Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina at Chapel Hill 1994
• Research
• 

  Selected Grants

  • Post-Translational and Epigenetic Control of Branched-Chain Amino Acid Metabolism awarded by National Institutes of Health 2018 - 2022
  • Novel SIRT5 Enzymatic Activity Regulates Cellular Mechanisms of Aging and Disease awarded by National Institutes of Health 2014 - 2019
  • SIRT5 Regulates Mitochondrial Metabolism in Aging and Disease awarded by Ellison Medical Foundation 2013 - 2018
  • Novel SIRT4 Enzymatic Activity Influence Cellular Mechanisms of Aging awarded by National Institutes of Health 2016 - 2017
  • Hormonal regulation of a Ca2+/AMPK signaling pathway awarded by National Institutes of Health 1984 - 2011
  • CaM Kinase Cascades in Endocrine Cells awarded by National Institutes of Health 1997 - 2011
  • Activation & Function Of Human Cam Kinase Iv In T-Cell awarded by National Institutes of Health 1995 - 1998
  • Activation And Function Of Human Cam Kinase Iv In T Cells awarded by National Institutes of Health 1995 - 1998
  • Activation And Function Of Human Cam Kinase Iv In T-Cells awarded by National Institutes of Health 1994 - 1998
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Huynh, FK, Mcdonnell, E, Anderson, KA, and Hirschey, MD. "Sirtuins." In Signaling Pathways in Liver Diseases: Third Edition, 374-384. September 28, 2015.  Full Text

  • Conference Papers

    • Bae, H, Anderson, K, Flood, LA, Skiba, NP, Hamm, HE, and Gräber, SG. "Molecular Determinants of Selectivity in Receptor-G protein Interaction." December 1, 1997.

  • Journal Articles

    • Anderson, KA, Madsen, AS, Olsen, CA, and Hirschey, MD. "Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio." Biochimica et biophysica acta 1858, no. 12 (December 2017): 991-998. (Review)  Full Text
    • Anderson, KA, Huynh, FK, Fisher-Wellman, K, Stuart, JD, Peterson, BS, Douros, JD, Wagner, GR, Thompson, JW, Madsen, AS, Green, MF, Sivley, RM, Ilkayeva, OR, Stevens, RD, Backos, DS, Capra, JA, Olsen, CA, Campbell, JE, Muoio, DM, Grimsrud, PA, and Hirschey, MD. "SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion." Cell metabolism 25, no. 4 (April 2017): 838-855.e15.  Full Text
    • Madsen, AS, Andersen, C, Daoud, M, Anderson, KA, Laursen, JS, Chakladar, S, Huynh, FK, Colaço, AR, Backos, DS, Fristrup, P, Hirschey, MD, and Olsen, CA. "Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH." The Journal of biological chemistry 291, no. 13 (March 2016): 7128-7141.  Full Text
    • Anderson, KA, Green, MF, Huynh, FK, Wagner, GR, and Hirschey, MD. "SnapShot: Mammalian Sirtuins." Cell 159, no. 4 (November 2014): 956-956.e1.  Full Text
    • Tan, M, Peng, C, Anderson, KA, Chhoy, P, Xie, Z, Dai, L, Park, J, Chen, Y, Huang, H, Zhang, Y, Ro, J, Wagner, GR, Green, MF, Madsen, AS, Schmiesing, J, Peterson, BS, Xu, G, Ilkayeva, OR, Muehlbauer, MJ, Braulke, T, Mühlhausen, C, Backos, DS, Olsen, CA, McGuire, PJ, Pletcher, SD, Lombard, DB, Hirschey, MD, and Zhao, Y. "Lysine glutarylation is a protein posttranslational modification regulated by SIRT5." Cell metabolism 19, no. 4 (April 2014): 605-617.  Full Text
    • Anderson, KA, Wang, D, and Hirschey, MD. "HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint?." Hepatology 57, no. 5 (May 2013): 1681-1683.  Full Text  Link to Item
    • Hershberger, KA, Motley, J, Hirschey, MD, and Anderson, KA. "Generating mammalian sirtuin tools for protein-interaction analysis." Methods Mol Biol 1077 (2013): 69-78.  Full Text  Link to Item
    • Anderson, KA, Lin, F, Ribar, TJ, Stevens, RD, Muehlbauer, MJ, Newgard, CB, and Means, AR. "Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse." Mol Endocrinol 26, no. 2 (February 2012): 281-291.  Full Text  Link to Item
    • Anderson, KA, and Hirschey, MD. "Mitochondrial protein acetylation regulates metabolism." Essays Biochem 52 (2012): 23-35. (Review)  Full Text  Link to Item
    • Green, MF, Anderson, KA, and Means, AR. "Characterization of the CaMKKβ-AMPK signaling complex." Cell Signal 23, no. 12 (December 2011): 2005-2012.  Full Text  Link to Item
    • Kokubo, M, Nishio, M, Ribar, TJ, Anderson, KA, West, AE, and Means, AR. "BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, no. 28 (July 2009): 8901-8913.  Full Text
    • Anderson, KA, and Means, AR. "Central control of feeding. (Published online)" F1000 Biol Rep 1 (January 21, 2009): 10-.  Full Text  Link to Item
    • Anderson, KA, Ribar, TJ, Lin, F, Noeldner, PK, Green, MF, Muehlbauer, MJ, Witters, LA, Kemp, BE, and Means, AR. "Hypothalamic CaMKK2 contributes to the regulation of energy balance." Cell Metab 7, no. 5 (May 2008): 377-388.  Full Text  Link to Item
    • Hurley, RL, Barré, LK, Wood, SD, Anderson, KA, Kemp, BE, Means, AR, and Witters, LA. "Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP." J Biol Chem 281, no. 48 (December 1, 2006): 36662-36672.  Full Text  Link to Item
    • Hurley, RL, Anderson, KA, Franzone, JM, Kemp, BE, Means, AR, and Witters, LA. "The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases." J Biol Chem 280, no. 32 (August 12, 2005): 29060-29066.  Full Text  Link to Item
    • Chow, FA, Anderson, KA, Noeldner, PK, and Means, AR. "The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription." J Biol Chem 280, no. 21 (May 27, 2005): 20530-20538.  Full Text  Link to Item
    • Anderson, KA, Noeldner, PK, Reece, K, Wadzinski, BE, and Means, AR. "Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex." J Biol Chem 279, no. 30 (July 23, 2004): 31708-31716.  Full Text  Link to Item
    • Lemrow, SM, Anderson, KA, Joseph, JD, Ribar, TJ, Noeldner, PK, and Means, AR. "Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus." J Biol Chem 279, no. 12 (March 19, 2004): 11664-11671.  Full Text  Link to Item
    • Anderson, KA, and Means, AR. "Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV." Mol Cell Biol 22, no. 1 (January 2002): 23-29.  Link to Item
    • Anderson, KA, Means, RL, Huang, QH, Kemp, BE, Goldstein, EG, Selbert, MA, Edelman, AM, Fremeau, RT, and Means, AR. "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta." J Biol Chem 273, no. 48 (November 27, 1998): 31880-31889.  Link to Item
    • Westphal, RS, Anderson, KA, Means, AR, and Wadzinski, BE. "A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A." Science 280, no. 5367 (May 22, 1998): 1258-1261.  Link to Item
    • Anderson, KA, and Kane, CD. "Ca²⁺/calmodulin-dependent protein kinase IV and calcium signaling." BioMetals 11, no. 4 (1998): 331-343.  Full Text
    • Bae, H, Anderson, K, Flood, LA, Skiba, NP, Hamm, HE, and Graber, SG. "Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions." The Journal of biological chemistry 272, no. 51 (December 1997): 32071-32077.  Full Text
    • Anderson, KA, Ribar, TJ, Illario, M, and Means, AR. "Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV." Mol Endocrinol 11, no. 6 (June 1997): 725-737.  Full Text  Link to Item
    • Means, AR, Ribar, TJ, Kane, CD, Hook, SS, and Anderson, KA. "Regulation and properties of the rat Ca2+/calmodulin-dependent protein kinase IV gene and its protein products." Recent Prog Horm Res 52 (1997): 389-406. (Review)  Link to Item
    • Chatila, T, Anderson, KA, Ho, N, and Means, AR. "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR." J Biol Chem 271, no. 35 (August 30, 1996): 21542-21548.  Link to Item
    • Edelman, AM, Mitchelhill, KI, Selbert, MA, Anderson, KA, Hook, SS, Stapleton, D, Goldstein, EG, Means, AR, and Kemp, BE. "Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence." J Biol Chem 271, no. 18 (May 3, 1996): 10806-10810.  Link to Item
    • Selbert, MA, Anderson, KA, Huang, QH, Goldstein, EG, Means, AR, and Edelman, AM. "Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation." J Biol Chem 270, no. 29 (July 21, 1995): 17616-17621.  Link to Item
    • Anderson, K, and Meissner, G. "T-tubule depolarization-induced SR Ca²⁺ release is controlled by dihydropyridine receptor- and Ca²⁺-dependent mechanisms in cell homogenates from rabbit skeletal muscle." Journal of General Physiology 105, no. 3 (1995): 363-383.
    • Anderson, K, Cohn, AH, and Meissner, G. "High-affinity [³H]PN200-110 and [³H]ryanodine binding to rabbit and frog skeletal muscle." American Journal of Physiology - Cell Physiology 266, no. 2 35-2 (1994): C462-C466.
    • Ma, J, Anderson, K, Shirokov, R, Levis, R, González, A, Karhanek, M, Hosey, MM, Meissner, G, and Ríos, E. "Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle." Journal of General Physiology 102, no. 3 (1993): 423-448.
    • Meissner, G, Lai, FA, Anderson, K, Xu, L, Liu, Q-Y, Herrmann-Frank, A, Rousseau, E, Jones, RV, and Lee, H-B. "Purification and reconstitution of the ryanodine- and caffeine-sensitive Ca²⁺ release channel complex from muscle sarcoplasmic reticulum." Advances in Experimental Medicine and Biology 304 (1991): 241-256.
    • Anderson, K, Lai, FA, Liu, QY, Rousseau, E, Erickson, HP, and Meissner, G. "Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex." J Biol Chem 264, no. 2 (January 15, 1989): 1329-1335.  Link to Item
    • Lai, FA, Anderson, K, Rousseau, E, Liu, Q-Y, and Meissner, G. "Evidence for a Ca²⁺ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum." Biochemical and Biophysical Research Communications 151, no. 1 (1988): 441-449.
    • Meissner, G, Rousseau, E, Lai, FA, Liu, Q-Y, and Anderson, KA. "Biochemical characterization of the Ca²⁺ release channel of skeletal and cardiac sarcoplasmic reticulum." Molecular and Cellular Biochemistry 82, no. 1-2 (1988): 59-65.  Full Text

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