P. E. Cruz, P. S. Subramaniam, and H. M. Johnson. “IFNγ induction of P21WAF1 in prostate cancer cells: Role in cell cycle and cell phenotype.” In Faseb Journal, 12:A283, 1998.
    • Kominsky, S., B. Torres, G. Bryan, A. Hobeika, T. Tanabe, P. Subramaniam, and H. M. Johnson. “IFNγ inhibition of cell growth in glioblastomas is accompanied by induction of the cyclin dependent kinase inhibitor p21.” In Faseb Journal, 12:A282, 1998.
    • Hobeika, A. C., P. S. Subramaniam, and H. M. Johnson. “Interferon induction of the tumor suppressor p21 inhibits cell cycle of tumor cells.” In Faseb Journal, Vol. 11, 1997.
    • Subramaniam, P. S., P. E. Cruz, A. C. Hobeika, and H. M. Johnson. “Type I IFN induction of the CDK-inhibitor P21^WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis in the daudi bcell line.” In Faseb Journal, Vol. 11, 1997.
    • Hobeika, A. C., P. S. Subramaniam, and H. M. Johnson. “Interferon induction of the tumor suppressor p21 inhibits cell cycle of tumor cells.” In Faseb Journal, 11:A1219–A1219. FEDERATION AMER SOC EXP BIOL, 1997.
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    • Subramaniam, P. S., P. E. Cruz, A. C. Hobeika, and H. M. Johnson. “Type I IFN induction of the CDK-inhibitor p21(WAF1) is accompanied by ordered G1 arrest, differentiation and apoptosis in the Daudi B-cell line.” In Faseb Journal, 11:A1219–A1219. FEDERATION AMER SOC EXP BIOL, 1997.
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    • Hobeika, A., P. S. Subramaniam, and H. M. Johnson. “Biochemical effects of type i interferons on prostate cancer cell cycle.” In Faseb Journal, Vol. 10, 1996.
    • HOBEIKA, A. C., and H. M. JOHNSON. “EVIDENCE THAT RESIDUES-121-149 OF THE STAPHYLOCOCCAL SUPERANTIGEN SEA ARE CRITICAL FOR SUPERANTIGEN ACTIVITY.” In Faseb Journal, 9:A1059–A1059. FEDERATION AMER SOC EXP BIOL, 1995.
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