Current Appointments & Affiliations
Assistant Research Professor of Pharmacology and Cancer Biology
·
2002 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of Sarah W. Stedman Nutrition and Metabolism Center
·
2011 - Present
Sarah Stedman Nutrition & Metabolism Center,
Duke Molecular Physiology Institute
Recent Publications
Statin therapy inhibits fatty acid synthase via dynamic protein modifications.
Journal Article Nat Commun · May 10, 2022 Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate. Recent discoveries have shown H ... Full text Link to item CiteDeglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Journal Article J Biol Chem · April 2022 A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be none ... Full text Link to item Citeβ-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
Journal Article Am J Physiol Endocrinol Metab · October 1, 2020 Sirtuins are a family of proteins that regulate biological processes such as cellular stress and aging by removing posttranslational modifications (PTMs). We recently identified several novel PTMs that can be removed by sirtuin 4 (SIRT4), which is found in ... Full text Link to item CiteRecent Grants
Studies on the Mechanisms by which SIRT5 Regulates Aging and Disease
ResearchResearch Scientist · Awarded by National Institutes of Health · 2019 - 2024Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism
ResearchSenior Research Scientist · Awarded by National Institutes of Health · 2018 - 2022SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease
ResearchResearch Scientist · Awarded by Ellison Medical Foundation · 2013 - 2018View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
1994
Ph.D.