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Amy Langdon Lark

Adjunct Assistant Professor in the Department of Pathology
F3196 VA Medical Center, Box 3712, Med. Ctr., Durham, NC 27710

Selected Publications

Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.

Journal Article Biomark Med · July 2018 AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Du ... Full text Link to item Cite

Intratumoral inflammation is associated with more aggressive prostate cancer.

Journal Article World J Urol · December 2013 PURPOSE: Inflammation may play a role in the development and progression of many cancers, including prostate cancer. We sought to test whether histological inflammation within prostate cancer was associated with more aggressive disease. METHODS: The slides ... Full text Link to item Cite

Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy.

Journal Article J Mol Diagn · March 2013 Prostate cancer is the most common cancer among men. The prospective discrimination of aggressive and clinically insignificant tumors still poses a significant and, as yet, unsolved problem. PITX2 DNA methylation is a strong prognostic biomarker in prostat ... Full text Link to item Cite

Endobronchial metastasis from primary anorectal melanoma.

Journal Article Am J Case Rep · 2013 PATIENT: Male, 64 FINAL DIAGNOSIS: Metastatic anorectal melanoma with endotracheal metastasis Symptoms: Fatigue • weight loss • hematochezia • cough MEDICATION: None Clinical Procedure: Biopsy of anal mass • rigid bronchoscopy Specialty: Internal medicine ... Full text Open Access Link to item Cite

Marked response of gliomatosis cerebri to temozolomide and whole brain radiotherapy.

Journal Article Clin Neurol Neurosurg · May 2012 Gliomatosis cerebri (GC) represents an unfortunate, rare variant of glioma with a very poor prognosis. Given this lesion's rarity, little information exists on appropriate treatment options. The diffuse, infiltrative nature of GC precludes any surgical res ... Full text Link to item Cite

Prostate biopsies from black men express higher levels of aggressive disease biomarkers than prostate biopsies from white men.

Journal Article Prostate Cancer Prostatic Dis · September 2011 A wide array of biomarkers is being investigated as predictors of prostate cancer (PCa) diagnosis and recurrence. We compared the expression of a small panel of these biomarkers as a function of race among men undergoing radical prostatectomy (RP). Prostat ... Full text Link to item Cite

Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer.

Journal Article J Urol · July 2010 PURPOSE: Radical prostatectomy is potentially curative in patients with clinically localized prostate cancer. However, biochemical recurrence affects 15% to 30% of men who undergo radical prostatectomy. We previously reported the prognostic potential of PI ... Full text Link to item Cite

Association between statins and prostate tumor inflammatory infiltrate in men undergoing radical prostatectomy.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2010 BACKGROUND: Cholesterol-lowering drugs known as statins have been reported to have significant anti-inflammatory properties. Given that inflammation may contribute to prostate cancer progression and that statins may reduce the risk for advanced prostate ca ... Full text Link to item Cite

FAK overexpression and p53 mutations are highly correlated in human breast cancer.

Journal Article Int J Cancer · October 1, 2009 Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to fi ... Full text Link to item Cite

High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype.

Journal Article Mod Pathol · October 2005 Focal adhesion kinase (FAK) is a protein tyrosine kinase expressed in invasive breast cancer that regulates antiapoptotic signaling. We have examined FAK expression by immunohistochemistry using anti-FAK 4.47 in breast tumor samples from a large population ... Full text Link to item Cite

Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis.

Journal Article Breast Cancer Res Treat · November 2004 Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in a subset of invasive breast cancers. FAK transmits signals that mediate several functions including tumor cell proliferation, migration, adhesion and survival. We used immuno ... Full text Link to item Cite

Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses.

Journal Article Clin Cancer Res · January 2003 PURPOSE: Focal adhesion kinase (FAK), a protein tyrosine kinase that functions in signaling events between cells and their extracellular matrix, is overexpressed in a variety of human solid tumors. To determine whether FAK expression is up-regulated in col ... Link to item Cite