Scholars@Duke

• Research
• 

  Selected Grants

  • Dissecting the role of the immune system in the radiation response of KRAS-mutant tumors awarded by National Institutes of Health 2017 - 2021
  • Dissecting the Mechanisms of Immune Mediated Radiation Resistance in Sarcomas awarded by Sarcoma Foundation of America 2017 - 2018
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Borchmann, Sven, Carolin Selenz, Mia Lohmann, Hanna Ludwig, Asmae Gassa, Johannes Brägelmann, Philipp Lohneis, et al. “Tripartite antigen-agnostic combination immunotherapy cures established poorly immunogenic tumors.” J Immunother Cancer 10, no. 10 (October 2022). https://doi.org/10.1136/jitc-2022-004781.
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    • Wisdom, Amy J., Yvonne M. Mowery, Cierra S. Hong, Jonathon E. Himes, Barzin Y. Nabet, Xiaodi Qin, Dadong Zhang, et al. “Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.” Nat Commun 11, no. 1 (December 17, 2020): 6410. https://doi.org/10.1038/s41467-020-19917-0.
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    • Wisdom, Amy J., and David G. Kirsch. “Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.” Cancer Res 80, no. 24 (December 15, 2020): 5459–61. https://doi.org/10.1158/0008-5472.CAN-20-3241.
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    • Wisdom, Amy, Yvonne Mowery, Cierra Hong, Xiaodi Qin, Dadong Zhang, Jonathon Himes, Lan Chen, et al. “A single cell atlas reveals distinct immune landscapes in transplant and primary tumors that determine response or resistance to immunotherapy,” 2020. https://doi.org/10.1101/2020.03.11.978387.
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    • Wisdom, Amy J., Cierra S. Hong, Alexander J. Lin, Yu Xiang, Daniel E. Cooper, Jin Zhang, Eric S. Xu, et al. “Neutrophils promote tumor resistance to radiation therapy.” Proc Natl Acad Sci U S A 116, no. 37 (September 10, 2019): 18584–89. https://doi.org/10.1073/pnas.1901562116.
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    • Mowery, Yvonne M., Kirtesh Patel, Mudit Chowdhary, Christel N. Rushing, Kingshuk Roy Choudhury, Jared R. Lowe, Adam C. Olson, et al. “Retrospective analysis of safety and efficacy of anti-PD-1 therapy and radiation therapy in advanced melanoma: A bi-institutional study.” Radiother Oncol 138 (September 2019): 114–20. https://doi.org/10.1016/j.radonc.2019.06.013.
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    • Lee, Chang-Lung, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, et al. “Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.” Jci Insight 4, no. 13 (July 11, 2019). https://doi.org/10.1172/jci.insight.128698.
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    • Wisdom, Amy J., and David G. Kirsch. “Functional assay to guide precision radiotherapy by assessing individual patient radiosensitivity.” Ebiomedicine 41 (March 2019): 26–27. https://doi.org/10.1016/j.ebiom.2019.03.002.
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    • Wisdom, Amy J., Yvonne M. Mowery, Richard F. Riedel, and David G. Kirsch. “Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.” Cancer 124, no. 19 (October 1, 2018): 3819–29. https://doi.org/10.1002/cncr.31517.
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    • Carpenter, David J., Yvonne M. Mowery, Gloria Broadwater, Anna Rodrigues, Amy J. Wisdom, Jennifer A. Dorth, Pretesh R. Patel, Cynthia K. Shortell, Robert Clough, and David M. Brizel. “The risk of carotid stenosis in head and neck cancer patients after radiation therapy.” Oral Oncol 80 (May 2018): 9–15. https://doi.org/10.1016/j.oraloncology.2018.02.021.
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    • Brownstein, Jeremy M., Amy J. Wisdom, Katherine D. Castle, Yvonne M. Mowery, Peter Guida, Chang-Lung Lee, Francesco Tommasino, et al. “Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma.” Mol Cancer Ther 17, no. 4 (April 2018): 858–68. https://doi.org/10.1158/1535-7163.MCT-17-0965.
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    • Castle, Katherine D., Mark Chen, Amy J. Wisdom, and David G. Kirsch. “Genetically engineered mouse models for studying radiation biology.” Transl Cancer Res 6, no. Suppl 5 (July 2017): S900–913. https://doi.org/10.21037/tcr.2017.06.19.
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    • Shammas, Ronnie L., Andrew M. Fales, Bridget M. Crawford, Amy J. Wisdom, Gayathri R. Devi, David A. Brown, Tuan Vo-Dinh, and Scott T. Hollenbeck. “Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation.” Plast Reconstr Surg 139, no. 4 (April 2017): 900e-910e. https://doi.org/10.1097/PRS.0000000000003187.
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    • Wisdom, Amy J., Yuan Cao, Noriko Itoh, Rory D. Spence, and Rhonda R. Voskuhl. “Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model.” J Neurosci Res 91, no. 7 (July 2013): 901–8. https://doi.org/10.1002/jnr.23219.
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    • Spence, Rory D., Amy J. Wisdom, Yuan Cao, Haley M. Hill, Chandler R. L. Mongerson, Briana Stapornkul, Noriko Itoh, Michael V. Sofroniew, and Rhonda R. Voskuhl. “Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.” J Neurosci 33, no. 26 (June 26, 2013): 10924–33. https://doi.org/10.1523/JNEUROSCI.0886-13.2013.
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    • Spence, Rory D., Mary E. Hamby, Elizabeth Umeda, Noriko Itoh, Sienmi Du, Amy J. Wisdom, Yuan Cao, et al. “Neuroprotection mediated through estrogen receptor-alpha in astrocytes.” Proc Natl Acad Sci U S A 108, no. 21 (May 24, 2011): 8867–72. https://doi.org/10.1073/pnas.1103833108.
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  • Book Sections

    • Wisdom, A. J., Y. M. Mowery, and D. G. Kirsch. “Radiation and immunotherapy for sarcoma.” In Immunotherapy of Sarcoma, 47–65, 2018. https://doi.org/10.1007/978-3-319-93530-0_4.
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  • Conference Papers

    • Kent, C. L., Y. M. Mowery, A. J. Wisdom, J. Himes, A. M. Bassil, D. Odhiambo, and D. G. Kirsch. “A Novel Combination of Immunotherapy and Radiation Therapy in a Primary Mouse Model of Soft Tissue Sarcoma With High Mutational Load.” In International Journal of Radiation Oncology, Biology, Physics, 111:S122–23, 2021. https://doi.org/10.1016/j.ijrobp.2021.07.280.
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